{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:38:53Z","timestamp":1792694333144,"version":"4.5.0"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100014364","name":"National Children's Research Centre","doi-asserted-by":"publisher","award":["D\/18\/6"],"award-info":[{"award-number":["D\/18\/6"]}],"id":[{"id":"10.13039\/100014364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"DOI":"10.1038\/s41390-026-05262-3","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:50:32Z","timestamp":1792691432000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Persistent postnatal alterations in microRNA expression in neonatal encephalopathy"],"prefix":"10.1038","author":[{"given":"Ellen A.","family":"Walls","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc P.","family":"O\u2019Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisling A.","family":"Garvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea M.","family":"Pavel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene M.","family":"Dempsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine B.","family":"Boylan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre M.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"5262_CR1","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1056\/NEJMcps050929","volume":"353","author":"S Shankaran","year":"2005","unstructured":"Shankaran, S. et al. Whole-body hypothermia for neonates with hypoxic\u2013ischemic encephalopathy. N. Engl. J. Med. 353, 1574\u20131584 (2005).","journal-title":"N. Engl. J. Med."},{"key":"5262_CR2","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1089\/neu.2008.0678","volume":"26","author":"S Shankaran","year":"2009","unstructured":"Shankaran, S. Neonatal encephalopathy: treatment with hypothermia. J. Neurotrauma 26, 437\u2013443 (2009).","journal-title":"J. Neurotrauma"},{"key":"5262_CR3","doi-asserted-by":"crossref","unstructured":"Ahearne, C. Short and long term prognosis in perinatal asphyxia: an update. World J. Clin. Pediatr. 5, 67 (2016).","DOI":"10.5409\/wjcp.v5.i1.67"},{"key":"5262_CR4","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1053\/j.nainr.2011.07.004","volume":"11","author":"K Allen","year":"2011","unstructured":"Allen, K. & Brandon, D. Hypoxic ischemic encephalopathy: pathophysiology and experimental treatments. Newborn Infant Nurs. Rev. 11, 125\u2013133 (2011).","journal-title":"Newborn Infant Nurs. Rev."},{"key":"5262_CR5","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.clp.2016.04.002","volume":"43","author":"M Rainaldi","year":"2016","unstructured":"Rainaldi, M. & Perlman, J. Pathophysiology of birth asphyxia. Clin. Perinatol. 43, 409\u2013422 (2016).","journal-title":"Clin. Perinatol."},{"key":"5262_CR6","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1542\/peds.102.4.885","volume":"102","author":"AJ Gunn","year":"1998","unstructured":"Gunn, A. J., Gluckman, P. D. & Gunn, T. R. Selective head cooling in newborn infants after perinatal asphyxia: a safety study. Pediatrics 102, 885\u2013892 (1998).","journal-title":"Pediatrics"},{"key":"5262_CR7","doi-asserted-by":"publisher","unstructured":"Jacobs, S. E. et al. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst. Rev. https:\/\/doi.org\/10.1002\/14651858.CD003311.pub3 (2013).","DOI":"10.1002\/14651858.CD003311.pub3"},{"key":"5262_CR8","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1159\/000522617","volume":"44","author":"G Wassink","year":"2022","unstructured":"Wassink, G., Harrison, S., Dhillon, S., Bennet, L. & Gunn, A. J. Prognostic neurobiomarkers in neonatal encephalopathy. Dev. Neurosci. 