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The cellular and molecular circuitry that underlies the generation of memory CD8<jats:sup>+<\/jats:sup> T cells remains elusive. Eosinophils can modulate inflammatory allergic responses and interact with lymphocytes to regulate their functions in immune defense. Here we report that eosinophils are required for the generation of memory CD8<jats:sup>+<\/jats:sup> T cells by inhibiting CD8<jats:sup>+<\/jats:sup> T cell apoptosis. Eosinophil-deficient mice display significantly impaired memory CD8<jats:sup>+<\/jats:sup> T cell response and weakened resistance against <jats:italic>Listeria monocytogenes<\/jats:italic> (<jats:italic>L.m<\/jats:italic>.) infection. Mechanistically, eosinophils secrete interleukin-4 (IL-4) to inhibit JNK\/Caspase-3 dependent apoptosis of CD8<jats:sup>+<\/jats:sup> T cells upon <jats:italic>L.m<\/jats:italic>. infection in vitro. Furthermore, active eosinophils are recruited into the spleen and secrete more IL-4 to suppress CD8<jats:sup>+<\/jats:sup> T cell apoptosis during early stage of <jats:italic>L.m<\/jats:italic>. infection in vivo. Adoptive transfer of wild-type (WT) eosinophils but not IL-4-deficient eosinophils into eosinophil-deficient mice could rescue the impaired CD8<jats:sup>+<\/jats:sup> T cell memory responses. Together, our findings suggest that eosinophil-derived IL-4 promotes the generation of CD8<jats:sup>+<\/jats:sup> T cell memory and enhances immune defense against <jats:italic>L.m<\/jats:italic>. infection. Our study reveals a new adjuvant role of eosinophils in memory T cell generation and provides clues for enhancing the vaccine potency via targeting eosinophils and related cytokines.<\/jats:p>","DOI":"10.1038\/s41392-024-01752-0","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T01:02:08Z","timestamp":1709082128000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Eosinophils promote CD8+ T cell memory generation to potentiate anti-bacterial immunity"],"prefix":"10.1038","volume":"9","author":[{"given":"Jun","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingjing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6666-705X","authenticated-orcid":false,"given":"Juan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9677-7647","authenticated-orcid":false,"given":"Xuetao","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"1752_CR1","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/s41586-022-05257-0","volume":"610","author":"M Hashimoto","year":"2022","unstructured":"Hashimoto, M. et al. 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