{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:38:55Z","timestamp":1787002735886,"version":"build-2736575974"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81941011, 31730030, 31650001, 31320103903"],"award-info":[{"award-number":["81941011, 31730030, 31650001, 31320103903"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31900749"],"award-info":[{"award-number":["31900749"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31971279, 31670988"],"award-info":[{"award-number":["31971279, 31670988"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004751","name":"Chinese Ministry of Science and Technology | Department of S and T for Social Development","doi-asserted-by":"publisher","award":["2017YFC1104001"],"award-info":[{"award-number":["2017YFC1104001"]}],"id":[{"id":"10.13039\/501100004751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004751","name":"Chinese Ministry of Science and Technology | Department of S and T for Social Development","doi-asserted-by":"publisher","award":["2017YFC1104002"],"award-info":[{"award-number":["2017YFC1104002"]}],"id":[{"id":"10.13039\/501100004751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7214301"],"award-info":[{"award-number":["7214301"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chinese Ministry of Science and Technology | Department of S and T for Social Development"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sig Transduct Target Ther"],"DOI":"10.1038\/s41392-022-01289-0","type":"journal-article","created":{"date-parts":[[2023,2,26]],"date-time":"2023-02-26T20:02:34Z","timestamp":1677441754000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Regeneration and functional recovery of the completely transected optic nerve in adult rats by CNTF-chitosan"],"prefix":"10.1038","volume":"8","author":[{"given":"Xiao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Wei","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwok-Fai","family":"So","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,27]]},"reference":[{"key":"1289_CR1","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1126\/science.aal5060","volume":"356","author":"B Laha","year":"2017","unstructured":"Laha, B., Stafford, B. K. & Huberman, A. D. Regenerating optic pathways from the eye to the brain. Science 356, 1031\u20131034 (2017).","journal-title":"Science"},{"key":"1289_CR2","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3389\/fncel.2020.00119","volume":"14","author":"SG Yang","year":"2020","unstructured":"Yang, S. G. et al. Strategies to promote long-distance optic nerve regeneration. Front. Cell. Neurosci. 14, 119 (2020).","journal-title":"Front. Cell. Neurosci."},{"key":"1289_CR3","doi-asserted-by":"publisher","first-page":"e241","DOI":"10.1371\/journal.pbio.0050241","volume":"5","author":"CA Leamey","year":"2007","unstructured":"Leamey, C. A. et al. Ten_m3 regulates eye-specific patterning in the mammalian visual pathway and is required for binocular vision. PLoS Biol. 5, e241 (2007).","journal-title":"PLoS Biol."},{"key":"1289_CR4","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1136\/jnnp.61.5.520","volume":"61","author":"J Pearce","year":"1996","unstructured":"Pearce, J. The Marcus Gunn pupil. J. Neurol. Neurosurg. Psychiatry 61, 520 (1996).","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"1289_CR5","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.cell.2021.10.029","volume":"185","author":"SG Varadarajan","year":"2022","unstructured":"Varadarajan, S. G., Hunyara, J. L., Hamilton, N. R., Kolodkin, A. L. & Huberman, A. D. Central nervous system regeneration. Cell 185, 77\u201394 (2022).","journal-title":"Cell"}],"container-title":["Signal Transduction and Targeted Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41392-022-01289-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41392-022-01289-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41392-022-01289-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,26]],"date-time":"2023-02-26T20:02:39Z","timestamp":1677441759000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41392-022-01289-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,27]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["1289"],"URL":"https:\/\/doi.org\/10.1038\/s41392-022-01289-0","relation":{},"ISSN":["2059-3635"],"issn-type":[{"value":"2059-3635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,27]]},"assertion":[{"value":"29 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"81"}}