44, 331\u2013343 (2022).","journal-title":"Dev. Neurosci."},{"key":"5262_CR9","doi-asserted-by":"publisher","first-page":"45","DOI":"10.2147\/CLEP.S4782","volume":"1","author":"V Ehrenstein","year":"2009","unstructured":"Ehrenstein, V. Association of Apgar scores with death and neurologic disability. Clin. Epidemiol. 1, 45\u201353 (2009).","journal-title":"Clin. Epidemiol."},{"key":"5262_CR10","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1136\/adc.67.7_Spec_No.765","volume":"67","author":"N Marlow","year":"1992","unstructured":"Marlow, N. Do we need an Apgar score? Arch. Dis. Child 67, 765\u2013767 (1992).","journal-title":"Arch. Dis. Child"},{"key":"5262_CR11","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1111\/j.1471-0528.2012.03335.x","volume":"119","author":"P Yeh","year":"2012","unstructured":"Yeh, P., Emary, K. & Impey, L. The relationship between umbilical cord arterial pH and serious adverse neonatal outcome: analysis of 51 519 consecutive validated samples. BJOG 119, 824\u2013831 (2012).","journal-title":"BJOG"},{"key":"5262_CR12","doi-asserted-by":"publisher","first-page":"276","DOI":"10.3390\/cells9020276","volume":"9","author":"CE Condrat","year":"2020","unstructured":"Condrat, C. E. et al. miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis. Cells 9, 276 (2020).","journal-title":"Cells"},{"key":"5262_CR13","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1001\/jamaneurol.2018.4182","volume":"76","author":"MP O\u2019Sullivan","year":"2019","unstructured":"O\u2019Sullivan, M. P. et al. Validation of altered umbilical cord blood microRNA expression in neonatal hypoxic-ischemic encephalopathy. JAMA Neurol. 76, 333 (2019).","journal-title":"JAMA Neurol."},{"key":"5262_CR14","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.jpeds.2015.04.060","volume":"167","author":"A-M Looney","year":"2015","unstructured":"Looney, A.-M. et al. Downregulation of umbilical cord blood levels of miR-374a in neonatal hypoxic ischemic encephalopathy. J. Pediatr. 167, 269\u2013273.e2 (2015).","journal-title":"J. Pediatr."},{"key":"5262_CR15","doi-asserted-by":"publisher","first-page":"4322","DOI":"10.1007\/s12035-020-02018-w","volume":"57","author":"S Casey","year":"2020","unstructured":"Casey, S. et al. Temporally altered miRNA expression in a piglet model of hypoxic ischemic brain injury. Mol. Neurobiol. 57, 4322\u20134344 (2020).","journal-title":"Mol. Neurobiol."},{"key":"5262_CR16","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1159\/000521356","volume":"119","author":"I Winkler","year":"2022","unstructured":"Winkler, I. et al. MicroRNA expression profiles as diagnostic and prognostic biomarkers of perinatal asphyxia and hypoxic-ischaemic encephalopathy. Neonatology 119, 204\u2013213 (2022).","journal-title":"Neonatology"},{"key":"5262_CR17","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.pedneo.2024.05.002","volume":"66","author":"Y-H Lai","year":"2025","unstructured":"Lai, Y.-H. et al. Circulating microRNAs as a biomarker signature of perinatal asphyxia. Pediatr. Neonatol. 66, 235\u2013240 (2025).","journal-title":"Pediatr. Neonatol."},{"key":"5262_CR18","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s40348-026-00220-9","volume":"13","author":"RM Patil","year":"2026","unstructured":"Patil, R. M. et al. miR223, miR30e, and miR30a show associations with perinatal metabolic acidosis in neonates with hypoxic\u2013ischemic encephalopathy. Mol. Cell. Pediatr. 13, 7 (2026).","journal-title":"Mol. Cell. Pediatr."