{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T00:52:15Z","timestamp":1794012735795,"version":"4.8.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T00:00:00Z","timestamp":1614470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T00:00:00Z","timestamp":1614470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81420108001"],"award-info":[{"award-number":["81420108001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870007"],"award-info":[{"award-number":["81870007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81930003"],"award-info":[{"award-number":["81930003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870007"],"award-info":[{"award-number":["81870007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010905","name":"National Science Foundation of China | Major Research Plan","doi-asserted-by":"publisher","award":["91642202"],"award-info":[{"award-number":["91642202"]}],"id":[{"id":"10.13039\/501100010905","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010905","name":"National Science Foundation of China | Major Research Plan","doi-asserted-by":"publisher","award":["91642202"],"award-info":[{"award-number":["91642202"]}],"id":[{"id":"10.13039\/501100010905","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010896","name":"National Science Foundation of China | International Cooperation and Exchange Programme","doi-asserted-by":"publisher","award":["81920108001"],"award-info":[{"award-number":["81920108001"]}],"id":[{"id":"10.13039\/501100010896","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sig Transduct Target Ther"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Eosinophils are terminally differentiated cells derived from hematopoietic stem cells (HSCs) in the bone marrow. Several studies have confirmed the effective roles of eosinophils in asthmatic airway pathogenesis. However, their regulatory functions have not been well elucidated. Here, increased C-C chemokine ligand 6 (CCL6) in asthmatic mice and the human orthologs CCL15 and CCL23 that are highly expressed in asthma patients are described, which are mainly derived from eosinophils. Using\n                    <jats:italic>Ccl6<\/jats:italic>\n                    knockout mice, further studies revealed CCL6-dependent allergic airway inflammation and committed eosinophilia in the bone marrow following ovalbumin (OVA) challenge and identified a CCL6-CCR1 regulatory axis in hematopoietic stem cells (HSCs). Eosinophil differentiation and airway inflammation were remarkably decreased by the specific CCR1 antagonist BX471. Thus, the study identifies that the CCL6-CCR1 axis is involved in the crosstalk between eosinophils and HSCs during the development of allergic airway inflammation, which also reveals a potential therapeutic strategy for targeting G protein-coupled receptors (GPCRs) for future clinical treatment of asthma.\n                  <\/jats:p>","DOI":"10.1038\/s41392-021-00482-x","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T19:35:02Z","timestamp":1614454502000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Eosinophil-derived chemokine (hCCL15\/23, mCCL6) interacts with CCR1 to promote eosinophilic airway inflammation"],"prefix":"10.1038","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1161-0130","authenticated-orcid":false,"given":"Xufei","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaqiong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhehua","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicheng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1770-8956","authenticated-orcid":false,"given":"Songmin","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huahao","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,28]]},"reference":[{"key":"482_CR1","unstructured":"GINA. Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma (GINA). Available from: http:\/\/www.ginasthma.org\/; Updated 2020."},{"key":"482_CR2","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.jaip.2014.06.005","volume":"2","author":"RS Zeiger","year":"2014","unstructured":"Zeiger, R. S. et al. High blood eosinophil count is a risk factor for future asthma exacerbations in adult persistent asthma. J. Allergy Clin. Immunol. Pr. 2, 741\u2013750 (2014).","journal-title":"J. Allergy Clin. Immunol. Pr."},{"key":"482_CR3","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1016\/j.jaci.2017.10.005","volume":"140","author":"SW Yancey","year":"2017","unstructured":"Yancey, S. W. et al. Biomarkers for severe eosinophilic asthma. J. Allergy Clin. Immunol. 