{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T20:39:11Z","timestamp":1768595951222,"version":"3.49.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1038\/s41390-025-04314-4","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T09:46:27Z","timestamp":1754559987000},"page":"1988-1990","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The potential for identification of biomarkers specific for childhood-onset lupus nephritis using bioinformatics"],"prefix":"10.1038","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8991-8277","authenticated-orcid":false,"given":"Scott E.","family":"Wenderfer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"4314_CR1","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.ekir.2022.10.014","volume":"8","author":"EY Chan","year":"2023","unstructured":"Chan, E. Y. et al. Long-term outcomes of children and adolescents with biopsy-proven childhood-onset lupus nephritis. Kidney Int. Rep. 8, 141\u2013150 (2023).","journal-title":"Kidney Int. Rep."},{"key":"4314_CR2","doi-asserted-by":"publisher","first-page":"3532","DOI":"10.1016\/j.ekir.2024.09.028","volume":"9","author":"DYH Yap","year":"2024","unstructured":"Yap, D. Y. H. et al. Long-term kidney outcome of lupus nephritis by renal response status. Kidney Int. Rep. 9, 3532\u20133541 (2024).","journal-title":"Kidney Int. Rep."},{"key":"4314_CR3","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1093\/rheumatology\/kead447","volume":"63","author":"EY-h Chan","year":"2023","unstructured":"Chan, E. Y. -h. et al. Renal relapse in children and adolescents with childhood-onset lupus nephritis: a 20-year study. Rheumatology 63, 953\u2013961 (2023).","journal-title":"Rheumatology"},{"key":"4314_CR4","doi-asserted-by":"publisher","unstructured":"Wu, X. et al. Identification of childhood-onset lupus nephritis through integrative bioinformatics: otoferlin as a novel biomarker. Pediatric Res. https:\/\/doi.org\/10.1038\/s41390-025-04171-1 (2025).","DOI":"10.1038\/s41390-025-04171-1"},{"key":"4314_CR5","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.cell.2006.08.040","volume":"127","author":"I Roux","year":"2006","unstructured":"Roux, I. et al. Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse. Cell 127, 277\u2013289 (2006).","journal-title":"Cell"},{"key":"4314_CR6","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1086\/303049","volume":"67","author":"S Yasunaga","year":"2000","unstructured":"Yasunaga, S. et al. OTOF encodes multiple long and short isoforms: genetic evidence that the long ones underlie recessive deafness DFNB9. Am. J. Hum. Genet. 67, 591\u2013600 (2000).","journal-title":"Am. J. Hum. Genet."},{"key":"4314_CR7","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01738-22","volume":"13","author":"H Ding","year":"2022","unstructured":"Ding, H. et al. Membrane protein OTOF is a type I interferon-induced entry inhibitor of HIV-1 in macrophages. mBio 13, e0173822 (2022).","journal-title":"mBio"},{"key":"4314_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-04302-8","volume":"12","author":"EDO Roberson","year":"2022","unstructured":"Roberson, E. D. O. et al. Transcriptomes of peripheral blood mononuclear cells from juvenile dermatomyositis patients show elevated inflammation even when clinically inactive. Sci. Rep. 12, 275 (2022).","journal-title":"Sci. Rep."},{"key":"4314_CR9","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.cell.2016.03.008","volume":"165","author":"R Banchereau","year":"2016","unstructured":"Banchereau, R. et al. Personalized Immunomonitoring Uncovers Molecular Networks That Stratify Lupus Patients. Cell 165, 551\u2013565 (2016).","journal-title":"Cell"},{"key":"4314_CR10","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1002\/art.37785","volume":"65","author":"BR Lauwerys","year":"2013","unstructured":"Lauwerys, B. R. et al. Down-regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon \u03b1\u2013kinoid. Arthritis Rheumatism 65, 447\u2013456 (2013).","journal-title":"Arthritis Rheumatism"},{"key":"4314_CR11","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1093\/rheumatology\/kew262","volume":"55","author":"J Ducreux","year":"2016","unstructured":"Ducreux, J. et al. Interferon \u03b1 kinoid induces neutralizing anti-interferon \u03b1 antibodies that decrease the expression of interferon-induced and b cell activation associated transcripts: analysis of extended follow-up data from the interferon \u03b1 kinoid phase i\/ii study. Rheumatology 55, 1901\u20131905 (2016).","journal-title":"Rheumatology"},{"key":"4314_CR12","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1186\/s13075-016-1050-x","volume":"18","author":"H Zhu","year":"2016","unstructured":"Zhu, H. et al. Whole-genome transcription and DNA methylation analysis of peripheral blood mononuclear cells identified aberrant gene regulation pathways in systemic lupus erythematosus. Arthritis Res. Ther. 18, 162 (2016).","journal-title":"Arthritis Res. Ther."},{"key":"4314_CR13","doi-asserted-by":"publisher","first-page":"e0196117","DOI":"10.1371\/journal.pone.0196117","volume":"13","author":"JE Wither","year":"2018","unstructured":"Wither, J. E. et al. Identification of a neutrophil-related gene expression signature that is enriched in adult systemic lupus erythematosus patients with active nephritis: clinical\/pathologic associations and etiologic mechanisms. PLoS ONE 13, e0196117 (2018).","journal-title":"PLoS ONE"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-025-04314-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-025-04314-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-025-04314-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:35:45Z","timestamp":1768552545000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-025-04314-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,7]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["4314"],"URL":"https:\/\/doi.org\/10.1038\/s41390-025-04314-4","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,7]]},"assertion":[{"value":"29 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The author declares no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}