{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:40:13Z","timestamp":1792651213496,"version":"4.5.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"DOI":"10.1038\/s41390-026-05545-9","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:53:27Z","timestamp":1792648407000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low prevalence of celiac disease in French children, a nationwide study"],"prefix":"10.1038","author":[{"given":"Marwa","family":"Hmimou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00e9","family":"Girard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Renoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Arrouy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryse","family":"Lapeyre-Mestre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5425-7352","authenticated-orcid":false,"given":"Emmanuel","family":"Mas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"5545_CR1","doi-asserted-by":"publisher","first-page":"508","DOI":"10.5137\/1019-5149.JTN.12347-14.0","volume":"25","author":"H Tekiner","year":"2015","unstructured":"Tekiner, H. Aretaeus of Cappadocia and his treatises on diseases. Turk. Neurosurg. 25, 508\u2013512 https:\/\/doi.org\/10.5137\/1019-5149.JTN.12347-14.0 (2015).","journal-title":"Turk. Neurosurg."},{"key":"5545_CR2","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.revmed.2023.07.006","volume":"44","author":"B Vauquelin","year":"2023","unstructured":"Vauquelin, B. & Riviere, P. Celiac disease. Rev. Med. Interne 44, 539\u2013545 https:\/\/doi.org\/10.1016\/j.revmed.2023.07.006 (2023).","journal-title":"Rev. Med. Interne"},{"key":"5545_CR3","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1097\/MPG.0b013e31821a23d0","volume":"54","author":"S Husby","year":"2012","unstructured":"Husby, S. et al. European society for pediatric gastroenterology, hepatology, and nutrition guidelines for the diagnosis of coeliac disease. J. Pediatr. Gastroenterol. Nutr. 54, 136\u2013160 https:\/\/doi.org\/10.1097\/MPG.0b013e31821a23d0 (2012).","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"5545_CR4","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.dld.2022.12.023","volume":"55","author":"E Lionetti","year":"2023","unstructured":"Lionetti, E. et al. Prevalence and detection rate of celiac disease in Italy: results of a SIGENP multicenter screening in school-age children. Dig. Liver Dis. 55, 608\u2013613 https:\/\/doi.org\/10.1016\/j.dld.2022.12.023 (2023).","journal-title":"Dig. Liver Dis."},{"key":"5545_CR5","doi-asserted-by":"publisher","first-page":"S20","DOI":"10.1097\/MPG.0000000000001912","volume":"66","author":"MJ Lentze","year":"2018","unstructured":"Lentze, M. J. et al. Chapter 2. ESPGHAN: 50 years memories-the early years. J. Pediatr. Gastroenterol. Nutr. 66, S20\u2013S28 https:\/\/doi.org\/10.1097\/MPG.0000000000001912 (2018).","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"5545_CR6","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1097\/MPG.0000000000002497","volume":"70","author":"S Husby","year":"2020","unstructured":"Husby, S. et al. European society paediatric gastroenterology, hepatology and nutrition guidelines for diagnosing coeliac disease 2020. J. Pediatr. Gastroenterol. Nutr. 70, 141\u2013156 https:\/\/doi.org\/10.1097\/MPG.0000000000002497 (2020).","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"5545_CR7","first-page":"31","volume":"2008","author":"F Bienvenu","year":"2008","unstructured":"Bienvenu, F. Strat\u00e9gie d\u2019exploration immunologique de la maladie c\u0153liaque. Rev. Francoph. Des. Lab. 2008, 31\u201336 (2008).","journal-title":"Rev. Francoph. Des. Lab."},{"key":"5545_CR8","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/apt.16337","volume":"54","author":"SE Roberts","year":"2021","unstructured":"Roberts, S. E. et al. Systematic review and meta-analysis: the incidence and prevalence of paediatric coeliac disease across Europe. Aliment Pharm. Ther. 54, 109\u2013128 https:\/\/doi.org\/10.1111\/apt.16337 (2021).","journal-title":"Aliment Pharm. Ther."