{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T17:33:43Z","timestamp":1794072823855,"version":"4.8.0"},"reference-count":499,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sig Transduct Target Ther"],"DOI":"10.1038\/s41392-026-02782-6","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T23:01:31Z","timestamp":1783983691000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Multiple organ dysfunction syndrome: molecular mechanisms and therapeutic strategies"],"prefix":"10.1038","volume":"11","author":[{"given":"Xuan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xujun","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7387-4804","authenticated-orcid":false,"given":"Dongshan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"2782_CR1","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/0002-9610(69)90011-7","volume":"117","author":"JJ Skillman","year":"1969","unstructured":"Skillman, J. J., Bushnell, L. S., Goldman, H. & Silen, W. Respiratory failure, hypotension, sepsis, and jaundice. A clinical syndrome associated with lethal hemorrhage from acute stress ulceration of the stomach. Am. J. Surg. 117, 523\u2013530 (1969).","journal-title":"Am. J. Surg."},{"key":"2782_CR2","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1097\/00000658-197308000-00001","volume":"178","author":"NL Tilney","year":"1973","unstructured":"Tilney, N. L., Bailey, G. L. & Morgan, A. P. Sequential system failure after rupture of abdominal aortic aneurysms: an unsolved problem in postoperative care. Ann. Surg. 178, 117\u2013122 (1973).","journal-title":"Ann. Surg."},{"key":"2782_CR3","first-page":"323","volume":"144","author":"B Eiseman","year":"1977","unstructured":"Eiseman, B., Beart, R. & Norton, L. Multiple organ failure. Surg. Gynecol. Obstet. 144, 323\u2013326 (1977).","journal-title":"Surg. Gynecol. Obstet."},{"key":"2782_CR4","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1001\/archsurg.1985.01390340007001","volume":"120","author":"RJ Goris","year":"1985","unstructured":"Goris, R. J., te Boekhorst, T. P., Nuytinck, J. K. & Gimbrere, J. S. Multiple-organ failure. Generalized autodestructive inflammation? Arch. Surg. 120, 1109\u20131115 (1985).","journal-title":"Arch. Surg."},{"key":"2782_CR5","first-page":"1644","volume":"101","author":"RC Bone","year":"1992","unstructured":"Bone, R. C. et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP\/SCCM Consensus Conference Committee. Am. Coll. Chest Physicians\/Soc. Crit. Care Med. Chest 101, 1644\u20131655 (1992).","journal-title":"Am. Coll. Chest Physicians\/Soc. Crit. Care Med. Chest"},{"key":"2782_CR6","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.kint.2021.06.028","volume":"100","author":"NH Lameire","year":"2021","unstructured":"Lameire, N. H. et al. Harmonizing acute and chronic kidney disease definition and classification: report of a Kidney Disease: Improving Global Outcomes (KDIGO) consensus conference. Kidney Int. 100, 516\u2013526 (2021).","journal-title":"Kidney Int."},{"key":"2782_CR7","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1164\/rccm.202303-0558WS","volume":"209","author":"MA Matthay","year":"2024","unstructured":"Matthay, M. A. et al. A new global definition of acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 209, 37\u201347 (2024).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2782_CR8","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41577-019-0215-7","volume":"20","author":"T Gong","year":"2020","unstructured":"Gong, T., Liu, L., Jiang, W. & Zhou, R. DAMP-sensing receptors in sterile inflammation and inflammatory diseases. Nat. Rev. Immunol. 20, 95\u2013112 (2020).","journal-title":"Nat. Rev. Immunol."},{"key":"2782_CR9","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1146\/annurev-pathmechdis-012419-032847","volume":"15","author":"J Zindel","year":"2020","unstructured":"Zindel, J. & Kubes, P. DAMPs, PAMPs, and LAMPs in immunity and sterile inflammation. Annu. Rev. Pathol. 15, 493\u2013518 (2020).","journal-title":"Annu. Rev. Pathol."},{"key":"2782_CR10","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/s41392-021-00816-9","volume":"6","author":"YY Zhang","year":"2021","unstructured":"Zhang, Y. Y. & Ning, B. T. Signaling pathways and intervention therapies in sepsis. Signal Transduct. Target Ther. 6, 407 (2021).","journal-title":"Signal Transduct. Target Ther."},{"key":"2782_CR11","doi-asserted-by":"publisher","first-page":"113","DOI":"10.5301\/ijao.5000382","volume":"38","author":"F Bruenger","year":"2015","unstructured":"Bruenger, F. et al. First successful combination of ECMO with cytokine removal therapy in cardiogenic septic shock: a case report. Int. J. Artif. Organs 38, 113\u2013116 (2015).","journal-title":"Int. J. Artif. Organs"},{"key":"2782_CR12","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1159\/000489921","volume":"46","author":"D Pomare Montin","year":"2018","unstructured":"Pomare Montin, D. et al. Biocompatibility and cytotoxic evaluation of new sorbent cartridges for blood hemoperfusion. Blood Purif. 46, 187\u2013195 (2018).","journal-title":"Blood Purif."},{"key":"2782_CR13","doi-asserted-by":"publisher","first-page":"e1012","DOI":"10.1097\/CCM.0000000000004555","volume":"48","author":"EF Carlton","year":"2020","unstructured":"Carlton, E. F. et al. Clinician accuracy in identifying and predicting organ dysfunction in critically Ill children. Crit. Care Med. 48, e1012\u2013e1019 (2020).","journal-title":"Crit. Care Med."},{"key":"2782_CR14","doi-asserted-by":"publisher","DOI":"10.1186\/cc5086","volume":"10","author":"VD Mayr","year":"2006","unstructured":"Mayr, V. D. et al. Causes of death and determinants of outcome in critically ill patients. Crit. Care 10, R154 (2006).","journal-title":"Crit. Care"},{"key":"2782_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/s40537-023-00719-2","volume":"10","author":"C Liu","year":"2023","unstructured":"Liu, C. et al. Early prediction of MODS interventions in the intensive care unit using machine learning. J. Big Data 10, 55 (2023).","journal-title":"J. Big Data"},{"key":"2782_CR16","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1164\/rccm.201502-0275OC","volume":"192","author":"MM Churpek","year":"2015","unstructured":"Churpek, M. M. et al. Incidence and prognostic value of the systemic inflammatory response syndrome and organ dysfunctions in ward patients. Am. J. Respir. Crit. Care Med. 192, 958\u2013964 (2015).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2782_CR17","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1097\/CCM.0000000000006369","volume":"52","author":"EA Harlan","year":"2024","unstructured":"Harlan, E. A., Ghous, M., Moscovice, I. S. & Valley, T. S. Characteristics of patients hospitalized in rural and urban ICUs From 2010 to 2019. Crit. Care Med. 52, 1577\u20131586 (2024).","journal-title":"Crit. Care Med."