{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:49:53Z","timestamp":1787960993947,"version":"build-2784847793"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82241205"],"award-info":[{"award-number":["82241205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400548"],"award-info":[{"award-number":["82400548"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170487"],"award-info":[{"award-number":["82170487"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370471"],"award-info":[{"award-number":["82370471"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82422007"],"award-info":[{"award-number":["82422007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270514"],"award-info":[{"award-number":["82270514"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Lab for Cardiovascular Precision Medicine, Capital Medical University"},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["L246020"],"award-info":[{"award-number":["L246020"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["JQ24038"],"award-info":[{"award-number":["JQ24038"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7232005"],"award-info":[{"award-number":["7232005"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Excellent Youth Science Fund of Capital Medical University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sig Transduct Target Ther"],"DOI":"10.1038\/s41392-026-02610-x","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:41:17Z","timestamp":1773906077000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fibrinogen\u2013Bmal1 signaling as a therapeutic target to limit aortic dissection by preserving VSMC contractility"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3868-0788","authenticated-orcid":false,"given":"Xiaohan","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqi","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojing","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongshan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinliang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meili","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"2610_CR1","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1161\/CIRCULATIONAHA.117.031264","volume":"137","author":"A Evangelista","year":"2018","unstructured":"Evangelista, A. et al. Insights from the international registry of acute aortic dissection: a 20-year experience of collaborative clinical research. Circulation 137, 1846\u20131860 (2018).","journal-title":"Circulation"},{"key":"2610_CR2","first-page":"100280","volume":"17","author":"X Tang","year":"2021","unstructured":"Tang, X. et al. Incidence and survival of aortic dissection in urban China: results from the national insurance claims for epidemiological research (NICER) study. Lancet Reg. Health West Pac. 17, 100280 (2021).","journal-title":"Lancet Reg. Health West Pac."},{"key":"2610_CR3","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.jvs.2020.06.103","volume":"73","author":"CA Latz","year":"2021","unstructured":"Latz, C. A. et al. Perioperative and long-term outcomes after thoracoabdominal aortic aneurysm repair of chronic dissection etiology. J. Vasc. Surg. 73, 797\u2013804 (2021).","journal-title":"J. Vasc. Surg."},{"key":"2610_CR4","doi-asserted-by":"publisher","first-page":"e885","DOI":"10.1097\/SLA.0000000000005840","volume":"278","author":"F Biancari","year":"2023","unstructured":"Biancari, F. et al. Current outcome after surgery for type A aortic dissection. Ann. Surg. 278, e885\u2013e892 (2023).","journal-title":"Ann. Surg."},{"key":"2610_CR5","first-page":"388","volume":"57","author":"J Wu","year":"2020","unstructured":"Wu, J. et al. Subacute\/chronic type A aortic dissection: a retrospective cohort study. Eur. J. Cardiothorac. Surg. 57, 388\u2013396 (2020).","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"2610_CR6","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1161\/CIRCULATIONAHA.104.511717","volume":"112","author":"PC Tang","year":"2005","unstructured":"Tang, P. C. et al. Hyperplastic cellular remodeling of the media in ascending thoracic aortic aneurysms. Circulation 112, 1098\u20131105 (2005).","journal-title":"Circulation"},{"key":"2610_CR7","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.1161\/CIRCULATIONAHA.120.049922","volume":"143","author":"JM Miano","year":"2021","unstructured":"Miano, J. M., Fisher, E. A. & Majesky, M. W. Fate and state of vascular smooth muscle cells in atherosclerosis. Circulation 143, 2110\u20132116 (2021).","journal-title":"Circulation"},{"key":"2610_CR8","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1172\/JCI111849","volume":"75","author":"CS Greenberg","year":"1985","unstructured":"Greenberg, C. S., Miraglia, C. C., Rickles, F. R. & Shuman, M. A. Cleavage of blood coagulation factor XIII and fibrinogen by thrombin during in vitro clotting. J. Clin. Invest. 