{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:02:31Z","timestamp":1789434151419,"version":"build-2803163510"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sig Transduct Target Ther"],"DOI":"10.1038\/s41392-026-02773-7","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:02:48Z","timestamp":1789430568000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hepassocin prevents age-related liver senescence and facilitates liver regeneration by activating AMPK"],"prefix":"10.1038","volume":"11","author":[{"given":"Yang","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shensi","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujia","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"E","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinlu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8119-3657","authenticated-orcid":false,"given":"Ronghua","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangming","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3629-0946","authenticated-orcid":false,"given":"Xiaoming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"2773_CR1","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1002\/hep.32239","volume":"76","author":"E Devaraj","year":"2022","unstructured":"Devaraj, E., Perumal, E., Subramaniyan, R. & Mustapha, N. Liver fibrosis: Extracellular vesicles mediated intercellular communication in perisinusoidal space. Hepatology 76, 275\u2013285 (2022).","journal-title":"Hepatology"},{"key":"2773_CR2","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/s41575-025-01099-z","volume":"22","author":"DG Le Couteur","year":"2025","unstructured":"Le Couteur, D. G. et al. Liver, ageing and disease. Nat. Rev. Gastroenterol. Hepatol. 22, 680\u2013695 (2025).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"2773_CR3","doi-asserted-by":"publisher","first-page":"5914","DOI":"10.1097\/JS9.0000000000002752","volume":"111","author":"B Wang","year":"2025","unstructured":"Wang, B., Xiong, Y., Huang, N., Li, J. & Zhang, S. Global, regional, and national burden of primary liver cancer among middle-aged and elderly populations from 2000 to 2021 with a prediction to 2050: a cross-sectional analysis from Global Burden of Disease Study 2021. Int J. Surg. 111, 5914\u20135926 (2025).","journal-title":"Int J. Surg."},{"key":"2773_CR4","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1111\/jgh.15073","volume":"35","author":"TP Chen","year":"2020","unstructured":"Chen, T. P., Lai, M., Lin, W. Y., Huang, K. C. & Yang, K. C. Metabolic profiles and fibrosis of nonalcoholic fatty liver disease in the elderly: a community-based study. J. Gastroenterol. Hepatol. 35, 1636\u20131643 (2020).","journal-title":"J. Gastroenterol. Hepatol."},{"key":"2773_CR5","doi-asserted-by":"publisher","first-page":"3061","DOI":"10.1097\/CM9.0000000000003439","volume":"137","author":"Q Li","year":"2024","unstructured":"Li, Q. & Wang, L. Navigating the complex role of senescence in liver disease. Chin. Med. J. 137, 3061\u20133072 (2024).","journal-title":"Chin. Med. J."},{"key":"2773_CR6","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1002\/hep.30834","volume":"71","author":"AM Papatheodoridi","year":"2020","unstructured":"Papatheodoridi, A. M., Chrysavgis, L., Koutsilieris, M. & Chatzigeorgiou, A. The role of senescence in the development of nonalcoholic fatty liver disease and progression to nonalcoholic steatohepatitis. Hepatology 71, 363\u2013374 (2020).","journal-title":"Hepatology"},{"key":"2773_CR7","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1016\/j.surg.2022.05.032","volume":"172","author":"A Ghanie","year":"2022","unstructured":"Ghanie, A., Formica, M. K. & Dhir, M. Systematic review and meta-analysis of 90-day and 30-day mortality after liver resection in the elderly. Surgery 172, 1164\u20131173 (2022).","journal-title":"Surgery"},{"key":"2773_CR8","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.ccell.2016.09.003","volume":"30","author":"T Eggert","year":"2016","unstructured":"Eggert, T. et al. Distinct functions of senescence-associated immune responses in liver tumor surveillance and tumor progression. Cancer Cell 30, 533\u2013547 (2016).","journal-title":"Cancer Cell"},{"key":"2773_CR9","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1006\/bbrc.1993.1678","volume":"193","author":"T Yamamoto","year":"1993","unstructured":"Yamamoto, T. et al. Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1. Biochem. Biophys. Res Commun. 193, 681\u2013687 (1993).","journal-title":"Biochem. Biophys. Res Commun."},{"key":"2773_CR10","doi-asserted-by":"publisher","first-page":"e115","DOI":"10.1002\/hem3.115","volume":"8","author":"J Personnaz","year":"2024","unstructured":"Personnaz, J., Guillou, H. & Kautz, L. Fibrinogen-like 1: a hepatokine linking liver physiology to hematology. Hemasphere 8, e115 (2024).","journal-title":"Hemasphere"},{"key":"2773_CR11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0167-4781(00)00056-7","volume":"1492","author":"H Hara","year":"2000","unstructured":"Hara, H. et al. Isolation and characterization of a novel liver-specific gene, hepassocin, upregulated during liver regeneration. Biochim. Biophys. Acta 1492, 31\u201344 (2000).","journal-title":"Biochim. Biophys. Acta"},{"key":"2773_CR12","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.cell.2018.11.010","volume":"176","author":"J Wang","year":"2019","unstructured":"Wang, J. et al. Fibrinogen-like protein 1 is a major immune inhibitory ligand of LAG-3. Cell 176, 334\u2013347.e312 (2019).","journal-title":"Cell"},{"key":"2773_CR13","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1136\/gut.2008.171124","volume":"59","author":"CY Li","year":"2010","unstructured":"Li, C. Y. et al. Recombinant human hepassocin stimulates proliferation of hepatocytes in vivo and improves survival in rats with fulminant hepatic failure. Gut 59, 817\u2013826 (2010).","journal-title":"Gut"},{"key":"2773_CR14","doi-asserted-by":"publisher","first-page":"13335","DOI":"10.1074\/jbc.M806393200","volume":"284","author":"HT Yu","year":"2009","unstructured":"Yu, H. T. et al. Specific expression and regulation of hepassocin in the liver and down-regulation of the correlation of HNF1alpha with decreased levels of hepassocin in human hepatocellular carcinoma. J. Biol. Chem. 284, 13335\u201313347 (2009).","journal-title":"J. Biol. Chem."},{"key":"2773_CR15","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1002\/lipd.12099","volume":"53","author":"KP Cheng","year":"2018","unstructured":"Cheng, K. P. et al. Unsaturated fatty acids increase the expression of hepassocin through a signal transducer and activator of transcription 3-dependent pathway in HepG2 cells. Lipids 53, 863\u2013869 (2018).","journal-title":"Lipids"},{"key":"2773_CR16","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1016\/j.cellsig.2014.04.013","volume":"26","author":"M Gao","year":"2014","unstructured":"Gao, M. et al. Hepassocin activates the EGFR\/ERK cascade and induces proliferation of L02 cells through the Src-dependent pathway. Cell Signal 26, 2161\u20132166 (2014).","journal-title":"Cell Signal"},{"key":"2773_CR17","doi-asserted-by":"publisher","first-page":"406","DOI":"10.14218\/JCTH.2023.00397","volume":"12","author":"Z Shafieizadeh","year":"2024","unstructured":"Shafieizadeh, Z., Shafieizadeh, Z., Davoudi, M., Afrisham, R. & Miao, X. Role of fibrinogen-like protein 1 in tumor recurrence following hepatectomy. J. Clin. Transl. Hepatol. 12, 406\u2013415 (2024).","journal-title":"J. Clin. Transl. Hepatol."