},{"key":"2782_CR18","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1378\/chest.109.4.1033","volume":"109","author":"F Proulx","year":"1996","unstructured":"Proulx, F. et al. Epidemiology of sepsis and multiple organ dysfunction syndrome in children. Chest 109, 1033\u20131037 (1996).","journal-title":"Chest"},{"key":"2782_CR19","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1097\/01.PCC.0000074266.10576.9B","volume":"4","author":"MC Kutko","year":"2003","unstructured":"Kutko, M. C. et al. Mortality rates in pediatric septic shock with and without multiple organ system failure. Pediatr. Crit. Care Med. 4, 333\u2013337 (2003).","journal-title":"Pediatr. Crit. Care Med."},{"key":"2782_CR20","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1046\/j.1440-1754.1999.355409.x","volume":"35","author":"A Goh","year":"1999","unstructured":"Goh, A. & Lum, L. Sepsis, severe sepsis and septic shock in paediatric multiple organ dysfunction syndrome. J. Paediatr. Child Health 35, 488\u2013492 (1999).","journal-title":"J. Paediatr. Child Health"},{"key":"2782_CR21","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s00535-018-1500-0","volume":"54","author":"T Sato","year":"2019","unstructured":"Sato, T., Shibata, W. & Maeda, S. Adhesion molecules and pancreatitis. J. Gastroenterol. 54, 99\u2013107 (2019).","journal-title":"J. Gastroenterol."},{"key":"2782_CR22","doi-asserted-by":"publisher","first-page":"G573","DOI":"10.1152\/ajpgi.00285.2020","volume":"319","author":"NL Komara","year":"2020","unstructured":"Komara, N. L. et al. Severe acute pancreatitis: capillary permeability model linking systemic inflammation to multiorgan failure. Am. J. Physiol. Gastrointest. Liver Physiol. 319, G573\u2013G583 (2020).","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2782_CR23","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1002\/bjs.11361","volume":"107","author":"E Cole","year":"2020","unstructured":"Cole, E. et al. Multiple organ dysfunction after trauma. Br. J. Surg. 107, 402\u2013412 (2020).","journal-title":"Br. J. Surg."},{"key":"2782_CR24","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-020-00330-3","volume":"15","author":"JMM van Breugel","year":"2020","unstructured":"van Breugel, J. M. M. et al. Global changes in mortality rates in polytrauma patients admitted to the ICU-a systematic review. World J. Emerg. Surg. 15, 55 (2020).","journal-title":"World J. Emerg. Surg."},{"key":"2782_CR25","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-016-0144-6","volume":"6","author":"A Villeneuve","year":"2016","unstructured":"Villeneuve, A. et al. Multiple organ dysfunction syndrome in critically ill children: clinical value of two lists of diagnostic criteria. Ann. Intensive Care 6, 40 (2016).","journal-title":"Ann. Intensive Care"},{"key":"2782_CR26","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1164\/rccm.201504-0781OC","volume":"193","author":"C Fleischmann","year":"2016","unstructured":"Fleischmann, C. et al. Assessment of global incidence and mortality of hospital-treated sepsis. current estimates and limitations. Am. J. Respir. Crit. Care Med. 193, 259\u2013272 (2016).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2782_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2431-8","volume":"23","author":"RS Nannan Panday","year":"2019","unstructured":"Nannan Panday, R. S., Lammers, E. M. J., Alam, N. & Nanayakkara, P. W. B. An overview of positive cultures and clinical outcomes in septic patients: a sub-analysis of the Prehospital Antibiotics Against Sepsis (PHANTASi) trial. Crit. Care 23, 182 (2019).","journal-title":"Crit. Care"},{"key":"2782_CR28","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-2186-7","volume":"22","author":"T Abe","year":"2018","unstructured":"Abe, T. et al. Characteristics, management, and in-hospital mortality among patients with severe sepsis in intensive care units in Japan: the FORECAST study. Crit. Care 22, 322 (2018).","journal-title":"Crit. Care"},{"key":"2782_CR29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003898","volume":"9","author":"F Costa","year":"2015","unstructured":"Costa, F. et al. Global morbidity and mortality of leptospirosis: a systematic review. PLoS Negl. Trop. Dis. 9, e0003898 (2015).","journal-title":"PLoS Negl. Trop. Dis."},{"key":"2782_CR30","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1016\/S0140-6736(14)62384-9","volume":"385","author":"T Wolf","year":"2015","unstructured":"Wolf, T. et al. Severe Ebola virus disease with vascular leakage and multiorgan failure: treatment of a patient in intensive care. Lancet 385, 1428\u20131435 (2015).","journal-title":"Lancet"},{"key":"2782_CR31","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1007\/s00134-015-4024-6","volume":"41","author":"S Jog","year":"2015","unstructured":"Jog, S. et al. Dengue infection with multiorgan dysfunction: SOFA score, arterial lactate and serum albumin levels are predictors of outcome. Intensive Care Med. 41, 2029\u20132030 (2015).","journal-title":"Intensive Care Med."},{"key":"2782_CR32","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3390\/pathogens14010071","volume":"14","author":"BN Gustifante","year":"2025","unstructured":"Gustifante, B. N. et al. Targeting T-cell activation for malaria immunotherapy: scoping review. Pathogens 14, 71 (2025).","journal-title":"Pathogens"},{"key":"2782_CR33","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1038\/ajg.2015.261","volume":"110","author":"H Nawaz","year":"2015","unstructured":"Nawaz, H. et al. Elevated serum triglycerides are independently associated with persistent organ failure in acute pancreatitis. Am. J. Gastroenterol. 110, 1497\u20131503 (2015).","journal-title":"Am. J. Gastroenterol."},{"key":"2782_CR34","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1053\/j.gastro.2019.07.064","volume":"158","author":"TH Baron","year":"2020","unstructured":"Baron, T. H., DiMaio, C. J., Wang, A. Y. & Morgan, K. A. American Gastroenterological Association clinical practice update: management of pancreatic necrosis. Gastroenterology 158, 67\u201375.e61 (2020).","journal-title":"Gastroenterology"},{"key":"2782_CR35","first-page":"291","volume":"121","author":"MC Ciorba","year":"2024","unstructured":"Ciorba, M. C. & Maegele, M. Polytrauma in children-epidemiology, acute diagnostic evaluation, and treatment. Dtsch Arztebl Int. 121, 291\u2013297 (2024).","journal-title":"Dtsch Arztebl Int."},{"key":"2782_CR36","first-page":"91","volume":"30","author":"F Martinez","year":"2018","unstructured":"Martinez, F. et al. Pelvic fracture in the patient with multiple injuries: factors and lesions associated with mortality. Emergencias 30, 91\u201397 (2018).","journal-title":"Emergencias"},{"key":"2782_CR37","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1097\/CCM.0000000000005055","volume":"49","author":"V Krishnamoorthy","year":"2021","unstructured":"Krishnamoorthy, V. et al. Association of early multiple organ dysfunction with clinical and functional outcomes over the year following traumatic brain injury: a transforming research and clinical knowledge in traumatic brain injury study. Crit. Care Med. 49, 1769\u20131778 (2021).","journal-title":"Crit. Care Med."