},{"key":"5262_CR19","unstructured":"Garvey, A. A. Multi\u2011modal Assessment of Newborns at Risk of Neonatal Hypoxic Ischaemic Encephalopathy \u2013 the MONItOr Study. Accessed 27 June 2025. [Doctoral Dissertation], University College Cork (2022)."},{"key":"5262_CR20","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/S0304-3940(02)01423-4","volume":"339","author":"C Ramakers","year":"2003","unstructured":"Ramakers, C., Ruijter, J. M., Deprez, R. H. L. & Moorman, A. F. M. Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data. Neurosci. Lett. 339, 62\u201366 (2003).","journal-title":"Neurosci. Lett."},{"key":"5262_CR21","doi-asserted-by":"publisher","first-page":"3657","DOI":"10.1007\/s12035-018-1321-4","volume":"56","author":"AM Looney","year":"2019","unstructured":"Looney, A. M. et al. Altered expression of umbilical cord blood levels of miR-181b and its downstream target mUCH-L1 in infants with moderate and severe neonatal hypoxic-ischaemic encephalopathy. Mol. Neurobiol. 56, 3657\u20133663 (2019).","journal-title":"Mol. Neurobiol."},{"key":"5262_CR22","doi-asserted-by":"publisher","first-page":"117664","DOI":"10.1016\/j.lfs.2020.117664","volume":"252","author":"Z Chen","year":"2020","unstructured":"Chen, Z., Hu, Y., Lu, R., Ge, M. & Zhang, L. MicroRNA-374a-5p inhibits neuroinflammation in neonatal hypoxic-ischemic encephalopathy via regulating NLRP3 inflammasome targeted Smad6. Life Sci. 252, 117664 (2020).","journal-title":"Life Sci."},{"key":"5262_CR23","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.835","volume":"8","author":"Z Wang","year":"2018","unstructured":"Wang, Z., Liu, Y., Shao, M., Wang, D. & Zhang, Y. Combined prediction of miR-210 and miR-374a for severity and prognosis of hypoxic\u2013ischemic encephalopathy. Brain Behav. 8, e00835 (2018).","journal-title":"Brain Behav."},{"key":"5262_CR24","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s12098-022-04392-w","volume":"90","author":"S Li","year":"2023","unstructured":"Li, S. et al. MicroRNAs in blood as diagnostic biomarkers for neonatal hypoxic\u2013ischemic encephalopathy. Indian J. Pediatr. 90, 93\u201393 (2023).","journal-title":"Indian J. Pediatr."},{"key":"5262_CR25","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1038\/s41423-019-0257-6","volume":"17","author":"B Li","year":"2020","unstructured":"Li, B., Dasgupta, C., Huang, L., Meng, X. & Zhang, L. MiRNA-210 induces microglial activation and regulates microglia-mediated neuroinflammation in neonatal hypoxic-ischemic encephalopathy. Cell. Mol. Immunol. 17, 976\u2013991 (2020).","journal-title":"Cell. Mol. Immunol."},{"key":"5262_CR26","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.21037\/tp-23-106","volume":"12","author":"Y Jin","year":"2023","unstructured":"Jin, Y. et al. Highly expressed miR-210 in the peripheral blood is closely associated with asphyxiated neonates. Transl. Pediatr. 12, 1181\u20131191 (2023).","journal-title":"Transl. Pediatr."},{"key":"5262_CR27","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1080\/02699052.2022.2087906","volume":"36","author":"Y Chen","year":"2022","unstructured":"Chen, Y., Zeng, H. & Liu, H. MiR-21 participates in the neuroprotection of diazoxide against hypoxic-ischemia encephalopathy by targeting PDCD4. Brain Inj. 36, 876\u2013885 (2022).","journal-title":"Brain Inj."