{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:39:30Z","timestamp":1792787970315,"version":"4.5.0"},"reference-count":286,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Heme-oxygenase-1 (HO-1) is a key regulatory factor in organ development, organ function, cellular metabolism, heme processing, and bilirubin production. HO-1 homeostasis is crucial for healthy pregnancy and fetus. Dysregulation of HO-1 adversely affects placentation, yolk sac development, cardiovascular development, immune function, angiogenesis, microcirculation, alters the oxidoreductive balance, and is associated with adverse respiratory outcomes and necrotizing enterocolitis. The impact of HO-1 on neonatal neurodevelopment is unknown and is currently being investigated by our laboratory. In this review, we will discuss the morbidities associated with HO-1 dysregulation and importantly, we will navigate the unknown. We will highlight how infection or inflammation affect HO-1 homeostasis, its implications on neonatal morbidities at the limits of viability, summarize the relevant basic, translational, clinical and epidemiologic studies. We will conclude with proposing new approaches for the future, filling the gap between what is currently known and unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Impact<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>What does this article add to the existing literature?<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>HO-1 pathway is relevant to pregnancy, fetus, neonatal, and later life outcomes.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Provides comprehensive organ systems-based evaluation of Heme-oxygenase-1 in pregnancy, fetus, extreme preterm, and periviable neonates.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Highlights how environmental factors, including infection, inflammation resulting in systemic dysregulation of HO-1 affects major neonatal morbidities.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Underscores that novel investigations to close the knowledge gap are forthcoming to transform the HO-1 field.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41390-026-05568-2","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:42:12Z","timestamp":1792741332000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of altered heme oxygenase-1 in caring for preterm neonates: navigating the unknown"],"prefix":"10.1038","author":[{"given":"Phoebe","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2020-7821","authenticated-orcid":false,"given":"Maide","family":"Ozen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"key":"5568_CR1","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/S0966-3274(98)80022-1","volume":"6","author":"J Woo","year":"1998","unstructured":"Woo, J. et al. Stress protein-induced immunosuppression: inhibition of cellular immune effector functions following overexpression of haem oxygenase (HSP 32). Transpl. Immunol. 6, 84\u201393 (1998).","journal-title":"Transpl. Immunol."},{"key":"5568_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2025.112843","volume":"266","author":"T Chiura","year":"2025","unstructured":"Chiura, T., Pham, M. N., Baum, D. A. & Mak, P. J. Interactions between heme and G-quadruplex DNA involve the oxygen of guanine. J. Inorg. Biochem. 266, 112843 (2025).","journal-title":"J. Inorg. Biochem"},{"key":"5568_CR3","doi-asserted-by":"publisher","first-page":"5624","DOI":"10.1039\/C9CS00268E","volume":"48","author":"T Shimizu","year":"2019","unstructured":"Shimizu, T., Lengalova, A., Mart\u00ednek, V. & Mart\u00ednkov\u00e1, M. Heme: emergent roles of heme in signal transduction, functional regulation and as catalytic centres. Chem. Soc. Rev. 48, 5624\u201357 (2019).","journal-title":"Chem. Soc. Rev."},{"key":"5568_CR4","doi-asserted-by":"publisher","first-page":"13194","DOI":"10.1074\/jbc.R112.422642","volume":"288","author":"HM Girvan","year":"2013","unstructured":"Girvan, H. M. & Munro, A. W. Heme sensor proteins. J. Biol. Chem. 288, 13194\u2013203 (2013).","journal-title":"J. Biol. Chem."},{"key":"5568_CR5","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3390\/ijms21249698","volume":"21","author":"DD Haines","year":"2020","unstructured":"Haines, D. D. & Tosaki, A. Heme degradation in pathophysiology of and countermeasures to inflammation-associated disease. Int. J. Mol. Sci. 21, 24 (2020).","journal-title":"Int. J. Mol. Sci."},{"key":"5568_CR6","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1002\/ptr.5273","volume":"29","author":"Z Csiki","year":"2015","unstructured":"Csiki, Z. et al. Orally delivered sour cherry seed extract (SCSE) affects cardiovascular and hematological parameters in humans. Phytother. Res. 29, 444\u20139 (2015).","journal-title":"Phytother. Res."},{"key":"5568_CR7","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1111\/j.1471-4159.1999.721187.x","volume":"72","author":"N Panahian","year":"1999","unstructured":"Panahian, N., Yoshiura, M. & Maines, M. D. Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice. J. Neurochem. 72, 1187\u2013203 (1999).","journal-title":"J. Neurochem"},{"key":"5568_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101549","volume":"298","author":"DA Hanna","year":"2022","unstructured":"Hanna, D. A. et al. Heme oxygenase-2 (HO-2) binds and buffers labile ferric heme in human embryonic kidney cells. J. Biol. Chem. 298, 101549 (2022).","journal-title":"J. Biol. Chem."},{"key":"5568_CR9","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1089\/ars.2005.7.1761","volume":"7","author":"MD Maines","year":"2005","unstructured":"Maines, M. D. The heme oxygenase system: Update 2005. Antioxid. Redox Signal 7, 1761\u20136 (2005).","journal-title":"Antioxid. Redox Signal"},{"key":"5568_CR10","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1146\/annurev.pharmtox.37.1.517","volume":"37","author":"MD Maines","year":"1997","unstructured":"Maines, M. D. The heme oxygenase system: A regulator of second messenger gases. Annu Rev. Pharm. Toxicol. 37, 517\u201354 (1997).","journal-title":"Annu Rev. Pharm. Toxicol."},{"key":"5568_CR11","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.freeradbiomed.2005.04.009","volume":"39","author":"Y-S Kim","year":"2005","unstructured":"Kim, Y.-S. & Dor\u00e9, S. Catalytically inactive heme oxygenase-2 mutant is cytoprotective. Free Radic. Biol. Med. 39, 558\u201364 (2005).","journal-title":"Free Radic. Biol. Med"},{"key":"5568_CR12","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1007\/s00277-023-05193-7","volume":"102","author":"R Liu","year":"2023","unstructured":"Liu, R. et al. Heme oxygenase 1 in erythropoiesis: an important regulator beyond catalyzing heme catabolism. Ann. Hematol. 102, 1323\u201332 (2023).","journal-title":"Ann. Hematol."},{"key":"5568_CR13","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3892\/mmr.2021.12545","volume":"25","author":"L-L Ma","year":"2022","unstructured":"Ma, L.-L. et al. Association between HO-1 gene promoter polymorphisms and diseases (Review). Mol. Med. Rep. 25, 29 (2022).","journal-title":"Mol. Med. Rep."},{"key":"5568_CR14","first-page":"595","volume":"39","author":"Y Wu","year":"2024","unstructured":"Wu, Y. et al. Self-assembled carbon monoxide nanogenerators managing sepsis through scavenging multiple inflammatory mediators. Bioact. Mater. 39, 595\u2013611 (2024).","journal-title":"Bioact. Mater."},{"key":"5568_CR15","doi-asserted-by":"publisher","first-page":"8650","DOI":"10.3390\/ijms21228650","volume":"21","author":"DT Tran","year":"2020","unstructured":"Tran, D. T. et al. The anti-inflammatory role of bilirubin on \u201cTwo-Hit\u201d sepsis animal model. Int. J. Mol. Sci. 21, 8650 (2020).","journal-title":"Int. J. Mol. Sci."},{"key":"5568_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms22041514","volume":"22","author":"A Yachie","year":"2021","unstructured":"Yachie, A. Heme oxygenase-1 deficiency and oxidative stress: A review of 9 independent human cases and animal models. Int J. Mol. Sci. 22, 1\u201316 (2021).","journal-title":"Int J. Mol. Sci."},{"key":"5568_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2014.00295","volume":"5","author":"H Zhao","year":"2015","unstructured":"Zhao, H., Ozen, M., Wong, R. J. & Stevenson, D. K. Heme oxygenase-1 in pregnancy and cancer: Similarities in cellular invasion, cytoprotection, angiogenesis, and immunomodulation. Front Pharm. 5, 1\u201310 (2015).","journal-title":"Front Pharm."},{"key":"5568_CR18","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1095\/biolreprod.111.093039","volume":"85","author":"H Zhao","year":"2011","unstructured":"Zhao, H. et al. Maternal heme oxygenase 1 regulates placental vasculature development via angiogenic factors in mice. Biol. Reprod. 85, 1005\u201312 (2011).","journal-title":"Biol. Reprod."},{"key":"5568_CR19","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1189\/jlb.1A0116-020RR","volume":"101","author":"H Zhao","year":"2017","unstructured":"Zhao, H., Kalish, F., Wong, R. J. & Stevenson, D. K. Infiltration of myeloid cells in the pregnant uterus is affected by heme oxygenase-1. J. Leukoc. Biol. 101, 217\u201326 (2017).","journal-title":"J. Leukoc. Biol."},{"key":"5568_CR20","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.placenta.2009.07.012","volume":"30","author":"H Zhao","year":"2009","unstructured":"Zhao, H. et al. Effect of heme oxygenase-1 deficiency on placental development. Placenta. 30, 861\u20138 (2009).","journal-title":"Placenta"},{"key":"5568_CR21","doi-asserted-by":"publisher","first-page":"376","DOI":"10.3390\/cells13050376","volume":"13","author":"ML Zenclussen","year":"2024","unstructured":"Zenclussen, M. L. et al. Absence of heme oxygenase-1 affects trophoblastic spheroid implantation and provokes dysregulation of stress and angiogenesis gene expression in the uterus. Cells 13, 376 (2024).","journal-title":"Cells"},{"key":"5568_CR22","first-page":"1","volume":"6","author":"ML Zenclussen","year":"2015","unstructured":"Zenclussen, M. L. et al. Heme oxygenase-1 is critically involved in placentation, spiral artery remodeling, and blood pressure regulation during murine pregnancy. Front Pharm. 6, 1\u201310 (2015).","journal-title":"Front Pharm."},{"key":"5568_CR23","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1002\/path.2946","volume":"225","author":"ML Zenclussen","year":"2011","unstructured":"Zenclussen, M. L. et al. Haem oxygenase-1 dictates intrauterine fetal survival in mice via carbon monoxide. J. Pathol. 225, 293\u2013304 (2011).","journal-title":"J. Pathol."},{"key":"5568_CR24","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1089\/ars.2019.7991","volume":"32","author":"MV Medina","year":"2020","unstructured":"Medina, M. V., Sapochnik, D., Garcia Sol\u00e1, M. & Coso, O. Regulation of the expression of heme oxygenase-1: Signal transduction, gene promoter activation, and beyond. Antioxid. Redox Signal 32, 1033\u201344 (2020).","journal-title":"Antioxid. Redox Signal"},{"key":"5568_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/antiox9121205","volume":"9","author":"DL Costa","year":"2020","unstructured":"Costa, D. L., Amaral, E. P., Andrade, B. B. & Sher, A. Modulation of inflammation and immune responses by heme oxygenase-1: Implications for infection with intracellular pathogens. Antioxidants 9, 1\u201330 (2020).","journal-title":"Antioxidants"},{"key":"5568_CR26","doi-asserted-by":"crossref","unstructured":"Ozen, M. et al. Heme oxygenase and the immune system in normal and pathological pregnancies. Front Pharmacol. 6, 84\u201396 (2015).","DOI":"10.3389\/fphar.2015.00084"},{"key":"5568_CR27","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.biosystems.2014.09.005","volume":"124","author":"TE Pronk","year":"2014","unstructured":"Pronk, T. E. et al. Comparison of the molecular topologies of stress-activated transcription factors HSF1, AP-1, NRF2, and NF-\u03baB in their induction kinetics of HMOX1. Biosystems 124, 75\u201385 (2014).","journal-title":"Biosystems"},{"key":"5568_CR28","doi-asserted-by":"publisher","first-page":"1347969","DOI":"10.1155\/2018\/1347969","volume":"2018","author":"X Zhang","year":"2018","unstructured":"Zhang, X. et al. Bach1: Function, regulation, and involvement in disease. Oxid. Med. Cell Longev. 2018, 1347969 (2018).","journal-title":"Oxid. Med. Cell Longev."},{"key":"5568_CR29","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1073\/pnas.0308083100","volume":"101","author":"J Sun","year":"2004","unstructured":"Sun, J. et al. Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network. Proc. Natl. Acad. Sci. USA 101, 1461\u20136 (2004).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"5568_CR30","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s00408-023-00639-1","volume":"201","author":"M Yang","year":"2023","unstructured":"Yang, M. et al. ETS1 ameliorates hyperoxia-induced bronchopulmonary dysplasia in mice by activating Nrf2\/HO-1 mediated ferroptosis. Lung 201, 425\u201341 (2023).","journal-title":"Lung"},{"key":"5568_CR31","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1093\/cvr\/cvae162","volume":"120","author":"J Tan","year":"2024","unstructured":"Tan, J. et al. CircCHSY1 protects hearts against ischaemia\/reperfusion injury by enhancing heme oxygenase 1 expression via miR-24-3p. Cardiovasc Res. 120, 1924\u201338 (2024).","journal-title":"Cardiovasc Res."