140, 1509\u20131518 (2017).","journal-title":"J. Allergy Clin. Immunol."},{"key":"482_CR4","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.immuni.2019.03.022","volume":"50","author":"M Dougan","year":"2019","unstructured":"Dougan, M., Dranoff, G. & Dougan, S. K. GM-CSF, IL-3, and IL-5 family of cytokines: regulators of inflammation. Immunity 50, 796\u2013811 (2019).","journal-title":"Immunity"},{"key":"482_CR5","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1126\/science.1099472","volume":"305","author":"JJ Lee","year":"2004","unstructured":"Lee, J. J. et al. Defining a link with asthma in mice congenitally deficient in eosinophils. Science 305, 1773\u20131776 (2004).","journal-title":"Science"},{"key":"482_CR6","doi-asserted-by":"publisher","first-page":"3296","DOI":"10.4049\/jimmunol.170.6.3296","volume":"170","author":"HH Shen","year":"2003","unstructured":"Shen, H. H. et al. A causative relationship exists between eosinophils and the development of allergic pulmonary pathologies in the mouse. J. Immunol. 170, 3296\u20133305 (2003).","journal-title":"J. Immunol."},{"key":"482_CR7","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.cell.2016.04.020","volume":"165","author":"ME Rothenberg","year":"2016","unstructured":"Rothenberg, M. E. Humanized anti-IL-5 antibody therapy. Cell 165, 509 (2016).","journal-title":"Cell"},{"key":"482_CR8","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1016\/S0140-6736(16)31322-8","volume":"388","author":"JM FitzGerald","year":"2016","unstructured":"FitzGerald, J. M. et al. Benralizumab, an anti-interleukin-5 receptor alpha monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet 388, 2128\u20132141 (2016).","journal-title":"Lancet"},{"key":"482_CR9","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/S2213-2600(15)00042-9","volume":"3","author":"M Castro","year":"2015","unstructured":"Castro, M. et al. Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials. Lancet Respir. Med. 3, 355\u2013366 (2015).","journal-title":"Lancet Respir. Med."},{"key":"482_CR10","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1016\/S0140-6736(16)31324-1","volume":"388","author":"ER Bleecker","year":"2016","unstructured":"Bleecker, E. R. et al. Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting beta2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial. Lancet 388, 2115\u20132127 (2016).","journal-title":"Lancet"},{"key":"482_CR11","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/S0140-6736(12)60988-X","volume":"380","author":"ID Pavord","year":"2012","unstructured":"Pavord, I. D. et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet 380, 651\u2013659 (2012).","journal-title":"Lancet"},{"key":"482_CR12","doi-asserted-by":"publisher","first-page":"6059","DOI":"10.4049\/jimmunol.1102299","volume":"187","author":"EA Jacobsen","year":"2011","unstructured":"Jacobsen, E. A., Zellner, K. R., Colbert, D., Lee, N. A. & Lee, J. J. Eosinophils regulate dendritic cells and Th2 pulmonary immune responses following allergen provocation. J. Immunol. 187, 6059\u20136068 (2011).","journal-title":"J. Immunol."},{"key":"482_CR13","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1038\/icb.2009.115","volume":"88","author":"LA Spencer","year":"2010","unstructured":"Spencer, L. A. & Weller, P. F. Eosinophils and Th2 immunity: contemporary insights. Immunol. Cell Biol. 88, 250\u2013256 (2010).","journal-title":"Immunol. Cell Biol."},{"key":"482_CR14","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1084\/jem.20071840","volume":"205","author":"EA Jacobsen","year":"2008","unstructured":"Jacobsen, E. A. et al. Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells. J. Exp. Med. 205, 699\u2013710 (2008).","journal-title":"J. Exp. Med."},{"key":"482_CR15","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1111\/j.1365-2222.2008.02958.x","volume":"38","author":"SP Hogan","year":"2008","unstructured":"Hogan, S. P. et al. Eosinophils: biological properties and role in health and disease. Clin. Exp. Allergy 38, 709\u2013750 (2008).","journal-title":"Clin. Exp. Allergy"},{"key":"482_CR16","doi-asserted-by":"publisher","first-page":"17406","DOI":"10.1074\/jbc.R113.546218","volume":"289","author":"KR Acharya","year":"2014","unstructured":"Acharya, K. R. & Ackerman, S. J. Eosinophil granule proteins: form and function. J. Biol. Chem. 289, 17406\u201317415 (2014).","journal-title":"J. Biol. Chem."},{"key":"482_CR17","doi-asserted-by":"publisher","first-page":"570","DOI":"10.3389\/fimmu.2014.00570","volume":"5","author":"F Davoine","year":"2014","unstructured":"Davoine, F. & Lacy, P. Eosinophil cytokines, chemokines, and growth factors: emerging roles in immunity. Front Immunol. 