},{"key":"2782_CR38","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-020-00328-x","volume":"15","author":"YT Wu","year":"2020","unstructured":"Wu, Y. T. et al. Pelvic injury prognosis is more closely related to vascular injury severity than anatomical fracture complexity: the WSES classification for pelvic trauma makes sense. World J. Emerg. Surg. 15, 48 (2020).","journal-title":"World J. Emerg. Surg."},{"key":"2782_CR39","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1097\/SLA.0000000000006270","volume":"281","author":"G Kang-Auger","year":"2025","unstructured":"Kang-Auger, G. et al. Burns and mental health: a matched cohort study. Ann. Surg. 281, 982\u2013988 (2025).","journal-title":"Ann. Surg."},{"key":"2782_CR40","first-page":"49","volume":"9","author":"QL He","year":"2022","unstructured":"He, Q. L. et al. Gastrointestinal dysfunction is associated with mortality in severe burn patients: a 10-year retrospective observational study from South China. Mil. Med. Res. 9, 49 (2022).","journal-title":"Mil. Med. Res."},{"key":"2782_CR41","doi-asserted-by":"publisher","first-page":"e889","DOI":"10.1097\/CCM.0000000000003275","volume":"46","author":"SD Hutchings","year":"2018","unstructured":"Hutchings, S. D. et al. Microcirculatory impairment is associated with multiple organ dysfunction following traumatic hemorrhagic shock: the MICROSHOCK Study. Crit. Care Med. 46, e889\u2013e896 (2018).","journal-title":"Crit. Care Med."},{"key":"2782_CR42","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/s41583-021-00488-y","volume":"22","author":"SG Daniele","year":"2021","unstructured":"Daniele, S. G. et al. Brain vulnerability and viability after ischaemia. Nat. Rev. Neurosci. 22, 553\u2013572 (2021).","journal-title":"Nat. Rev. Neurosci."},{"key":"2782_CR43","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1213\/ANE.0000000000005388","volume":"133","author":"SJ Davies","year":"2021","unstructured":"Davies, S. J. & Mythen, M. Hemodynamic and intestinal microcirculatory changes in a phenylephrine corrected porcine model of hemorrhage. Anesth. Analg. 133, 1060\u20131069 (2021).","journal-title":"Anesth. Analg."},{"key":"2782_CR44","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1007\/s001340050328","volume":"23","author":"C Hamilton-Davies","year":"1997","unstructured":"Hamilton-Davies, C. et al. Comparison of commonly used clinical indicators of hypovolaemia with gastrointestinal tonometry. Intensive Care Med. 23, 276\u2013281 (1997).","journal-title":"Intensive Care Med."},{"key":"2782_CR45","doi-asserted-by":"publisher","first-page":"e540","DOI":"10.1016\/S2542-5196(18)30240-7","volume":"2","author":"O Andrews","year":"2018","unstructured":"Andrews, O. et al. Implications for workability and survivability in populations exposed to extreme heat under climate change: a modelling study. Lancet Planet Health 2, e540\u2013e547 (2018).","journal-title":"Lancet Planet Health"},{"key":"2782_CR46","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41572-021-00334-6","volume":"8","author":"A Bouchama","year":"2022","unstructured":"Bouchama, A. et al. Classic and exertional heatstroke. Nat. Rev. Dis. Prim. 8, 8 (2022).","journal-title":"Nat. Rev. Dis. Prim."},{"key":"2782_CR47","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1136\/bjsports-2018-099881","volume":"53","author":"S Racinais","year":"2019","unstructured":"Racinais, S. et al. Core temperature up to 41.5 masculineC during the UCI Road Cycling World Championships in the heat. Br. J. Sports Med. 53, 426\u2013429 (2019).","journal-title":"Br. J. Sports Med."},{"key":"2782_CR48","doi-asserted-by":"publisher","first-page":"105909","DOI":"10.1016\/j.envint.2020.105909","volume":"144","author":"RD Meade","year":"2020","unstructured":"Meade, R. D. et al. Physiological factors characterizing heat-vulnerable older adults: a narrative review. Environ. Int. 144, 105909 (2020).","journal-title":"Environ. Int."},{"key":"2782_CR49","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1097\/01.shk.0000239767.64786.de","volume":"27","author":"M Frink","year":"2007","unstructured":"Frink, M. et al. Influence of sex and age on mods and cytokines after multiple injuries. Shock 27, 151\u2013156 (2007).","journal-title":"Shock"},{"key":"2782_CR50","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1097\/PCC.0000000000003123","volume":"24","author":"J Fernandez-Sarmiento","year":"2023","unstructured":"Fernandez-Sarmiento, J. et al. Endothelial and glycocalyx biomarkers in children with sepsis after one bolus of unbalanced or balanced crystalloids. Pediatr. Crit. Care Med. 24, 213\u2013221 (2023).","journal-title":"Pediatr. Crit. Care Med."},{"key":"2782_CR51","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1681\/ASN.0000000712","volume":"36","author":"C de Roquetaillade","year":"2025","unstructured":"de Roquetaillade, C. et al. Progression of kidney fibrosis after sepsis: the underestimated role of resident macrophages and recruited monocytes. J. Am. Soc. Nephrol. 36, 1417\u20131427 (2025).","journal-title":"J. Am. Soc. Nephrol."},{"key":"2782_CR52","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1038\/s41590-020-0673-x","volume":"21","author":"A Roquilly","year":"2020","unstructured":"Roquilly, A. et al. Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis. Nat. Immunol. 21, 636\u2013648 (2020).","journal-title":"Nat. Immunol."},{"key":"2782_CR53","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1165\/rcmb.2005-0241OC","volume":"35","author":"UA Maus","year":"2006","unstructured":"Maus, U. A. et al. Resident alveolar macrophages are replaced by recruited monocytes in response to endotoxin-induced lung inflammation. Am. J. Respir. Cell Mol. Biol. 35, 227\u2013235 (2006).","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2782_CR54","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1093\/jleuko\/qiae146","volume":"116","author":"Z Wang","year":"2024","unstructured":"Wang, Z. et al. Recruitment of neutrophils in glomeruli in early mouse sepsis is associated with E-selectin expression and activation of endothelial nuclear factor kappa-light-chain-enhancer of activated B cells and mitogen-activated protein kinase pathways. J. Leukoc. Biol. 116, 1479\u20131497 (2024).","journal-title":"J. Leukoc. Biol."},{"key":"2782_CR55","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/j.mucimm.2025.03.005","volume":"18","author":"F Wang","year":"2025","unstructured":"Wang, F. et al. Single-cell sequencing reveals the same heterogeneity of neutrophils in heatstroke-induced lung and liver injury. Mucosal Immunol. 18, 742\u2013756 (2025).","journal-title":"Mucosal Immunol."},{"key":"2782_CR56","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1144229","volume":"14","author":"E Maneta","year":"2023","unstructured":"Maneta, E. et al. Endothelial dysfunction and immunothrombosis in sepsis. Front. Immunol. 14, 1144229 (2023).","journal-title":"Front. Immunol."