},{"key":"5568_CR32","doi-asserted-by":"publisher","first-page":"101289","DOI":"10.1016\/j.redox.2019.101289","volume":"26","author":"L Zhao","year":"2019","unstructured":"Zhao, L. et al. Corrigendum to \u201cMicroRNA-140\u20135p aggravates doxorubicin-induced cardiotoxicity by promoting myocardial oxidative stress via targeting Nrf2 and Sirt2\u201d [Redox Biol. 15 (2018) 284\u2013296]. Redox Biol. 26, 101289 (2019).","journal-title":"Redox Biol."},{"key":"5568_CR33","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1007\/s11064-016-1975-0","volume":"41","author":"P Wang","year":"2016","unstructured":"Wang, P. et al. MicroRNA-93 downregulation ameliorates cerebral ischemic injury through the Nrf2\/HO-1 defense pathway. Neurochem Res. 41, 2627\u201335 (2016).","journal-title":"Neurochem Res"},{"key":"5568_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pgen.1006896","volume":"13","author":"M Pu","year":"2017","unstructured":"Pu, M. et al. MiR-1254 suppresses HO-1 expression through seed region-dependent silencing and non-seed interaction with TFAP2A transcript to attenuate NSCLC growth. PLoS Genet 13, 1\u201325e1006896 (2017).","journal-title":"PLoS Genet"},{"key":"5568_CR35","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3390\/antiox10010087","volume":"10","author":"M Mascar\u00f3","year":"2021","unstructured":"Mascar\u00f3, M. et al. Nuclear localization of heme oxygenase-1 in pathophysiological conditions: Does it explain the dual role in cancer? Antioxid. (Basel) 10, 87 (2021).","journal-title":"Antioxid. (Basel)"},{"key":"5568_CR36","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1159\/000546624","volume":"48","author":"M Ozen","year":"2025","unstructured":"Ozen, M. et al. Chorioamnionitis induces a unique time course of inflammatory changes and immune reponses in the brain and spleen. Dev. Neurosci. 48, 167\u2013181 (2025).","journal-title":"Dev. Neurosci."},{"key":"5568_CR37","doi-asserted-by":"publisher","first-page":"e0252642","DOI":"10.1371\/journal.pone.0252642","volume":"16","author":"M Ozen","year":"2021","unstructured":"Ozen, M. et al. Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring. PLoS One 16, e0252642 (2021).","journal-title":"PLoS One"},{"key":"5568_CR38","doi-asserted-by":"publisher","first-page":"5773","DOI":"10.3390\/ijms22115773","volume":"22","author":"M Ozen","year":"2021","unstructured":"Ozen, M. et al. Chorioamnionitis precipitates perinatal alterations of heme-oxygenase-1 (HO-1) homeostasis in the developing rat brain. Int. J. Mol. Sci. 22, 5773 https:\/\/doi.org\/10.3390\/ijms22115773 (2021).","journal-title":"Int. J. Mol. Sci."},{"key":"5568_CR39","doi-asserted-by":"publisher","first-page":"3520","DOI":"10.3390\/ijerph18073520","volume":"18","author":"R Nakasone","year":"2021","unstructured":"Nakasone, R. et al. The role of heme oxygenase-1 promoter polymorphisms in perinatal disease. Int. J. Environ. Res. Public Health 18, 3520 (2021).","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"5568_CR40","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/j.freeradbiomed.2004.07.008","volume":"37","author":"M Exner","year":"2004","unstructured":"Exner, M., Minar, E., Wagner, O. & Schillinger, M. The role of heme oxygenase-1 promoter polymorphisms in human disease. Free Radic. Biol. Med. 37, 1097\u2013104 (2004).","journal-title":"Free Radic. Biol. Med"},{"key":"5568_CR41","first-page":"1","volume":"22","author":"A Fern\u00e1ndez-Fierro","year":"2021","unstructured":"Fern\u00e1ndez-Fierro, A. et al. Immune modulation by inhibitors of the ho system. Int J. Mol. Sci. 22, 1\u201318 (2021).","journal-title":"Int J. Mol. Sci."},{"key":"5568_CR42","doi-asserted-by":"publisher","first-page":"66","DOI":"10.3389\/fimmu.2020.00066","volume":"11","author":"G Canesin","year":"2020","unstructured":"Canesin, G., Hejazi, S. M., Swanson, K. D. & Wegiel, B. Heme-derived metabolic signals dictate immune responses. Front Immunol. 11, 66 (2020).","journal-title":"Front Immunol."},{"key":"5568_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.earlhumdev.2016.06.001","volume":"98","author":"JH Weitkamp","year":"2016","unstructured":"Weitkamp, J. H. et al. Histological chorioamnionitis shapes the neonatal transcriptomic immune response. Early Hum. Dev. 98, 1\u20136 (2016).","journal-title":"Early Hum. Dev."},{"key":"5568_CR44","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1086\/302729","volume":"66","author":"N Yamada","year":"2000","unstructured":"Yamada, N. et al. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am. J. Hum. Genet 66, 187\u201395 (2000).","journal-title":"Am. J. Hum. Genet"},{"key":"5568_CR45","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.atherosclerosis.2003.11.021","volume":"173","author":"K Ono","year":"2004","unstructured":"Ono, K. et al. A promoter variant of the heme oxygenase-1 gene may reduce the incidence of ischemic heart disease in Japanese. Atherosclerosis 173, 313\u20137 (2004).","journal-title":"Atherosclerosis"},{"key":"5568_CR46","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s12887-024-04537-0","volume":"24","author":"J Fan","year":"2024","unstructured":"Fan, J. et al. Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and HMOX1 polymorphisms and susceptibility to neonatal severe hyperbilirubinemia in Chinese Han population. BMC Pediatr. 24, 82 (2024).","journal-title":"BMC Pediatr."},{"key":"5568_CR47","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1016\/j.jpeds.2014.08.041","volume":"165","author":"Y Zhou","year":"2014","unstructured":"Zhou, Y. et al. Quantitative trait analysis of polymorphisms in two bilirubin metabolism enzymes to physiologic bilirubin levels in Chinese newborns. J. Pediatr. 165, 1154\u20131160.e1 (2014).","journal-title":"J. Pediatr."},{"key":"5568_CR48","doi-asserted-by":"publisher","first-page":"e0132034","DOI":"10.1371\/journal.pone.0132034","volume":"10","author":"H Yang","year":"2015","unstructured":"Yang, H. et al. Multiple genetic modifiers of bilirubin metabolism involvement in significant neonatal hyperbilirubinemia in patients of chinese descent. PLoS One 10, e0132034 (2015).","journal-title":"PLoS One"},{"key":"5568_CR49","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1203\/01.PDR.0000072329.56635.35","volume":"54","author":"M Kanai","year":"2003","unstructured":"Kanai, M. et al. Neonatal hyperbilirubinemia in Japanese neonates: analysis of the heme oxygenase-1 gene and fetal hemoglobin composition in cord blood. Pediatr. Res. 54, 165\u201371 (2003).","journal-title":"Pediatr. Res."},{"key":"5568_CR50","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s00277-014-2123-z","volume":"94","author":"P Warang","year":"2015","unstructured":"Warang, P. et al. Do UGT1A1 and HMOX1 gene promoter polymorphisms increase the risk of hyperbilirubinemia and gallstones in patients with hereditary spherocytosis? Ann. Hematol. 94, 169\u201371 (2015).","journal-title":"Ann. Hematol."},{"key":"5568_CR51","doi-asserted-by":"publisher","first-page":"e104251","DOI":"10.1371\/journal.pone.0104251","volume":"9","author":"Y Zhou","year":"2014","unstructured":"Zhou, Y. et al. Association of UGT1A1 variants and hyperbilirubinemia in breast-fed full-term Chinese infants. PLoS One 9, e104251 (2014).","journal-title":"PLoS One"},{"key":"5568_CR52","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1111\/j.1651-2227.2009.01678.x","volume":"99","author":"OG Bozkaya","year":"2010","unstructured":"Bozkaya, O. G. et al. Prolonged unconjugated hyperbilirubinaemia associated with the haem oxygenase-1 gene promoter polymorphism. Acta Paediatr. 99, 679\u201383 (2010).","journal-title":"Acta Paediatr."},{"key":"5568_CR53","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1007\/s00431-013-2091-7","volume":"172","author":"PK Tiwari","year":"2013","unstructured":"Tiwari, P. K. et al. Heme oxygenase-1 gene variants and hyperbilirubinemia risk in North Indian newborns. Eur. J. Pediatr. 172, 1627\u201332 (2013).","journal-title":"Eur. J. Pediatr."},{"key":"5568_CR54","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1111\/ped.12591","volume":"57","author":"Y Katayama","year":"2015","unstructured":"Katayama, Y. et al. Association of HMOX1 gene promoter polymorphisms with hyperbilirubinemia in the early neonatal period. Pediatr. Int. 57, 645\u20139 (2015).","journal-title":"Pediatr. Int"},{"key":"5568_CR55","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s12887-016-0685-8","volume":"16","author":"Y-H Weng","year":"2016","unstructured":"Weng, Y.-H., Chiu, Y.-W., Cheng, S.-W. & Yang, C.-Y. Risk assessment of gene variants for neonatal hyperbilirubinemia in Taiwan. BMC Pediatr. 16, 144 (2016).","journal-title":"BMC Pediatr."},{"key":"5568_CR56","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1089\/gtmb.2010.0132","volume":"15","author":"S D\u2019Silva","year":"2011","unstructured":"D\u2019Silva, S. et al. Association of (GT)n repeats promoter polymorphism of heme oxygenase-1 gene with serum bilirubin levels in healthy indian adults. Genet Test. Mol. Biomark. 15, 215\u20138 (2011).","journal-title":"Genet Test. Mol. Biomark."},{"key":"5568_CR57","doi-asserted-by":"publisher","first-page":"e764","DOI":"10.1542\/peds.2006-1385","volume":"119","author":"S Immenschuh","year":"2007","unstructured":"Immenschuh, S. et al. Marked hyperbilirubinemia associated with the heme oxygenase-1 gene promoter microsatellite polymorphism in a boy with autoimmune hemolytic anemia. Pediatrics 119, e764\u20137 (2007).","journal-title":"Pediatrics"},{"key":"5568_CR58","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1161\/HYPERTENSIONAHA.114.03337","volume":"64","author":"T Kaartokallio","year":"2014","unstructured":"Kaartokallio, T. et al. Microsatellite polymorphism in the heme oxygenase 1 promoter is associated with nonsevere and late-onset preeclampsia. Hypertension 64, 172\u20137 (2014).","journal-title":"Hypertension"},{"key":"5568_CR59","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1080\/10641955.2019.1582664","volume":"38","author":"V Sandrim","year":"2019","unstructured":"Sandrim, V. et al. Circulating HO-1 levels are not associated with plasma sFLT-1 and GT n HMOX1 polymorphism in preeclampsia. Hypertens. Pregnancy 38, 73\u20137 (2019).","journal-title":"Hypertens. Pregnancy"},{"key":"5568_CR60","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1093\/molehr\/gah024","volume":"10","author":"D Denschlag","year":"2004","unstructured":"Denschlag, D. et al. The size of a microsatellite polymorphism of the haem oxygenase 1 gene is associated with idiopathic recurrent miscarriage. Mol. Hum. Reprod. 10, 211\u20134 (2004).","journal-title":"Mol. Hum. Reprod."},{"key":"5568_CR61","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/pr.2015.44","volume":"77","author":"DJ Askenazi","year":"2015","unstructured":"Askenazi, D. J. et al. Genetic polymorphisms of heme-oxygenase 1 (HO-1) may impact on acute kidney injury, bronchopulmonary dysplasia, and mortality in premature infants. Pediatr. Res. 77, 793\u20138 (2015).","journal-title":"Pediatr. Res"},{"key":"5568_CR62","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1080\/14767058.2019.1570115","volume":"34","author":"JF Zhou","year":"2021","unstructured":"Zhou, J. F. et al. Association between genetic polymorphism of heme oxygenase 1 promoter and neonatal hyperbilirubinemia: a meta-analysis. J. Matern. -Fetal Neonatal Med. 34, 12\u201323 (2021).","journal-title":"J. Matern. -Fetal Neonatal Med."},{"key":"5568_CR63","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3389\/fphar.2012.00119","volume":"3","author":"JA Araujo","year":"2012","unstructured":"Araujo, J. A., Zhang, M. & Yin, F. Heme oxygenase-1, oxidation, inflammation, and atherosclerosis. Front Pharm. 3, 119 (2012).","journal-title":"Front Pharm."},{"key":"5568_CR64","doi-asserted-by":"publisher","first-page":"4749","DOI":"10.4049\/jimmunol.177.7.4749","volume":"177","author":"S Tsuchihashi","year":"2006","unstructured":"Tsuchihashi, S. et al. Basal rather than induced heme oxygenase-1 levels are crucial in the antioxidant cytoprotection. J. Immunol. 177, 4749\u201357 (2006).","journal-title":"J. Immunol."},{"key":"5568_CR65","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1161\/ATVBAHA.110.207316","volume":"30","author":"H Taha","year":"2010","unstructured":"Taha, H. et al. Role of heme oxygenase-1 in human endothelial cells: lesson from the promoter allelic variants. Arterioscler Thromb. Vasc. Biol. 30, 1634\u201341 (2010).","journal-title":"Arterioscler Thromb. Vasc. Biol."},{"key":"5568_CR66","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s12031-007-0005-8","volume":"32","author":"T Stahnke","year":"2007","unstructured":"Stahnke, T. et al. Differential upregulation of heme oxygenase-1 (HSP32) in glial cells after oxidative stress and in demyelinating disorders. J. Mol. Neurosci. 32, 25\u201337 (2007).","journal-title":"J. Mol. Neurosci."