{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:58:46Z","timestamp":1790099926531,"version":"4.0.1"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1127\/2 ChemBioSys\u2014 Project ID 239748522"],"award-info":[{"award-number":["SFB1127\/2 ChemBioSys\u2014 Project ID 239748522"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1127\/2 ChemBioSys\u2014 Project ID 239748522"],"award-info":[{"award-number":["SFB1127\/2 ChemBioSys\u2014 Project ID 239748522"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sig Transduct Target Ther"],"DOI":"10.1038\/s41392-024-01902-4","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T06:37:46Z","timestamp":1724049466000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Biofilms and exopolysaccharides in Pseudomonas aeruginosa: pathogenesis, immune evasion, and lung\u2013brain signaling during pneumonia"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4455-0971","authenticated-orcid":false,"given":"Shuaibing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7260-9921","authenticated-orcid":false,"given":"Pierre","family":"Stallforth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"1902_CR1","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1016\/j.cell.2024.03.001","volume":"187","author":"E Granton","year":"2024","unstructured":"Granton, E. et al. Biofilm exopolysaccharides alter sensory-neuron-mediated sickness during lung infection. Cell 187, 1874\u20131888.e1814 (2024).","journal-title":"Cell"},{"key":"1902_CR2","doi-asserted-by":"publisher","first-page":"6400","DOI":"10.1073\/pnas.1617357114","volume":"114","author":"C Regenbogen","year":"2017","unstructured":"Regenbogen, C. et al. Behavioral and neural correlates to multisensory detection of sick humans. Proc. Natl Acad. Sci. USA 114, 6400\u20136405 (2017).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1902_CR3","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/s41579-020-00477-5","volume":"19","author":"E Rossi","year":"2021","unstructured":"Rossi, E. et al. Pseudomonas aeruginosa adaptation and evolution in patients with cystic fibrosis. Nat. Rev. Microbiol. 19, 331\u2013342 (2021).","journal-title":"Nat. Rev. Microbiol."},{"key":"1902_CR4","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1126\/science.284.5418.1318","volume":"284","author":"JW Costerton","year":"1999","unstructured":"Costerton, J. W., Stewart, P. S. & Greenberg, E. P. Bacterial biofilms: a common cause of persistent infections. Science 284, 1318\u20131322 (1999).","journal-title":"Science"},{"key":"1902_CR5","doi-asserted-by":"publisher","first-page":"S172","DOI":"10.1016\/S1569-1993(11)60021-0","volume":"10","author":"Z Zhou","year":"2011","unstructured":"Zhou, Z. et al. The ENaC-overexpressing mouse as a model of cystic fibrosis lung disease. J. Cyst. Fibros. 10, S172\u2013S182 (2011).","journal-title":"J. Cyst. Fibros."}],"container-title":["Signal Transduction and Targeted Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41392-024-01902-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41392-024-01902-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41392-024-01902-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T06:37:48Z","timestamp":1724049468000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41392-024-01902-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,19]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1902"],"URL":"https:\/\/doi.org\/10.1038\/s41392-024-01902-4","relation":{},"ISSN":["2059-3635"],"issn-type":[{"value":"2059-3635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,19]]},"assertion":[{"value":"7 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"204"}}