{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:04:34Z","timestamp":1790949874336,"version":"4.1.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000054","name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["1R01CA218657"],"award-info":[{"award-number":["1R01CA218657"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["T32HD095134"],"award-info":[{"award-number":["T32HD095134"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Prostate Cancer Prostatic Dis"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The differential impacts of radical prostatectomy (RP) and external beam radiotherapy (EBRT) on sexual health in gay and bisexual men (GBM) with prostate cancer remain understudied, limiting recommendations incorporating preferred sexual behavior.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Secondary analysis of Restore-2 compared outcomes in GBM after RP (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009127) or EBRT (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200927).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to RP, EBRT was associated with lower rates of climacturia (11% vs. 59%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), condom-related erectile dysfunction (27% vs. 51%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047), and decreased penile length\/girth (49% vs. 69%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.07), but higher rates of anodyspareunia (33% vs. 14%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.06).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Exploratory findings suggest EBRT for insertive intercourse, RP for receptive intercourse.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41391-025-01007-1","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:58:58Z","timestamp":1754441938000},"page":"638-641","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Treatment choice and sexual health outcomes in gay and bisexual men with prostate cancer"],"prefix":"10.1038","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4606-5574","authenticated-orcid":false,"given":"Daniel R.","family":"Dickstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex J.","family":"Bates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0452-0252","authenticated-orcid":false,"given":"Christopher W.","family":"Wheldon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Haggart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine M. C.","family":"Talley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah C.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8862-531X","authenticated-orcid":false,"given":"B. R. Simon","family":"Rosser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"1007_CR1","unstructured":"National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae): Prostate Cancer: National Comprehensive Cancer Network; 2025 [updated April 16, 2025]. Available from: https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/prostate.pdf."},{"key":"1007_CR2","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/s41585-023-00778-3","volume":"20","author":"DR Dickstein","year":"2023","unstructured":"Dickstein DR, Edwards CR, Lehrer EJ, Tarras ES, Gallitto M, Sfakianos J, et al. Sexual health and treatment-related sexual dysfunction in sexual and gender minorities with prostate cancer. Nat Rev Urol. 2023;20:332\u201355.","journal-title":"Nat Rev Urol"},{"key":"1007_CR3","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.ijrobp.2025.01.023","volume":"122","author":"DR Dickstein","year":"2025","unstructured":"Dickstein DR, Kapouranis T, Sigel K, Wheldon CW, Nvepu E, Javier NM, et al. Sexual Health Outcomes in Sexual Minority and Heterosexual Men After Prostate Radiation Therapy. Int J Radiat Oncol Biol Phys. 2025;122:416\u201323.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1007_CR4","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/s41575-024-00932","volume":"21","author":"DR Dickstein","year":"2024","unstructured":"Dickstein DR, Edwards CR, Rowan CR, Avanessian B, Chubak BM, Wheldon CW, et al. Pleasurable and problematic receptive anal intercourse and diseases of the colon, rectum and anus. Nat Rev Gastroenterol Hepatol. 2024;21:377\u2013405. https:\/\/doi.org\/10.1038\/s41575-024-00932.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"1007_CR5","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/s41585-022-00600-6","volume":"19","author":"DR Dickstein","year":"2022","unstructured":"Dickstein DR, Marshall DC. Top, bottom or vers? Creating a more equitable health system for sexual and gender minority patients with prostate cancer. Nat Rev Urol. 2022;19:321\u20132.","journal-title":"Nat Rev Urol"},{"key":"1007_CR6","doi-asserted-by":"publisher","unstructured":"Rosser BRS, Kohli N, Bates AJ, Talley KMC, Wright MM, Polter EJ, et al. Does sexual rehabilitation work for gay and bisexual prostate cancer patients? Acceptability, feasibility, and efficacy results from the Restore-2 randomized controlled trial. J Cancer Surviv. 2024. https:\/\/doi.org\/10.1007\/s11764-024-01672-6.","DOI":"10.1007\/s11764-024-01672-6"},{"key":"1007_CR7","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1177\/17407745221077678","volume":"19","author":"BRS Rosser","year":"2022","unstructured":"Rosser BRS, Wright M, Hoefer CJ, Polter EJ, Kohli N, Wheldon CW, et al. Recruiting an underserved, difficult to reach population into a cancer trial: Strategies from the Restore-2 Rehabilitation Trial for gay and bisexual prostate cancer patients. Clin Trials. 2022;19:239\u201350.","journal-title":"Clin Trials"},{"key":"1007_CR8","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1056\/NEJMoa2403365","volume":"391","author":"N van As","year":"2024","unstructured":"van As N, Griffin C, Tree A, Patel J, Ostler P, van der Voet H, et al. Phase 3 Trial of stereotactic body radiotherapy in localized prostate cancer. N Engl J Med. 2024;391:1413\u201325.","journal-title":"N Engl J Med"},{"key":"1007_CR9","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.ijrobp.2024.05.003","volume":"120","author":"GS Alexander","year":"2024","unstructured":"Alexander GS, Krc RF, Assif JW, Sun K, Molitoris JK, Tran P, et al. Conditional risk and predictive factors associated with late toxicity in patients with prostate cancer treated with external beam radiation therapy alone in the randomized Trial RTOG 0126. 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