},{"key":"5568_CR67","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1038\/sj.ki.5001565","volume":"70","author":"KA Nath","year":"2006","unstructured":"Nath, K. A. Heme oxygenase-1: A provenance for cytoprotective pathways in the kidney and other tissues. Kidney Int. 70, 432\u201343 (2006).","journal-title":"Kidney Int"},{"key":"5568_CR68","doi-asserted-by":"publisher","first-page":"3921","DOI":"10.3390\/nu17243921","volume":"17","author":"J Pham","year":"2025","unstructured":"Pham, J., Refesse, M., Saeed, A. & Latunde-Dada, G. O. Haem oxygenase-1, ferroptosis and disorders-A narrative review. Nutrients 17, 3921 (2025).","journal-title":"Nutrients"},{"key":"5568_CR69","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1096\/fasebj.13.13.1800","volume":"13","author":"DM Suttner","year":"1999","unstructured":"Suttner, D. M. & Dennery, P. A. Reversal of HO-1 related cytoprotection with increased expression is due to reactive iron. FASEB J. 13, 1800\u20139 (1999).","journal-title":"FASEB J."},{"key":"5568_CR70","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3390\/neurosci3020020","volume":"3","author":"M Cressatti","year":"2022","unstructured":"Cressatti, M. & Schipper, H. M. Dysregulation of a heme oxygenase\u2013synuclein axis in Parkinson disease. NeuroSci 3, 284\u201399 (2022).","journal-title":"NeuroSci"},{"key":"5568_CR71","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2025.104735","volume":"172","author":"Z Li","year":"2025","unstructured":"Li, Z. et al. Ferroptosis, NF-\u03baB expression, and antioxidant imbalance in chorioamnionitis-associated preterm birth. J. Reprod. Immunol. 172, 104735 (2025).","journal-title":"J. Reprod. Immunol."},{"key":"5568_CR72","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1183\/09031936.00185008","volume":"35","author":"L Didon","year":"2010","unstructured":"Didon, L. et al. Lung-specific inactivation of CCAAT\/enhancer binding protein \u03b1 causes a pathological pattern characteristic of COPD. Eur. Respir. J. 35, 186\u201397 (2010).","journal-title":"Eur. Respir. J."},{"key":"5568_CR73","doi-asserted-by":"publisher","first-page":"e2531158","DOI":"10.1001\/jamanetworkopen.2025.31158","volume":"8","author":"LS Peterson","year":"2025","unstructured":"Peterson, L. S. et al. Histologic chorioamnionitis and neurodevelopment in preterm infants. JAMA Netw. Open 8, e2531158 (2025).","journal-title":"JAMA Netw. Open"},{"key":"5568_CR74","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2022.113988","volume":"351","author":"JD Reiss","year":"2022","unstructured":"Reiss, J. D. et al. Perinatal infection, inflammation, preterm birth, and brain injury: A review with proposals for future investigations. Exp. Neurol. 351, 113988 (2022).","journal-title":"Exp. Neurol."},{"key":"5568_CR75","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/s41390-021-01633-0","volume":"91","author":"VG Jain","year":"2022","unstructured":"Jain, V. G., Willis, K. A., Jobe, A. & Ambalavanan, N. Chorioamnionitis and neonatal outcomes. Pediatr. Res. 91, 289\u201396 (2022).","journal-title":"Pediatr. Res"},{"key":"5568_CR76","doi-asserted-by":"publisher","first-page":"623.e1","DOI":"10.1016\/j.ajog.2022.05.042","volume":"227","author":"VG Jain","year":"2022","unstructured":"Jain, V. G. et al. Acute histologic chorioamnionitis independently and directly increases the risk for brain abnormalities seen on magnetic resonance imaging in very preterm infants. Am. J. Obstet. Gynecol. 227, 623.e1\u2013623.e13 (2022).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"5568_CR77","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.intimp.2004.09.011","volume":"5","author":"AC Zenclussen","year":"2005","unstructured":"Zenclussen, A. C. et al. Heme oxygenase as a therapeutic target in immunological pregnancy complications. Int Immunopharmacol. 5, 41\u201351 (2005).","journal-title":"Int Immunopharmacol."},{"key":"5568_CR78","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1165\/rcmb.2010-0519OC","volume":"45","author":"S Kunzmann","year":"2011","unstructured":"Kunzmann, S. et al. Antenatal inflammation reduces expression of caveolin-1 and influences multiple signaling pathways in preterm fetal lungs. Am. J. Respir. Cell Mol. Biol. 45, 969\u201376 (2011).","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"5568_CR79","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.3390\/biom13121768","volume":"13","author":"K Grzeszczak","year":"2023","unstructured":"Grzeszczak, K. et al. Oxidative stress in pregnancy. Biomolecules 13, 1768 (2023).","journal-title":"Biomolecules"},{"key":"5568_CR80","first-page":"1348","volume":"15","author":"A-D Assani","year":"2025","unstructured":"Assani, A.-D. et al. Pregnancy under pressure: Oxidative stress as a common thread in maternal disorders. Life (Basel) 15, 1348 (2025).","journal-title":"Life (Basel)"},{"key":"5568_CR81","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3389\/fphar.2014.00288","volume":"5","author":"A Schumacher","year":"2015","unstructured":"Schumacher, A. & Zenclussen, A. C. Effects of heme oxygenase-1 on innate and adaptive immune responses promoting pregnancy success and allograft tolerance. Front Pharm. 5, 288 (2015).","journal-title":"Front Pharm."},{"key":"5568_CR82","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1111\/j.1651-2227.2012.02729.x","volume":"101","author":"RJ Wong","year":"2012","unstructured":"Wong, R. J., Zhao, H. & Stevenson, D. K. A deficiency in haem oxygenase-1 induces foetal growth restriction by placental vasculature defects. Acta Paediatr. Int. J. Paediatr. 101, 827\u201334 (2012).","journal-title":"Acta Paediatr. Int. J. Paediatr."},{"key":"5568_CR83","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2019.07.016","volume":"1866","author":"V Gallardo","year":"2020","unstructured":"Gallardo, V., Gonz\u00e1lez, M., Toledo, F. & Sobrevia, L. Role of heme oxygenase 1 and human chorionic gonadotropin in pregnancy associated diseases. Biochim Biophys. Acta Mol. Basis Dis. 1866, 165522 (2020).","journal-title":"Biochim Biophys. Acta Mol. Basis Dis."},{"key":"5568_CR84","doi-asserted-by":"publisher","first-page":"7569","DOI":"10.3390\/ijms25147569","volume":"25","author":"J Torres-Torres","year":"2024","unstructured":"Torres-Torres, J. et al. A narrative review on the pathophysiology of preeclampsia. Int. J. Mol. Sci. 25, 7569 (2024).","journal-title":"Int. J. Mol. Sci."},{"key":"5568_CR85","doi-asserted-by":"publisher","first-page":"9675","DOI":"10.3390\/ijms22189675","volume":"22","author":"H Zhao","year":"2021","unstructured":"Zhao, H., Wong, R. J. & Stevenson, D. K. The impact of hypoxia in early pregnancy on placental cells. Int. J. Mol. Sci. 22, 9675 (2021).","journal-title":"Int. J. Mol. Sci."},{"key":"5568_CR86","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1530\/REP-21-0314","volume":"163","author":"H-H Shen","year":"2021","unstructured":"Shen, H.-H. et al. HIF1A-induced heme oxygenase 1 promotes the survival of decidual stromal cells against excess heme-mediated oxidative stress. Reproduction 163, 33\u201343 (2021).","journal-title":"Reproduction"},{"key":"5568_CR87","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.placenta.2013.01.004","volume":"34","author":"K Levytska","year":"2013","unstructured":"Levytska, K., Kingdom, J., Baczyk, D. & Drewlo, S. Heme oxygenase-1 in placental development and pathology. Placenta 34, 291\u20138 (2013).","journal-title":"Placenta"},{"key":"5568_CR88","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.placenta.2020.09.065","volume":"103","author":"R Inoue","year":"2021","unstructured":"Inoue, R., Irie, Y. & Akagi, R. Role of heme oxygenase-1 in human placenta on iron supply to fetus. Placenta 103, 53\u20138 (2021).","journal-title":"Placenta"},{"key":"5568_CR89","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.placenta.2003.10.012","volume":"25","author":"S Watanabe","year":"2004","unstructured":"Watanabe, S. et al. Marked developmental changes in heme oxygenase-1 (HO-1) expression in the mouse placenta: Correlation between HO-1 expression and placental development. Placenta 25, 387\u201395 (2004).","journal-title":"Placenta"},{"key":"5568_CR90","first-page":"R641","volume":"306","author":"JP Warrington","year":"2014","unstructured":"Warrington, J. P. et al. Heme oxygenase 1 promotes migration and \u03b2 epithelial Na channel expression in cytotrophoblasts. Am. J. Physiol. 306, R641\u20136 (2014).","journal-title":"Am. J. Physiol."},{"key":"5568_CR91","doi-asserted-by":"publisher","first-page":"e72153","DOI":"10.1371\/journal.pone.0072153","volume":"8","author":"S Wang","year":"2013","unstructured":"Wang, S. et al. Reduced expression of Enac in Placenta tissues of patients with severe preeclampsia is related to compromised trophoblastic cell migration and invasion during pregnancy. PLoS One 8, e72153 (2013).","journal-title":"PLoS One"},{"key":"5568_CR92","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.placenta.2009.03.004","volume":"30","author":"D McCaig","year":"2009","unstructured":"McCaig, D. & Lyall, F. Inhibitors of heme oxygenase reduce invasion of human primary cytotrophoblast cells in vitro. Placenta 30, 536\u20138 (2009).","journal-title":"Placenta"},{"key":"5568_CR93","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.placenta.2012.11.008","volume":"34","author":"GI Marino","year":"2013","unstructured":"Marino, G. I. & Kotsias, B. A. Expression of the epithelial sodium channel sensitive to amiloride (ENaC) in normal and preeclamptic human placenta. Placenta 34, 197\u2013200 (2013).","journal-title":"Placenta"},{"key":"5568_CR94","doi-asserted-by":"publisher","first-page":"C1157","DOI":"10.1152\/ajpcell.1995.268.5.C1157","volume":"268","author":"FJ McDonald","year":"1995","unstructured":"McDonald, F. J., Price, M. P., Snyder, P. M. & Welsh, M. J. Cloning and expression of the beta- and gamma-subunits of the human epithelial sodium channel. Am. J. Physiol. -Cell Physiol. 268, C1157\u201363 (1995).","journal-title":"Am. J. Physiol. -Cell Physiol."},{"key":"5568_CR95","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.reprotox.2021.11.008","volume":"107","author":"C Meakin","year":"2022","unstructured":"Meakin, C., Barrett, E. S. & Aleksunes, L. M. Extravillous trophoblast migration and invasion: Impact of environmental chemicals and pharmaceuticals. Reprod. Toxicol. 107, 60\u20138 (2022).","journal-title":"Reprod. Toxicol."},{"key":"5568_CR96","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.placenta.2020.07.007","volume":"99","author":"D Wu","year":"2020","unstructured":"Wu, D. et al. Heme oxygenase-1 gene modified human placental mesenchymal stem cells promote placental angiogenesis and spiral artery remodeling by improving the balance of angiogenic factors in vitro. Placenta 99, 70\u20137 (2020).","journal-title":"Placenta"},{"key":"5568_CR97","doi-asserted-by":"publisher","first-page":"R1495","DOI":"10.1152\/ajpregu.00325.2011","volume":"301","author":"EM George","year":"2011","unstructured":"George, E. M. et al. Induction of heme oxygenase-1 attenuates sFlt-1-induced hypertension in pregnant rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 301, R1495\u2013500 (2011). www.ajpregu.org[Internet]Available from.","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"5568_CR98","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1095\/biolreprod.107.064899","volume":"78","author":"H Zhao","year":"2008","unstructured":"Zhao, H. et al. Regulation of maternal and fetal hemodynamics by heme oxygenase in mice. Biol. Reprod. 78, 744\u201351 (2008).","journal-title":"Biol. Reprod."},{"key":"5568_CR99","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2023.100822","volume":"23","author":"M Rana","year":"2023","unstructured":"Rana, M. et al. Expression of angiogenic factors in the placenta of heme oxygenase-1 deficient mouse embryo. Reprod. Biol. 23, 100822 (2023).","journal-title":"Reprod. Biol."},{"key":"5568_CR100","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3389\/fendo.2019.00055","volume":"10","author":"A Malhotra","year":"2019","unstructured":"Malhotra, A. et al. Neonatal Morbidities of Fetal Growth Restriction: Pathophysiology and Impact. Front Endocrinol. (Lausanne) 10, 55 (2019).","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"5568_CR101","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1097\/01.LAB.0000017167.26718.F2","volume":"82","author":"D Kreiser","year":"2002","unstructured":"Kreiser, D. et al. Heme oxygenase-1 modulates fetal growth in the rat. Lab. Investig. 82, 687\u201392 (2002).","journal-title":"Lab. Investig."},{"key":"5568_CR102","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms21197123","volume":"21","author":"H Yao","year":"2020","unstructured":"Yao, H. et al. Heme oxygenase 1 and 2 differentially regulate glucose metabolism and adipose tissue mitochondrial respiration: Implications for metabolic dysregulation. Int J. Mol. Sci. 21, 1\u201314 (2020).","journal-title":"Int J. Mol. Sci."},{"key":"5568_CR103","unstructured":"Balasundaram P., Farhana A. Immunology at the Maternal-Fetal Interface. StatPearls Publishing. (2025)."},{"key":"5568_CR104","doi-asserted-by":"publisher","first-page":"e42301","DOI":"10.1371\/journal.pone.0042301","volume":"7","author":"A Schumacher","year":"2012","unstructured":"Schumacher, A. et al. Blockage of heme oxygenase-1 abrogates the protective effect of regulatory T cells on murine pregnancy and promotes the maturation of dendritic cells. PLoS One 7, e42301 (2012).","journal-title":"PLoS One"},{"key":"5568_CR105","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1095\/biolreprod.103.022640","volume":"70","author":"SM Blois","year":"2004","unstructured":"Blois, S. M. et al. Lineage, maturity, and phenotype of uterine murine dendritic cells throughout gestation indicate a protective role in maintaining pregnancy. Biol. Reprod. 