{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T17:47:21Z","timestamp":1776275241680,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"DOI":"10.1038\/s41390-026-04968-8","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:51:00Z","timestamp":1776271860000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cross-sectional associations of clinical predictors and physical activity in pediatric inflammatory bowel disease"],"prefix":"10.1038","author":[{"given":"Carlos","family":"Mart\u00edn-Mart\u00ednez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neus","family":"Saloni-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"S\u00e1nchez-Llorente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Velasco-Rodr\u00edguez-Belv\u00eds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa Ana","family":"Mu\u00f1oz-Codoceo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Palomino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"4968_CR1","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1001\/jamapediatrics.2015.1982","volume":"169","author":"MJ Rosen","year":"2015","unstructured":"Rosen, M. J., Dhawan, A. & Saeed, S. A. Inflammatory bowel disease in children and adolescents. JAMA Pediatr. 169, 1053\u20131060 (2015).","journal-title":"JAMA Pediatr."},{"key":"4968_CR2","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1007\/s00431-017-2988-7","volume":"176","author":"K Maratova","year":"2017","unstructured":"Maratova, K. et al. Musculoskeletal system in children and adolescents with inflammatory bowel disease: normal muscle force, decreased trabecular bone mineral density and low prevalence of vertebral fractures. Eur. J. Pediatr. 176, 1355\u20131363 (2017).","journal-title":"Eur. J. Pediatr."},{"key":"4968_CR3","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.cgh.2009.01.022","volume":"7","author":"SB Marcus","year":"2009","unstructured":"Marcus, S. B. et al. Fatigue and health-related quality of life in pediatric inflammatory bowel disease. Clin. Gastroenterol. Hepatol. 7, 554\u2013561 (2009).","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"4968_CR4","doi-asserted-by":"publisher","first-page":"286","DOI":"10.5223\/pghn.2020.23.3.286","volume":"23","author":"LC Silva","year":"2020","unstructured":"Silva, L. C., Seixas, R. B. P. M. & de Carvalho, E. Quality of life in children and adolescents with inflammatory bowel disease: impact and predictive factors. Pediatr. Gastroenterol. Hepatol. Nutr. 23, 286 (2020).","journal-title":"Pediatr. Gastroenterol. Hepatol. Nutr."},{"key":"4968_CR5","doi-asserted-by":"publisher","unstructured":"Legeret, C. et al. Favorable impact of long-term exercise on disease symptoms in pediatric patients with inflammatory bowel disease. BMC Pediatr. 19, https:\/\/doi.org\/10.1186\/S12887-019-1680-7 (2019)","DOI":"10.1186\/S12887-019-1680-7"},{"key":"4968_CR6","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1097\/MPG.0000000000003816","volume":"77","author":"LE Scheffers","year":"2023","unstructured":"Scheffers, L. E. et al. Physical training and healthy diet improved bowel symptoms, quality of life, and fatigue in children with inflammatory bowel disease. J. Pediatr. Gastroenterol. Nutr. 77, 214\u2013221 (2023).","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"4968_CR7","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1111\/apt.14832","volume":"48","author":"G van den Brink","year":"2018","unstructured":"van den Brink, G. et al. Clinical disease activity is associated with anxiety and depressive symptoms in adolescents and young adults with inflammatory bowel disease. Aliment Pharm. Ther. 48, 358\u2013369 (2018).","journal-title":"Aliment Pharm. Ther."},{"key":"4968_CR8","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.jpeds.2010.10.020","volume":"158","author":"HE Ploeger","year":"2011","unstructured":"Ploeger, H. E. et al. Exercise capacity in pediatric patients with inflammatory bowel disease. J. Pediatr. 158, 814\u2013819 (2011).","journal-title":"J. Pediatr."