},{"key":"2773_CR18","doi-asserted-by":"crossref","unstructured":"Yang, Y. et al. Protective role of hepassocin against hepatic endoplasmic reticulum stress in mice. Int. J. Mol. Sci. 23, 13325 (2022).","DOI":"10.3390\/ijms232113325"},{"key":"2773_CR19","doi-asserted-by":"crossref","unstructured":"Wang, C. C. et al. Compensatory increase of serum hepassocin protects hyperthyroidism-induced hepatic dysfunction. Biomedicines 11, 1936 (2023).","DOI":"10.3390\/biomedicines11071936"},{"key":"2773_CR20","doi-asserted-by":"crossref","unstructured":"Yang, Y. et al. Recombinant human HPS protects mice and nonhuman primates from acute liver injury. Int. J. Mol. Sci. 22, 12886 (2021).","DOI":"10.3390\/ijms222312886"},{"key":"2773_CR21","doi-asserted-by":"publisher","first-page":"e58084","DOI":"10.1371\/journal.pone.0058084","volume":"8","author":"V Demchev","year":"2013","unstructured":"Demchev, V. et al. Targeted deletion of fibrinogen like protein 1 reveals a novel role in energy substrate utilization. PLoS One 8, e58084 (2013).","journal-title":"PLoS One"},{"key":"2773_CR22","doi-asserted-by":"publisher","first-page":"5279","DOI":"10.1111\/febs.16430","volume":"289","author":"Y Yang","year":"2022","unstructured":"Yang, Y. et al. HPS protects the liver against steatosis, cell death, inflammation, and fibrosis in mice with steatohepatitis. FEBS J. 289, 5279\u20135304 (2022).","journal-title":"FEBS J."},{"key":"2773_CR23","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.bbrc.2015.07.078","volume":"465","author":"H Nayeb-Hashemi","year":"2015","unstructured":"Nayeb-Hashemi, H. et al. Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development. Biochem. Biophys. Res. Commun. 465, 167\u2013173 (2015).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2773_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.101315","volume":"4","author":"X Xing","year":"2023","unstructured":"Xing, X. et al. Integrated omics landscape of hepatocellular carcinoma suggests proteomic subtypes for precision therapy. Cell Rep. Med. 4, 101315 (2023).","journal-title":"Cell Rep. Med."},{"key":"2773_CR25","doi-asserted-by":"crossref","unstructured":"Chandrasekaran, P. & Weiskirchen, R. The role of SCAP\/SREBP as central regulators of lipid metabolism in hepatic steatosis. Int. J. Mol. Sci. 25, 1109 (2024).","DOI":"10.3390\/ijms25021109"},{"key":"2773_CR26","doi-asserted-by":"publisher","first-page":"549241","DOI":"10.1155\/2012\/549241","volume":"2012","author":"DA Rudnick","year":"2012","unstructured":"Rudnick, D. A. & Davidson, N. O. Functional relationships between lipid metabolism and liver regeneration. Int J. Hepatol. 2012, 549241 (2012).","journal-title":"Int J. Hepatol."},{"key":"2773_CR27","doi-asserted-by":"crossref","unstructured":"Stern, M. Energy deprivation in youth and old age. J. Cell Sci. 138, jcs264018 (2025).","DOI":"10.1242\/jcs.264018"},{"key":"2773_CR28","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s00109-021-02040-y","volume":"99","author":"E Molina","year":"2021","unstructured":"Molina, E., Hong, L. & Chefetz, I. AMPK\u03b1-like proteins as LKB1 downstream targets in cell physiology and cancer. J. Mol. Med. 99, 651\u2013662 (2021).","journal-title":"J. Mol. Med."},{"key":"2773_CR29","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1002\/hep.22660","volume":"49","author":"M V\u00e1zquez-Chantada","year":"2009","unstructured":"V\u00e1zquez-Chantada, M. et al. Evidence for LKB1\/AMP-activated protein kinase\/endothelial nitric oxide synthase cascade regulated by hepatocyte growth factor, S-adenosylmethionine, and nitric oxide in hepatocyte proliferation. Hepatology 49, 608\u2013617 (2009).","journal-title":"Hepatology"},{"key":"2773_CR30","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1016\/j.jcmgh.2022.07.016","volume":"14","author":"G Yin","year":"2022","unstructured":"Yin, G. et al. Glia maturation factor-\u03b2 supports liver regeneration by remodeling actin network to enhance STAT3 proliferative signals. Cell Mol. Gastroenterol. Hepatol. 