70, 1018\u201323 (2004).","journal-title":"Biol. Reprod."},{"key":"5568_CR106","doi-asserted-by":"publisher","first-page":"16442","DOI":"10.1074\/jbc.M113.532069","volume":"289","author":"LMA Al-Huseini","year":"2014","unstructured":"Al-Huseini, L. M. A. et al. Heme oxygenase-1 regulates dendritic cell function through modulation of p38 MAPK-CREB\/ATF1 signaling. J. Biol. Chem. 289, 16442\u201351 (2014).","journal-title":"J. Biol. Chem."},{"key":"5568_CR107","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.4049\/jimmunol.174.4.1820","volume":"174","author":"S Blois","year":"2005","unstructured":"Blois, S. et al. Intercellular adhesion molecule-1\/LFA-1 cross talk is a proximate mediator capable of disrupting immune integration and tolerance mechanism at the feto-maternal interface in murine pregnancies. J. Immunol. 174, 1820\u20139 (2005).","journal-title":"J. Immunol."},{"key":"5568_CR108","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1161\/HYPERTENSIONAHA.113.02403","volume":"63","author":"N Linzke","year":"2014","unstructured":"Linzke, N. et al. Carbon monoxide promotes proliferation of uterine natural killer cells and remodeling of spiral arteries in pregnant hypertensive heme oxygenase-1 mutant mice. Hypertension 63, 580\u20138 (2014).","journal-title":"Hypertension"},{"key":"5568_CR109","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1016\/j.transproceed.2011.03.037","volume":"43","author":"Z Shen","year":"2011","unstructured":"Shen, Z. et al. Immunoregulation effect by overexpression of heme oxygenase-1 on cardiac xenotransplantation. Transpl. Proc. 43, 1994\u20137 (2011).","journal-title":"Transpl. Proc."},{"key":"5568_CR110","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jri.2005.10.001","volume":"69","author":"ML Zenclussen","year":"2006","unstructured":"Zenclussen, M. L. et al. Over-expression of heme oxygenase-1 by adenoviral gene transfer improves pregnancy outcome in a murine model of abortion. J. Reprod. Immunol. 69, 35\u201352 (2006).","journal-title":"J. Reprod. Immunol."},{"key":"5568_CR111","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.174775","volume":"918","author":"C-Y Chiang","year":"2022","unstructured":"Chiang, C.-Y. et al. Schisandrin B promotes Foxp3+ regulatory T cell expansion by activating heme oxygenase-1 in dendritic cells and exhibits immunomodulatory effects in Th2-mediated allergic asthma. Eur. J. Pharm. 918, 174775 (2022).","journal-title":"Eur. J. Pharm."},{"key":"5568_CR112","doi-asserted-by":"crossref","unstructured":"Costa, M. et al. Heme-oxygenase-1 attenuates oxidative functions of antigen presenting cells and promotes regulatory T cell differentiation during fasciola hepatica infection. Antioxidants (Basel) 10, 1\u201321 (2021).","DOI":"10.3390\/antiox10121938"},{"key":"5568_CR113","doi-asserted-by":"publisher","first-page":"e47556","DOI":"10.1371\/journal.pone.0047556","volume":"7","author":"K Karimi","year":"2012","unstructured":"Karimi, K. et al. A lactobacillus rhamnosus strain induces a heme oxygenase dependent increase in Foxp3+ regulatory T cells. PLoS One 7, e47556 (2012).","journal-title":"PLoS One"},{"key":"5568_CR114","doi-asserted-by":"publisher","first-page":"e187","DOI":"10.1016\/j.jss.2010.11.917","volume":"166","author":"L Sun","year":"2011","unstructured":"Sun, L. et al. Hepatic overexpression of heme oxygenase-1 improves liver allograft survival by expanding T regulatory cells. J. Surg. Res. 166, e187\u201394 (2011).","journal-title":"J. Surg. Res."},{"key":"5568_CR115","doi-asserted-by":"publisher","first-page":"4826","DOI":"10.1182\/blood-2010-12-324038","volume":"117","author":"D Mougiakakos","year":"2011","unstructured":"Mougiakakos, D. et al. The impact of inflammatory licensing on heme oxygenase-1\u2013mediated induction of regulatory T cells by human mesenchymal stem cells. Blood 117, 4826\u201335 (2011).","journal-title":"Blood"},{"key":"5568_CR116","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1080\/08820139.2025.2511081","volume":"54","author":"M Romao-Veiga","year":"2025","unstructured":"Romao-Veiga, M. et al. M1 monocyte polarization and deficient immunomodulation in preeclampsia. Immunol. Invest. 54, 1081\u201398 (2025).","journal-title":"Immunol. Invest"},{"key":"5568_CR117","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.cytogfr.2024.07.007","volume":"78","author":"T Habelrih","year":"2024","unstructured":"Habelrih, T. et al. Inflammatory mechanisms of preterm labor and emerging anti-inflammatory interventions. Cytokine Growth Factor Rev. 78, 50\u201363 (2024).","journal-title":"Cytokine Growth Factor Rev."},{"key":"5568_CR118","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-33523-4","volume":"15","author":"L Song","year":"2025","unstructured":"Song, L. et al. M2 macrophages undergoing ferroptosis regulate uterine smooth muscle contraction to facilitate labor onset. Sci. Rep. 15, 45152 (2025).","journal-title":"Sci. Rep."},{"key":"5568_CR119","first-page":"1014","volume":"60","author":"J Zivaljevic","year":"2024","unstructured":"Zivaljevic, J., Jovandaric, M. Z., Babic, S. & Raus, M. Complications of preterm birth\u2014the importance of care for the outcome: A narrative review. Med. (B Aires) 60, 1014 (2024). https:\/\/www.mdpi.com\/1648-9144\/60\/6\/1014[Internet]Available from.","journal-title":"Med. (B Aires)"},{"key":"5568_CR120","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1001\/archpedi.154.6.544","volume":"154","author":"S Rogers","year":"2000","unstructured":"Rogers, S. et al. Antioxidant capacity and oxygen radical diseases in the preterm newborn. Arch. Pediatr. Adolesc. Med. 154, 544\u20138 (2000).","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"5568_CR121","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1007\/s00431-006-0375-x","volume":"166","author":"Z Mar\u00f3ti","year":"2007","unstructured":"Mar\u00f3ti, Z. et al. Heme oxygenase-1 expression in premature and mature neonates during the first week of life. Eur. J. Pediatr. 166, 1033\u20138 (2007).","journal-title":"Eur. J. Pediatr."},{"key":"5568_CR122","doi-asserted-by":"crossref","unstructured":"Pabelick C. M., Thompson M. A., Britt R. D. Effects of hyperoxia on the developing airway and pulmonary vasculature. In: Advances in Experimental Medicine and Biology. Springer New York LLC; 2017. p. 179\u201394.","DOI":"10.1007\/978-3-319-63245-2_11"},{"key":"5568_CR123","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1203\/00006450-200301000-00010","volume":"53","author":"PA Dennery","year":"2003","unstructured":"Dennery, P. A. et al. Developmental expression of heme oxygenase in the rat lung. Pediatr. Res. 53, 42\u20137 (2003).","journal-title":"Pediatr. Res"},{"key":"5568_CR124","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/sj.bjp.0705988","volume":"144","author":"SJ Stanford","year":"2005","unstructured":"Stanford, S. J. et al. Transition from placental to air breathing stimulates haem-oxygenase-1 expression without functional consequence for pulmonary vascular adaptation in pigs and mice. Br. J. Pharm. 144, 467\u201376 (2005).","journal-title":"Br. J. Pharm."},{"key":"5568_CR125","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s12969-021-00661-8","volume":"20","author":"AS Chau","year":"2020","unstructured":"Chau, A. S. et al. Heme oxygenase-1 deficiency presenting with interstitial lung disease and hemophagocytic flares. Pediatr. Rheumatol. Online J. 20, 19 (2020).","journal-title":"Pediatr. Rheumatol. Online J."},{"key":"5568_CR126","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/S0002-9440(10)63365-2","volume":"165","author":"MH Kapturczak","year":"2004","unstructured":"Kapturczak, M. H. et al. Animal model heme oxygenase-1 modulates early inflammatory responses evidence from the heme oxygenase-1-deficient mouse. Am. J. Pathol. 165, 1045\u201353 (2004).","journal-title":"Am. J. Pathol."},{"key":"5568_CR127","doi-asserted-by":"publisher","first-page":"6054","DOI":"10.1182\/blood-2010-03-272138","volume":"116","author":"G Kovtunovych","year":"2010","unstructured":"Kovtunovych, G. et al. Dysfunction of the heme recycling system in heme oxygenase 1-deficient mice: effects on macrophage viability and tissue iron distribution. Blood 116, 6054\u201362 (2010).","journal-title":"Blood"},{"key":"5568_CR128","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/s00011-018-1151-x","volume":"67","author":"AA Waza","year":"2018","unstructured":"Waza, A. A. et al. A review on heme oxygenase-1 induction: is it a necessary evil. Inflamm. Res. 67, 579\u201388 (2018).","journal-title":"Inflamm. Res."},{"key":"5568_CR129","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1172\/JCI4165","volume":"103","author":"A Yachie","year":"1999","unstructured":"Yachie, A. et al. Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J. Clin. Investig. 103, 129\u201335 (1999).","journal-title":"J. Clin. Investig."},{"key":"5568_CR130","doi-asserted-by":"publisher","first-page":"3091","DOI":"10.1111\/j.1582-4934.2008.00494.x","volume":"13","author":"AER Kartikasari","year":"2009","unstructured":"Kartikasari, A. E. R. et al. Hepcidin suppression and defective iron recycling account for dysregulation of iron homeostasis in heme oxygenase-1 deficiency. J. Cell Mol. Med. 13, 3091\u2013102 (2009).","journal-title":"J. Cell Mol. Med."},{"key":"5568_CR131","doi-asserted-by":"publisher","first-page":"10919","DOI":"10.1073\/pnas.94.20.10919","volume":"94","author":"KD Poss","year":"1997","unstructured":"Poss, K. D. & Tonegawa, S. Heme oxygenase 1 is required for mammalian\u2009iron\u2009reutilization. Proc. Natl. Acad. Sci. 94, 10919\u201324 (1997).","journal-title":"Proc. Natl. Acad. Sci."},{"key":"5568_CR132","doi-asserted-by":"publisher","first-page":"473709","DOI":"10.1155\/2011\/473709","volume":"2011","author":"ST Fraser","year":"2011","unstructured":"Fraser, S. T., Midwinter, R. G., Berger, B. S. & Stocker, R. Heme oxygenase-1: A critical link between iron metabolism, erythropoiesis, and development. Adv. Hematol. 2011, 473709 (2011).","journal-title":"Adv. Hematol."},{"key":"5568_CR133","doi-asserted-by":"publisher","first-page":"2732","DOI":"10.1182\/bloodadvances.2018019737","volume":"2","author":"KS Kim","year":"2018","unstructured":"Kim, K. S. et al. Infused wild-type macrophages reside and self-renew in the liver to rescue the hemolysis and anemia of Hmox1-deficient mice. Blood Adv. 2, 2732\u201343 (2018).","journal-title":"Blood Adv."},{"key":"5568_CR134","doi-asserted-by":"publisher","first-page":"10925","DOI":"10.1073\/pnas.94.20.10925","volume":"94","author":"KD Poss","year":"1997","unstructured":"Poss, K. D. & Tonegawa, S. Reduced stress defense in heme oxygenase 1-deficient\u2009cells. Proc. Natl. Acad. Sci. 94, 10925\u201330 (1997).","journal-title":"Proc. Natl. Acad. Sci."},{"key":"5568_CR135","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1053\/hupa.2002.30217","volume":"33","author":"A Kawashima","year":"2002","unstructured":"Kawashima, A. et al. Heme oxygenase-1 deficiency: the first autopsy case. Hum. Pathol. 33, 125\u201330 (2002).","journal-title":"Hum. Pathol."},{"key":"5568_CR136","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.8986","volume":"12","author":"SSM Alla","year":"2024","unstructured":"Alla, S. S. M. et al. A rare case of heme oxygenase deficiency: A case report and literature review. Clin. Case Rep. 12, e8986 (2024).","journal-title":"Clin. Case Rep."},{"key":"5568_CR137","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1124\/jpet.107.126409","volume":"323","author":"PW Buehler","year":"2007","unstructured":"Buehler, P. W., D\u2019Agnillo, F., Hoffman, V. & Alayash, A. I. Effects of endogenous ascorbate on oxidation, oxygenation, and toxicokinetics of cell-free modified hemoglobin after exchange transfusion in rat and guinea pig. J. Pharm. Exp. Ther. 323, 49\u201360 (2007).","journal-title":"J. Pharm. Exp. Ther."},{"key":"5568_CR138","doi-asserted-by":"publisher","first-page":"6054","DOI":"10.1182\/blood-2010-03-272138","volume":"116","author":"G Kovtunovych","year":"2010","unstructured":"Kovtunovych, G. et al. Dysfunction of the heme recycling system in heme oxygenase 1\u2013deficient mice: effects on macrophage viability and tissue iron distribution. Blood 116, 6054\u201362 (2010).","journal-title":"Blood"},{"key":"5568_CR139","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1007\/s00431-008-0673-6","volume":"167","author":"I Farkas","year":"2008","unstructured":"Farkas, I. et al. Increased heme oxygenase-1 expression in premature infants with respiratory distress syndrome. Eur. J. Pediatr. 167, 1379\u201383 (2008).","journal-title":"Eur. J. Pediatr."},{"key":"5568_CR140","unstructured":"Yadav S., Lee B. Neonatal Respiratory Stress Syndrome. StatPearls. (2023)."