5, 570 (2014).","journal-title":"Front Immunol."},{"key":"482_CR18","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/cr.2018.2","volume":"28","author":"C Zhang","year":"2018","unstructured":"Zhang, C. et al. Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis. Cell Res. 28, 323\u2013335 (2018).","journal-title":"Cell Res."},{"key":"482_CR19","doi-asserted-by":"crossref","first-page":"5084","DOI":"10.4049\/jimmunol.152.10.5084","volume":"152","author":"A Orlofsky","year":"1994","unstructured":"Orlofsky, A., Lin, E. Y. & Prystowsky, M. B. Selective induction of the beta chemokine C10 by IL-4 in mouse macrophages. J. Immunol. 152, 5084\u20135091 (1994).","journal-title":"J. Immunol."},{"key":"482_CR20","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1165\/rcmb.2002-0009OC","volume":"27","author":"JA Belperio","year":"2002","unstructured":"Belperio, J. A. et al. Interaction of IL-13 and C10 in the pathogenesis of bleomycin-induced pulmonary fibrosis. Am. J. Respir. Cell Mol. Biol. 27, 419\u2013427 (2002).","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"482_CR21","doi-asserted-by":"crossref","first-page":"6071","DOI":"10.4049\/jimmunol.162.10.6071","volume":"162","author":"CM Hogaboam","year":"1999","unstructured":"Hogaboam, C. M. et al. Immunomodulatory role of C10 chemokine in a murine model of allergic bronchopulmonary aspergillosis. J. Immunol. 162, 6071\u20136079 (1999).","journal-title":"J. Immunol."},{"key":"482_CR22","doi-asserted-by":"publisher","first-page":"5474","DOI":"10.4049\/jimmunol.179.8.5474","volume":"179","author":"AL Coelho","year":"2007","unstructured":"Coelho, A. L. et al. The chemokine CCL6 promotes innate immunity via immune cell activation and recruitment. J. Immunol. 179, 5474\u20135482 (2007).","journal-title":"J. Immunol."},{"key":"482_CR23","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/S0002-9440(10)65370-9","volume":"154","author":"VC Asensio","year":"1999","unstructured":"Asensio, V. C. et al. C10 is a novel chemokine expressed in experimental inflammatory demyelinating disorders that promotes recruitment of macrophages to the central nervous system. Am. J. Pathol. 154, 1181\u20131191 (1999).","journal-title":"Am. J. Pathol."},{"key":"482_CR24","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1023\/A:1020535106684","volume":"18","author":"W Wang","year":"1998","unstructured":"Wang, W., Bacon, K. B., Oldham, E. R. & Schall, T. J. Molecular cloning and functional characterization of human MIP-1 delta, a new C-C chemokine related to mouse CCF-18 and C10. J. Clin. Immunol. 18, 214\u2013222 (1998).","journal-title":"J. Clin. Immunol."},{"key":"482_CR25","doi-asserted-by":"publisher","first-page":"7341","DOI":"10.4049\/jimmunol.174.11.7341","volume":"174","author":"RD Berahovich","year":"2005","unstructured":"Berahovich, R. D. et al. Proteolytic activation of alternative CCR1 ligands in inflammation. J. Immunol. 174, 7341\u20137351 (2005).","journal-title":"J. Immunol."},{"key":"482_CR26","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/nm.4332","volume":"23","author":"M Toussaint","year":"2017","unstructured":"Toussaint, M. et al. Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation. Nat. Med. 23, 681\u2013691 (2017).","journal-title":"Nat. Med."},{"key":"482_CR27","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1084\/jem.20050548","volume":"201","author":"H Iwasaki","year":"2005","unstructured":"Iwasaki, H. et al. Identification of eosinophil lineage-committed progenitors in the murine bone marrow. J. Exp. Med. 201, 1891\u20131897 (2005).","journal-title":"J. Exp. Med."},{"key":"482_CR28","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.4049\/jimmunol.172.3.1872","volume":"172","author":"B Ma","year":"2004","unstructured":"Ma, B. et al. The C10\/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling. J. Immunol. 172, 1872\u20131881 (2004).","journal-title":"J. Immunol."},{"key":"482_CR29","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1038\/s41580-018-0049-3","volume":"19","author":"D Wootten","year":"2018","unstructured":"Wootten, D., Christopoulos, A., Marti-Solano, M., Babu, M. M. & Sexton, P. M. Mechanisms of signalling and biased agonism in G protein-coupled receptors. Nat. Rev. Mol. Cell Biol. 19, 638\u2013653 (2018).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"482_CR30","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.jaci.2008.10.022","volume":"123","author":"Z Allakhverdi","year":"2009","unstructured":"Allakhverdi, Z. et al. CD34+ hemopoietic progenitor cells are potent effectors of allergic inflammation. J. Allergy Clin. Immunol. 