},{"key":"2782_CR57","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s10495-018-1464-9","volume":"23","author":"ME Cen","year":"2018","unstructured":"Cen, M. E. et al. Gastrointestinal microecology: a crucial and potential target in acute pancreatitis. Apoptosis 23, 377\u2013387 (2018).","journal-title":"Apoptosis"},{"key":"2782_CR58","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/s41577-021-00536-9","volume":"21","author":"A Bonaventura","year":"2021","unstructured":"Bonaventura, A. et al. Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19. Nat. Rev. Immunol. 21, 319\u2013329 (2021).","journal-title":"Nat. Rev. Immunol."},{"key":"2782_CR59","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08030-y","volume":"10","author":"KT Urak","year":"2019","unstructured":"Urak, K. T. et al. RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome. Nat. Commun. 10, 116 (2019).","journal-title":"Nat. Commun."},{"key":"2782_CR60","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1056\/NEJM200005043421806","volume":"342","author":"LB Ware","year":"2000","unstructured":"Ware, L. B. & Matthay, M. A. The acute respiratory distress syndrome. N. Engl. J. Med. 342, 1334\u20131349 (2000).","journal-title":"N. Engl. J. Med."},{"key":"2782_CR61","doi-asserted-by":"publisher","first-page":"345","DOI":"10.5858\/arpa.2015-0519-RA","volume":"140","author":"Y Butt","year":"2016","unstructured":"Butt, Y., Kurdowska, A. & Allen, T. C. Acute lung injury: a clinical and molecular review. Arch. Pathol. Lab Med. 140, 345\u2013350 (2016).","journal-title":"Arch. Pathol. Lab Med."},{"key":"2782_CR62","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105294","volume":"107","author":"ZL Li","year":"2024","unstructured":"Li, Z. L. et al. Renal tubular epithelial cells response to injury in acute kidney injury. EBioMedicine 107, 105294 (2024).","journal-title":"EBioMedicine"},{"key":"2782_CR63","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1038\/ki.2011.339","volume":"81","author":"K Singbartl","year":"2012","unstructured":"Singbartl, K. & Kellum, J. A. AKI in the ICU: definition, epidemiology, risk stratification, and outcomes. Kidney Int. 81, 819\u2013825 (2012).","journal-title":"Kidney Int."},{"key":"2782_CR64","doi-asserted-by":"publisher","DOI":"10.1186\/cc11454","volume":"17","author":"JA Kellum","year":"2013","unstructured":"Kellum, J. A., Lameire, N. & Group, K. A. G. W. Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1). Crit. Care 17, 204 (2013).","journal-title":"Crit. Care"},{"key":"2782_CR65","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/S0140-6736(19)31894-X","volume":"394","author":"RT Stravitz","year":"2019","unstructured":"Stravitz, R. T. & Lee, W. M. Acute liver failure. Lancet 394, 869\u2013881 (2019).","journal-title":"Lancet"},{"key":"2782_CR66","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1097\/01.CCM.0000266683.64081.02","volume":"35","author":"A Rudiger","year":"2007","unstructured":"Rudiger, A. & Singer, M. Mechanisms of sepsis-induced cardiac dysfunction. Crit. Care Med. 35, 1599\u20131608 (2007).","journal-title":"Crit. Care Med."},{"key":"2782_CR67","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-025-05309-7","volume":"29","author":"DE Soranno","year":"2025","unstructured":"Soranno, D. E. et al. A review of gut failure as a cause and consequence of critical illness. Crit. Care 29, 91 (2025).","journal-title":"Crit. Care"},{"key":"2782_CR68","doi-asserted-by":"publisher","first-page":"1477160","DOI":"10.3389\/fimmu.2024.1477160","volume":"15","author":"L Li","year":"2024","unstructured":"Li, L. et al. Coagulopathy and acute pancreatitis: pathophysiology and clinical treatment. Front. Immunol. 15, 1477160 (2024).","journal-title":"Front. Immunol."},{"key":"2782_CR69","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1164\/rccm.202406-1241OC","volume":"211","author":"RBE van Amstel","year":"2025","unstructured":"van Amstel, R. B. E. et al. Temporal transitions of the hyperinflammatory and hypoinflammatory phenotypes in critical illness. Am. J. Respir. Crit. Care Med. 211, 347\u2013356 (2025).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2782_CR70","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002338","volume":"14","author":"J Hazeldine","year":"2017","unstructured":"Hazeldine, J. et al. Prehospital immune responses and development of multiple organ dysfunction syndrome following traumatic injury: a prospective cohort study. PLoS Med. 14, e1002338 (2017).","journal-title":"PLoS Med."},{"key":"2782_CR71","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002352","volume":"14","author":"CP Cabrera","year":"2017","unstructured":"Cabrera, C. P. et al. Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: a prospective cohort study. PLoS Med. 14, e1002352 (2017).","journal-title":"PLoS Med."},{"key":"2782_CR72","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1097\/MPA.0000000000000998","volume":"47","author":"RK Padhan","year":"2018","unstructured":"Padhan, R. K. et al. Primary and secondary organ failures cause mortality differentially in acute pancreatitis and should be distinguished. Pancreas 47, 302\u2013307 (2018).","journal-title":"Pancreas"},{"key":"2782_CR73","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1053\/j.gastro.2018.11.082","volume":"156","author":"A Habtezion","year":"2019","unstructured":"Habtezion, A., Gukovskaya, A. S. & Pandol, S. J. Acute Pancreatitis: A Multifaceted Set Of Organelle And Cellular Interactions. Gastroenterology 156, 1941\u20131950 (2019).","journal-title":"Gastroenterology"},{"key":"2782_CR74","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1053\/j.gastro.2019.01.269","volume":"156","author":"G Trikudanathan","year":"2019","unstructured":"Trikudanathan, G. et al. Current Concepts In Severe Acute And Necrotizing Pancreatitis: An Evidence-based Approach. Gastroenterology 156, 1994\u20132007 e1993 (2019).","journal-title":"Gastroenterology"},{"key":"2782_CR75","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103161","volume":"72","author":"A Sorby-Adams","year":"2024","unstructured":"Sorby-Adams, A. et al. A model of mitochondrial superoxide production during ischaemia-reperfusion injury for therapeutic development and mechanistic understanding. Redox Biol. 72, 103161 (2024).","journal-title":"Redox Biol."},{"key":"2782_CR76","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1093\/cvr\/cvw100","volume":"111","author":"VR Pell","year":"2016","unstructured":"Pell, V. R. et al. Succinate metabolism: a new therapeutic target for myocardial reperfusion injury. Cardiovasc. Res. 111, 134\u2013141 (2016).","journal-title":"Cardiovasc. Res."},{"key":"2782_CR77","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.redox.2015.08.020","volume":"6","author":"DN Granger","year":"2015","unstructured":"Granger, D. N. & Kvietys, P. R. Reperfusion injury and reactive oxygen species: the evolution of a concept. Redox Biol. 6, 524\u2013551 (2015).","journal-title":"Redox Biol."