},{"key":"5568_CR141","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1086\/688890","volume":"6","author":"Y Gao","year":"2016","unstructured":"Gao, Y. et al. Unique aspects of the developing lung circulation: structural development and regulation of vasomotor tone. Pulm. Circ. 6, 407\u201325 (2016).","journal-title":"Pulm. Circ."},{"key":"5568_CR142","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.redox.2013.01.013","volume":"1","author":"G Yang","year":"2013","unstructured":"Yang, G. et al. Heme oxygenase-1 regulates postnatal lung repair after hyperoxia: Role of \u03b2-catenin\/hnRNPK signaling. Redox Biol. 1, 234\u201343 (2013).","journal-title":"Redox Biol."},{"key":"5568_CR143","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.172983","volume":"873","author":"H Lin","year":"2020","unstructured":"Lin, H. & Wang, X. The effects of gasotransmitters on bronchopulmonary dysplasia. Eur. J. Pharm. 873, 172983 (2020).","journal-title":"Eur. J. Pharm."},{"key":"5568_CR144","doi-asserted-by":"publisher","first-page":"L749","DOI":"10.1152\/ajplung.00236.2013","volume":"306","author":"AC Anyanwu","year":"2014","unstructured":"Anyanwu, A. C. et al. Suppression of inflammatory cell trafficking and alveolar simplification by the heme oxygenase-1 product carbon monoxide. Am. J. Physiol. -Lung Cell. Mol. Physiol. 306, L749\u201363 (2014).","journal-title":"Am. J. Physiol. -Lung Cell. Mol. Physiol."},{"key":"5568_CR145","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s12931-019-1063-5","volume":"20","author":"S Endesfelder","year":"2019","unstructured":"Endesfelder, S. et al. Antioxidative effects of caffeine in a hyperoxia-based rat model of bronchopulmonary dysplasia. Respir. Res. 20, 88 (2019).","journal-title":"Respir. Res"},{"key":"5568_CR146","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7140496","volume":"2020","author":"W Osiak","year":"2020","unstructured":"Osiak, W., W\u0105troba, S., Kapka-Skrzypczak, L. & Kurzepa, J. Two faces of heme catabolic pathway in newborns: A potential role of bilirubin and carbon monoxide in neonatal inflammatory diseases. Oxid. Med. Cell. Longev. 2020, 7140496 (2020).","journal-title":"Oxid. Med. Cell. Longev."},{"key":"5568_CR147","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1203\/PDR.0b013e318191eedc","volume":"65","author":"S Kassovska-Bratinova","year":"2009","unstructured":"Kassovska-Bratinova, S., Yang, G., Igarashi, K. & Dennery, P. A. Bach1 modulates heme oxygenase-1 expression in the neonatal mouse lung. Pediatr. Res. 65, 145\u20139 (2009).","journal-title":"Pediatr. Res"},{"key":"5568_CR148","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-016-0793-0","volume":"14","author":"X Chi","year":"2016","unstructured":"Chi, X. et al. Induction of heme oxygenase-1 by hemin protects lung against orthotopic autologous liver transplantation-induced acute lung injury in rats. J. Transl. Med. 14, 35 (2016).","journal-title":"J. Transl. Med"},{"key":"5568_CR149","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.taap.2016.10.002","volume":"311","author":"A Patel","year":"2016","unstructured":"Patel, A. et al. Omeprazole induces heme oxygenase-1 in fetal human pulmonary microvascular endothelial cells via hydrogen peroxide-independent Nrf2 signaling pathway. Toxicol. Appl Pharm. 311, 26\u201333 (2016).","journal-title":"Toxicol. Appl Pharm."},{"key":"5568_CR150","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2023.171109","volume":"170","author":"Zwen Zhao","year":"2023","unstructured":"Zhao, Z. wen et al. Irisin alleviates hyperoxia-induced bronchopulmonary dysplasia through activation of Nrf2\/HO-1 pathway. Pept. (NY) 170, 171109 (2023).","journal-title":"Pept. (NY)"},{"key":"5568_CR151","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1089\/ars.2013.5791","volume":"21","author":"PA Dennery","year":"2014","unstructured":"Dennery, P. A. Heme oxygenase in neonatal lung injury and repair. Antioxid. Redox Signal 21, 1881\u201392 (2014).","journal-title":"Antioxid. Redox Signal"},{"key":"5568_CR152","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.1007\/s10753-023-01885-4","volume":"46","author":"M Wang","year":"2023","unstructured":"Wang, M. et al. Regulating NLRP3 inflammasome\u2013induced pyroptosis via Nrf2: TBHQ limits hyperoxia-induced lung injury in a mouse model of bronchopulmonary dysplasia. Inflammation 46, 2386\u2013401 (2023).","journal-title":"Inflammation"},{"key":"5568_CR153","doi-asserted-by":"publisher","first-page":"097","DOI":"10.1055\/s-2003-38315","volume":"20","author":"HS Falciglia","year":"2003","unstructured":"Falciglia, H. S. et al. Role of antioxidant nutrients and lipid peroxidation in premature infants with respiratory distress syndrome and bronchopulmonary dysplasia. Am. J. Perinatol. 20, 097\u2013108 (2003).","journal-title":"Am. J. Perinatol."},{"key":"5568_CR154","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1159\/000356167","volume":"105","author":"LML Dix","year":"2014","unstructured":"Dix, L. M. L. et al. Early end-tidal carbon monoxide levels, patency of the ductus arteriosus and regional cerebral oxygenation in preterm infants. Neonatology 105, 161\u20135 (2014).","journal-title":"Neonatology"},{"key":"5568_CR155","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/chd.12714","volume":"14","author":"SL Crockett","year":"2019","unstructured":"Crockett, S. L., Berger, C. D., Shelton, E. L. & Reese, J. Molecular and mechanical factors contributing to ductus arteriosus patency and closure. Congenit. Heart Dis. 14, 15\u201320 (2019).","journal-title":"Congenit. Heart Dis."},{"key":"5568_CR156","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1056\/NEJMra1005408","volume":"364","author":"J Neu","year":"2011","unstructured":"Neu, J. & Walker, W. A. Necrotizing Enterocolitis. N. Engl. J. Med. 364, 255\u201364 (2011). http:\/\/www.nejm.org\/doi\/abs\/10.1056\/NEJMra1005408[Internet]Available from.","journal-title":"N. Engl. J. Med."},{"key":"5568_CR157","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1152\/ajpgi.00363.2012","volume":"304","author":"S Schulz","year":"2013","unstructured":"Schulz, S. et al. Heme oxygenase-1 deficiency promotes the development of necrotizing enterocolitis-like intestinal injury in a newborn mouse model. Am. J. Physiol. Gastrointest. Liver Physiol. 304, 991\u20131001 (2013). http:\/\/www.ajpgi.org[Internet]Available from.","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"5568_CR158","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1152\/ajpgi.00055.2005","volume":"289","author":"BS Zuckerbraun","year":"2005","unstructured":"Zuckerbraun, B. S. et al. Carbon monoxide protects against the development of experimental necrotizing enterocolitis. Am. J. Physiol. Gastrointest. Liver Physiol. 289, 607\u201313 (2005). http:\/\/www.ajpgi.org[Internet]Available from.","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"5568_CR159","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1097\/01.CCM.0000050442.54044.06","volume":"31","author":"H Fujii","year":"2003","unstructured":"Fujii, H. et al. Protective role of heme oxygenase-1 in the intestinal tissue injury in an experimental model of sepsis. Crit. Care Med. 31, 893\u2013902 (2003).","journal-title":"Crit. Care Med"},{"key":"5568_CR160","doi-asserted-by":"publisher","first-page":"745.e1","DOI":"10.1016\/j.ajog.2020.05.001","volume":"223","author":"KK Venkatesh","year":"2020","unstructured":"Venkatesh, K. K. et al. Histologic chorioamnionitis and risk of neurodevelopmental impairment at age 10 years among extremely preterm infants born before 28 weeks of gestation. Am. J. Obstet. Gynecol. 223, 745.e1\u2013745.e10 (2020).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"5568_CR161","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s10571-025-01540-6","volume":"45","author":"X Zhang","year":"2025","unstructured":"Zhang, X. et al. Targeting Neuroinflammation in Preterm White Matter Injury: Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes. Cell Mol. Neurobiol. 45, 23 (2025).","journal-title":"Cell Mol. Neurobiol."},{"key":"5568_CR162","doi-asserted-by":"crossref","unstructured":"Fleiss, B. et al. Microglia-mediated neurodegeneration in perinatal brain injuries. Biomolecules. 11, 99 (2021).","DOI":"10.3390\/biom11010099"},{"key":"5568_CR163","doi-asserted-by":"crossref","unstructured":"Kim, P. et al. SRI 73rd Annual Meeting: Scientific Program & Abstracts: Critical disruption of adult brain mononuclear cell homeostasis is marked by Heme-oxygenase-1 (HO-1) dyregulation in activating inflammatory and inhibitory immune checkpoint pathways after perinatal CHORIO. In: Reproductive Sciences. vol. 33, pp. 1\u2013382 (2026).","DOI":"10.1007\/s43032-026-02073-z"},{"key":"5568_CR164","doi-asserted-by":"crossref","unstructured":"Wolanske N. et al. SRI 73rd Annual Meeting: Scientific Program & Abstracts. Heme-oxygenase-1 (HO-1) dysregulation ignites unique, differential and persistent oxidative microenvironment in brain microglia after perinatal chorioamnionitis in adults. In: Reproductive Sciences. vol. 33, pp. 1\u2013382 (2026).","DOI":"10.21203\/rs.3.rs-10705004\/v1"},{"key":"5568_CR165","doi-asserted-by":"publisher","first-page":"200","DOI":"10.3389\/fnins.2017.00200","volume":"11","author":"MCB Paton","year":"2017","unstructured":"Paton, M. C. B. et al. Perinatal brain injury as a consequence of preterm birth and intrauterine inflammation: Designing targeted stem cell therapies. Front Neurosci. 11, 200 (2017).","journal-title":"Front Neurosci."},{"key":"5568_CR166","doi-asserted-by":"publisher","first-page":"e89061","DOI":"10.1371\/journal.pone.0089061","volume":"9","author":"CA Blok","year":"2014","unstructured":"Blok, C. A. et al. Unmyelinated white matter loss in the preterm brain is associated with early increased levels of end-tidal carbon monoxide. PLoS One 9, e89061 (2014).","journal-title":"PLoS One"},{"key":"5568_CR167","doi-asserted-by":"publisher","first-page":"174","DOI":"10.2174\/1570162X12666140526122709","volume":"12","author":"SS Ambegaokar","year":"2014","unstructured":"Ambegaokar, S. S. & Kolson, D. L. Heme oxygenase-1 dysregulation in the brain: Implications for HIV-associated neurocognitive disorders. Curr. HIV Res. 12, 174\u201388 (2014).","journal-title":"Curr. HIV Res"},{"key":"5568_CR168","doi-asserted-by":"publisher","DOI":"10.31083\/FBL36630","volume":"30","author":"L Huo","year":"2025","unstructured":"Huo, L., Liu, X. & Wang, H. Leukemia inhibitory factor attenuates hypoxic\u2013ischemic white matter injury via NLRP3 inflammasome activity suppressing through the Nrf2\/HO-1 pathway. Front. Biosci. \u2013 Landmark 30, 36630 (2025).","journal-title":"Front. Biosci. \u2013 Landmark"},{"key":"5568_CR169","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1213\/ANE.0000000000007547","volume":"141","author":"C Li","year":"2025","unstructured":"Li, C. et al. Influence of sevoflurane postconditioning on hypoxic-ischemic brain injury via Nrf2-regulated ferroptosis in neonatal rats. Anesth. Analg. 141, 648\u201359 (2025).","journal-title":"Anesth. Analg."},{"key":"5568_CR170","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6622598","volume":"2021","author":"WI Egesa","year":"2021","unstructured":"Egesa, W. I. et al. Germinal matrix-intraventricular hemorrhage: A tale of preterm infants. Int J. Pediatr. 2021, 6622598 (2021).","journal-title":"Int J. Pediatr."},{"key":"5568_CR171","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms21218343","volume":"21","author":"I Atienza-navarro","year":"2020","unstructured":"Atienza-navarro, I., Alves-martinez, P., Lubian-lopez, S. & Garcia-alloza, M. Germinal matrix-intraventricular hemorrhage of the preterm newborn and preclinical models: Inflammatory considerations. Int J. Mol. Sci. 21, 1\u201324 (2020).","journal-title":"Int J. Mol. Sci."},{"key":"5568_CR172","doi-asserted-by":"publisher","first-page":"10171","DOI":"10.3390\/ijms241210171","volume":"24","author":"M Alshareef","year":"2023","unstructured":"Alshareef, M. et al. Complement drives chronic inflammation and progressive hydrocephalus in murine neonatal germinal matrix hemorrhage. Int J. Mol. Sci. 24, 10171 (2023).","journal-title":"Int J. Mol. Sci."},{"key":"5568_CR173","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1227\/NEU.0000000000000524","volume":"75","author":"JM Strahle","year":"2014","unstructured":"Strahle, J. M. et al. Role of hemoglobin and iron in hydrocephalus after neonatal intraventricular hemorrhage. Neurosurgery 75, 696\u2013705 (2014).","journal-title":"Neurosurgery"},{"key":"5568_CR174","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s00234-015-1487-7","volume":"57","author":"T Morita","year":"2015","unstructured":"Morita, T. et al. Low-grade intraventricular hemorrhage disrupts cerebellar white matter in preterm infants: evidence from diffusion tensor imaging. Neuroradiology 57, 507\u201314 (2015).","journal-title":"Neuroradiology"},{"key":"5568_CR175","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-10-100","volume":"10","author":"M Gram","year":"2013","unstructured":"Gram, M. et al. Hemoglobin induces inflammation after preterm intraventricular hemorrhage by methemoglobin formation. J. Neuroinflamm. 10, 100 (2013). http:\/\/www.jneuroinflammation.com\/content\/10\/1\/100[Internet]Available from.","journal-title":"J. Neuroinflamm."