{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T02:56:51Z","timestamp":1780714611273,"version":"3.54.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"DOI":"10.1038\/s41390-026-04941-5","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:54:45Z","timestamp":1777478085000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Daily clinical markers in metabolic bone disease of prematurity"],"prefix":"10.1038","author":[{"given":"Hiroko","family":"Tomotaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichi","family":"Tomotaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouji","family":"Motokura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Araki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Takita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"4941_CR1","doi-asserted-by":"publisher","first-page":"332","DOI":"10.4274\/jcrpe.galenos.2019.2019.0091","volume":"12","author":"S Chacham","year":"2020","unstructured":"Chacham, S., Pasi, R., Chegondi, M., Ahmad, N. & Mohanty, S. B. Metabolic bone disease in premature neonates: an unmet challenge. J. Clin. Res. Pediatr. Endocrinol. 12, 332\u2013339 (2020).","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"key":"4941_CR2","doi-asserted-by":"publisher","first-page":"3515","DOI":"10.3390\/nu15163515","volume":"15","author":"S Perrone","year":"2023","unstructured":"Perrone, S. et al. Prenatal and neonatal bone health: updated review on early identification of newborns at high risk for osteopenia. Nutrients 15, 3515 (2023).","journal-title":"Nutrients"},{"key":"4941_CR3","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1111\/j.1440-1754.2011.02019.x","volume":"47","author":"A Lothe","year":"2011","unstructured":"Lothe, A., Sinn, J. & Stone, M. Metabolic bone disease of prematurity and secondary hyperparathyroidism. J. Paediatr. Child Health 47, 550\u2013553 (2011).","journal-title":"J. Paediatr. Child Health"},{"key":"4941_CR4","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1177\/0148607113499590","volume":"38","author":"S Viswanathan","year":"2014","unstructured":"Viswanathan, S. et al. Metabolic bone disease: a continued challenge in extremely low birth weight infants. J. Parenter. Enteral Nutr. 38, 982\u2013990 (2014).","journal-title":"J. Parenter. Enteral Nutr."},{"key":"4941_CR5","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1111\/ped.12961","volume":"58","author":"Y Dowa","year":"2016","unstructured":"Dowa, Y. et al. Screening for secondary hyperparathyroidism in preterm infants. Pediatr. Int. 58, 988\u2013992 (2016).","journal-title":"Pediatr. Int."},{"key":"4941_CR6","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1002\/jpen.1993","volume":"45","author":"K Motokura","year":"2021","unstructured":"Motokura, K. et al. Appropriate phosphorus intake by parenteral nutrition prevents metabolic bone disease of prematurity in extremely low-birth-weight infants. J. Parenter. Enteral Nutr. 45, 1319\u20131326 (2021).","journal-title":"J. Parenter. Enteral Nutr."},{"key":"4941_CR7","doi-asserted-by":"publisher","first-page":"E12","DOI":"10.1111\/jpc.12052","volume":"49","author":"A Moreira","year":"2013","unstructured":"Moreira, A., February, M. & Geary, C. Parathyroid hormone levels in neonates with suspected osteopenia. J. Paediatr. Child Health 49, E12\u2013E16 (2013).","journal-title":"J. Paediatr. Child Health"},{"key":"4941_CR8","doi-asserted-by":"publisher","first-page":"F560","DOI":"10.1136\/archdischild-2018-316330","volume":"104","author":"A Chinoy","year":"2019","unstructured":"Chinoy, A., Mughal, M. Z. & Padidela, R. Metabolic bone disease of prematurity: causes, recognition, prevention, treatment and long-term consequences. Arch. Dis. Child Fetal Neonatal Ed. 104, F560\u2013F566 (2019).","journal-title":"Arch. Dis. Child Fetal Neonatal Ed."},{"key":"4941_CR9","first-page":"85","volume":"1","author":"SE Rustico","year":"2014","unstructured":"Rustico, S. E., Calabria, A. C. & Garber, S. J. Metabolic bone disease of prematurity. J. Clin. Transl. Endocrinol. 1, 85\u201391 (2014).","journal-title":"J. Clin. Transl. Endocrinol."},{"key":"4941_CR10","doi-asserted-by":"publisher","first-page":"e1676","DOI":"10.1542\/peds.2013-0420","volume":"131","author":"SA Abrams","year":"2013","unstructured":"Abrams, S. A.Committee on Nutrition Calcium and vitamin D requirements of enterally fed preterm infants. Pediatrics 131, e1676\u2013e1683 (2013).","journal-title":"Pediatrics"},{"key":"4941_CR11","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1177\/0148607113487216","volume":"37","author":"D Nehra","year":"2013","unstructured":"Nehra, D. et al.American Society for Parenteral and Enteral Nutrition A.S.P.E.N. clinical guidelines: nutrition support of neonatal patients at risk for metabolic bone disease. J. Parenter. Enteral Nutr. 37, 570\u2013598 (2013).","journal-title":"J. Parenter. Enteral Nutr."