14, 1123\u20131145 (2022).","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"2773_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.474","volume":"8","author":"L Racioppi","year":"2017","unstructured":"Racioppi, L. et al. Calcium\/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration. Cell Death Dis. 8, e3076 (2017).","journal-title":"Cell Death Dis."},{"key":"2773_CR32","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1053\/j.gastro.2012.05.050","volume":"143","author":"N Mart\u00ednez-L\u00f3pez","year":"2012","unstructured":"Mart\u00ednez-L\u00f3pez, N. et al. Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1. Gastroenterology 143, 787\u2013798.e713 (2012).","journal-title":"Gastroenterology"},{"key":"2773_CR33","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1111\/bph.12422","volume":"170","author":"AG Stewart","year":"2013","unstructured":"Stewart, A. G. et al. Plasminogen-stimulated airway smooth muscle cell proliferation is mediated by urokinase and annexin A2, involving plasmin-activated cell signalling. Br. J. Pharm. 170, 1421\u20131435 (2013).","journal-title":"Br. J. Pharm."},{"key":"2773_CR34","doi-asserted-by":"crossref","unstructured":"Lisek, M., Tomczak, J., Boczek, T. & Zylinska, L. Calcium-associated proteins in neuroregeneration. Biomolecules 14, 183 (2024).","DOI":"10.3390\/biom14020183"},{"key":"2773_CR35","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1016\/j.celrep.2018.01.086","volume":"22","author":"V Maillet","year":"2018","unstructured":"Maillet, V. et al. LKB1 as a gatekeeper of hepatocyte proliferation and genomic integrity during liver regeneration. Cell Rep. 22, 1994\u20132005 (2018).","journal-title":"Cell Rep."},{"key":"2773_CR36","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1358\/dot.2005.41.7.893622","volume":"41","author":"K Terui","year":"2005","unstructured":"Terui, K. & Ozaki, M. The role of STAT3 in liver regeneration. Drugs Today 41, 461\u2013469 (2005).","journal-title":"Drugs Today"},{"key":"2773_CR37","doi-asserted-by":"publisher","first-page":"103782","DOI":"10.1016\/j.redox.2025.103782","volume":"85","author":"E Petsouki","year":"2025","unstructured":"Petsouki, E., Gerakopoulos, V., Gianniou, D. D., Heiss, E. H. & Trougakos, I. P. Involvement of NRF2 and AMPK signaling in aging and progeria: a digest. Redox Biol. 85, 103782 (2025).","journal-title":"Redox Biol."},{"key":"2773_CR38","doi-asserted-by":"publisher","first-page":"12279","DOI":"10.1074\/jbc.REV120.011356","volume":"295","author":"P Zhao","year":"2020","unstructured":"Zhao, P. & Saltiel, A. R. From overnutrition to liver injury: AMP-activated protein kinase in nonalcoholic fatty liver diseases. J. Biol. Chem. 295, 12279\u201312289 (2020).","journal-title":"J. Biol. Chem."},{"key":"2773_CR39","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","volume":"149","author":"M Laplante","year":"2012","unstructured":"Laplante, M. & Sabatini, D. M. mTOR signaling in growth control and disease. Cell 149, 274\u2013293 (2012).","journal-title":"Cell"},{"key":"2773_CR40","doi-asserted-by":"crossref","unstructured":"Xu, F., Hua, C., Tautenhahn, H. M., Dirsch, O. & Dahmen, U. The role of autophagy for the regeneration of the aging liver. Int. J. Mol. Sci. 21, 3606 (2020).","DOI":"10.3390\/ijms21103606"},{"key":"2773_CR41","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.jhep.2013.08.025","volume":"60","author":"G Merlen","year":"2014","unstructured":"Merlen, G. et al. AMPK\u03b11 controls hepatocyte proliferation independently of energy balance by regulating Cyclin A2 expression. J. Hepatol. 60, 152\u2013159 (2014).","journal-title":"J. Hepatol."