},{"key":"5568_CR176","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.3390\/ijms19082260","volume":"19","author":"M Nitti","year":"2018","unstructured":"Nitti, M. et al. Heme oxygenase 1 in the nervous system: Does it favor neuronal cell survival or induce neurodegeneration? Int J. Mol. Sci. 19, 2260 (2018).","journal-title":"Int J. Mol. Sci."},{"key":"5568_CR177","doi-asserted-by":"publisher","first-page":"5400","DOI":"10.3390\/ijms16035400","volume":"16","author":"H Schipper","year":"2015","unstructured":"Schipper, H. & Song, W. A heme oxygenase-1 transducer model of degenerative and developmental brain disorders. Int. J. Mol. Sci. 16, 5400\u201319 (2015).","journal-title":"Int. J. Mol. Sci."},{"key":"5568_CR178","doi-asserted-by":"publisher","first-page":"923","DOI":"10.3390\/antiox11050923","volume":"11","author":"YH Wu","year":"2022","unstructured":"Wu, Y. H. & Hsieh, H. L. Roles of heme oxygenase-1 in neuroinflammation and brain disorders. Antioxidants 11, 923 (2022).","journal-title":"Antioxidants"},{"key":"5568_CR179","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.clim.2005.10.012","volume":"118","author":"L Mar\u00f3di","year":"2006","unstructured":"Mar\u00f3di, L. Innate cellular immune responses in newborns. Clin. Immunol. 118, 137\u201344 (2006).","journal-title":"Clin. Immunol."},{"key":"5568_CR180","doi-asserted-by":"crossref","unstructured":"Melville, J. M. & Moss, T. J. M. The immune consequences of preterm birth. Front Neurosci. 7, 79\u201387 (2013).","DOI":"10.3389\/fnins.2013.00079"},{"key":"5568_CR181","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3109\/14767058.2010.482605","volume":"24","author":"T Strunk","year":"2011","unstructured":"Strunk, T. et al. Innate immunity in human newborn infants: prematurity means more than immaturity. J. Matern Fetal Neonatal Med. 24, 25\u201331 (2011).","journal-title":"J. Matern Fetal Neonatal Med"},{"key":"5568_CR182","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1203\/01.PDR.0000132664.66975.79","volume":"56","author":"T Strunk","year":"2004","unstructured":"Strunk, T. et al. Differential maturation of the innate immune response in human fetuses. Pediatr. Res. 56, 219\u201326 (2004).","journal-title":"Pediatr. Res"},{"key":"5568_CR183","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1128\/IAI.00535-10","volume":"79","author":"AJ Currie","year":"2011","unstructured":"Currie, A. J. et al. Preterm infants have deficient monocyte and lymphocyte cytokine responses to group B streptococcus. Infect. Immun. 79, 1588\u201396 (2011).","journal-title":"Infect. Immun."},{"key":"5568_CR184","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1034\/j.1398-9995.2000.00118.x","volume":"55","author":"PG Holt","year":"2000","unstructured":"Holt, P. G. & Jones, C. A. The development of the immune system during pregnancy and early life. Allergy 55, 688\u201397 (2000).","journal-title":"Allergy"},{"key":"5568_CR185","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1159\/000101567","volume":"92","author":"A P\u00e9rez","year":"2007","unstructured":"P\u00e9rez, A. et al. NK cell increase in neonates from the preterm to the full-term period of gestation. Neonatology 92, 158\u201363 (2007).","journal-title":"Neonatology"},{"key":"5568_CR186","first-page":"1353","volume":"13","author":"RA Pereira","year":"2025","unstructured":"Pereira, R. A. & Lu\u00eds Amant\u00e9a, S. The immune system of preterm infant: A review for the pediatrician. Pediatr. Child Health 13, 1353 (2025).","journal-title":"Pediatr. Child Health"},{"key":"5568_CR187","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202250224","volume":"53","author":"S De Biasi","year":"2023","unstructured":"De Biasi, S. et al. Healthy preterm newborns: Altered innate immunity and impaired monocyte function. Eur. J. Immunol. 53, e2250224 (2023).","journal-title":"Eur. J. Immunol."},{"key":"5568_CR188","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/j.1365-3083.2010.02473.x","volume":"73","author":"JC Walker","year":"2011","unstructured":"Walker, J. C. et al. Development of lymphocyte subpopulations in preterm infants. Scand. J. Immunol. 73, 53\u20138 (2011).","journal-title":"Scand. J. Immunol."},{"key":"5568_CR189","doi-asserted-by":"publisher","first-page":"2948","DOI":"10.1182\/blood-2007-01-069245","volume":"110","author":"K Kaur","year":"2007","unstructured":"Kaur, K., Chowdhury, S., Greenspan, N. S. & Schreiber, J. R. Decreased expression of tumor necrosis factor family receptors involved in humoral immune responses in preterm neonates. Blood 110, 2948\u201354 (2007).","journal-title":"Blood"},{"key":"5568_CR190","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adr0942","volume":"17","author":"O Olaloye","year":"2025","unstructured":"Olaloye, O. et al. A single-cell atlas of circulating immune cells over the first 2 months of age in extremely premature infants. Sci. Transl. Med. 17, eadr0942 (2025).","journal-title":"Sci. Transl. Med"},{"key":"5568_CR191","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/pr.2012.6","volume":"71","author":"R Correa-Rocha","year":"2012","unstructured":"Correa-Rocha, R. et al. Preterm neonates show marked leukopenia and lymphopenia that are associated with increased regulatory T-cell values and diminished IL-7. Pediatr. Res. 71, 590\u20137 (2012).","journal-title":"Pediatr. Res"},{"key":"5568_CR192","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/s41390-019-0582-6","volume":"87","author":"D Sabic","year":"2020","unstructured":"Sabic, D. & Koenig, J. M. A perfect storm: fetal inflammation and the developing immune system. Pediatr. Res. 87, 319\u201326 (2020).","journal-title":"Pediatr. Res"},{"key":"5568_CR193","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/j.1471-0528.1999.tb08088.x","volume":"106","author":"O Baud","year":"1999","unstructured":"Baud, O. et al. Amniotic fluid concentrations of interleukin-1beta, interleukin-6 and TNF-alpha in chorioamnionitis before 32 weeks of gestation: Histological associations and neonatal outcome. Br. J. Obstet. Gynaecol. 106, 72\u20137 (1999).","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"5568_CR194","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1055\/s-0033-1361823","volume":"32","author":"SG Kallapur","year":"2014","unstructured":"Kallapur, S. G. et al. Fetal immune response to chorioamnionitis. Semin Reprod. Med. 32, 56\u201367 (2014).","journal-title":"Semin Reprod. Med."},{"key":"5568_CR195","doi-asserted-by":"publisher","first-page":"324","DOI":"10.3389\/fphys.2019.00324","volume":"10","author":"TR Yellowhair","year":"2019","unstructured":"Yellowhair, T. R. et al. CXCR2 blockade mitigates neural cell injury following preclinical chorioamnionitis. Front Physiol. 10, 324 (2019).","journal-title":"Front Physiol."},{"key":"5568_CR196","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1111\/cei.13059","volume":"191","author":"J Schwarz","year":"2018","unstructured":"Schwarz, J. et al. Granulocytic myeloid-derived suppressor cells (GR-MDSC) accumulate in cord blood of preterm infants and remain elevated during the neonatal period. Clin. Exp. Immunol. 191, 328\u201337 (2018).","journal-title":"Clin. Exp. Immunol."},{"key":"5568_CR197","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1164\/rccm.200406-745OC","volume":"171","author":"BW Kramer","year":"2005","unstructured":"Kramer, B. W. et al. Endotoxin-induced chorioamnionitis modulates innate immunity of monocytes in preterm sheep. Am. J. Respir. Crit. Care Med. 171, 73\u20137 (2005).","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"5568_CR198","doi-asserted-by":"publisher","first-page":"7052","DOI":"10.1167\/iovs.11-7380","volume":"52","author":"ML Chen","year":"2011","unstructured":"Chen, M. L. et al. Placenta microbiology and histology and the risk for severe retinopathy of prematurity. Invest Ophthalmol. Vis. Sci. 52, 7052\u20138 (2011).","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"5568_CR199","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1007\/s00428-004-1151-9","volume":"446","author":"C Pfisterer","year":"2005","unstructured":"Pfisterer, C., Faber, R. & Horn, L.-C. Chorioamnionitis-induced changes of fetal extramedullar hematopoiesis in the second trimester of gestation. Is diagnosis from fetal autopsy possible? Virchows Arch. 446, 150\u20136 (2005).","journal-title":"Virchows Arch."},{"key":"5568_CR200","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.5858\/2006-130-1786-MITLOS","volume":"130","author":"RN Miranda","year":"2006","unstructured":"Miranda, R. N. et al. Myelopoiesis in the liver of stillborns with evidence of intrauterine infection. Arch. Pathol. Lab Med. 130, 1786\u201391 (2006).","journal-title":"Arch. Pathol. Lab Med"},{"key":"5568_CR201","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-025-03272-1","volume":"30","author":"S Wang","year":"2025","unstructured":"Wang, S. et al. Identifying the anti-infection NK and T cell subgroups in preterm newborns with sepsis using single-cell RNA-seq analysis. Eur. J. Med. Res. 30, 1030 (2025).","journal-title":"Eur. J. Med. Res."},{"key":"5568_CR202","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.humimm.2015.01.017","volume":"76","author":"DE Noyola","year":"2015","unstructured":"Noyola, D. E. et al. Dynamics of the NK-cell subset redistribution induced by cytomegalovirus infection in preterm infants. Hum. Immunol. 76, 118\u201323 (2015).","journal-title":"Hum. Immunol."},{"key":"5568_CR203","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1177\/1933719111432873","volume":"19","author":"JM Melville","year":"2012","unstructured":"Melville, J. M. et al. Changes in fetal thymic immune cell populations in a sheep model of intrauterine inflammation. Reprod. Sci. 19, 740\u20137 (2012).","journal-title":"Reprod. Sci."},{"key":"5568_CR204","doi-asserted-by":"publisher","first-page":"68","DOI":"10.4049\/jimmunol.1900941","volume":"204","author":"KR Qazi","year":"2020","unstructured":"Qazi, K. R. et al. Extremely preterm infants have significant alterations in their conventional T cell compartment during the first weeks of life. J. Immunol. 204, 68\u201377 (2020).","journal-title":"J. Immunol."},{"key":"5568_CR205","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/pr.2016.232","volume":"81","author":"CM Jackson","year":"2017","unstructured":"Jackson, C. M. et al. Pro-inflammatory immune responses in leukocytes of premature infants exposed to maternal chorioamnionitis or funisitis. Pediatr. Res. 81, 384\u201390 (2017).","journal-title":"Pediatr. Res."},{"key":"5568_CR206","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/pr.2016.254","volume":"81","author":"DC Rito","year":"2017","unstructured":"Rito, D. C. et al. Augmented Th17-type immune responses in preterm neonates exposed to histologic chorioamnionitis. Pediatr. Res. 81, 639\u201345 (2017).","journal-title":"Pediatr. Res"},{"key":"5568_CR207","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.3389\/fimmu.2020.01194","volume":"11","author":"V Golubinskaya","year":"2020","unstructured":"Golubinskaya, V. et al. Expression of S100A alarmins in cord blood monocytes is highly associated with chorioamnionitis and fetal inflammation in preterm infants. Front Immunol. 11, 1194 (2020).","journal-title":"Front Immunol."},{"key":"5568_CR208","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2022.101345","volume":"27","author":"N Fleiss","year":"2022","unstructured":"Fleiss, N., Tarun, S. & Polin, R. A. Infection prevention for extremely low birth weight infants in the NICU. Semin Fetal Neonatal Med. 27, 101345 (2022).","journal-title":"Semin Fetal Neonatal Med"},{"key":"5568_CR209","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12637","volume":"24","author":"O Yoshino","year":"2025","unstructured":"Yoshino, O. & Ono, Y. The physiological role of macrophages in reproductive organs. Reprod. Med. Biol. 24, e12637 (2025).","journal-title":"Reprod. Med. Biol."},{"key":"5568_CR210","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/pr.2015.22","volume":"77","author":"S Schulz","year":"2015","unstructured":"Schulz, S. et al. Heme oxygenase-1 confers protection and alters T-cell populations in a mouse model of neonatal intestinal inflammation. Pediatr. Res. 77, 640\u20138 (2015).","journal-title":"Pediatr. Res."},{"key":"5568_CR211","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1093\/rheumatology\/kew251","volume":"55","author":"L van Bon","year":"2016","unstructured":"van Bon, L. et al. Low heme oxygenase-1 levels in patients with systemic sclerosis are associated with an altered Toll-like receptor response: another role for CXCL4? Rheumatol. (Oxf.) 55, 2066\u201373 (2016).","journal-title":"Rheumatol. (Oxf.)"},{"key":"5568_CR212","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1159\/000343097","volume":"103","author":"B Weinberger","year":"2013","unstructured":"Weinberger, B. et al. Effects of bilirubin on neutrophil responses in newborn infants. Neonatology 103, 105\u201311 (2013).","journal-title":"Neonatology"},{"key":"5568_CR213","doi-asserted-by":"publisher","first-page":"3013","DOI":"10.4049\/jimmunol.1401075","volume":"193","author":"AP Gobert","year":"2014","unstructured":"Gobert, A. P. et al. Heme oxygenase-1 dysregulates macrophage polarization and the immune response to Helicobacter pylori. J. Immunol. 