},{"key":"2782_CR78","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1161\/CIRCULATIONAHA.116.021618","volume":"134","author":"C Woods","year":"2016","unstructured":"Woods, C. et al. In vivo post-cardiac arrest myocardial dysfunction is supported by Ca2+\/calmodulin-dependent protein kinase II-mediated calcium long-term potentiation and mitigated by Alda-1, an agonist of aldehyde dehydrogenase type 2. Circulation 134, 961\u2013977 (2016).","journal-title":"Circulation"},{"key":"2782_CR79","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.kint.2017.08.014","volume":"93","author":"WM Raup-Konsavage","year":"2018","unstructured":"Raup-Konsavage, W. M. et al. Neutrophil peptidyl arginine deiminase-4 has a pivotal role in ischemia\/reperfusion-induced acute kidney injury. Kidney Int. 93, 365\u2013374 (2018).","journal-title":"Kidney Int."},{"key":"2782_CR80","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1097\/00003246-200104000-00020","volume":"29","author":"M Ohara","year":"2001","unstructured":"Ohara, M. et al. Peritoneal lavage with oxygenated perfluorochemical preserves intestinal mucosal barrier function after ischemia-reperfusion and ameliorates lung injury. Crit. Care Med. 29, 782\u2013788 (2001).","journal-title":"Crit. Care Med."},{"key":"2782_CR81","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1097\/00003246-199409000-00014","volume":"22","author":"K Koike","year":"1994","unstructured":"Koike, K. et al. Gut ischemia\/reperfusion produces lung injury independent of endotoxin. Crit. Care Med. 22, 1438\u20131444 (1994).","journal-title":"Crit. Care Med."},{"key":"2782_CR82","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1097\/00000658-200108000-00014","volume":"234","author":"DW Harkin","year":"2001","unstructured":"Harkin, D. W. et al. Bactericidal\/permeability-increasing protein attenuates systemic inflammation and acute lung injury in porcine lower limb ischemia-reperfusion injury. Ann. Surg. 234, 233\u2013244 (2001).","journal-title":"Ann. Surg."},{"key":"2782_CR83","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1006\/jsre.1994.1131","volume":"57","author":"P Baron","year":"1994","unstructured":"Baron, P. et al. Gut failure and translocation following burn and sepsis. J. Surg. Res. 57, 197\u2013204 (1994).","journal-title":"J. Surg. Res."},{"key":"2782_CR84","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-025-05278-x","volume":"29","author":"Y Wang","year":"2025","unstructured":"Wang, Y., Weng, L., Wu, X. & Du, B. The role of programmed cell death in organ dysfunction induced by opportunistic pathogens. Crit. Care 29, 43 (2025).","journal-title":"Crit. Care"},{"key":"2782_CR85","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2025.116765","volume":"233","author":"S Chen","year":"2025","unstructured":"Chen, S. et al. Targeting GSDMD JX06 inhibits PANoptosis and multiple organ injury. Biochem Pharm. 233, 116765 (2025).","journal-title":"Biochem Pharm."},{"key":"2782_CR86","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jare.2022.01.014","volume":"41","author":"R Zou","year":"2022","unstructured":"Zou, R. et al. DNA-PKcs promotes sepsis-induced multiple organ failure by triggering mitochondrial dysfunction. J. Adv. Res. 41, 39\u201348 (2022).","journal-title":"J. Adv. Res."},{"key":"2782_CR87","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.cmet.2023.11.014","volume":"36","author":"T Konig","year":"2024","unstructured":"Konig, T. & McBride, H. M. Mitochondrial-derived vesicles in metabolism, disease, and aging. Cell Metab. 36, 21\u201335 (2024).","journal-title":"Cell Metab."},{"key":"2782_CR88","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1164\/rccm.201211-1983OC","volume":"187","author":"O Takasu","year":"2013","unstructured":"Takasu, O. et al. Mechanisms of cardiac and renal dysfunction in patients dying of sepsis. Am. J. Respir. Crit. Care Med. 187, 509\u2013517 (2013).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2782_CR89","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/s41392-025-02253-4","volume":"10","author":"X Xu","year":"2025","unstructured":"Xu, X., Pang, Y. & Fan, X. Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances. Signal Transduct. Target Ther. 10, 190 (2025).","journal-title":"Signal Transduct. Target Ther."},{"key":"2782_CR90","doi-asserted-by":"publisher","first-page":"102968","DOI":"10.1016\/j.redox.2023.102968","volume":"68","author":"FM Lira Chavez","year":"2023","unstructured":"Lira Chavez, F. M. et al. Restoring the infected powerhouse: mitochondrial quality control in sepsis. Redox Biol. 68, 102968 (2023).","journal-title":"Redox Biol."},{"key":"2782_CR91","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1186\/cc3753","volume":"9","author":"C Ince","year":"2005","unstructured":"Ince, C. The microcirculation is the motor of sepsis. Crit. Care 9, S13\u2013S19 (2005).","journal-title":"Crit. Care"},{"key":"2782_CR92","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1213\/ANE.0000000000005023","volume":"131","author":"NP Juffermans","year":"2020","unstructured":"Juffermans, N. P., van den Brom, C. E. & Kleinveld, D. J. B. Targeting endothelial dysfunction in acute critical illness to reduce organ failure. Anesth. Analg. 131, 1708\u20131720 (2020).","journal-title":"Anesth. Analg."},{"key":"2782_CR93","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2534-2","volume":"23","author":"JA Hippensteel","year":"2019","unstructured":"Hippensteel, J. A. et al. Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation. Crit. Care 23, 259 (2019).","journal-title":"Crit. Care"},{"key":"2782_CR94","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ccc.2016.08.006","volume":"33","author":"A Sauaia","year":"2017","unstructured":"Sauaia, A., Moore, F. A. & Moore, E. E. Postinjury inflammation and organ dysfunction. Crit. Care Clin. 33, 167\u2013191 (2017).","journal-title":"Crit. Care Clin."},{"key":"2782_CR95","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1097\/ALN.0000000000001907","volume":"128","author":"M Trieu","year":"2018","unstructured":"Trieu, M. et al. Vasculotide, an Angiopoietin-1 Mimetic, restores microcirculatory perfusion and microvascular leakage and decreases fluid resuscitation requirements in hemorrhagic shock. Anesthesiology 128, 361\u2013374 (2018).","journal-title":"Anesthesiology"},{"key":"2782_CR96","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0538-5","volume":"9","author":"L Chen","year":"2018","unstructured":"Chen, L. et al. Neutrophil extracellular traps promote macrophage pyroptosis in sepsis. Cell Death Dis. 9, 597 (2018).","journal-title":"Cell Death Dis."},{"key":"2782_CR97","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1080\/19490976.2019.1629235","volume":"11","author":"M Stephens","year":"2020","unstructured":"Stephens, M. & von der Weid, P. Y. Lipopolysaccharides modulate intestinal epithelial permeability and inflammation in a species-specific manner. Gut Microbes 11, 421\u2013432 (2020).","journal-title":"Gut Microbes"},{"key":"2782_CR98","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.carbpol.2019.05.036","volume":"219","author":"L Shi","year":"2019","unstructured":"Shi, L. et al. Chitosan oligosaccharide-mediated attenuation of LPS-induced inflammation in IPEC-J2 cells is related to the TLR4\/NF-kappaB signaling pathway. Carbohydr. Polym. 