{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:50:47Z","timestamp":1779310247625,"version":"3.51.4"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ME 1509\/2-1"],"award-info":[{"award-number":["ME 1509\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006396","name":"Alexion Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006396","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012496","name":"Swiss National Science Foundation | nccr \u2013 on the move","doi-asserted-by":"publisher","award":["3200-0-239903, 310030E_238141 and CRSII_222718_10000065"],"award-info":[{"award-number":["3200-0-239903, 310030E_238141 and CRSII_222718_10000065"]}],"id":[{"id":"10.13039\/100012496","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sig Transduct Target Ther"],"DOI":"10.1038\/s41392-026-02684-7","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T06:49:46Z","timestamp":1775544586000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Triggering multiple sclerosis: infection with Epstein-Barr virus activates multiple pre-existing autoreactive B and T cells"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2570-6785","authenticated-orcid":false,"given":"Edgar","family":"Meinl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6419-1940","authenticated-orcid":false,"given":"Christian","family":"M\u00fcnz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"2684_CR1","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.cell.2025.12.031","volume":"189","author":"H Kim","year":"2026","unstructured":"Kim, H. et al. Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation. Cell 189, 603\u2013619.e625 (2026).","journal-title":"Cell"},{"key":"2684_CR2","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.cell.2025.12.046","volume":"189","author":"J Wang","year":"2026","unstructured":"Wang, J. et al. EBV infection and HLA-DR15 jointly drive multiple sclerosis by myelin peptide presentation. Cell 189, 569\u2013584.e514 (2026).","journal-title":"Cell"},{"key":"2684_CR3","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.cell.2025.12.032","volume":"189","author":"OG Thomas","year":"2026","unstructured":"Thomas, O. G. et al. Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis. Cell 189, 585\u2013602.e538 (2026).","journal-title":"Cell"},{"key":"2684_CR4","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/s41579-025-01181-y","volume":"23","author":"C M\u00fcnz","year":"2025","unstructured":"M\u00fcnz, C. Epstein-Barr virus pathogenesis and emerging control strategies. Nat. Rev. Microbiol 23, 667\u2013679 (2025).","journal-title":"Nat. Rev. Microbiol"},{"key":"2684_CR5","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/S1474-4422(15)00334-8","volume":"15","author":"R Hohlfeld","year":"2016","unstructured":"Hohlfeld, R., Dornmair, K., Meinl, E. & Wekerle, H. The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets. Lancet Neurol. 15, 198\u2013209 (2016).","journal-title":"Lancet Neurol."}],"container-title":["Signal Transduction and Targeted Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41392-026-02684-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41392-026-02684-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41392-026-02684-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T06:49:53Z","timestamp":1775544593000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41392-026-02684-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,7]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2684"],"URL":"https:\/\/doi.org\/10.1038\/s41392-026-02684-7","relation":{},"ISSN":["2059-3635"],"issn-type":[{"value":"2059-3635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,7]]},"assertion":[{"value":"4 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"123"}}