},{"key":"5262_CR28","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s10495-020-01596-3","volume":"25","author":"J Liu","year":"2020","unstructured":"Liu, J., Zhang, S., Huang, Y. & Sun, L. miR-21 protects neonatal rats from hypoxic-ischemic brain damage by targeting CCL3. Apoptosis 25, 275\u2013289 (2020).","journal-title":"Apoptosis"},{"key":"5262_CR29","doi-asserted-by":"publisher","DOI":"10.18632\/aging.205513","author":"J Geng","year":"2024","unstructured":"Geng, J. et al. MicroRNA-124 negatively regulates STAT3 to alleviate hypoxic-ischemic brain damage by inhibiting oxidative stress. Aging https:\/\/doi.org\/10.18632\/aging.205513 (2024).","journal-title":"Aging"},{"key":"5262_CR30","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1007\/s10571-019-00769-2","volume":"40","author":"L Xiong","year":"2020","unstructured":"Xiong, L. et al. Overexpression of miR-124 protects against neurological dysfunction induced by neonatal hypoxic\u2013ischemic brain injury. Cell Mol. Neurobiol. 40, 737\u2013750 (2020).","journal-title":"Cell Mol. Neurobiol."},{"key":"5262_CR31","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s11064-017-2452-0","volume":"43","author":"W Gong","year":"2018","unstructured":"Gong, W., Qie, S., Huang, P. & Xi, J. Protective effect of miR-374a on chemical hypoxia-induced damage of PC12 cells in vitro via the GADD45\u03b1\/JNK signaling pathway. Neurochem. Res. 43, 581\u2013590 (2018).","journal-title":"Neurochem. Res."},{"key":"5262_CR32","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s12031-019-01340-w","volume":"69","author":"F Jiang","year":"2019","unstructured":"Jiang, F., Yang, M., Wu, C. & Wang, J. Potential roles of miR-374a-5p in mediating neuroprotective effects and related molecular mechanism. J. Mol. Neurosci. 69, 123\u2013132 (2019).","journal-title":"J. Mol. Neurosci."},{"key":"5262_CR33","doi-asserted-by":"publisher","first-page":"102124","DOI":"10.1016\/j.jflm.2021.102124","volume":"78","author":"S-Y Kim","year":"2021","unstructured":"Kim, S.-Y., Jang, S. J., Jung, Y.-H. & Na, J.-Y. Difference in microRNA levels in the post-mortem blood from different sampling sites: a proof of concept. J. Forensic Leg. Med. 78, 102124 (2021).","journal-title":"J. Forensic Leg. Med."},{"key":"5262_CR34","doi-asserted-by":"publisher","first-page":"e6981","DOI":"10.7717\/peerj.6981","volume":"7","author":"J Juracek","year":"2019","unstructured":"Juracek, J., Piler, P., Janku, P., Radova, L. & Slaby, O. Identification of microRNA signatures in umbilical cord blood associated with maternal characteristics. PeerJ 7, e6981 (2019).","journal-title":"PeerJ"},{"key":"5262_CR35","doi-asserted-by":"publisher","first-page":"120395","DOI":"10.1016\/j.jns.2022.120395","volume":"442","author":"J Vistbakka","year":"2022","unstructured":"Vistbakka, J., Sumelahti, M.-L., Lehtim\u00e4ki, T. & Hagman, S. Temporal variability of serum miR-191, miR-223, miR-128, and miR-24 in multiple sclerosis: a 4-year follow-up study. J. Neurol. Sci. 442, 120395 (2022).","journal-title":"J. Neurol. Sci."},{"key":"5262_CR36","first-page":"1408","volume":"24","author":"Y Shi","year":"2020","unstructured":"Shi, Y., Li, K., Xu, K. & Liu, Q.-H. MiR-155-5p accelerates cerebral ischemia-reperfusion injury via targeting DUSP14 by regulating NF-\u03baB and MAPKs signaling pathways. Eur. Rev. Med. Pharmacol. Sci. 24, 1408\u20131419 (2020).","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"5262_CR37","first-page":"5","volume":"2","author":"T Denayer","year":"2014","unstructured":"Denayer, T., St\u00f6hr, T. & Roy, M. V. Animal models in translational medicine: validation and prediction. New Horiz. Transl. Med. 2, 5 (2014).","journal-title":"New Horiz. Transl. Med."},{"key":"5262_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-57166-z","volume":"19","author":"F Dakroub","year":"2024","unstructured":"Dakroub, F. et al. MicroRNAs as biomarkers of brain injury in neonatal encephalopathy: an observational cohort study. Sci. Rep. 19, 6645 (2024).","journal-title":"Sci. Rep."