123, 472\u2013478 (2009).","journal-title":"J. Allergy Clin. Immunol."},{"key":"482_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.74","volume":"7","author":"LX Xia","year":"2016","unstructured":"Xia, L. X. et al. Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2. Cell Death Dis. 7, e2175 (2016).","journal-title":"Cell Death Dis."},{"key":"482_CR32","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1067\/mai.2003.1382","volume":"111","author":"A Menzies-Gow","year":"2003","unstructured":"Menzies-Gow, A. et al. Anti\u2013IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics. J. Allergy Clin. Immunol. 111, 714\u2013719 (2003).","journal-title":"J. Allergy Clin. Immunol."},{"key":"482_CR33","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/nri3062","volume":"11","author":"KY King","year":"2011","unstructured":"King, K. Y. & Goodell, M. A. Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response. Nat. Rev. Immunol. 11, 685\u2013692 (2011).","journal-title":"Nat. Rev. Immunol."},{"key":"482_CR34","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1146\/annurev-immunol-032713-120145","volume":"32","author":"JW Griffith","year":"2014","unstructured":"Griffith, J. W., Sokol, C. L. & Luster, A. D. Chemokines and chemokine receptors: positioning cells for host defense and immunity. Annu Rev. Immunol. 32, 659\u2013702 (2014).","journal-title":"Annu Rev. Immunol."},{"key":"482_CR35","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1111\/cea.13249","volume":"48","author":"YV Virkud","year":"2018","unstructured":"Virkud, Y. V. et al. Novel eosinophilic gene expression networks associated with IgE in two distinct asthma populations. Clin. Exp. Allergy 48, 1654\u20131664 (2018).","journal-title":"Clin. Exp. Allergy"},{"key":"482_CR36","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/j.1365-2222.2011.03894.x","volume":"42","author":"P Joubert","year":"2012","unstructured":"Joubert, P. et al. Expression and regulation of CCL15 by human airway smooth muscle cells. Clin. Exp. Allergy 42, 85\u201394 (2012).","journal-title":"Clin. Exp. Allergy"},{"key":"482_CR37","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1124\/pr.111.005074","volume":"65","author":"GE White","year":"2013","unstructured":"White, G. E., Iqbal, A. J. & Greaves, D. R. CC chemokine receptors and chronic inflammation\u2013therapeutic opportunities and pharmacological challenges. Pharm. Rev. 65, 47\u201389 (2013).","journal-title":"Pharm. Rev."},{"key":"482_CR38","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.jaci.2016.11.027","volume":"140","author":"BP Tian","year":"2017","unstructured":"Tian, B. P. et al. Bcl-2 inhibitors reduce steroid-insensitive airway inflammation. J. Allergy Clin. Immunol. 140, 418\u2013430 (2017).","journal-title":"J. Allergy Clin. Immunol."},{"key":"482_CR39","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1172\/JCI0214040","volume":"109","author":"HJ Anders","year":"2002","unstructured":"Anders, H. J. et al. A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. J. Clin. Invest. 109, 251\u2013259 (2002). 2002.","journal-title":"J. Clin. Invest."},{"key":"482_CR40","doi-asserted-by":"crossref","unstructured":"Bandukwala, H. S. et al. Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation. J. Exp. Med. 204, 1875\u20131889, (2007).","DOI":"10.1084\/jem.20061134"},{"key":"482_CR41","doi-asserted-by":"crossref","unstructured":"Dyer, K. D. et al. Functionally competent eosinophils differentiated ex vivo in high purity from normal mouse bone marrow. J. Immunol. 181, 4004\u20134009.","DOI":"10.4049\/jimmunol.181.6.4004"}],"container-title":["Signal Transduction and Targeted Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41392-021-00482-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41392-021-00482-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41392-021-00482-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T00:54:17Z","timestamp":1697936057000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41392-021-00482-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,28]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["482"],"URL":"https:\/\/doi.org\/10.1038\/s41392-021-00482-x","relation":{},"ISSN":["2059-3635"],"issn-type":[{"value":"2059-3635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,28]]},"assertion":[{"value":"3 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"91"}}