},{"key":"4941_CR12","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1097\/MPG.0000000000003642","volume":"76","author":"ND Embleton","year":"2023","unstructured":"Embleton, N. D. et al. Enteral Nutrition in Preterm Infants (2022): a position paper from the ESPGHAN Committee on Nutrition and Invited Experts. J. Pediatr. Gastroenterol. Nutr. 76, 248\u2013268 (2023).","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"4941_CR13","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1016\/j.clnu.2018.05.029","volume":"37","author":"WA Mihatsch","year":"2018","unstructured":"Mihatsch, W. A. et al. ESPGHAN\/ESPEN\/ESPR\/CSPEN guidelines on pediatric parenteral nutrition. Clin. Nutr. 37, 2303\u20132305 (2018).","journal-title":"Clin. Nutr."},{"key":"4941_CR14","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.3390\/nu13051470","volume":"13","author":"W Mihatsch","year":"2021","unstructured":"Mihatsch, W., Thome, U. & Saenz de Pipaon, M. Update on calcium and phosphorus requirements of preterm infants and recommendations for enteral mineral intake. Nutrients 13, 1470 (2021).","journal-title":"Nutrients"},{"key":"4941_CR15","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12887-020-1958-9","volume":"20","author":"S Bolisetty","year":"2020","unstructured":"Bolisetty, S. et al. Standardised neonatal parenteral nutrition formulations\u2014Australasian neonatal parenteral nutrition consensus update 2017. BMC Pediatr. 20, 59 (2020).","journal-title":"BMC Pediatr."},{"key":"4941_CR16","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1097\/MPG.0b013e3181adaee0","volume":"50","author":"C Agostoni","year":"2010","unstructured":"Agostoni, C. et al.ESPGHAN Committee on Nutrition Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition. J. Pediatr. Gastroenterol. Nutr. 50, 85\u201391 (2010).","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"4941_CR17","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/s41390-019-0501-x","volume":"86","author":"S Ukarapong","year":"2019","unstructured":"Ukarapong, S. et al. Vitamin D status among preterm infants with cholestasis and metabolic bone disease. Pediatr. Res. 86, 725\u2013731 (2019).","journal-title":"Pediatr. Res."},{"key":"4941_CR18","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/jp.2014.97","volume":"34","author":"A Moreira","year":"2014","unstructured":"Moreira, A. et al. Parathyroid hormone as a marker for metabolic bone disease of prematurity. J. Perinatol. 34, 787\u2013791 (2014).","journal-title":"J. Perinatol."},{"key":"4941_CR19","doi-asserted-by":"publisher","DOI":"10.1111\/ped.15108","volume":"64","author":"S Hanaoka","year":"2022","unstructured":"Hanaoka, S. et al. Comparison of two methods measuring serum alkaline phosphatase in neonates. Pediatr. Int. 64, e15108 (2022).","journal-title":"Pediatr. Int."},{"key":"4941_CR20","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1177\/00045632241245942","volume":"61","author":"T Matejek","year":"2024","unstructured":"Matejek, T., Zapletalova, B., Stranik, J., Zaloudkova, L. & Palicka, V. Reference values of parathyroid hormone in very low birth weight infants. Ann. Clin. Biochem. 61, 372\u2013385 (2024).","journal-title":"Ann. Clin. Biochem."},{"key":"4941_CR21","doi-asserted-by":"publisher","first-page":"2860","DOI":"10.1080\/14767058.2018.1450858","volume":"32","author":"T Matejek","year":"2019","unstructured":"Matejek, T. et al. Parathyroid hormone\u2014reference values and association with other bone metabolism markers in very low birth weight infants\u2014pilot study. J. Matern. Fetal Neonatal Med. 32, 2860\u20132867 (2019).","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"4941_CR22","doi-asserted-by":"publisher","first-page":"3786","DOI":"10.3390\/nu12123786","volume":"12","author":"A Avila-Alvarez","year":"2020","unstructured":"Avila-Alvarez, A. et al. Metabolic bone disease of prematurity: risk factors and associated short-term outcomes. Nutrients 12, 3786 (2020).","journal-title":"Nutrients"},{"key":"4941_CR23","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1136\/bmj.3.5872.137","volume":"3","author":"JM Round","year":"1973","unstructured":"Round, J. M. Plasma calcium, magnesium, phosphorus, and alkaline phosphatase levels in normal British schoolchildren. Br. Med. J. 3, 137\u2013140 (1973).","journal-title":"Br. Med. J."