{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:43:52Z","timestamp":1790520232596,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Prostate Cancer Prostatic Dis"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Limited data exist on the role of holmium laser enucleation of the prostate (HoLEP), thulium laser enucleation of the prostate (ThuLEP), and transurethral resection of the prostate (TURP) in patients with prostate cancer (PCa). We aimed to analyze their perioperative outcomes and trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>The German Nationwide Inpatient Data (GRAND) registry was used to identify male patients diagnosed with PCa who underwent HoLEP, ThuLEP, or TURP between 2005 and 2022. Multivariable regression analyses were performed to compare perioperative morbidity and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 221,768 procedures in patients with PCa were performed: 8160 HoLEP, 2285 ThuLEP, and 211,323 TURP. Although TURP remains the predominant technique, the use of HoLEP and ThuLEP has increased significantly in recent years, representing 17% of all cases by 2022. Perioperative outcomes were worse for TURP, with higher transfusion (8.8%) and ICU admission rates (1.7%) compared to HoLEP and ThuLEP (both 2.5% and \u22641.2%, respectively). Postoperative urinary retention and incontinence rates were also lower for laser enucleation techniques than TURP. In patients with PCa undergoing TURP, perioperative outcomes were worse compared to those without PCa, while outcomes for HoLEP and ThuLEP were comparable regardless of PCa status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HoLEP and ThuLEP offer improved perioperative outcomes compared to TURP in patients with PCa.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41391-025-00980-x","type":"journal-article","created":{"date-parts":[[2025,5,18]],"date-time":"2025-05-18T23:58:49Z","timestamp":1747612729000},"page":"138-143","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Perioperative outcomes of HoLEP, ThuLEP, and TURP in patients with prostate cancer: results from the GRAND study"],"prefix":"10.1038","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7707-8426","authenticated-orcid":false,"given":"Nikolaos","family":"Pyrgidis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0340-0304","authenticated-orcid":false,"given":"Gerald Bastian","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Weinhold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Atzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo Federico","family":"Stadelmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iason","family":"Papadopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Stief","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Marcon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"980_CR1","doi-asserted-by":"publisher","first-page":"e754","DOI":"10.1016\/S2666-7568(22)00213-6","volume":"3","author":"AF Awedew","year":"2022","unstructured":"Awedew AF, Han H, Abbasi B, Abbasi-Kangevari M, Ahmed MB, Almidani O, et al. The global, regional, and national burden of benign prostatic hyperplasia in 204 countries and territories from 2000 to 2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Healthy Longev. 2022;3:e754\u201376.","journal-title":"Lancet Healthy Longev"},{"key":"980_CR2","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.eururo.2010.06.005","volume":"58","author":"SA Ahyai","year":"2010","unstructured":"Ahyai SA, Gilling P, Kaplan SA, Kuntz RM, Madersbacher S, Montorsi F, et al. Meta-analysis of functional outcomes and complications following transurethral procedures for lower urinary tract symptoms resulting from benign prostatic enlargement. Eur Urol. 2010;58:384\u201397.","journal-title":"Eur Urol"},{"key":"980_CR3","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.eururo.2023.04.008","volume":"84","author":"S Gravas","year":"2023","unstructured":"Gravas S, Gacci M, Gratzke C, Herrmann TRW, Karavitakis M, Kyriazis I, et al. Summary paper on the 2023 European Association of Urology guidelines on the management of non-neurogenic male lower urinary tract symptoms. Eur Urol. 2023;84:207\u201322.","journal-title":"Eur Urol"},{"key":"980_CR4","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.urology.2015.06.002","volume":"86","author":"MA Elkoushy","year":"2015","unstructured":"Elkoushy MA, Elshal AM, Elhilali MM. Incidental prostate cancer diagnosis during holmium laser enucleation: assessment of predictors, survival, and disease progression. Urology. 2015;86:552\u20137.","journal-title":"Urology"},{"key":"980_CR5","doi-asserted-by":"publisher","first-page":"471","DOI":"10.23736\/S2724-6051.19.03564-1","volume":"73","author":"AB Porcaro","year":"2021","unstructured":"Porcaro AB, Tafuri A, Inverardi D, Amigoni N, Sebben M, Pirozzi M, et al. Incidental prostate cancer after transurethral resection of the prostate: analysis of incidence and risk factors in 458 patients. 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Prostate Cancer Prostatic Dis. 2024;27:48\u201353.","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"980_CR8","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1016\/j.eururo.2014.06.017","volume":"67","author":"JN Cornu","year":"2015","unstructured":"Cornu JN, Ahyai S, Bachmann A, de la Rosette J, Gilling P, Gratzke C, et al. A systematic review and meta-analysis of functional outcomes and complications following transurethral procedures for lower urinary tract symptoms resulting from benign prostatic obstruction: an update. Eur Urol. 2015;67:1066\u201396.","journal-title":"Eur Urol"},{"key":"980_CR9","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/j.1464-410X.2006.06529.x","volume":"99","author":"M Marszalek","year":"2007","unstructured":"Marszalek M, Ponholzer A, Rauchenwald M, Madersbacher S. Palliative transurethral resection of the prostate: functional outcome and impact on survival. 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World J Urol. 2018;36:2035\u201341.","journal-title":"World J Urol"},{"key":"980_CR14","doi-asserted-by":"crossref","unstructured":"Tamalunas A, Keller P, Schott M, Stadelmeier LF, Kidess M, Atzler M, et al. Propensity score-matched evaluation of palliative transurethral resection and holmium laser enucleation of the prostate for bladder outlet obstruction in patients with prostate cancer. Prostate Cancer Prostatic Dis. 2024;28:153\u20139.","DOI":"10.1038\/s41391-024-00831-1"},{"key":"980_CR15","first-page":"00002","volume":"S2405-4569","author":"J Marcon","year":"2025","unstructured":"Marcon J, Keller P, Pyrgidis N, Atzler M, Kidess M, G\u00f6tz M, et al. Trends and perioperative outcomes of surgical treatments for benign prostatic hyperplasia in Germany: results from the GRAND study. Eur Urol Focus. 2025;S2405-4569:00002\u20131.","journal-title":"Eur Urol Focus"},{"key":"980_CR16","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/0090-4295(91)80170-C","volume":"38","author":"AW Mazur","year":"1991","unstructured":"Mazur AW, Thompson IM. Efficacy and morbidity of \u201cchannel\u201d TURP. Urology. 1991;38:526\u20138.","journal-title":"Urology"},{"key":"980_CR17","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1097\/JU.0000000000004159","volume":"212","author":"R Leni","year":"2024","unstructured":"Leni R, Vickers AJ, Brasso K, Montorsi F, Briganti A, Nielsen TK, et al. Management and oncologic outcomes of incidental prostate cancer after transurethral resection of the prostate in Denmark. 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All data used in this work are stored anonymized at the German Federal Statistical Office.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}