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While preeclampsia\/eclampsia (P\/E) is clinically more severe, pregnancy-related hypertension (PR-HTN) may involve longer in-utero exposure to hemodynamic stress. This study examined how distinct HDP exposures influence longitudinal white matter measures in adolescents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using a longitudinal cohort with two MRI timepoints (baseline ages 9\u201311 years; 2-year follow-up ages 11\u201313.8 years), we modeled fiber volume (FV) and fractional anisotropy (FA) using linear mixed-effects models. Analyses were sex-stratified and adjusted for prenatal exposures, maternal age, race\/ethnicity, and income. False discovery rate (FDR) correction was applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In female adolescents, PR-HTN was significantly associated with lower FV across bilateral association, projection, and limbic pathways, alongside reduced FV and FA in the corpus callosum and forceps major\/minor (\n                      <jats:italic>q<\/jats:italic>\n                      \u2009&lt;\u20090.05). Conversely, P\/E exposure showed no FDR-significant associations. No significant associations were observed in males for either HDP subtype.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Chronic in-utero exposure to PR-HTN, rather than acute P\/E, is associated with widespread reductions in white matter structural integrity in females. These findings support subtype-specific and developmentally sensitive associations between HDP exposure and offspring brain development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Impact<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>This study demonstrates that pregnancy-related hypertension, a traditionally \u201cmilder\u201d disorder, has more pronounced long-term impacts on adolescent white matter scaffolding than preeclampsia\/eclampsia.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The results highlight a female-specific vulnerability to chronic prenatal hypertensive stress, manifesting as reduced volumetric and microstructural integrity in critical commissural and association white matter tracts.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>These findings shift the clinical focus toward the neurodevelopmental risks of chronic gestational hypertension, suggesting that maternal cardiovascular health throughout the entire pregnancy is a vital determinant of offspring brain development.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41390-026-05511-5","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:20:19Z","timestamp":1790864419000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prenatal exposure to hypertensive disorders and adolescent brain white matter development"],"prefix":"10.1038","author":[{"given":"Vida","family":"Rebello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinging","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M.","family":"Talge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedyeh","family":"Ahmadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew O.","family":"Odegaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica M.","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marybel R.","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Kan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette","family":"Boden-Albala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina A.","family":"Uban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"5511_CR1","doi-asserted-by":"publisher","first-page":"100864","DOI":"10.1016\/j.jacadv.2024.100864","volume":"3","author":"AA Radparvar","year":"2024","unstructured":"Radparvar, A. 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