},{"key":"4968_CR9","first-page":"e29282","volume":"14","author":"S Ahmed","year":"2022","unstructured":"Ahmed, S., Alam, S. & Alsabri, M. Health-related quality of life in pediatric inflammatory bowel disease patients: a narrative review. Cureus 14, e29282 (2022).","journal-title":"Cureus"},{"key":"4968_CR10","first-page":"CD013527","volume":"2023","author":"M Nascimento Leite","year":"2023","unstructured":"Nascimento Leite, M. et al. Physical activity and education about physical activity for chronic musculoskeletal pain in children and adolescents. Cochrane Database Syst. Rev. 2023, CD013527 (2023).","journal-title":"Cochrane Database Syst. Rev."},{"key":"4968_CR11","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1038\/nri3041","volume":"11","author":"M Gleeson","year":"2011","unstructured":"Gleeson, M. et al. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat. Rev. Immunol. 11, 607\u2013610 (2011).","journal-title":"Nat. Rev. Immunol."},{"key":"4968_CR12","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1080\/17461391.2011.566357","volume":"12","author":"J Zaragoza Casterad","year":"2012","unstructured":"Zaragoza Casterad, J. et al. Validation of a short physical activity recall questionnaire completed by Spanish adolescents. Eur. J. Sport Sci. 12, 283\u2013291 (2012).","journal-title":"Eur. J. Sport Sci."},{"key":"4968_CR13","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.amepre.2004.12.003","volume":"28","author":"R Telama","year":"2005","unstructured":"Telama, R. et al. Physical activity from childhood to adulthood: a 21-year tracking study. Am. J. Prev. Med. 28, 267\u2013273 (2005).","journal-title":"Am. J. Prev. Med."},{"key":"4968_CR14","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.1651-2227.1985.tb10092.x","volume":"318","author":"R Telama","year":"1985","unstructured":"Telama, R. et al. Atherosclerosis precursors in Finnish children and adolescents. X. Leisure-time physical activity. Acta Paediatr. Scand. Suppl. 318, 169\u2013180 (1985).","journal-title":"Acta Paediatr. Scand. Suppl."},{"key":"4968_CR15","doi-asserted-by":"publisher","first-page":"3417","DOI":"10.1007\/s00431-024-05575-7","volume":"183","author":"M Velasco Rodr\u00edguez-Belv\u00eds","year":"2024","unstructured":"Velasco Rodr\u00edguez-Belv\u00eds, M. et al. Transcultural adaptation and validation of IMPACT-III and IMPACT-III-P in Spanish families: a multicenter study from SEGHNP. Eur. J. Pediatr. 183, 3417\u20133430 (2024).","journal-title":"Eur. J. Pediatr."},{"key":"4968_CR16","first-page":"557","volume":"35","author":"A Otley","year":"2002","unstructured":"Otley, A. et al. The IMPACT questionnaire: a valid measure of health-related quality of life in pediatric inflammatory bowel disease. J. Pediatr. Gastroenterol. Nutr. 35, 557\u2013563 (2002).","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"4968_CR17","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1002\/acr2.11431","volume":"4","author":"A Ali","year":"2022","unstructured":"Ali, A., Schmidt, M., Piskin, D., Crowley, E. & Berard, R. Epidemiology of musculoskeletal manifestations in pediatric inflammatory bowel disease: a systematic review. ACR Open Rheumatol. 4, 547 (2022).","journal-title":"ACR Open Rheumatol."},{"key":"4968_CR18","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1136\/thoraxjnl-2015-207488","volume":"71","author":"AL Quittner","year":"2016","unstructured":"Quittner, A. L. et al. International Committee on Mental Health in Cystic Fibrosis: Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus statements for screening and treating depression and anxiety. Thorax 71, 26\u201334 (2016).","journal-title":"Thorax"},{"key":"4968_CR19","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1186\/s12887-025-05632-6","volume":"25","author":"E J. Cockcroft","year":"2025","unstructured":"J. Cockcroft, E., Chithuranjan, D., Narendran, P., C. Andrews, R. & P. Dias, R. Quality of life and physical activity in type 1 diabetes. BMC Pediatr. 25, 345 (2025).","journal-title":"BMC Pediatr."},{"key":"4968_CR20","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1055\/s-0032-1304323","volume":"33","author":"H Ploeger","year":"2012","unstructured":"Ploeger, H. et al. Exercise and inflammation in pediatric Crohn\u2019s disease. Int. J. Sports Med. 33, 671\u2013679 (2012).","journal-title":"Int. J. Sports Med."