},{"key":"2773_CR42","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1258\/ebm.2011.010352","volume":"236","author":"M Varela-Rey","year":"2011","unstructured":"Varela-Rey, M., Beraza, N., Lu, S. C., Mato, J. M. & Mart\u00ednez-Chantar, M. L. Role of AMP-activated protein kinase in the control of hepatocyte priming and proliferation during liver regeneration. Exp. Biol. Med. 236, 402\u2013408 (2011).","journal-title":"Exp. Biol. Med."},{"key":"2773_CR43","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1016\/j.cub.2003.10.031","volume":"13","author":"A Woods","year":"2003","unstructured":"Woods, A. et al. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr. Biol. 13, 2004\u20132008 (2003).","journal-title":"Curr. Biol."},{"key":"2773_CR44","doi-asserted-by":"publisher","first-page":"300","DOI":"10.2741\/1529","volume":"10","author":"M Kwon","year":"2005","unstructured":"Kwon, M., MacLeod, T. J., Zhang, Y. & Waisman, D. M. S100A10, annexin A2, and annexin a2 heterotetramer as candidate plasminogen receptors. Front. Biosci. 10, 300\u2013325 (2005).","journal-title":"Front. Biosci."},{"key":"2773_CR45","doi-asserted-by":"publisher","first-page":"3297","DOI":"10.4049\/jimmunol.179.5.3297","volume":"179","author":"Y Zhang","year":"2007","unstructured":"Zhang, Y., Zhou, Z. H., Bugge, T. H. & Wahl, L. M. Urokinase-type plasminogen activator stimulation of monocyte matrix metalloproteinase-1 production is mediated by plasmin-dependent signaling through annexin A2 and inhibited by inactive plasmin. J. Immunol. 179, 3297\u20133304 (2007).","journal-title":"J. Immunol."},{"key":"2773_CR46","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/s41586-024-07376-2","volume":"630","author":"KP Matchett","year":"2024","unstructured":"Matchett, K. P. et al. Multimodal decoding of human liver regeneration. Nature 630, 158\u2013165 (2024).","journal-title":"Nature"},{"key":"2773_CR47","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/s41580-022-00547-x","volume":"24","author":"GR Steinberg","year":"2023","unstructured":"Steinberg, G. R. & Hardie, D. G. New insights into activation and function of the AMPK. Nat. Rev. Mol. Cell Biol. 24, 255\u2013272 (2023).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2773_CR48","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.tem.2013.06.002","volume":"24","author":"GR Steinberg","year":"2013","unstructured":"Steinberg, G. R., Dandapani, M. & Hardie, D. G. AMPK: mediating the metabolic effects of salicylate-based drugs? Trends Endocrinol. Metab. 24, 481\u2013487 (2013).","journal-title":"Trends Endocrinol. Metab."},{"key":"2773_CR49","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1478-3231.2007.01628.x","volume":"28","author":"PN Martins","year":"2008","unstructured":"Martins, P. N., Theruvath, T. P. & Neuhaus, P. Rodent models of partial hepatectomies. Liver Int. 28, 3\u201311 (2008).","journal-title":"Liver Int."},{"key":"2773_CR50","doi-asserted-by":"publisher","first-page":"100086","DOI":"10.1016\/j.xpro.2020.100086","volume":"1","author":"M Charni-Natan","year":"2020","unstructured":"Charni-Natan, M. & Goldstein, I. Protocol for primary mouse hepatocyte isolation. STAR Protoc. 1, 100086 (2020).","journal-title":"STAR Protoc."}],"container-title":["Signal Transduction and Targeted Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41392-026-02773-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41392-026-02773-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41392-026-02773-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:02:52Z","timestamp":1789430572000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41392-026-02773-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,15]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2773"],"URL":"https:\/\/doi.org\/10.1038\/s41392-026-02773-7","relation":{},"ISSN":["2059-3635"],"issn-type":[{"value":"2059-3635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,15]]},"assertion":[{"value":"13 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"387"}}