219, 269\u2013279 (2019).","journal-title":"Carbohydr. Polym."},{"key":"2782_CR99","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.1042\/CS20160373","volume":"130","author":"Y Han","year":"2016","unstructured":"Han, Y. et al. Cardiac troponin I exacerbates myocardial ischaemia\/reperfusion injury by inducing the adhesion of monocytes to vascular endothelial cells via a TLR4\/NF-kappaB-dependent pathway. Clin. Sci. 130, 2279\u20132293 (2016).","journal-title":"Clin. Sci."},{"key":"2782_CR100","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.124050","volume":"404","author":"X Liu","year":"2021","unstructured":"Liu, X. et al. Amorphous silica nanoparticles induce inflammation via activation of NLRP3 inflammasome and HMGB1\/TLR4\/MYD88\/NF-kb signaling pathway in HUVEC cells. J. Hazard Mater. 404, 124050 (2021).","journal-title":"J. Hazard Mater."},{"key":"2782_CR101","doi-asserted-by":"publisher","first-page":"516","DOI":"10.3389\/fimmu.2018.00516","volume":"9","author":"SM Lee","year":"2018","unstructured":"Lee, S. M. et al. Recognition of Double-Stranded RNA and Regulation of Interferon Pathway by Toll-Like Receptor 10. Front. Immunol. 9, 516 (2018).","journal-title":"Front. Immunol."},{"key":"2782_CR102","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2023.107949","volume":"175","author":"N Ma","year":"2023","unstructured":"Ma, N. et al. Bisphenol P exposure in C57BL\/6 mice caused gut microbiota dysbiosis and induced intestinal barrier disruption via LPS\/TLR4\/NF-kappaB signaling pathway. Environ. Int. 175, 107949 (2023).","journal-title":"Environ. Int."},{"key":"2782_CR103","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106473","volume":"185","author":"XS Chen","year":"2022","unstructured":"Chen, X. S. et al. Losartan attenuates sepsis-induced cardiomyopathy by regulating macrophage polarization via TLR4-mediated NF-kappaB and MAPK signaling. Pharm. Res. 185, 106473 (2022).","journal-title":"Pharm. Res."},{"key":"2782_CR104","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.jhep.2020.01.011","volume":"73","author":"C Engelmann","year":"2020","unstructured":"Engelmann, C. et al. Toll-like receptor 4 is a therapeutic target for prevention and treatment of liver failure. J. Hepatol. 73, 102\u2013112 (2020).","journal-title":"J. Hepatol."},{"key":"2782_CR105","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1042\/CS20170262","volume":"132","author":"M Andrade-Silva","year":"2018","unstructured":"Andrade-Silva, M. et al. TLR2 and TLR4 play opposite role in autophagy associated with cisplatin-induced acute kidney injury. Clin. Sci. 132, 1725\u20131739 (2018).","journal-title":"Clin. Sci."},{"key":"2782_CR106","doi-asserted-by":"publisher","first-page":"4071","DOI":"10.1182\/blood-2003-04-1290","volume":"104","author":"J Pugin","year":"2004","unstructured":"Pugin, J. et al. Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock. Blood 104, 4071\u20134079 (2004).","journal-title":"Blood"},{"key":"2782_CR107","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2112882","volume":"14","author":"M Qi-Xiang","year":"2022","unstructured":"Qi-Xiang, M. et al. Intestinal TLR4 deletion exacerbates acute pancreatitis through gut microbiota dysbiosis and Paneth cells deficiency. Gut Microbes 14, 2112882 (2022).","journal-title":"Gut Microbes"},{"key":"2782_CR108","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/j.tips.2023.10.001","volume":"44","author":"Z Li","year":"2023","unstructured":"Li, Z. et al. Potential therapeutic targets for trauma management. Trends Pharm. Sci. 44, 891\u2013901 (2023).","journal-title":"Trends Pharm. Sci."},{"key":"2782_CR109","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.3390\/antiox13111398","volume":"13","author":"R Yubolphan","year":"2024","unstructured":"Yubolphan, R. et al. Berberine mitigates sepsis-associated acute kidney injury in aged rats by preserving mitochondrial integrity and inhibiting TLR4\/NF-kappaB and NLRP3 inflammasome activations. Antioxidants 13, 1398 (2024).","journal-title":"Antioxidants"},{"key":"2782_CR110","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s10753-022-01715-z","volume":"46","author":"L Huang","year":"2023","unstructured":"Huang, L. et al. PCSK9 promotes endothelial dysfunction during sepsis via the TLR4\/MyD88\/NF-kappaB and NLRP3 Pathways. Inflammation 46, 115\u2013128 (2023).","journal-title":"Inflammation"},{"key":"2782_CR111","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/s41423-019-0213-5","volume":"16","author":"K Shi","year":"2019","unstructured":"Shi, K., Zhang, J., Dong, J. F. & Shi, F. D. Dissemination of brain inflammation in traumatic brain injury. Cell Mol. Immunol. 16, 523\u2013530 (2019).","journal-title":"Cell Mol. Immunol."},{"key":"2782_CR112","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.kint.2018.10.035","volume":"95","author":"SJ Han","year":"2019","unstructured":"Han, S. J. et al. Intestinal toll-like receptor 9 deficiency leads to Paneth cell hyperplasia and exacerbates kidney, intestine, and liver injury after ischemia\/reperfusion injury. Kidney Int. 95, 859\u2013879 (2019).","journal-title":"Kidney Int."},{"key":"2782_CR113","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1164\/rccm.201604-0892OC","volume":"196","author":"S Lee","year":"2017","unstructured":"Lee, S. et al. NLRP3 inflammasome deficiency protects against microbial sepsis via increased lipoxin B(4) synthesis. Am. J. Respir. Crit. Care Med. 196, 713\u2013726 (2017).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2782_CR114","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02645-3","volume":"9","author":"W Wang","year":"2018","unstructured":"Wang, W. et al. Zika virus infection induces host inflammatory responses by facilitating NLRP3 inflammasome assembly and interleukin-1beta secretion. Nat. Commun. 9, 106 (2018).","journal-title":"Nat. Commun."},{"key":"2782_CR115","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/s41401-021-00619-2","volume":"43","author":"F Yin","year":"2022","unstructured":"Yin, F. et al. Caspase-11 promotes NLRP3 inflammasome activation via the cleavage of pannexin1 in acute kidney disease. Acta Pharm. Sin. 43, 86\u201395 (2022).","journal-title":"Acta Pharm. Sin."},{"key":"2782_CR116","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s12026-024-09580-8","volume":"73","author":"P Wang","year":"2024","unstructured":"Wang, P. et al. Pinocembrin activation of DPP9 inhibits NLRP1 inflammasome activation to alleviate cerebral ischemia\/reperfusion-induced lung and intestinal injury. Immunol. Res. 73, 13 (2024).","journal-title":"Immunol. Res."},{"key":"2782_CR117","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.4049\/jimmunol.1201065","volume":"189","author":"M Kovarova","year":"2012","unstructured":"Kovarova, M. et al. NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice. J. Immunol. 189, 2006\u20132016 (2012).","journal-title":"J. Immunol."