{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:41:59Z","timestamp":1789072919790,"version":"build-2803163510"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"DOI":"10.1038\/s41390-026-05104-2","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:16:58Z","timestamp":1780075018000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of complete blood count parameters with adverse outcomes in acute pediatric pneumonia"],"prefix":"10.1038","author":[{"given":"Lin","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enmei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"5104_CR1","first-page":"3","volume":"32","author":"D Marangu","year":"2019","unstructured":"Marangu, D. & Zar, H. J. Childhood pneumonia in low-and-middle-income countries: an update [J]. Paediatr. Respir. Rev. 32, 3\u20139 (2019).","journal-title":"Paediatr. Respir. Rev."},{"key":"5104_CR2","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1016\/S2214-109X(18)30408-X","volume":"7","author":"DA McAllister","year":"2019","unstructured":"McAllister, D. A. et al. Global, regional, and national estimates of pneumonia morbidity and mortality in children younger than 5 years between 2000 and 2015: a systematic analysis [J]. Lancet Glob. Health 7, e47\u2013e57 (2019).","journal-title":"Lancet Glob. Health"},{"key":"5104_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2024.1417644","volume":"12","author":"W Gong","year":"2024","unstructured":"Gong, W. et al. Research progress of biomarkers in evaluating the severity and prognostic value of severe pneumonia in children [J]. Front. Pediatr. 12, 1417644 (2024).","journal-title":"Front. Pediatr."},{"key":"5104_CR4","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.immuni.2024.04.008","volume":"57","author":"L Nicolai","year":"2024","unstructured":"Nicolai, L., Pekayvaz, K. & Massberg, S. Platelets: orchestrators of immunity in host defense and beyond [J]. Immunity 57, 957\u2013972 (2024).","journal-title":"Immunity"},{"key":"5104_CR5","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.hrtlng.2023.12.001","volume":"64","author":"J Zhu","year":"2024","unstructured":"Zhu, J. et al. Prognostic value of hemoglobin in patients with sepsis: a systematic review and meta-analysis [J]. Heart Lung 64, 93\u201399 (2024).","journal-title":"Heart Lung"},{"key":"5104_CR6","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkae016","volume":"12","author":"Q Ye","year":"2024","unstructured":"Ye, Q. et al. Serial platelet count as a dynamic prediction marker of hospital mortality among septic patients [J]. Burns Trauma 12, tkae016 (2024).","journal-title":"Burns Trauma"},{"key":"5104_CR7","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1093\/cid\/ciab598","volume":"74","author":"LS Peetluk","year":"2022","unstructured":"Peetluk, L. S. et al. A clinical prediction model for unsuccessful pulmonary tuberculosis treatment outcomes [J]. Clin. Infect. Dis. 74, 973\u2013982 (2022).","journal-title":"Clin. Infect. Dis."},{"key":"5104_CR8","unstructured":"World Health Organization. Guidelines for the Management of Common Childhood Illnesses. Available at: https:\/\/www.who.int\/maternal_child_adolescent\/documents\/child_hospital_care\/en\/. Accessed 17 September 2017."},{"key":"5104_CR9","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.arcped.2018.02.001","volume":"25","author":"G Tourniaire","year":"2018","unstructured":"Tourniaire, G. et al. [Anemia, a new severity factor in young infants with acute viral bronchiolitis?]. Arch. Pediatr. 25, 189\u2013193 (2018).","journal-title":"Arch. Pediatr."},{"key":"5104_CR10","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1002\/ppul.25892","volume":"57","author":"IF Chang","year":"2022","unstructured":"Chang, I. F. et al. The association of anemia with the clinical outcomes of community-acquired pneumonia in children [J]. Pediatr. Pulmonol. 57, 1416\u20131424 (2022).","journal-title":"Pediatr. Pulmonol."},{"key":"5104_CR11","doi-asserted-by":"crossref","unstructured":"Florin, T. A. et al. Biomarkers and Disease Severity in Children With Community-Acquired Pneumonia. Pediatrics 145, e20193728 (2020). Erratum in: Pediatrics. 146:e2020011452. (2020).","DOI":"10.1542\/peds.2020-011452"},{"key":"5104_CR12","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1042\/CS20210879","volume":"136","author":"ME Long","year":"2022","unstructured":"Long, M. E., Mallampalli, R. K. & Horowitz, J. C. Pathogenesis of pneumonia and acute lung injury [J]. Clin. Sci. 136, 747\u2013769 (2022).","journal-title":"Clin. Sci."