75, 1463\u20131470 (1985).","journal-title":"J. Clin. Invest."},{"key":"2610_CR9","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1146\/annurev.me.39.020188.002201","volume":"39","author":"D Collen","year":"1988","unstructured":"Collen, D., Stump, D. C. & Gold, H. K. Thrombolytic therapy. Annu. Rev. Med. 39, 405\u2013423 (1988).","journal-title":"Annu. Rev. Med."},{"key":"2610_CR10","doi-asserted-by":"publisher","first-page":"3005","DOI":"10.1016\/j.jtha.2023.08.014","volume":"21","author":"AS Wolberg","year":"2023","unstructured":"Wolberg, A. S. Fibrinogen and fibrin: synthesis, structure, and function in health and disease. J. Thromb. Haemost. 21, 3005\u20133015 (2023).","journal-title":"J. Thromb. Haemost."},{"key":"2610_CR11","doi-asserted-by":"publisher","first-page":"8189","DOI":"10.1007\/s11033-020-05880-y","volume":"47","author":"FJ Zadeh","year":"2020","unstructured":"Zadeh, F. J., Mohammadtaghizadeh, M., Bahadori, H., Saki, N. & Rezaeeyan, H. The role of exogenous Fibrinogen in cardiac surgery: stop bleeding or induce cardiovascular disease. Mol. Biol. Rep. 47, 8189\u20138198 (2020).","journal-title":"Mol. Biol. Rep."},{"key":"2610_CR12","doi-asserted-by":"crossref","unstructured":"Kryczka, K. E., Kruk, M., Demkow, M. & Lubiszewska, B. Fibrinogen and a triad of thrombosis, inflammation, and the renin-angiotensin system in premature coronary artery disease in women: a new insight into sex-related differences in the pathogenesis of the disease. Biomolecules. 11, 1036 (2021).","DOI":"10.3390\/biom11071036"},{"key":"2610_CR13","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.bbi.2016.10.017","volume":"60","author":"EA Ellins","year":"2017","unstructured":"Ellins, E. A., Rees, D. A., Deanfield, J. E., Steptoe, A. & Halcox, J. P. Increased fibrinogen responses to psychophysiological stress predict future endothelial dysfunction implications for cardiovascular disease? Brain Behav. Immun. 60, 233\u2013239 (2017).","journal-title":"Brain Behav. Immun."},{"key":"2610_CR14","doi-asserted-by":"publisher","first-page":"8970480","DOI":"10.34133\/2020\/8970480","volume":"2020","author":"X Zuo","year":"2020","unstructured":"Zuo, X. et al. Spheroids of endothelial cells and vascular smooth muscle cells promote cell migration in hyaluronic acid and fibrinogen composite hydrogels. Research 2020, 8970480 (2020).","journal-title":"Research"},{"key":"2610_CR15","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1182\/blood-2003-08-2886","volume":"103","author":"B Kerlin","year":"2004","unstructured":"Kerlin, B. et al. Cause-effect relation between hyperfibrinogenemia and vascular disease. Blood 103, 1728\u20131734 (2004).","journal-title":"Blood"},{"key":"2610_CR16","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nm1198","volume":"11","author":"P Petzelbauer","year":"2005","unstructured":"Petzelbauer, P. et al. The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury. Nat. Med. 11, 298\u2013304 (2005).","journal-title":"Nat. Med"},{"key":"2610_CR17","doi-asserted-by":"publisher","first-page":"e988","DOI":"10.1097\/CCM.0000000000001860","volume":"44","author":"S Bergt","year":"2016","unstructured":"Bergt, S. et al. The fibrin-derived peptide B\u03b215-42 (FX06) ameliorates vascular leakage and improves survival and neurocognitive recovery: implications from two animal models of cardiopulmonary resuscitation. Crit. Care Med. 44, e988\u2013e995 (2016).","journal-title":"Crit. Care Med."},{"key":"2610_CR18","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1097\/SHK.0000000000001207","volume":"51","author":"F Wu","year":"2019","unstructured":"Wu, F. & Kozar, R. A. Fibrinogen protects against barrier dysfunction through maintaining cell surface syndecan-1 in vitro. Shock 51, 740\u2013744 (2019).","journal-title":"Shock"},{"key":"2610_CR19","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1083\/jcb.132.6.1177","volume":"132","author":"P Koolwijk","year":"1996","unstructured":"Koolwijk, P. et al. Cooperative effect of TNFalpha, bFGF, and VEGF on the formation of tubular structures of human microvascular endothelial cells in a fibrin matrix. Role of urokinase activity. J. Cell Biol. 132, 1177\u20131188 (1996).","journal-title":"J. Cell Biol."