},{"key":"5262_CR39","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-91514-x","volume":"15","author":"ES Peeples","year":"2025","unstructured":"Peeples, E. S. The time-sensitive nature of microRNA expression after neonatal hypoxic-ischemic encephalopathy. Sci. Rep. 15, 7153 (2025).","journal-title":"Sci. Rep."},{"key":"5262_CR40","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1038\/s41390-022-02196-4","volume":"93","author":"ES Peeples","year":"2023","unstructured":"Peeples, E. S. MicroRNA therapeutic targets in neonatal hypoxic\u2013ischemic brain injury: a narrative review. Pediatr. Res. 93, 780\u2013788 (2023).","journal-title":"Pediatr. Res."},{"key":"5262_CR41","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1080\/00207454.2020.1744594","volume":"131","author":"D-W Wang","year":"2021","unstructured":"Wang, D.-W., Lou, X.-Q., Liu, Z.-L., Zhang, N. & Pang, L. LncRNA SNHG1 protects SH-SY5Y cells from hypoxic injury through miR-140-5p\/Bcl-XL axis. Int. J. Neurosci. 131, 336\u2013345 (2021).","journal-title":"Int. J. Neurosci."},{"key":"5262_CR42","doi-asserted-by":"publisher","unstructured":"Zhang, J., Han, J., Li, N. & Zhou, W. Deciphering the Protective Role of HIF-1\u03b1 downregulation on HIBD through the MALAT1\/miR-140-5p\/TGFBR1\/NF-\u03baB signaling pathway. Mol. Neurobiol. https:\/\/doi.org\/10.1007\/s12035-024-04451-7 (2024).","DOI":"10.1007\/s12035-024-04451-7"},{"key":"5262_CR43","doi-asserted-by":"publisher","first-page":"3847","DOI":"10.1080\/21691401.2019.1666859","volume":"47","author":"J Cai","year":"2019","unstructured":"Cai, J. et al. Knockdown of lncRNA Gm11974 protect against cerebral ischemic reperfusion through miR-766-3p\/NR3C2 axis. Artif. Cells Nanomed. Biotechnol. 47, 3847\u20133853 (2019).","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"5262_CR44","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.brainres.2015.06.046","volume":"1622","author":"L Xiang","year":"2015","unstructured":"Xiang, L., Ren, Y., Cai, H., Zhao, W. & Song, Y. MicroRNA-132 aggravates epileptiform discharges via suppression of BDNF\/TrkB signaling in cultured hippocampal neurons. Brain Res. 1622, 484\u2013495 (2015).","journal-title":"Brain Res."},{"key":"5262_CR45","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.pcl.2004.03.002","volume":"51","author":"ML Zupanc","year":"2004","unstructured":"Zupanc, M. L. Neonatal seizures. Pediatr. Clin. North Am. 51, 961\u2013978 (2004).","journal-title":"Pediatr. Clin. North Am."},{"key":"5262_CR46","doi-asserted-by":"publisher","first-page":"8121","DOI":"10.2147\/IJN.S221383","volume":"14","author":"Y Ma","year":"2019","unstructured":"Ma, Y. et al. Exosomal transfer of cisplatin-induced miR-425-3p confers cisplatin resistance In NSCLC through activating autophagy. Int. J. Nanomed. 14, 8121\u20138132 (2019).","journal-title":"Int. J. Nanomed."},{"key":"5262_CR47","doi-asserted-by":"publisher","first-page":"128","DOI":"10.3390\/cancers15010128","volume":"15","author":"J Gasparello","year":"2022","unstructured":"Gasparello, J. et al. MicroRNAs miR-584-5p and miR-425-3p are up-regulated in plasma of colorectal cancer (CRC) patients: targeting with inhibitor peptide nucleic acids is associated with induction of apoptosis in colon cancer cell lines. Cancers 15, 128 (2022).","journal-title":"Cancers"},{"key":"5262_CR48","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1002\/iid3.392","volume":"9","author":"J Li","year":"2021","unstructured":"Li, J., Tu, J., Gao, H. & Tang, L. MicroRNA-425-3p inhibits myocardial inflammation and cardiomyocyte apoptosis in mice with viral myocarditis through targeting TGF-\u03b21. Immun. Inflamm. Dis. 9, 288\u2013298 (2021).","journal-title":"Immun. Inflamm. Dis."