193, 3013\u201322 (2014).","journal-title":"J. Immunol."},{"key":"5568_CR214","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/s41390-018-0028-6","volume":"84","author":"K Fujioka","year":"2018","unstructured":"Fujioka, K. et al. Heme oxygenase-1 deficiency promotes severity of sepsis in a non-surgical preterm mouse model. Pediatr. Res. 84, 139\u201345 (2018).","journal-title":"Pediatr. Res"},{"key":"5568_CR215","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56928-4","volume":"10","author":"S Dreschers","year":"2020","unstructured":"Dreschers, S. et al. Impaired functional capacity of polarised neonatal macrophages. Sci. Rep. 10, 624 (2020).","journal-title":"Sci. Rep."},{"key":"5568_CR216","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.toxlet.2007.10.010","volume":"176","author":"X Li","year":"2008","unstructured":"Li, X. et al. Maternally administered lipopolysaccharide (LPS) upregulates the expression of heme oxygenase-1 in fetal liver: The role of reactive oxygen species. Toxicol. Lett. 176, 169\u201377 (2008).","journal-title":"Toxicol. Lett."},{"key":"5568_CR217","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1136\/archdischild-2016-310532","volume":"102","author":"AL Solebo","year":"2017","unstructured":"Solebo, A. L., Teoh, L. & Rahi, J. Epidemiology of blindness in children. Arch. Dis. Child 102, 853\u20137 (2017).","journal-title":"Arch. Dis. Child"},{"key":"5568_CR218","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpeds.2024.100159","volume":"8","author":"E Koc","year":"2024","unstructured":"Koc, E. & Bas, A. Y. Retinopathy of prematurity (ROP): From the perspective of the neonatologist. Glob. Pediatr. 8, 100159 (2024).","journal-title":"Glob. Pediatr."},{"key":"5568_CR219","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3345\/cep.2021.00773","volume":"65","author":"EH Hong","year":"2022","unstructured":"Hong, E. H., Shin, Y. U. & Cho, H. Retinopathy of prematurity: a review of epidemiology and current treatment strategies. Clin. Exp. Pediatr. 65, 115\u201326 (2022).","journal-title":"Clin. Exp. Pediatr."},{"key":"5568_CR220","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s10456-007-9066-0","volume":"10","author":"J Chen","year":"2007","unstructured":"Chen, J. & Smith, L. E. H. Retinopathy of prematurity. Angiogenesis 10, 133\u201340 (2007).","journal-title":"Angiogenesis"},{"key":"5568_CR221","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.freeradbiomed.2025.11.018","volume":"243","author":"Y Liu","year":"2026","unstructured":"Liu, Y. et al. Microglial HMOX1 drives retinal angiogenesis via modulation of endothelial STAT3 signaling. Free Radic. Biol. Med. 243, 29\u201342 (2026).","journal-title":"Free Radic. Biol. Med"},{"key":"5568_CR222","doi-asserted-by":"publisher","first-page":"e725","DOI":"10.1542\/neo.20-12-e725","volume":"20","author":"A Dyson","year":"2019","unstructured":"Dyson, A. & Kent, A. L. The effect of preterm birth on renal development and renal health outcome. Neoreviews 20, e725\u201336 (2019).","journal-title":"Neoreviews"},{"key":"5568_CR223","first-page":"S124","volume":"63","author":"BM Brenner","year":"1997","unstructured":"Brenner, B. M. & Mackenzie, H. S. Nephron mass as a risk factor for progression of renal disease. Kidney Int. Suppl. 63, S124\u20137 (1997).","journal-title":"Kidney Int. Suppl."},{"key":"5568_CR224","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1007\/s00467-016-3333-5","volume":"31","author":"SL Hemker","year":"2016","unstructured":"Hemker, S. L., Sims-Lucas, S. & Ho, J. Role of hypoxia during nephrogenesis. Pediatr. Nephrol. 31, 1571\u20137 (2016).","journal-title":"Pediatr. Nephrol."},{"key":"5568_CR225","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s11248-016-9986-9","volume":"26","author":"V Atsaves","year":"2017","unstructured":"Atsaves, V. et al. Phenotypic characterization of a novel HO-1 depletion model in the rat. Transgenic Res. 26, 51\u201364 (2017).","journal-title":"Transgenic Res"},{"key":"5568_CR226","doi-asserted-by":"publisher","first-page":"387","DOI":"10.23876\/j.krcp.20.091","volume":"39","author":"M Nath","year":"2020","unstructured":"Nath, M. & Agarwal, A. New insights into the role of heme oxygenase-1 in acute kidney injury. Kidney Res. Clin. Pr. 39, 387\u2013401 (2020).","journal-title":"Kidney Res. Clin. Pr."},{"key":"5568_CR227","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s11658-019-0142-4","volume":"24","author":"T Zhang","year":"2019","unstructured":"Zhang, T. & Xiang, L. Honokiol alleviates sepsis-induced acute kidney injury in mice by targeting the miR-218-5p\/heme oxygenase-1 signaling pathway. Cell Mol. Biol. Lett. 24, 15 (2019).","journal-title":"Cell Mol. Biol. Lett."},{"key":"5568_CR228","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.122209","volume":"334","author":"EHM Hassanein","year":"2023","unstructured":"Hassanein, E. H. M. et al. Nrf2\/HO-1 as a therapeutic target in renal fibrosis. Life Sci. 334, 122209 (2023).","journal-title":"Life Sci."},{"key":"5568_CR229","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1161\/HYPERTENSIONAHA.108.114884","volume":"52","author":"T Vera","year":"2008","unstructured":"Vera, T., Kelsen, S. & Stec, D. E. Kidney-specific induction of heme oxygenase-1 prevents angiotensin II hypertension. Hypertension 52, 660\u20135 (2008).","journal-title":"Hypertension"},{"key":"5568_CR230","doi-asserted-by":"publisher","DOI":"10.3389\/fneph.2023.1156346","volume":"3","author":"H Zhai","year":"2023","unstructured":"Zhai, H., Ni, L. & Wu, X. The roles of heme oxygenase-1 in renal disease. Front. Nephrol. 3, 1156346 (2023).","journal-title":"Front. Nephrol."},{"key":"5568_CR231","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1097\/AOG.0000000000004377","volume":"137","author":"C Beck","year":"2021","unstructured":"Beck, C. et al. Chorioamnionitis and risk for maternal and neonatal sepsis: A systematic review and meta-analysis. Obstet. Gynecol. 137, 1007\u201322 (2021).","journal-title":"Obstet. Gynecol."},{"key":"5568_CR232","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.eimc.2024.07.010","volume":"43","author":"E Rubio-Mora","year":"2025","unstructured":"Rubio-Mora, E. et al. Neonatal sepsis: Epidemiology and comparison between preterm and term newborns. Enferm. Infecc. Microbiol Clin. 43, 197\u2013204 (2025).","journal-title":"Enferm. Infecc. Microbiol Clin."},{"key":"5568_CR233","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1159\/000539245","volume":"121","author":"G Klinger","year":"2024","unstructured":"Klinger, G. et al. Late-onset sepsis among extremely preterm infants of 24-28 weeks gestation: An international comparison in 10 high-income countries. Neonatology 121, 761\u201371 (2024).","journal-title":"Neonatology"},{"key":"5568_CR234","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2022-058813","volume":"150","author":"DD Flannery","year":"2022","unstructured":"Flannery, D. D. et al. Late-onset sepsis among very preterm infants. Pediatrics 150, e2022058813 (2022).","journal-title":"Pediatrics"},{"key":"5568_CR235","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3390\/antibiotics14010006","volume":"14","author":"C Kariniotaki","year":"2024","unstructured":"Kariniotaki, C. et al. Neonatal sepsis: A comprehensive review. Antibiotics (Basel) 14, 6 (2024).","journal-title":"Antibiotics (Basel)"},{"key":"5568_CR236","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1097\/SHK.0000000000000689","volume":"47","author":"K Fujioka","year":"2017","unstructured":"Fujioka, K. et al. Induction of heme oxygenase-1 attenuates the severity of sepsis in a non-surgical preterm mouse model. Shock 47, 242\u201350 (2017).","journal-title":"Shock"},{"key":"5568_CR237","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2025.156175","volume":"274","author":"T Li","year":"2025","unstructured":"Li, T. et al. The role of Heme oxygenase-1 (HO-1) in sepsis-associated organ damage: A systematic review. Pathol. Res. Pr. 274, 156175 (2025).","journal-title":"Pathol. Res. Pr."},{"key":"5568_CR238","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.freeradbiomed.2024.11.007","volume":"226","author":"S He","year":"2025","unstructured":"He, S. et al. Ginsenoside Rb1 targets to HO-1 to improve sepsis by inhibiting ferroptosis. Free Radic. Biol. Med. 226, 13\u201328 (2025).","journal-title":"Free Radic. Biol. Med"},{"key":"5568_CR239","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2019.108073","volume":"673","author":"GS Drummond","year":"2019","unstructured":"Drummond, G. S. et al. HO-1 overexpression and underexpression: Clinical implications. Arch. Biochem Biophys. 673, 108073 (2019).","journal-title":"Arch. Biochem Biophys."},{"key":"5568_CR240","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1542\/peds.93.1.1","volume":"93","author":"T Valaes","year":"1994","unstructured":"Valaes, T. et al. Control of jaundice in preterm newborns by an inhibitor of bilirubin production: Studies with tin-mesoporphyrin. Pediatrics 93, 1\u201311 (1994).","journal-title":"Pediatrics"},{"issue":"Suppl 1","key":"5568_CR241","doi-asserted-by":"publisher","first-page":"S101","DOI":"10.1038\/sj.jp.7210655","volume":"21","author":"JC Mart\u00ednez","year":"2001","unstructured":"Mart\u00ednez, J. C. et al. Treatment of hyperbilirubinemia pharmacologic approach SnMP(tin-mesoporphyrin). J. Perinatol. 21, (Suppl 1), S101\u20133 (2001). discussion S104-7.","journal-title":"J. Perinatol."},{"key":"5568_CR242","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1038\/jp.2017.6","volume":"37","author":"M Kaplan","year":"2017","unstructured":"Kaplan, M., Wong, R. J. & Stevenson, D. K. Heme oxygenase-1 promoter polymorphisms: Do they modulate neonatal hyperbilirubinemia? J. Perinatol. 37, 901\u20135 (2017).","journal-title":"J. Perinatol."},{"key":"5568_CR243","first-page":"558","volume":"45","author":"S Ullah","year":"2016","unstructured":"Ullah, S., Rahman, K. & Hedayati, M. Hyperbilirubinemia in neonates: types, causes, clinical examinations, preventive measures and treatments: A narrative review article. Iran. J. Public Health 45, 558\u201368 (2016).","journal-title":"Iran. J. Public Health"},{"key":"5568_CR244","doi-asserted-by":"publisher","first-page":"2428","DOI":"10.1182\/blood-2012-04-426247","volume":"120","author":"AY-L So","year":"2012","unstructured":"So, A. Y.-L. et al. Regulation of APC development, immune response, and autoimmunity by Bach1\/HO-1 pathway in mice. Blood 120, 2428\u201337 (2012).","journal-title":"Blood"},{"key":"5568_CR245","doi-asserted-by":"publisher","first-page":"861","DOI":"10.3390\/antiox11050861","volume":"11","author":"J de Oliveira","year":"2022","unstructured":"de Oliveira, J., Denadai, M. B. & Costa, D. L. Crosstalk between heme oxygenase-1 and iron metabolism in macrophages: Implications for the modulation of inflammation and immunity. Antioxid. (Basel) 11, 861 (2022).","journal-title":"Antioxid. (Basel)"},{"key":"5568_CR246","doi-asserted-by":"publisher","first-page":"601","DOI":"10.3324\/haematol.2014.116368","volume":"100","author":"ST Fraser","year":"2015","unstructured":"Fraser, S. T. et al. Heme oxygenase-1 deficiency alters erythroblastic island formation, steady-state erythropoiesis and red blood cell lifespan in mice. Haematologica 100, 601\u201310 (2015).","journal-title":"Haematologica"},{"key":"5568_CR247","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.freeradbiomed.2020.10.016","volume":"161","author":"D Singh","year":"2020","unstructured":"Singh, D., Wasan, H. & Reeta, K. H. Heme oxygenase-1 modulation: A potential therapeutic target for COVID-19 and associated complications. Free Radic. Biol. Med. 161, 263\u201371 (2020).","journal-title":"Free Radic. Biol. Med"},{"key":"5568_CR248","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1161\/ATVBAHA.123.318780","volume":"43","author":"JD Dimitrov","year":"2023","unstructured":"Dimitrov, J. D., Roumenina, L. T., Perrella, G. & Rayes, J. Basic mechanisms of hemolysis-associated thrombo-inflammation and immune dysregulation. Arterioscler Thromb. Vasc. Biol. 43, 1349\u201361 (2023).","journal-title":"Arterioscler Thromb. Vasc. Biol."},{"key":"5568_CR249","doi-asserted-by":"publisher","first-page":"e37360","DOI":"10.1097\/MD.0000000000037360","volume":"103","author":"EI Obeagu","year":"2024","unstructured":"Obeagu, E. I., Igwe, M. C. & Obeagu, G. U. Oxidative stress\u2019s impact on red blood cells: Unveiling implications for health and disease. Medicine 103, e37360 (2024).","journal-title":"Medicine"},{"key":"5568_CR250","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1089\/ars.2008.2142","volume":"10","author":"S Ghaffari","year":"2008","unstructured":"Ghaffari, S. Oxidative stress in the regulation of normal and neoplastic hematopoiesis. Antioxid. Redox Signal 10, 1923\u201340 (2008).","journal-title":"Antioxid. Redox Signal"},{"key":"5568_CR251","doi-asserted-by":"publisher","DOI":"10.1002\/hem3.70294","volume":"10","author":"P Quaranta","year":"2026","unstructured":"Quaranta, P. et al. Evolution of hematopoietic stem cell potential from preterm to term neonates. Hemasphere 10, e70294 (2026).","journal-title":"Hemasphere"},{"key":"5568_CR252","first-page":"797","volume":"22","author":"JW Dang","year":"2019","unstructured":"Dang, J. W., Lei, X. P., Li, Q. P. & Dong, W. B. Asiaticoside attenuates hyperoxia-induced lung injury in vitro and in vivo. Iran. J. Basic Med. Sci. 22, 797\u2013805 (2019).","journal-title":"Iran. J. Basic Med. Sci."