},{"key":"2610_CR20","first-page":"673","volume":"57","author":"HF Dvorak","year":"1987","unstructured":"Dvorak, H. F. et al. Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing. Lab Invest 57, 673\u2013686 (1987).","journal-title":"Lab Invest"},{"key":"2610_CR21","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.ajem.2017.10.001","volume":"36","author":"J Liu","year":"2018","unstructured":"Liu, J., Sun, L. L., Wang, J. & Ji, G. The relationship between fibrinogen and in-hospital mortality in patients with type A acute aortic dissection. Am. J. Emerg. Med. 36, 741\u2013744 (2018).","journal-title":"Am. J. Emerg. Med."},{"key":"2610_CR22","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.21037\/atm-20-5466","volume":"8","author":"S Yang","year":"2020","unstructured":"Yang, S., Xue, Y., Liu, J., Zhang, H. & Jiang, W. Is fibrinogen plasma level a risk factor for the first 24-hour death of medically treated acute type A aortic dissection patients?. Ann. Transl. Med. 8, 1015 (2020).","journal-title":"Ann. Transl. Med."},{"key":"2610_CR23","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1172\/JCI82337","volume":"126","author":"C Zhang","year":"2016","unstructured":"Zhang, C. et al. Matricellular protein CCN3 mitigates abdominal aortic aneurysm. J. Clin. Invest. 126, 1282\u20131299 (2016).","journal-title":"J. Clin. Invest"},{"key":"2610_CR24","doi-asserted-by":"publisher","unstructured":"Zhang, W. et al. Downregulation of RhoA\/ROCK1\/YAP\/F-actin causing decreased aortic smooth muscle cell stiffness promotes aortic dissection formation. Life Metabolism. https:\/\/doi.org\/10.1093\/lifemeta\/loae022 (2024).","DOI":"10.1093\/lifemeta\/loae022"},{"key":"2610_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41392-022-01259-6","volume":"8","author":"X Pang","year":"2023","unstructured":"Pang, X. et al. Targeting integrin pathways: mechanisms and advances in therapy. Signal Transduct. Target Ther. 8, 1 (2023).","journal-title":"Signal Transduct. Target Ther."},{"key":"2610_CR26","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1161\/CIRCULATIONAHA.121.056640","volume":"145","author":"L Pan","year":"2022","unstructured":"Pan, L. et al. Legumain is an endogenous modulator of integrin \u03b1v\u03b23 triggering vascular degeneration, dissection, and rupture. Circulation 145, 659\u2013674 (2022).","journal-title":"Circulation"},{"key":"2610_CR27","doi-asserted-by":"publisher","first-page":"7400","DOI":"10.1021\/acs.nanolett.9b03080","volume":"19","author":"F Viela","year":"2019","unstructured":"Viela, F., Speziale, P., Pietrocola, G. & Dufr\u00eane, Y. F. Mechanostability of the fibrinogen bridge between staphylococcal surface protein ClfA and endothelial cell integrin \u03b1(V)\u03b2(3). Nano Lett. 19, 7400\u20137410 (2019).","journal-title":"Nano Lett."},{"key":"2610_CR28","doi-asserted-by":"publisher","first-page":"12267","DOI":"10.1016\/S0021-9258(19)38340-1","volume":"265","author":"JW Smith","year":"1990","unstructured":"Smith, J. W., Ruggeri, Z. M., Kunicki, T. J. & Cheresh, D. A. Interaction of integrins alpha v beta 3 and glycoprotein IIb-IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites. J. Biol. Chem. 265, 12267\u201312271 (1990).","journal-title":"J. Biol. Chem."},{"key":"2610_CR29","doi-asserted-by":"publisher","first-page":"6230","DOI":"10.1158\/1078-0432.CCR-20-1205","volume":"26","author":"ZH Jin","year":"2020","unstructured":"Jin, Z. H. et al. Radiotheranostic agent (64)Cu-cyclam-RAFT-c(-RGDfK-)(4) for management of peritoneal metastasis in ovarian cancer. Clin. Cancer Res. 26, 6230\u20136241 (2020).","journal-title":"Clin. Cancer Res."},{"key":"2610_CR30","first-page":"283","volume":"92","author":"Y Xu","year":"2019","unstructured":"Xu, Y., Pi, W. & Rudic, R. D. Old and new roles and evolving complexities of cardiovascular clocks. Yale J. Biol. Med. 92, 283\u2013290 (2019).","journal-title":"Yale J. Biol. Med."},{"key":"2610_CR31","doi-asserted-by":"publisher","first-page":"1294505","DOI":"10.3389\/fcvm.2023.1294505","volume":"10","author":"G Erdoes","year":"2023","unstructured":"Erdoes, G., Ahmed, A., Kurz, S. D., Gerber, D. & Bolliger, D. Perioperative hemostatic management of patients with type A aortic dissection. Front Cardiovasc Med. 10, 1294505 (2023).","journal-title":"Front Cardiovasc Med."},{"key":"2610_CR32","doi-asserted-by":"publisher","unstructured":"Zhang, L., Zhou, J. & Kong, W. Extracellular matrix in vascular homeostasis and disease. Nat. Rev. Cardiol. https:\/\/doi.org\/10.1038\/s41569-024-01103-0 (2025).","DOI":"10.1038\/s41569-024-01103-0"},{"key":"2610_CR33","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1093\/eurheartj\/16.suppl_A.11","volume":"16","author":"EB Smith","year":"1995","unstructured":"Smith, E. B. Fibrinogen, fibrin and the arterial wall. Eur. Heart J. 16, 11\u201314 (1995). discussion 14-15.","journal-title":"Eur. Heart J."