{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:24:40Z","timestamp":1791811480363,"version":"4.3.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1038\/s41390-025-04367-5","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:10:16Z","timestamp":1758586216000},"page":"1338-1350","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Detection of peripheral infusion-related infiltration and extravasation in neonates: a scoping review"],"prefix":"10.1038","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9359-0895","authenticated-orcid":false,"given":"Matheus F. P. T.","family":"van Rens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1144-163X","authenticated-orcid":false,"given":"Anita","family":"Huis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3096-9635","authenticated-orcid":false,"given":"Kevin","family":"Hugill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4487-2962","authenticated-orcid":false,"given":"Robin","family":"van der Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3194-7005","authenticated-orcid":false,"given":"Willem P.","family":"de Boode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"4367_CR1","doi-asserted-by":"crossref","unstructured":"van Rens, M. R. et al. The NAVIGATE project: a GloVANet-WoCoVA position statement on the nomenclature for vascular access devices. J. Vasc. Access 26, 1439\u20131446 (2025).","DOI":"10.1177\/11297298241291248"},{"key":"4367_CR2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-047788","volume":"11","author":"M van Rens","year":"2021","unstructured":"van Rens, M. et al. Evaluation of unmodifiable and potentially modifiable factors affecting peripheral intravenous device-related complications in neonates: a retrospective observational study. BMJ Open 11, e047788 (2021).","journal-title":"BMJ Open"},{"key":"4367_CR3","first-page":"230","volume":"3","author":"J Pettit","year":"2003","unstructured":"Pettit, J. Assessment of the infant with a peripheral intravenous device. Adv. Neonatal Care 3, 230\u2013240 (2003).","journal-title":"Adv. Neonatal Care"},{"key":"4367_CR4","doi-asserted-by":"publisher","first-page":"360","DOI":"10.5301\/jva.5000558","volume":"17","author":"M Legemaat","year":"2016","unstructured":"Legemaat, M. et al. Peripheral intravenous cannulation: complication rates in the neonatal population: a multicenter observational study. J. Vasc. Access. 17, 360 (2016).","journal-title":"J. Vasc. Access."},{"key":"4367_CR5","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1097\/NAN.0000000000000532","volume":"47","author":"B Nickel","year":"2024","unstructured":"Nickel, B. et al. Infusion therapy standards of practice, 9th edition. J. Infus. Nurs. 47, S1\u2013S285 (2024).","journal-title":"J. Infus. Nurs."},{"key":"4367_CR6","doi-asserted-by":"publisher","first-page":"326","DOI":"10.29252\/wjps.9.3.326","volume":"9","author":"L Alexander","year":"2020","unstructured":"Alexander, L. Extravasation injuries: a trivial injury often overlooked with disastrous consequences. World J. Plast. Surg. 9, 326\u2013330 (2020).","journal-title":"World J. Plast. Surg."},{"key":"4367_CR7","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1053\/j.nainr.2013.09.001","volume":"13","author":"V Beall","year":"2013","unstructured":"Beall, V., Hall, B., Mulholland, J. T. & Gephart, S. M. Neonatal extravasation: an overview and algorithm for evidence-based treatment. Newborn Inf. Nurs. Rev. 13, 189\u2013195 (2013).","journal-title":"Newborn Inf. Nurs. Rev."},{"key":"4367_CR8","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1097\/ANC.0000000000000690","volume":"20","author":"EM Bosque","year":"2020","unstructured":"Bosque, E. M. Development of an alarm algorithm, with nanotechnology multimodal sensor, to predict impending infusion failure and improve safety of peripheral intravenous catheters in neonates. Adv. Neonatal Care 20, 233\u2013243 (2020).","journal-title":"Adv. Neonatal Care"},{"key":"4367_CR9","doi-asserted-by":"crossref","unstructured":"Cheng, M.