{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T11:02:08Z","timestamp":1780311728120,"version":"3.54.0"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Ministry of Economy and Competitiveness | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/00157"],"award-info":[{"award-number":["PI21\/00157"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sig Transduct Target Ther"],"DOI":"10.1038\/s41392-026-02660-1","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T10:06:56Z","timestamp":1780308416000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elongation of spinal cord reactive astrocytes via LRP1\/TRK signaling"],"prefix":"10.1038","volume":"11","author":[{"given":"Francisco Javier","family":"Rodriguez-Jimenez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Selles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavla","family":"Jendelova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3208-7705","authenticated-orcid":false,"given":"Slaven","family":"Erceg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"2660_CR1","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1007\/s12035-019-01851-y","volume":"57","author":"I Sonn","year":"2020","unstructured":"Sonn, I., Nakamura, M., Renault-Mihara, F. & Okano, H. Polarization of Reactive Astrocytes in Response to Spinal Cord Injury is Enhanced by M2 Macrophage-Mediated Activation of Wnt\/beta-Catenin Pathway. Mol Neurobiol 57, 1847\u20131862 (2020).","journal-title":"Mol Neurobiol"},{"key":"2660_CR2","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1074\/jbc.M109.008326","volume":"285","author":"V Moreno-Manzano","year":"2010","unstructured":"Moreno-Manzano, V. et al. FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status. J Biol Chem 285, 1333\u20131342 (2010).","journal-title":"J Biol Chem"},{"key":"2660_CR3","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1002\/stem.1189","volume":"30","author":"FJ Rodriguez-Jimnez","year":"2012","unstructured":"Rodriguez-Jimnez, F. J. et al. FM19G11 favors spinal cord injury regeneration and stem cell self-renewal by mitochondrial uncoupling and glucose metabolism induction. Stem Cells 30, 2221\u20132233 (2012).","journal-title":"Stem Cells"},{"key":"2660_CR4","doi-asserted-by":"publisher","first-page":"ra18","DOI":"10.1126\/scisignal.2000188","volume":"2","author":"Y Shi","year":"2009","unstructured":"Shi, Y. et al. Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway. Sci Signal 2, ra18 (2009).","journal-title":"Sci Signal"},{"key":"2660_CR5","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1179\/1743132812Y.0000000025","volume":"34","author":"S Zhao","year":"2012","unstructured":"Zhao, S. et al. Activation of Akt\/GSK-3beta\/beta-catenin signaling pathway is involved in survival of neurons after traumatic brain injury in rats. Neurol Res 34, 400\u2013407 (2012).","journal-title":"Neurol Res"}],"container-title":["Signal Transduction and Targeted Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41392-026-02660-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41392-026-02660-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41392-026-02660-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T10:06:57Z","timestamp":1780308417000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41392-026-02660-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2660"],"URL":"https:\/\/doi.org\/10.1038\/s41392-026-02660-1","relation":{},"ISSN":["2059-3635"],"issn-type":[{"value":"2059-3635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,1]]},"assertion":[{"value":"21 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All animal experiments involved in this study were approved by the Animal Ethics Committee of the CIPF with number GVA 2020\/VSC\/PEA\/0104.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"206"}}