},{"key":"5545_CR9","doi-asserted-by":"publisher","first-page":"507","DOI":"10.14309\/ajg.0000000000000523","volume":"115","author":"JA King","year":"2020","unstructured":"King, J. A. et al. Incidence of Celiac disease is increasing over time: a systematic review and meta-analysis. Am. J. Gastroenterol. 115, 507\u2013525 https:\/\/doi.org\/10.14309\/ajg.0000000000000523 (2020).","journal-title":"Am. J. Gastroenterol."},{"key":"5545_CR10","first-page":"107","volume":"30","author":"JJ Baudon","year":"2001","unstructured":"Baudon, J. J. et al. Incidence of symptomatic celiac disease in French children. Presse Med. 30, 107\u2013110 (2001).","journal-title":"Presse Med."},{"key":"5545_CR11","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.revmed.2014.11.009","volume":"36","author":"G Moulis","year":"2015","unstructured":"Moulis, G. et al. French health insurance databases: what interest for medical research?. Rev. Med. Interne 36, 411\u2013417 https:\/\/doi.org\/10.1016\/j.revmed.2014.11.009 (2015).","journal-title":"Rev. Med. Interne"},{"key":"5545_CR12","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.therap.2024.05.003","volume":"79","author":"O Maillard","year":"2024","unstructured":"Maillard, O. et al. Use of the French National Health Data System (SNDS) in pharmacoepidemiology: a systematic review in its maturation phase. Therapie 79, 659\u2013669 https:\/\/doi.org\/10.1016\/j.therap.2024.05.003 (2024).","journal-title":"Therapie"},{"key":"5545_CR13","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1001\/jamapediatrics.2023.2900","volume":"177","author":"M Lassalle","year":"2023","unstructured":"Lassalle, M., Zureik, M. & Dray-Spira, R. Proton pump inhibitor use and risk of serious infections in young children. JAMA Pediatr. 177, 1028\u20131038 https:\/\/doi.org\/10.1001\/jamapediatrics.2023.2900 (2023).","journal-title":"JAMA Pediatr."},{"key":"5545_CR14","doi-asserted-by":"publisher","first-page":"e2441874","DOI":"10.1001\/jamanetworkopen.2024.41874","volume":"7","author":"Z Valtuille","year":"2024","unstructured":"Valtuille, Z. et al. Pediatric hospitalizations and emergency department visits related to mental health conditions and self-harm. JAMA Netw. Open 7, e2441874 https:\/\/doi.org\/10.1001\/jamanetworkopen.2024.41874 (2024).","journal-title":"JAMA Netw. Open"},{"key":"5545_CR15","doi-asserted-by":"publisher","first-page":"e0285467","DOI":"10.1371\/journal.pone.0285467","volume":"18","author":"J Pergeline","year":"2023","unstructured":"Pergeline, J. et al. Social deprivation and the use of healthcare services over one year by children less than 18 years of age in 2018: a French nationwide observational study. PLoS ONE 18, e0285467 https:\/\/doi.org\/10.1371\/journal.pone.0285467 (2023).","journal-title":"PLoS ONE"},{"key":"5545_CR16","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.cgh.2017.06.037","volume":"16","author":"P Singh","year":"2018","unstructured":"Singh, P. et al. Global prevalence of celiac disease: systematic review and meta-analysis. Clin. Gastroenterol. Hepatol. 16, 823\u2013836.e822 https:\/\/doi.org\/10.1016\/j.cgh.2017.06.037 (2018).","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"5545_CR17","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.clinre.2015.05.024","volume":"39","author":"H Garnier-Lengline","year":"2015","unstructured":"Garnier-Lengline, H., Cerf-Bensussan, N. & Ruemmele, F. M. Celiac disease in children. Clin. Res. Hepatol. Gastroenterol. 39, 544\u2013551 https:\/\/doi.org\/10.1016\/j.clinre.2015.05.024 (2015).","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"5545_CR18","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1186\/s13052-021-01183-5","volume":"47","author":"M Pedretti","year":"2021","unstructured":"Pedretti, M. et al. Is the clinical pattern of pediatric celiac disease changing? A thirty-years real-life experience of an Italian center. Ital. J. Pediatr. 47, 235 https:\/\/doi.org\/10.1186\/s13052-021-01183-5 (2021).","journal-title":"Ital. J. Pediatr."