-Y. et al. Wearable sensor patch for early extravasation detection. In Proc. 2016 IEEE 66th Electronic Components and Technology Conference (ECTC) 1632\u20131637 (IEEE, 2016).","DOI":"10.1109\/ECTC.2016.82"},{"key":"4367_CR10","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1097\/WON.0000000000000728","volume":"48","author":"V Boyar","year":"2021","unstructured":"Boyar, V. & Galiczewski, C. Reducing peripheral intravenous catheter extravasation in neonates: a quality improvement project. J. Wound Ostomy Cont. Nurs. 48, 31\u201338 (2021).","journal-title":"J. Wound Ostomy Cont. Nurs."},{"key":"4367_CR11","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1097\/NAN.0000000000000431","volume":"44","author":"GJ Cline","year":"2021","unstructured":"Cline, G. J., Pohlod, V., Burger, K. J. & Amankwah, E. K. Measuring the validity and reliability of the vascular access complication staging and treatment instrument in a pediatric population. J. Infus. Nurs. 44, 225\u2013243 (2021).","journal-title":"J. Infus. Nurs."},{"key":"4367_CR12","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1177\/11297298231177723","volume":"25","author":"V D\u2019Andrea","year":"2024","unstructured":"D\u2019Andrea, V. et al. Optical detection of infiltration during peripheral intravenous infusion in neonates. J. Vasc. Access 25, 1780\u20131785 (2024).","journal-title":"J. Vasc. Access"},{"key":"4367_CR13","doi-asserted-by":"publisher","first-page":"44","DOI":"10.2309\/j.java.2019.002.003","volume":"24","author":"D Doellman","year":"2019","unstructured":"Doellman, D. & Rineair, S. A. The use of optical detection for continuous monitoring of pediatric IV sites. J. Assoc. Vasc. Access 24, 44\u201347 (2019).","journal-title":"J. Assoc. Vasc. Access"},{"key":"4367_CR14","unstructured":"Joanna Briggs Institute. JBI Manual for evidence synthesis. [cited 2025 10 Mar]. Latest Edition. Available from: https:\/\/jbi-global-wiki.refined.site\/space\/MANUAL\/355862497 (Joanna Briggs Institute, 2025)."},{"key":"4367_CR15","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/XEB.0000000000000277","volume":"19","author":"MDJ Peters","year":"2021","unstructured":"Peters, M. D. J. et al. Updated methodological guidance for the conduct of scoping reviews. JBI Evid. Implement. 19, 3\u201310 (2021).","journal-title":"JBI Evid. Implement."},{"key":"4367_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-016-0116-4","volume":"16","author":"AC Tricco","year":"2016","unstructured":"Tricco, A. C. et al. A scoping review on the conduct and reporting of scoping reviews. BMC Med. Res. Methodol. 16, 15 (2016).","journal-title":"BMC Med. Res. Methodol."},{"key":"4367_CR17","doi-asserted-by":"publisher","first-page":"467","DOI":"10.7326\/M18-0850","volume":"169","author":"AC Tricco","year":"2018","unstructured":"Tricco, A. C. et al. PRISMA Extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann. Intern. Med. 169, 467\u2013473 (2018).","journal-title":"Ann. Intern. Med."},{"key":"4367_CR18","unstructured":"Clarivate Analytics. EndNote [Internet]. 2020 [cited 2025 Mar 10]. Available from: https:\/\/www.endnote.com\/."},{"key":"4367_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0384-4","volume":"5","author":"MHH Ouzzani","year":"2016","unstructured":"Ouzzani, M. H. H., Fedorowicz, Z. & Elmagarmid, A. Rayyan\u2014a web and mobile app for systematic reviews. Syst. Rev. 5, 210 (2016).","journal-title":"Syst. Rev."},{"key":"4367_CR20","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1891\/0730-0832.20.5.33","volume":"20","author":"LS Franck","year":"2001","unstructured":"Franck, L. S., Hummel, D., Connell, K., Quinn, D. & Montgomery, J. The safety and efficacy of peripheral intravenous catheters in ill neonates. Neonatal Netw. 20, 33\u201338 (2001).","journal-title":"Neonatal Netw."