},{"key":"5262_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2026.150235","volume":"1881","author":"X Yang","year":"2026","unstructured":"Yang, X. et al. miR-425-5p in the early diagnosis of neonatal brain injury and its involvement in the inflammatory response of brain injury via WTAP. Brain Res. 1881, 150235 (2026).","journal-title":"Brain Res."},{"key":"5262_CR50","doi-asserted-by":"crossref","unstructured":"Huang, J. et al. IRE1\u03b1 inhibition attenuates neuronal pyroptosis via miR-125\/NLRP1 pathway in a neonatal hypoxic-ischemic encephalopathy rat model. J. Neuroinflammation https:\/\/link.springer.com\/article\/10.1186\/s12974-020-01796-3 (2020).","DOI":"10.1186\/s12974-020-01796-3"},{"key":"5262_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2023.114317","volume":"362","author":"F Ke","year":"2023","unstructured":"Ke, F. et al. MiR-155 promotes inflammation and apoptosis via targeting SIRT1 in hypoxic-ischemic brain damage. Exp. Neurol. 362, 114317 (2023).","journal-title":"Exp. Neurol."},{"key":"5262_CR52","doi-asserted-by":"publisher","unstructured":"Dahiya, D. et al. A role for myeloid miR-155 in regulating hypoxia induced seizures in neonatal C57BL\/J6 mice. Preprint at https:\/\/doi.org\/10.1101\/2022.09.22.508924 (2022).","DOI":"10.1101\/2022.09.22.508924"},{"key":"5262_CR53","first-page":"1281","volume":"29","author":"J Yang","year":"2020","unstructured":"Yang, J. & Guo, Y. The expression and clinical significance of serum miR-424, miR-205 and miR-155 in neonates with asphyxia. Int. J. Early Child. Spec. Educ. 29, 1281 (2020).","journal-title":"Int. J. Early Child. Spec. Educ."},{"key":"5262_CR54","doi-asserted-by":"publisher","DOI":"10.1038\/srep20429","volume":"6","author":"Y Yuan","year":"2016","unstructured":"Yuan, Y. et al. Crosstalk between miRNAs and their regulated genes network in stroke. Sci. Rep. 6, 20429 (2016).","journal-title":"Sci. Rep."},{"key":"5262_CR55","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12944-023-01794-3","volume":"22","author":"S Li","year":"2023","unstructured":"Li, S. et al. Direct targeting of DOCK4 by miRNA-181d in oxygen-glucose deprivation\/reoxygenation-mediated neuronal injury. Lipids Health Dis. 22, 34 (2023).","journal-title":"Lipids Health Dis."},{"key":"5262_CR56","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1007\/s12031-016-0849-x","volume":"61","author":"X Xia","year":"2017","unstructured":"Xia, X. et al. NFAT5 protects astrocytes against oxygen\u2013glucose\u2013serum deprivation\/restoration damage via the SIRT1\/Nrf2 pathway. J. Mol. Neurosci. 61, 96\u2013104 (2017).","journal-title":"J. Mol. Neurosci."},{"key":"5262_CR57","doi-asserted-by":"publisher","DOI":"10.1186\/1750-2187-8-5","volume":"8","author":"CYK Cheung","year":"2013","unstructured":"Cheung, C. Y. K. & Ko, B. C. B. NFAT5 in cellular adaptation to hypertonic stress\u2014regulations and functional significance. J. Mol. Signal. 8, 5 (2013).","journal-title":"J. Mol. Signal."},{"key":"5262_CR58","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.jpeds.2020.08.051","volume":"228","author":"MP O\u2019Sullivan","year":"2021","unstructured":"O\u2019Sullivan, M. P. et al. Up-regulation of Nfat5 mRNA and Fzd4 mRNA as a marker of poor outcome in neonatal hypoxic-ischemic encephalopathy. J. Pediatr. 228, 74\u201381.e2 (2021).","journal-title":"J. Pediatr."