},{"key":"5545_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmer.2025.101237","volume":"89","author":"P Wang","year":"2026","unstructured":"Wang, P. et al. Increased delays of care during the COVID-19 pandemic: experience of a lung cancer rapid diagnostic center. Respiratory Med. Res. 89, 101237. https:\/\/doi.org\/10.1016\/j.resmer.2025.101237 (2026).","journal-title":"Respiratory Med. Res."},{"key":"5545_CR20","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.dld.2012.06.016","volume":"44","author":"CJ Wingren","year":"2012","unstructured":"Wingren, C. J., Agardh, D. & Merlo, J. Sex differences in coeliac disease risk: a Swedish sibling design study. Dig. Liver Dis. 44, 909\u2013913 https:\/\/doi.org\/10.1016\/j.dld.2012.06.016 (2012).","journal-title":"Dig. Liver Dis."},{"key":"5545_CR21","doi-asserted-by":"publisher","unstructured":"Imran. Spectrum of clinical presentation of celiac disease in pediatric population. Cureus 13, e15582 https:\/\/doi.org\/10.7759\/cureus.15582 (2021).","DOI":"10.7759\/cureus.15582"},{"key":"5545_CR22","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1542\/peds.2014-1787","volume":"135","author":"CA Aronsson","year":"2015","unstructured":"Aronsson, C. A. et al. Age at gluten introduction and risk of celiac disease. Pediatrics 135, 239\u2013245 https:\/\/doi.org\/10.1542\/peds.2014-1787 (2015).","journal-title":"Pediatrics"},{"key":"5545_CR23","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/ajg.2015.219","volume":"111","author":"B Lebwohl","year":"2016","unstructured":"Lebwohl, B. et al. Gluten introduction, breastfeeding, and celiac disease: back to the drawing board. Am. J. Gastroenterol. 111, 12\u201314 https:\/\/doi.org\/10.1038\/ajg.2015.219 (2016).","journal-title":"Am. J. Gastroenterol."},{"key":"5545_CR24","doi-asserted-by":"publisher","first-page":"6028","DOI":"10.3748\/wjg.15.6028","volume":"15","author":"R Gupta","year":"2009","unstructured":"Gupta, R. et al. Indian task force for celiac disease: current status. World J. Gastroenterol. 15, 6028\u20136033 https:\/\/doi.org\/10.3748\/wjg.15.6028 (2009).","journal-title":"World J. Gastroenterol."},{"key":"5545_CR25","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.revmed.2025.03.424","volume":"46","author":"G Moulis","year":"2025","unstructured":"Moulis, G., Zadro, Y., Sommet, A., Lapeyre-Mestre, M. & Lafaurie, M. Use of real-world data for the development and the follow-up of drugs in rare diseases. The example of immune thrombocytopenia and autoimmune hemolytic anemia. Rev. Med. Interne 46, 287\u2013292 https:\/\/doi.org\/10.1016\/j.revmed.2025.03.424 (2025).","journal-title":"Rev. Med. Interne"},{"key":"5545_CR26","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-019-4693-2","volume":"12","author":"DR Duerksen","year":"2019","unstructured":"Duerksen, D. R., Lix, L. M. & Leslie, W. D. Development of an administrative definition for celiac disease. BMC Res. Notes 12, 661. https:\/\/doi.org\/10.1186\/s13104-019-4693-2 (2019).","journal-title":"BMC Res. Notes"},{"key":"5545_CR27","unstructured":"Remboursement des produits sans gluten, https:\/\/www.afdiag.fr\/fr\/au-quotidien\/remboursement-des-produits-sans-gluten\/."},{"key":"5545_CR28","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1111\/apa.15562","volume":"110","author":"F Norstrom","year":"2021","unstructured":"Norstrom, F. et al. Family socio-economic status and childhood coeliac disease seem to be unrelated-A cross-sectional screening study. Acta Paediatr. 110, 1346\u20131352 https:\/\/doi.org\/10.1111\/apa.15562 (2021).","journal-title":"Acta Paediatr."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-026-05545-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-026-05545-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-026-05545-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:53:28Z","timestamp":1792648408000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-026-05545-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,22]]},"references-count":28,"alternative-id":["5545"],"URL":"https:\/\/doi.org\/10.1038\/s41390-026-05545-9","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,22]]},"assertion":[{"value":"17 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}