},{"key":"4367_CR21","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1177\/1129729817747532","volume":"19","author":"GO Gerceker","year":"2018","unstructured":"Gerceker, G. O. et al. Infiltration and extravasation in pediatric patients: a prevalence study in a children\u2019s hospital. J. Vasc. Access 19, 266\u2013271 (2018).","journal-title":"J. Vasc. Access"},{"key":"4367_CR22","doi-asserted-by":"publisher","DOI":"10.1590\/0034-7167-2019-0300","volume":"73","author":"EDC Rodrigues","year":"2020","unstructured":"Rodrigues, E. D. C. et al. Content translation and validation of the pediatric PIV infiltration scale into Brazilian Portuguese. Rev. Bras. Enferm. 73, e20190300 (2020).","journal-title":"Rev. Bras. Enferm."},{"key":"4367_CR23","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1097\/NAN.0b013e31825af323","volume":"35","author":"R Simona","year":"2012","unstructured":"Simona, R. A pediatric peripheral intravenous infiltration assessment tool. J. Infus. Nurs. 35, 243\u2013248 (2012).","journal-title":"J. Infus. Nurs."},{"key":"4367_CR24","doi-asserted-by":"publisher","first-page":"e13","DOI":"10.1016\/j.pedn.2018.10.011","volume":"44","author":"M Incekar","year":"2019","unstructured":"Incekar, M. et al. Turkish validation of the infiltration scale in infants. J. Pediatr. Nurs. 44, e13\u2013e19 (2019).","journal-title":"J. Pediatr. Nurs."},{"key":"4367_CR25","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.pedn.2012.01.005","volume":"27","author":"BF Tofani","year":"2012","unstructured":"Tofani, B. F. et al. Quality improvement project to reduce infiltration and extravasation events in a pediatric hospital. J. Pediatr. Nurs. 27, 682\u2013689 (2012).","journal-title":"J. Pediatr. Nurs."},{"key":"4367_CR26","doi-asserted-by":"crossref","unstructured":"Lin, J.-S., Kuo, C.-W., Huang, W.-C., & Lee, H.-C. A sensor-fusion approach system for detecting early extravasation of infant intravenous infusion. In Proc. 18th International Conference on Information Processing in Sensor Networks 344\u2013345 (ACM, 2019).","DOI":"10.1145\/3302506.3312485"},{"key":"4367_CR27","doi-asserted-by":"crossref","unstructured":"Mabrouk, S. et al. Multi-modal local physiological sensing at the intravenous catheter insertion site: towards automated IV infiltration detection. (Georgia Institute of Technology, 2020).","DOI":"10.1109\/SENSORS47125.2020.9278903"},{"key":"4367_CR28","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1177\/11297298231185536","volume":"25","author":"MF van Rens","year":"2024","unstructured":"van Rens, M. F. et al. Peripheral intravenous therapy infiltration\/extravasation (PIVIE) risks and the potential for earlier notification of events using a novel sensor technology in a neonatal population. J. Vasc. Access 25, 1801\u20131807 (2024).","journal-title":"J. Vasc. Access"},{"key":"4367_CR29","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1097\/JPN.0000000000000589","volume":"37","author":"C McIntyre","year":"2023","unstructured":"McIntyre, C. et al. Neonatal vascular access practice and complications: an observational study of 1375 catheter days. J. Perinat. Neonatal Nurs. 37, 332\u2013339 (2023).","journal-title":"J. Perinat. Neonatal Nurs."},{"key":"4367_CR30","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1097\/NAN.0000000000000131","volume":"38","author":"JT Taylor","year":"2015","unstructured":"Taylor, J. T. Implementing an evidence-based practice project in the prevention of peripheral intravenous site infiltrations in children. J. Infus. Nurs. 38, 430\u2013435 (2015).","journal-title":"J. Infus. Nurs."},{"key":"4367_CR31","doi-asserted-by":"publisher","first-page":"309","DOI":"10.4274\/jpr.galenos.2020.98470","volume":"7","author":"AGG Kahraman","year":"2020","unstructured":"Kahraman, A. G. G. et al. The effect of a nurse education program on infiltration and extravasation in pediatric patients at a university hospital. J. Pediatr. Res. 7, 309\u2013315 (2020).","journal-title":"J. Pediatr. Res."