},{"key":"5568_CR253","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1016\/j.jhep.2019.06.020","volume":"71","author":"B G\u00f6rg","year":"2019","unstructured":"G\u00f6rg, B. et al. O-GlcNAcylation-dependent upregulation of HO1 triggers ammonia-induced oxidative stress and senescence in hepatic encephalopathy. J. Hepatol. 71, 930\u201341 (2019).","journal-title":"J. Hepatol."},{"key":"5568_CR254","doi-asserted-by":"publisher","first-page":"556","DOI":"10.4252\/wjsc.v14.i7.556","volume":"14","author":"N Dong","year":"2022","unstructured":"Dong, N. et al. Intratracheal administration of umbilical cord-derived mesenchymal stem cells attenuates hyperoxia-induced multi-organ injury via heme oxygenase-1 and JAK\/STAT pathways. World J. Stem Cells 14, 556\u201376 (2022).","journal-title":"World J. Stem Cells"},{"key":"5568_CR255","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1007\/s11011-024-01519-0","volume":"40","author":"MM Atabaki","year":"2025","unstructured":"Atabaki, M. M., Ghotbeddin, Z., Rahimi, K. & Tabandeh, M. R. The potential of alphapinene as a therapeutic agent for maternal hypoxia-induced cognitive impairments: A study on HO-1 and Nrf2 gene expression in rats. Metab. Brain Dis. 40, 112 (2025).","journal-title":"Metab. Brain Dis."},{"key":"5568_CR256","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s10735-025-10457-9","volume":"56","author":"S Maodaa","year":"2025","unstructured":"Maodaa, S. et al. Perinatal nicotine-induced neurotoxicity and behavioral alterations in newborn mice are associated with oxidative stress, inflammation and downregulated Nrf2\/HO-1 signaling: protective role of Anethum graveolens. J. Mol. Histol. 56, 179 (2025).","journal-title":"J. Mol. Histol."},{"key":"5568_CR257","doi-asserted-by":"publisher","first-page":"238","DOI":"10.3341\/kjo.2007.21.4.238","volume":"21","author":"JU Jang","year":"2007","unstructured":"Jang, J. U. et al. Effects of heme oxygenase-1 inducer and inhibitor on experimental autoimmune uveoretinitis. Korean J. Ophthalmol. 21, 238\u201343 (2007).","journal-title":"Korean J. Ophthalmol."},{"key":"5568_CR258","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1080\/10408398.2017.1358139","volume":"59","author":"H Mollazadeh","year":"2019","unstructured":"Mollazadeh, H. et al. Immune modulation by curcumin: The role of interleukin-10. Crit. Rev. Food Sci. Nutr. 59, 89\u2013101 (2019).","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"5568_CR259","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/emm.2007.30","volume":"39","author":"H-O Pae","year":"2007","unstructured":"Pae, H.-O. et al. Roles of heme oxygenase-1 in curcumin-induced growth inhibition in rat smooth muscle cells. Exp. Mol. Med. 39, 267\u201377 (2007).","journal-title":"Exp. Mol. Med"},{"key":"5568_CR260","doi-asserted-by":"publisher","first-page":"4437","DOI":"10.1021\/jm0511435","volume":"49","author":"JZ Vlahakis","year":"2006","unstructured":"Vlahakis, J. Z. et al. Imidazole\u2212dioxolane compounds as isozyme-selective heme oxygenase inhibitors. J. Med. Chem. 49, 4437\u201341 (2006).","journal-title":"J. Med. Chem."},{"key":"5568_CR261","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2023.112238","volume":"244","author":"T Chiura","year":"2023","unstructured":"Chiura, T. et al. Interactions of azole-based inhibitors with human heme oxygenase. J. Inorg. Biochem 244, 112238 (2023).","journal-title":"J. Inorg. Biochem"},{"key":"5568_CR262","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1111\/cbdd.12015","volume":"80","author":"V Sorrenti","year":"2012","unstructured":"Sorrenti, V. et al. Evaluation of imidazole-based compounds as heme oxygenase-1 inhibitors. Chem. Biol. Drug Des. 80, 876\u201386 (2012).","journal-title":"Chem. Biol. Drug Des."},{"key":"5568_CR263","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1161\/CIRCRESAHA.107.154781","volume":"101","author":"KM Kim","year":"2007","unstructured":"Kim, K. M. et al. Carbon monoxide induces heme oxygenase-1 via activation of protein kinase R-like endoplasmic reticulum kinase and inhibits endothelial cell apoptosis triggered by endoplasmic reticulum stress. Circ. Res. 101, 919\u201327 (2007).","journal-title":"Circ. Res"},{"key":"5568_CR264","doi-asserted-by":"publisher","first-page":"2835","DOI":"10.1093\/emboj\/20.11.2835","volume":"20","author":"K Ogawa","year":"2001","unstructured":"Ogawa, K. et al. Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1. EMBO J. 20, 2835\u201343 (2001).","journal-title":"EMBO J."},{"key":"5568_CR265","doi-asserted-by":"publisher","first-page":"5375","DOI":"10.1074\/jbc.272.9.5375","volume":"272","author":"PJ Lee","year":"1997","unstructured":"Lee, P. J. et al. Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia. J. Biol. Chem. 272, 5375\u201381 (1997).","journal-title":"J. Biol. Chem."},{"key":"5568_CR266","doi-asserted-by":"publisher","first-page":"5474","DOI":"10.3390\/molecules25225474","volume":"25","author":"S Saha","year":"2020","unstructured":"Saha, S. et al. An overview of Nrf2 signaling pathway and its role in inflammation. Molecules 25, 5474 (2020).","journal-title":"Molecules"},{"key":"5568_CR267","first-page":"55","volume":"5","author":"S Sobo\u010danec","year":"2016","unstructured":"Sobo\u010danec, S. et al. Response to hyperoxia is associated with similar ho-1 gene expression level in lungs of aging CBA mice of both sexes. Biochem Biophys. Rep. 5, 55\u201362 (2016).","journal-title":"Biochem Biophys. Rep."},{"key":"5568_CR268","doi-asserted-by":"publisher","DOI":"10.1038\/srep26358","volume":"6","author":"L-F Wang","year":"2016","unstructured":"Wang, L.-F. et al. Knockout of ho-1 protects the striatum from ferrous iron-induced injury in a male-specific manner in mice. Sci. Rep. 6, 26358 (2016).","journal-title":"Sci. Rep."},{"key":"5568_CR269","doi-asserted-by":"publisher","first-page":"L175","DOI":"10.1152\/ajplung.2000.279.1.L175","volume":"279","author":"PJ Lee","year":"2000","unstructured":"Lee, P. J. et al. AP-1 and STAT mediate hyperoxia-induced gene transcription of heme oxygenase-1. Am. J. Physiol. -Lung Cell. Mol. Physiol. 279, L175\u201382 (2000).","journal-title":"Am. J. Physiol. -Lung Cell. Mol. Physiol."},{"key":"5568_CR270","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1042\/bj20021619","volume":"371","author":"E Balogun","year":"2003","unstructured":"Balogun, E. et al. Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem. J. 371, 887\u201395 (2003).","journal-title":"Biochem. J."},{"key":"5568_CR271","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.3389\/fimmu.2020.01467","volume":"11","author":"SC Funes","year":"2020","unstructured":"Funes, S. C. et al. Naturally derived heme-oxygenase 1 inducers and their therapeutic application to immune-mediated diseases. Front Immunol. 11, 1467 (2020).","journal-title":"Front Immunol."},{"key":"5568_CR272","first-page":"268","volume":"56","author":"H-Y Jang","year":"2020","unstructured":"Jang, H.-Y. et al. Roles of JNK\/Nrf2 pathway on hemin-induced heme oxygenase-1 activation in MCF-7 human breast cancer cells. Med. (Kaunas.) 56, 268 (2020).","journal-title":"Med. (Kaunas.)"},{"key":"5568_CR273","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s11658-020-00226-9","volume":"25","author":"J Zhao","year":"2020","unstructured":"Zhao, J. et al. Asiaticoside inhibits TGF-\u03b21-induced mesothelial-mesenchymal transition and oxidative stress via the Nrf2\/HO-1 signaling pathway in the human peritoneal mesothelial cell line HMrSV5. Cell Mol. Biol. Lett. 25, 33 (2020).","journal-title":"Cell Mol. Biol. Lett."},{"key":"5568_CR274","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01819-19","volume":"64","author":"JL Willix","year":"2020","unstructured":"Willix, J. L. et al. Activation of heme oxygenase expression by cobalt protoporphyrin treatment prevents pneumonic plague caused by inhalation of yersinia pestis. Antimicrob. Agents Chemother. 64, e01819-19 (2020).","journal-title":"Antimicrob. Agents Chemother."},{"key":"5568_CR275","doi-asserted-by":"publisher","first-page":"8615","DOI":"10.1007\/s11033-023-08765-y","volume":"50","author":"K Rahimi","year":"2023","unstructured":"Rahimi, K. et al. The effects of alpha-pinene on the Nrf2-HO1 signaling pathway in gastric damage in rats. Mol. Biol. Rep. 50, 8615\u201322 (2023).","journal-title":"Mol. Biol. Rep."},{"key":"5568_CR276","doi-asserted-by":"publisher","first-page":"838","DOI":"10.3390\/coatings11070838","volume":"11","author":"J Ajarem","year":"2021","unstructured":"Ajarem, J. et al. Anethum graveolens prevents liver and kidney injury, oxidative stress and inflammation in mice exposed to nicotine perinatally. Coatings 11, 838 (2021).","journal-title":"Coatings"},{"key":"5568_CR277","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.ejmech.2019.02.027","volume":"167","author":"L Salerno","year":"2019","unstructured":"Salerno, L. et al. Progress in the development of selective heme oxygenase-1 inhibitors and their potential therapeutic application. Eur. J. Med. Chem. 167, 439\u201353 (2019).","journal-title":"Eur. J. Med. Chem."},{"key":"5568_CR278","doi-asserted-by":"publisher","first-page":"S35","DOI":"10.1038\/jp.2010.173","volume":"31","author":"RJ Wong","year":"2011","unstructured":"Wong, R. J. et al. In vitro inhibition of heme oxygenase isoenzymes by metalloporphyrins. J. Perinatol. 31, S35\u201341 (2011).","journal-title":"J. Perinatol."},{"key":"5568_CR279","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1203\/00006450-199302000-00021","volume":"33","author":"HJ Verman","year":"1993","unstructured":"Verman, H. J., Ekstrand, B. C. & Stevenson, D. K. Selection of metalloporphyrin heme oxygenase inhibitors based on potency and photoreactivity. Pediatr. Res. 33, 195\u2013200 (1993).","journal-title":"Pediatr. Res"},{"key":"5568_CR280","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1161\/CIRCRESAHA.109.199505","volume":"106","author":"CA Gleissner","year":"2010","unstructured":"Gleissner, C. A. et al. CXCL4 downregulates the atheroprotective hemoglobin receptor CD163 in human macrophages. Circ. Res. 106, 203\u201311 (2010).","journal-title":"Circ. Res"},{"key":"5568_CR281","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphys.2012.00001","volume":"3","author":"CA Gleissner","year":"2012","unstructured":"Gleissner, C. A. Macrophage phenotype modulation by CXCL4 in atherosclerosis. Front Physiol. 3, 1 (2012).","journal-title":"Front Physiol."},{"key":"5568_CR282","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101768","volume":"38","author":"H Rezai","year":"2021","unstructured":"Rezai, H. et al. MZe786, a hydrogen sulfide-releasing aspirin prevents preeclampsia in heme oxygenase-1 haplodeficient pregnancy under high soluble flt-1 environment. Redox Biol. 38, 101768 (2021).","journal-title":"Redox Biol."},{"key":"5568_CR283","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.7150\/ijbs.59404","volume":"17","author":"R Wei","year":"2021","unstructured":"Wei, R. et al. Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells. Int J. Biol. Sci. 17, 2703\u201317 (2021).","journal-title":"Int J. Biol. Sci."},{"key":"5568_CR284","doi-asserted-by":"publisher","DOI":"10.1186\/2045-9912-2-4","volume":"2","author":"T El-Mousleh","year":"2012","unstructured":"El-Mousleh, T. et al. Exploring the potential of low doses carbon monoxide as therapy in pregnancy complications. Med. Gas. Res. 2, 4 (2012).","journal-title":"Med. Gas. Res"},{"key":"5568_CR285","doi-asserted-by":"publisher","first-page":"e188","DOI":"10.1016\/j.thromres.2012.07.002","volume":"130","author":"K Maruyama","year":"2012","unstructured":"Maruyama, K. et al. Carbon monoxide (CO)-releasing molecule-derived CO regulates tissue factor and plasminogen activator inhibitor type 1 in human endothelial cells. Thromb. Res. 130, e188\u201393 (2012).","journal-title":"Thromb. Res"},{"key":"5568_CR286","first-page":"1398","volume":"27","author":"C Wang","year":"2025","unstructured":"Wang, C., Wang, M. X. & Zhu, Y. P. Human umbilical cord mesenchymal stem cells protect against neonatal white matter injury by activating the Nrf2\/Keap1\/HO-1 signaling pathway. Zhongguo Dang Dai Er Ke Za Zhi 27, 1398\u2013407 (2025).","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-026-05568-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-026-05568-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-026-05568-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:01:58Z","timestamp":1792785718000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-026-05568-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,23]]},"references-count":286,"alternative-id":["5568"],"URL":"https:\/\/doi.org\/10.1038\/s41390-026-05568-2","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,23]]},"assertion":[{"value":"27 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"Patient consent was not required for this review article.","order":2,"name":"Ethics","label":"Consent statement","group":{"name":"EthicsHeading","label":"Ethics"}}]}}