},{"key":"2782_CR118","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s13238-016-0326-x","volume":"8","author":"R Yan","year":"2017","unstructured":"Yan, R. & Liu, Z. LRRK2 enhances Nod1\/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation. Protein Cell 8, 55\u201366 (2017).","journal-title":"Protein Cell"},{"key":"2782_CR119","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07447-9","volume":"9","author":"Q Gong","year":"2018","unstructured":"Gong, Q. et al. Structural basis of RIP2 activation and signaling. Nat. Commun. 9, 4993 (2018).","journal-title":"Nat. Commun."},{"key":"2782_CR120","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/nature17631","volume":"532","author":"AM Keestra-Gounder","year":"2016","unstructured":"Keestra-Gounder, A. M. et al. NOD1 and NOD2 signalling links ER stress with inflammation. Nature 532, 394\u2013397 (2016).","journal-title":"Nature"},{"key":"2782_CR121","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.immuni.2014.12.010","volume":"41","author":"R Caruso","year":"2014","unstructured":"Caruso, R., Warner, N., Inohara, N. & Nunez, G. NOD1 and NOD2: signaling, host defense, and inflammatory disease. Immunity 41, 898\u2013908 (2014).","journal-title":"Immunity"},{"key":"2782_CR122","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.jacc.2016.10.073","volume":"69","author":"A Val-Blasco","year":"2017","unstructured":"Val-Blasco, A. et al. Role of NOD1 in heart failure progression via regulation of Ca(2+) handling. J. Am. Coll. Cardiol. 69, 423\u2013433 (2017).","journal-title":"J. Am. Coll. Cardiol."},{"key":"2782_CR123","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1016\/j.jhep.2019.01.019","volume":"70","author":"G Lassailly","year":"2019","unstructured":"Lassailly, G. et al. Nucleotide-binding oligomerization domain 1 (NOD1) modulates liver ischemia reperfusion through the expression adhesion molecules. J. Hepatol. 70, 1159\u20131169 (2019).","journal-title":"J. Hepatol."},{"key":"2782_CR124","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1038\/ki.2014.403","volume":"87","author":"M Zhou","year":"2015","unstructured":"Zhou, M. et al. Progranulin protects against renal ischemia\/reperfusion injury in mice. Kidney Int. 87, 918\u2013929 (2015).","journal-title":"Kidney Int."},{"key":"2782_CR125","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2023.152358","volume":"228","author":"R Jiao","year":"2023","unstructured":"Jiao, R. et al. Irisin attenuates fine particulate matter induced acute lung injury by regulating Nod2\/NF-kappaB signaling pathway. Immunobiology 228, 152358 (2023).","journal-title":"Immunobiology"},{"key":"2782_CR126","doi-asserted-by":"crossref","unstructured":"Ozbay Kurt, F. G. et al. S100A9 and HMGB1 orchestrate MDSC-mediated immunosuppression in melanoma through TLR4 signaling. J. Immunother. Cancer 12, e009552 (2024).","DOI":"10.1136\/jitc-2024-009552"},{"key":"2782_CR127","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s10020-021-00323-1","volume":"27","author":"T Totoki","year":"2021","unstructured":"Totoki, T. et al. Specific detection of high mobility group box 1 degradation product with a novel ELISA. Mol. Med. 27, 59 (2021).","journal-title":"Mol. Med."},{"key":"2782_CR128","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/s41401-021-00676-7","volume":"43","author":"C Deng","year":"2022","unstructured":"Deng, C. et al. Targeting HMGB1 for the treatment of sepsis and sepsis-induced organ injury. Acta Pharm. Sin. 43, 520\u2013528 (2022).","journal-title":"Acta Pharm. Sin."},{"key":"2782_CR129","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.redox.2017.08.001","volume":"13","author":"W Abdulmahdi","year":"2017","unstructured":"Abdulmahdi, W. et al. HMGB1 redox during sepsis. Redox Biol. 13, 600\u2013607 (2017).","journal-title":"Redox Biol."},{"key":"2782_CR130","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s12072-018-9911-9","volume":"13","author":"R Yang","year":"2019","unstructured":"Yang, R. & Tonnesseen, T. I. DAMPs and sterile inflammation in drug hepatotoxicity. Hepatol. Int. 13, 42\u201350 (2019).","journal-title":"Hepatol. Int."},{"key":"2782_CR131","doi-asserted-by":"publisher","first-page":"23143","DOI":"10.1021\/jacs.3c06799","volume":"145","author":"H Koide","year":"2023","unstructured":"Koide, H. et al. Design of an anti-HMGB1 synthetic antibody for in vivo ischemic\/reperfusion injury therapy. J. Am. Chem. Soc. 145, 23143\u201323151 (2023).","journal-title":"J. Am. Chem. Soc."},{"key":"2782_CR132","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.jhep.2025.02.026","volume":"83","author":"X Zhou","year":"2025","unstructured":"Zhou, X. et al. Sour neuronal signalling attenuates macrophage-mediated liver injury. J. Hepatol. 83, 738\u2013749 (2025).","journal-title":"J. Hepatol."},{"key":"2782_CR133","doi-asserted-by":"publisher","first-page":"2734","DOI":"10.1016\/j.ymthe.2023.06.016","volume":"31","author":"C Li","year":"2023","unstructured":"Li, C. et al. Genetic and pharmacological inhibition of GRPR protects against acute kidney injury via attenuating renal inflammation and necroptosis. Mol. Ther. 31, 2734\u20132754 (2023).","journal-title":"Mol. Ther."},{"key":"2782_CR134","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1093\/cvr\/cvaa148","volume":"117","author":"HA Prag","year":"2021","unstructured":"Prag, H. A. et al. Mechanism of succinate efflux upon reperfusion of the ischaemic heart. Cardiovasc. Res. 117, 1188\u20131201 (2021).","journal-title":"Cardiovasc. Res."},{"key":"2782_CR135","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.pharmthera.2016.01.008","volume":"159","author":"J Gilissen","year":"2016","unstructured":"Gilissen, J., Jouret, F., Pirotte, B. & Hanson, J. Insight into SUCNR1 (GPR91) structure and function. Pharm. Ther. 159, 56\u201365 (2016).","journal-title":"Pharm. Ther."},{"key":"2782_CR136","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.immuni.2023.03.003","volume":"56","author":"F Zhu","year":"2023","unstructured":"Zhu, F. et al. The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome. Immunity 56, 753\u2013767.e758 (2023).","journal-title":"Immunity"},{"key":"2782_CR137","doi-asserted-by":"publisher","first-page":"627","DOI":"10.3389\/fimmu.2018.00627","volume":"9","author":"M Martinez-Florensa","year":"2018","unstructured":"Martinez-Florensa, M. et al. Conserved bacterial-binding peptides of the scavenger-like human lymphocyte receptor CD6 protect from mouse experimental sepsis. Front. Immunol. 9, 627 (2018).","journal-title":"Front. Immunol."},{"key":"2782_CR138","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48360-8","volume":"15","author":"L Oliveira","year":"2024","unstructured":"Oliveira, L. et al. CD5L as a promising biological therapeutic for treating sepsis. Nat. Commun. 15, 4119 (2024).","journal-title":"Nat. Commun."},{"key":"2782_CR139","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.kint.2023.12.007","volume":"105","author":"Y Li","year":"2024","unstructured":"Li, Y. et al. Fibroblastic reticular cell-derived exosomes are a promising therapeutic approach for septic acute kidney injury. Kidney Int. 105, 508\u2013523 (2024).","journal-title":"Kidney Int."