},{"key":"4367_CR32","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1186\/s12887-020-02346-9","volume":"20","author":"KM Chan","year":"2020","unstructured":"Chan, K. M. et al. Clinical practice guideline on the prevention and management of neonatal extravasation injury: a before-and-after study design. BMC Pediatr. 20, 445 (2020).","journal-title":"BMC Pediatr."},{"key":"4367_CR33","first-page":"547","volume":"118","author":"RK Hackenberg","year":"2021","unstructured":"Hackenberg, R. K. et al. Extravasation injuries of the limbs in neonates and children-development of a treatment algorithm. Dtsch. Arztebl. Int. 118, 547\u2013554 (2021).","journal-title":"Dtsch. Arztebl. Int."},{"key":"4367_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.980725","volume":"10","author":"M van Rens","year":"2022","unstructured":"van Rens, M. et al. The ABBA project (Assess Better Before Access): a retrospective cohort study of neonatal intravascular device outcomes. Front. Pediatr. 10, 980725 (2022).","journal-title":"Front. Pediatr."},{"key":"4367_CR35","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/j.1744-1609.2011.00213.x","volume":"9","author":"D Warren","year":"2011","unstructured":"Warren, D. Implementation of a protocol for the prevention and management of extravasation injuries in the neonatal intensive care patient. Int. J. Evid. Based Healthc. 9, 165\u2013171 (2011).","journal-title":"Int. J. Evid. Based Healthc."},{"key":"4367_CR36","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.pedn.2018.01.003","volume":"41","author":"K Watterson","year":"2018","unstructured":"Watterson, K. et al. S.T.I.C.K.: a quality improvement pediatric IV infiltration prevention bundle. J. Pediatr. Nurs. 41, 38\u201341 (2018).","journal-title":"J. Pediatr. Nurs."},{"key":"4367_CR37","volume":"2015","author":"N Marsh","year":"2015","unstructured":"Marsh, N., Webster, J., Mihala, G. & Rickard, C. M. Devices and dressings to secure peripheral venous catheters to prevent complications. Cochrane Database Syst. Rev. 2015, CD011070 (2015).","journal-title":"Cochrane Database Syst. Rev."},{"key":"4367_CR38","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1177\/0310057X211062614","volume":"50","author":"MD Mecoli","year":"2022","unstructured":"Mecoli, M. D. et al. Factors associated with intraoperative intravenous catheter extravasation in children. Anaesth. Inten. Care 50, 306\u2013311 (2022).","journal-title":"Anaesth. Inten. Care"},{"key":"4367_CR39","doi-asserted-by":"publisher","first-page":"E91","DOI":"10.1111\/j.1440-1754.2010.01934.x","volume":"48","author":"J Wu","year":"2012","unstructured":"Wu, J. & Mu, D. Vascular catheter-related complications in newborns. J. Paediatr. Child Health 48, E91\u201395 (2012).","journal-title":"J. Paediatr. Child Health"},{"key":"4367_CR40","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1097\/SAP.0b013e3182085915","volume":"67","author":"SG Talbot","year":"2011","unstructured":"Talbot, S. G. & Rogers, G. F. Pediatric compartment syndrome caused by intravenous infiltration. Ann. Plast. Surg. 67, 531\u2013533 (2011).","journal-title":"Ann. Plast. Surg."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-025-04367-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-025-04367-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-025-04367-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:51:43Z","timestamp":1776844303000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-025-04367-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,23]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["4367"],"URL":"https:\/\/doi.org\/10.1038\/s41390-025-04367-5","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,23]]},"assertion":[{"value":"13 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}