},{"key":"4941_CR24","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.clinbiochem.2014.07.012","volume":"47","author":"S Gallo","year":"2014","unstructured":"Gallo, S. et al. Redefining normal bone and mineral clinical biochemistry reference intervals for healthy infants in Canada. Clin. Biochem. 47, 27\u201332 (2014).","journal-title":"Clin. Biochem."},{"key":"4941_CR25","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1007\/s00467-023-06145-z","volume":"39","author":"A Peris Vidal","year":"2024","unstructured":"Peris Vidal, A. et al. Urinary excretion of calcium, phosphate, magnesium, and uric acid in healthy infants and young children. Influence of feeding practices in early infancy. Pediatr. Nephrol. 39, 761\u2013770 (2024).","journal-title":"Pediatr. Nephrol."},{"key":"4941_CR26","unstructured":"O\u2019Callaghan, K. M. & Roth, D. E. Fetal and neonatal calcium, phosphorus, and magnesium homeostasis. in Fetal and Neonatal Physiology 6th edn (Polin, R. A., Abman, S. H., Rowitch, D. H. & Benitz, W. E., eds) 265\u2013282 (Elsevier, 2022)."},{"key":"4941_CR27","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/1471-2431-11-76","volume":"11","author":"TR Fenton","year":"2011","unstructured":"Fenton, T. R., Lyon, A. W. & Rose, M. S. Cord blood calcium, phosphate, magnesium, and alkaline phosphatase gestational age-specific reference intervals for preterm infants. BMC Pediatr. 11, 76 (2011).","journal-title":"BMC Pediatr."},{"key":"4941_CR28","doi-asserted-by":"publisher","first-page":"3985","DOI":"10.1113\/jphysiol.2014.273979","volume":"592","author":"E Lederer","year":"2014","unstructured":"Lederer, E. Regulation of serum phosphate. J. Physiol. 592, 3985\u20133995 (2014).","journal-title":"J. Physiol."},{"key":"4941_CR29","first-page":"220","volume":"53","author":"J Senterre","year":"1988","unstructured":"Senterre, J. & Salle, B. Renal aspects of calcium and phosphorus metabolism in preterm infants. Biol. Neonate 53, 220\u2013229 (1988).","journal-title":"Biol. Neonate"},{"key":"4941_CR30","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1111\/j.1651-2227.2000.tb00395.x","volume":"89","author":"MC Backstr\u00f6m","year":"2000","unstructured":"Backstr\u00f6m, M. C. et al. Bone isoenzyme of serum alkaline phosphatase and serum inorganic phosphate in metabolic bone disease of prematurity. Acta Paediatr. 89, 867\u2013873 (2000).","journal-title":"Acta Paediatr."},{"key":"4941_CR31","doi-asserted-by":"publisher","first-page":"101076","DOI":"10.1016\/j.siny.2019.101076","volume":"25","author":"A Sethi","year":"2020","unstructured":"Sethi, A., Priyadarshi, M. & Agarwal, R. Mineral and bone physiology in the foetus, preterm and full-term neonates. Semin. Fetal Neonatal Med. 25, 101076 (2020).","journal-title":"Semin. Fetal Neonatal Med."},{"key":"4941_CR32","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1007\/s00467-004-1574-1","volume":"19","author":"N Aladangady","year":"2004","unstructured":"Aladangady, N., Coen, P. G., White, M. P., Rae, M. D. & Beattie, T. J. Urinary excretion of calcium and phosphate in preterm infants. Pediatr. Nephrol. 19, 1225\u20131231 (2004).","journal-title":"Pediatr. Nephrol."},{"key":"4941_CR33","doi-asserted-by":"publisher","first-page":"3267","DOI":"10.1111\/apa.70253","volume":"114","author":"T Matejek","year":"2025","unstructured":"Matejek, T. et al. Urinary calcium and phosphorus excretion in vitamin D-sufficient preterm infants: establishing age-specific normative data. Acta Paediatr. 114, 3267\u20133278 (2025).","journal-title":"Acta Paediatr."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-026-04941-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-026-04941-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-026-04941-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T13:14:36Z","timestamp":1780665276000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-026-04941-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,29]]},"references-count":33,"alternative-id":["4941"],"URL":"https:\/\/doi.org\/10.1038\/s41390-026-04941-5","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,29]]},"assertion":[{"value":"18 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors have disclosed information regarding the study on their website, and the patients\u2019 guardians were provided the opportunity to refuse participation.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent statement"}}]}}