},{"key":"4968_CR21","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1097\/MPG.0000000000003905","volume":"77","author":"N Bevers","year":"2023","unstructured":"Bevers, N. et al. Fatigue and physical activity patterns in children with inflammatory bowel disease. J. Pediatr. Gastroenterol. Nutr. 77, 628\u2013633 (2023).","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"4968_CR22","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.crohns.2011.05.003","volume":"5","author":"D Turner","year":"2011","unstructured":"Turner, D. et al. C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) or both? A systematic evaluation in pediatric ulcerative colitis. J. Crohns Colitis 5, 423\u2013429 (2011).","journal-title":"J. Crohns Colitis"},{"key":"4968_CR23","doi-asserted-by":"crossref","unstructured":"Clough, J. et al. Biomarkers in inflammatory bowel disease: a practical guide. Ther. Adv. Gastroenterol. 17, 17562848241251600 (2024)","DOI":"10.1177\/17562848241251600"},{"key":"4968_CR24","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1007\/s40265-023-01888-3","volume":"83","author":"BM Skjellerudsveen","year":"2023","unstructured":"Skjellerudsveen, B. M., Skoie, I. M., Dalen, I., Grimstad, T. & Omdal, R. The effect of biological treatment on fatigue in inflammatory bowel disease: a systematic review and meta-analysis. Drugs 83, 909 (2023).","journal-title":"Drugs"},{"key":"4968_CR25","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1093\/jcag\/gwad021","volume":"6","author":"B Oketola","year":"2023","unstructured":"Oketola, B. et al. Physical activity for quiescent and mildly active inflammatory bowel disease: a systematic review and meta-analysis. J. Can. Assoc. Gastroenterol. 6, 162\u2013171 (2023).","journal-title":"J. Can. Assoc. Gastroenterol."},{"key":"4968_CR26","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1123\/pes.2022-0078","volume":"36","author":"L Hill","year":"2023","unstructured":"Hill, L. et al. Physical activity in pediatric inflammatory bowel disease: a scoping review. Pediatr. Exerc Sci. 36, 44\u201356 (2023).","journal-title":"Pediatr. Exerc Sci."},{"key":"4968_CR27","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/s41390-020-01313-5","volume":"90","author":"J Vanhelst","year":"2021","unstructured":"Vanhelst, J. et al. Daily physical activity patterns in children and adolescents with inflammatory bowel disease. Pediatr. Res. 90, 847\u2013852 (2021).","journal-title":"Pediatr. Res."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-026-04968-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-026-04968-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-026-04968-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:51:02Z","timestamp":1776271862000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-026-04968-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,15]]},"references-count":27,"alternative-id":["4968"],"URL":"https:\/\/doi.org\/10.1038\/s41390-026-04968-8","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,15]]},"assertion":[{"value":"7 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Carlos Mart\u00edn-Mart\u00ednez: Conceptualization, Methodology, Formal analysis, Writing\u2014original draft preparation, Visualization, Project administration. Neus Saloni-G\u00f3mez: Methodology, Investigation, Data curation, Writing\u2014review and editing. Paula S\u00e1nchez-Llorente: Methodology, Investigation, Data curation, Writing\u2014review and editing. Laura Palomino: Investigation, Data curation, Writing\u2014review and editing. Marta Velasco-Rodr\u00edguez-Belv\u00eds: Formal analysis, Visualization, Writing\u2014review and editing. Rosana Mu\u00f1oz-Codoceo: Conceptualization, Supervision, Writing\u2014review and editing.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Written informed consent was obtained from all participants and\/or their legal guardians prior to inclusion in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent statement"}}]}}