},{"key":"5262_CR59","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01862-w","volume":"17","author":"X Hu","year":"2020","unstructured":"Hu, X. et al. Rh-CSF1 attenuates neuroinflammation via the CSF1R\/PLCG2\/PKC\u03b5 pathway in a rat model of neonatal HIE. J. Neuroinflammation 17, 182 (2020).","journal-title":"J. Neuroinflammation"},{"key":"5262_CR60","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1097\/POC.0000000000000181","volume":"18","author":"E Dameron","year":"2019","unstructured":"Dameron, E. Invited product profile: the Mitra microsampling device. Point Care 18, 26\u201332 (2019).","journal-title":"Point Care"},{"key":"5262_CR61","first-page":"288","volume":"27","author":"R Zakaria","year":"2016","unstructured":"Zakaria, R., Allen, K. J., Koplin, J. J., Roche, P. & Greaves, R. F. Advantages and challenges of dried blood spot analysis by mass spectrometry across the total testing process. EJIFCC 27, 288\u2013317 (2016).","journal-title":"EJIFCC"},{"key":"5262_CR62","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/pr.2015.276","volume":"79","author":"V Ponnusamy","year":"2016","unstructured":"Ponnusamy, V. et al. A study of microRNAs from dried blood spots in newborns after perinatal asphyxia: a simple and feasible biosampling method. Pediatr. Res. 79, 799\u2013805 (2016).","journal-title":"Pediatr. Res."},{"key":"5262_CR63","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-474","volume":"15","author":"P Leidinger","year":"2014","unstructured":"Leidinger, P., Backes, C., Meder, B., Meese, E. & Keller, A. The human miRNA repertoire of different blood compounds. BMC Genom. 15, 474 (2014).","journal-title":"BMC Genom."},{"key":"5262_CR64","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1111\/ene.15424","volume":"29","author":"E Chouery","year":"2022","unstructured":"Chouery, E., Mehawej, C., Sabbagh, S., Bleik, J. & Megarbane, A. Early infantile epileptic encephalopathy related to NECAP1: clinical delineation of the disease and review. Eur. J. Neurol. 29, 2486\u20132492 (2022).","journal-title":"Eur. J. Neurol."},{"key":"5262_CR65","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s10038-018-0556-2","volume":"64","author":"T Mizuguchi","year":"2019","unstructured":"Mizuguchi, T. et al. A novel homozygous truncating variant of NECAP1 in early infantile epileptic encephalopathy: the second case report of EIEE21. J. Hum. Genet. 64, 347\u2013350 (2019).","journal-title":"J. Hum. Genet."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-026-05262-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-026-05262-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-026-05262-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:50:34Z","timestamp":1792691434000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-026-05262-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,22]]},"references-count":65,"alternative-id":["5262"],"URL":"https:\/\/doi.org\/10.1038\/s41390-026-05262-3","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,22]]},"assertion":[{"value":"29 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"D.M.M. is funded by the ELEVATE Strategic Partnership Programme, co-funded by Research Ireland and the Cerebral Palsy Foundation.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"Ethical approval was obtained from the Clinical Research Ethics Committee of the Cork Teaching Hospitals (ECM 5 (5) 04\/07\/17) and written informed parental consent was obtained.","order":2,"name":"Ethics","label":"Consent statement","group":{"name":"EthicsHeading","label":"Ethics"}}]}}