},{"key":"2610_CR34","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1161\/ATVBAHA.121.317346","volume":"42","author":"J Oller","year":"2022","unstructured":"Oller, J. et al. Rewiring vascular metabolism prevents sudden death due to aortic ruptures-brief report. Arterioscler Thromb. Vasc. Biol. 42, 462\u2013469 (2022).","journal-title":"Arterioscler Thromb. Vasc. Biol."},{"key":"2610_CR35","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1161\/CIRCULATIONAHA.120.051171","volume":"143","author":"J Oller","year":"2021","unstructured":"Oller, J. et al. Extracellular tuning of mitochondrial respiration leads to aortic aneurysm. Circulation 143, 2091\u20132109 (2021).","journal-title":"Circulation"},{"key":"2610_CR36","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.020231","volume":"10","author":"G G\u00e4bel","year":"2021","unstructured":"G\u00e4bel, G. et al. Parallel murine and human aortic wall genomics reveals metabolic reprogramming as key driver of abdominal aortic aneurysm progression. J. Am. Heart Assoc. 10, e020231 (2021).","journal-title":"J. Am. Heart Assoc."},{"key":"2610_CR37","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1172\/JCI76881","volume":"125","author":"Z Xie","year":"2015","unstructured":"Xie, Z. et al. Smooth-muscle BMAL1 participates in blood pressure circadian rhythm regulation. J. Clin. Invest. 125, 324\u2013336 (2015).","journal-title":"J. Clin. Invest"},{"key":"2610_CR38","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1161\/ATVBAHA.120.314318","volume":"40","author":"G Yang","year":"2020","unstructured":"Yang, G. et al. Bmal1 deletion in myeloid cells attenuates atherosclerotic lesion development and restrains abdominal aortic aneurysm formation in hyperlipidemic mice. Arterioscler Thromb. Vasc. Biol. 40, 1523\u20131532 (2020).","journal-title":"Arterioscler Thromb. Vasc. Biol."},{"key":"2610_CR39","doi-asserted-by":"publisher","first-page":"3577","DOI":"10.1111\/bph.70033","volume":"182","author":"J Li","year":"2025","unstructured":"Li, J. et al. Fibrin induces infiltration of macrophages and neutrophils via integrin \u03b1M\u03b22 and triggers aortic dissection. Br. J. Pharm. 182, 3577\u20133593 (2025).","journal-title":"Br. J. Pharm."},{"key":"2610_CR40","doi-asserted-by":"publisher","first-page":"385","DOI":"10.3109\/07420528.2014.983604","volume":"32","author":"J Vitale","year":"2015","unstructured":"Vitale, J. et al. Chronobiology of acute aortic rupture or dissection: a systematic review and a meta-analysis of the literature. Chronobiol. Int. 32, 385\u2013394 (2015).","journal-title":"Chronobiol. Int"},{"key":"2610_CR41","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.pcad.2013.04.001","volume":"56","author":"R Manfredini","year":"2013","unstructured":"Manfredini, R. et al. Chronobiology in aortic diseases - \u201cis this really a random phenomenon?. Prog. Cardiovasc Dis. 56, 116\u2013124 (2013).","journal-title":"Prog. Cardiovasc Dis."},{"key":"2610_CR42","doi-asserted-by":"publisher","first-page":"324ra316","DOI":"10.1126\/scitranslmed.aad3305","volume":"8","author":"G Yang","year":"2016","unstructured":"Yang, G. et al. Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival. Sci. Transl. Med. 8, 324ra316 (2016).","journal-title":"Sci. Transl. Med."},{"key":"2610_CR43","doi-asserted-by":"crossref","unstructured":"General Assembly of the World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. J. Am. Coll Dent. 81, 14\u201318 (2014).","DOI":"10.1515\/jwiet-2014-0117"}],"container-title":["Signal Transduction and Targeted Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41392-026-02610-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41392-026-02610-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41392-026-02610-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:41:22Z","timestamp":1773906082000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41392-026-02610-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,19]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2610"],"URL":"https:\/\/doi.org\/10.1038\/s41392-026-02610-x","relation":{},"ISSN":["2059-3635"],"issn-type":[{"value":"2059-3635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,19]]},"assertion":[{"value":"4 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"103"}}