},{"key":"5104_CR13","doi-asserted-by":"crossref","unstructured":"Chen, Y. & Gaber, T. Hypoxia\/HIF modulates immune responses [J]. Biomedicines 9, 260 (2021).","DOI":"10.3390\/biomedicines9030260"},{"key":"5104_CR14","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1378\/chest.12-1235","volume":"143","author":"E Prina","year":"2013","unstructured":"Prina, E. et al. Thrombocytosis is a marker of poor outcome in community-acquired pneumonia [J]. Chest 143, 767\u2013775 (2013).","journal-title":"Chest"},{"key":"5104_CR15","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.cegh.2018.02.007","volume":"6","author":"A Jain","year":"2018","unstructured":"Jain, A., Awasthi, N. & Awasthi, S. Low platelet counts predict mortality in severe community acquired pneumonia in children under 5 years of age: a hospital based observational study [J]. Clin. Epidemiol. Glob. Health 6, 188\u2013191 (2018).","journal-title":"Clin. Epidemiol. Glob. Health"},{"key":"5104_CR16","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1080\/09537104.2016.1219032","volume":"28","author":"O Gorelik","year":"2017","unstructured":"Gorelik, O. et al. Prognostic significance of platelet count changes during hospitalization for community-acquired pneumonia [J]. Platelets 28, 380\u2013386 (2017).","journal-title":"Platelets"},{"key":"5104_CR17","first-page":"474","volume":"122","author":"R Zahorec","year":"2021","unstructured":"Zahorec, R. Neutrophil-to-lymphocyte ratio, past, present and future perspectives [J]. Bratisl. Lek. Listy 122, 474\u2013488 (2021).","journal-title":"Bratisl. Lek. Listy"},{"key":"5104_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-79431-7","volume":"11","author":"M Song","year":"2021","unstructured":"Song, M., Graubard, B. I., Rabkin, C. S. & Engels, E. A. Neutrophil-to-lymphocyte ratio and mortality in the United States general population [J]. Sci. Rep. 11, 464 (2021).","journal-title":"Sci. Rep."},{"key":"5104_CR19","doi-asserted-by":"crossref","unstructured":"Buonacera, A., Stancanelli, B., Colaci, M. & Malatino, L. Neutrophil to lymphocyte ratio: an emerging marker of the relationships between the immune system and diseases [J]. Int. J. Mol. Sci. 23, 3636 (2022).","DOI":"10.3390\/ijms23073636"},{"key":"5104_CR20","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.630","volume":"5","author":"S Kuikel","year":"2022","unstructured":"Kuikel, S. et al. Neutrophil-lymphocyte ratio as a predictor of adverse outcome in patients with community-acquired pneumonia: a systematic review [J]. Health Sci. Rep. 5, e630 (2022).","journal-title":"Health Sci. Rep."},{"key":"5104_CR21","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1189\/jlb.0808491","volume":"85","author":"J Unsinger","year":"2009","unstructured":"Unsinger, J., Kazama, H., McDonough, J. S., Hotchkiss, R. S. & Ferguson, T. A. Differential lymphopenia-induced homeostatic proliferation for CD4+ and CD8+ T cells following septic injury [J]. J. Leukoc. Biol. 85, 382\u2013390 (2009).","journal-title":"J. Leukoc. Biol."},{"key":"5104_CR22","doi-asserted-by":"publisher","first-page":"4261","DOI":"10.1182\/blood.V87.10.4261.bloodjournal87104261","volume":"87","author":"A Ayala","year":"1996","unstructured":"Ayala, A., Herdon, C. D., Lehman, D. L., Ayala, C. A. & Chaudry, I. H. Differential induction of apoptosis in lymphoid tissues during sepsis: variation in onset, frequency, and the nature of the mediators [J]. Blood 87, 4261\u20134275 (1996).","journal-title":"Blood"},{"key":"5104_CR23","doi-asserted-by":"publisher","first-page":"e524","DOI":"10.1093\/cid\/ciaa1138","volume":"73","author":"TA Florin","year":"2021","unstructured":"Florin, T. A. et al. Proadrenomedullin predicts severe disease in children with suspected community-acquired pneumonia [J]. Clin. Infect. Dis. 73, e524\u2013e530 (2021).","journal-title":"Clin. Infect. Dis."},{"key":"5104_CR24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-38731-4","volume":"13","author":"A Chandna","year":"2023","unstructured":"Chandna, A. et al. Defining the role of host biomarkers in the diagnosis and prognosis of the severity of childhood pneumonia: a prospective cohort study [J]. Sci. Rep. 13, 12024 (2023).","journal-title":"Sci. Rep."},{"key":"5104_CR25","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.12.10013","volume":"12","author":"S Kazi","year":"2022","unstructured":"Kazi, S. et al. The utility of chest x-ray and lung ultrasound in the management of infants and children presenting with severe pneumonia in low-and middle-income countries: a pragmatic scoping review [J]. J. Glob. Health 12, 10013 (2022).","journal-title":"J. Glob. Health"},{"key":"5104_CR26","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.21037\/qims-22-508","volume":"13","author":"C Chu","year":"2023","unstructured":"Chu, C. et al. Multidimensional analysis using low-dose computed tomography to evaluate the severity of Mycoplasma pneumoniae pneumonia in children [J]. Quant. Imaging Med. Surg. 13, 1874\u20131886 (2023).","journal-title":"Quant. Imaging Med. Surg."},{"key":"5104_CR27","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1186\/s12887-025-05804-4","volume":"25","author":"J Liu","year":"2025","unstructured":"Liu, J. et al. Comparative analysis of the clinical characteristics of severe Mycoplasma pneumoniae pneumonia and severe bacterial pneumonia in children [J]. BMC Pediatr. 25, 439 (2025).","journal-title":"BMC Pediatr."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-026-05104-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-026-05104-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-026-05104-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:16:59Z","timestamp":1780075019000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-026-05104-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":27,"alternative-id":["5104"],"URL":"https:\/\/doi.org\/10.1038\/s41390-026-05104-2","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]},"assertion":[{"value":"18 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}