},{"key":"2782_CR140","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adt7589","volume":"11","author":"TN Zhang","year":"2025","unstructured":"Zhang, T. N. et al. Endothelial CLEC5A drives barrier dysfunction and vascular leakage responsible for lung injury in bacterial pneumonia and sepsis. Sci. Adv. 11, eadt7589 (2025).","journal-title":"Sci. Adv."},{"key":"2782_CR141","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/s41577-024-01112-7","volume":"25","author":"Z Zhang","year":"2025","unstructured":"Zhang, Z. & Zhang, C. Regulation of cGAS-STING signalling and its diversity of cellular outcomes. Nat. Rev. Immunol. 25, 425\u2013444 (2025).","journal-title":"Nat. Rev. Immunol."},{"key":"2782_CR142","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.tibtech.2016.10.002","volume":"35","author":"T Johannssen","year":"2017","unstructured":"Johannssen, T. & Lepenies, B. Glycan-based cell targeting to modulate immune responses. Trends Biotechnol. 35, 334\u2013346 (2017).","journal-title":"Trends Biotechnol."},{"key":"2782_CR143","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.jhep.2017.05.021","volume":"67","author":"LEB Savio","year":"2017","unstructured":"Savio, L. E. B. et al. CD39 limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury. J. Hepatol. 67, 716\u2013726 (2017).","journal-title":"J. Hepatol."},{"key":"2782_CR144","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105470","volume":"166","author":"Y Zhu","year":"2021","unstructured":"Zhu, Y. et al. Diphenyleneiodonium enhances P2X7 dependent non-opsonized phagocytosis and suppresses inflammasome activation via blocking CX43-mediated ATP leakage. Pharm. Res. 166, 105470 (2021).","journal-title":"Pharm. Res."},{"key":"2782_CR145","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1007\/s10495-021-01663-3","volume":"26","author":"A Murao","year":"2021","unstructured":"Murao, A. et al. Release mechanisms of major DAMPs. Apoptosis 26, 152\u2013162 (2021).","journal-title":"Apoptosis"},{"key":"2782_CR146","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.4049\/jimmunol.1600802","volume":"198","author":"JM Horvatinovich","year":"2017","unstructured":"Horvatinovich, J. M. et al. Soluble CD83 inhibits T cell activation by binding to the TLR4\/MD-2 complex on CD14(+) monocytes. J. Immunol. 198, 2286\u20132301 (2017).","journal-title":"J. Immunol."},{"key":"2782_CR147","doi-asserted-by":"publisher","first-page":"2681","DOI":"10.1681\/ASN.2016121272","volume":"28","author":"ME Stremska","year":"2017","unstructured":"Stremska, M. E. et al. IL233, a Novel IL-2 and IL-33 hybrid cytokine, ameliorates renal injury. J. Am. Soc. Nephrol. 28, 2681\u20132693 (2017).","journal-title":"J. Am. Soc. Nephrol."},{"key":"2782_CR148","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.3389\/fimmu.2020.01356","volume":"11","author":"S Pace","year":"2020","unstructured":"Pace, S. & Werz, O. Impact of androgens on inflammation-related lipid mediator biosynthesis in innate immune cells. Front. Immunol. 11, 1356 (2020).","journal-title":"Front. Immunol."},{"key":"2782_CR149","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12823","volume":"7","author":"RS Beard Jr.","year":"2016","unstructured":"Beard, R. S. Jr. et al. Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome. Nat. Commun. 7, 12823 (2016).","journal-title":"Nat. Commun."},{"key":"2782_CR150","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12423","volume":"13","author":"L Wang","year":"2024","unstructured":"Wang, L. et al. Endothelial cell-derived extracellular vesicles expressing surface VCAM1 promote sepsis-related acute lung injury by targeting and reprogramming monocytes. J. Extracell. Vesicles 13, e12423 (2024).","journal-title":"J. Extracell. Vesicles"},{"key":"2782_CR151","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/s41385-019-0143-7","volume":"12","author":"AC Luissint","year":"2019","unstructured":"Luissint, A. C. et al. Macrophage-dependent neutrophil recruitment is impaired under conditions of increased intestinal permeability in JAM-A-deficient mice. Mucosal Immunol. 12, 668\u2013678 (2019).","journal-title":"Mucosal Immunol."},{"key":"2782_CR152","doi-asserted-by":"publisher","first-page":"602094","DOI":"10.3389\/fimmu.2020.602094","volume":"11","author":"CS Bonilha","year":"2020","unstructured":"Bonilha, C. S., Benson, R. A., Brewer, J. M. & Garside, P. Targeting opposing immunological roles of the junctional adhesion molecule-a in autoimmunity and cancer. Front. Immunol. 11, 602094 (2020).","journal-title":"Front. Immunol."},{"key":"2782_CR153","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.158571","volume":"7","author":"W Huang","year":"2022","unstructured":"Huang, W. et al. JAML promotes acute kidney injury mainly through a macrophage-dependent mechanism. JCI Insight 7, e158571 (2022).","journal-title":"JCI Insight"},{"key":"2782_CR154","doi-asserted-by":"publisher","DOI":"10.1172\/JCI177896","volume":"134","author":"N Yehya","year":"2024","unstructured":"Yehya, N. et al. Inflammatory and tissue injury marker dynamics in pediatric acute respiratory distress syndrome. J. Clin. Investig. 134, e177896 (2024).","journal-title":"J. Clin. Investig."},{"key":"2782_CR155","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-022-04070-5","volume":"26","author":"MR Atreya","year":"2022","unstructured":"Atreya, M. R. et al. Integrated PERSEVERE and endothelial biomarker risk model predicts death and persistent MODS in pediatric septic shock: a secondary analysis of a prospective observational study. Crit. Care 26, 210 (2022).","journal-title":"Crit. Care"},{"key":"2782_CR156","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36865-7","volume":"14","author":"X Wang","year":"2023","unstructured":"Wang, X. et al. N(6)-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice. Nat. Commun. 14, 1185 (2023).","journal-title":"Nat. Commun."},{"key":"2782_CR157","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155733","volume":"130","author":"Z Li","year":"2024","unstructured":"Li, Z. et al. Targeting macrophagic RasGRP1 with catechin hydrate ameliorates sepsis-induced multiorgan dysfunction. Phytomedicine 130, 155733 (2024).","journal-title":"Phytomedicine"},{"key":"2782_CR158","doi-asserted-by":"publisher","first-page":"e137","DOI":"10.1097\/SLA.0000000000005571","volume":"278","author":"NM Patel","year":"2023","unstructured":"Patel, N. M. et al. Inhibition of the JAK\/STAT pathway with baricitinib reduces the multiple organ dysfunction caused by hemorrhagic shock in rats. Ann. Surg. 278, e137\u2013e146 (2023).","journal-title":"Ann. Surg."},{"key":"2782_CR159","doi-asserted-by":"publisher","first-page":"16037","DOI":"10.1038\/nrdp.2016.37","volume":"2","author":"S Gando","year":"2016","unstructured":"Gando, S., Levi, M. & Toh, C. H. Disseminated intravascular coagulation. Nat. Rev. Dis. Prim. 2, 16037 (2016).","journal-title":"Nat. Rev. Dis. Prim."},{"key":"2782_CR160","doi-asserted-by":"publisher","DOI":"10.1172\/JCI147191","volume":"132","author":"X Tang","year":"2022","unstructured":"Tang, X. et al. KLF2 regulates neutrophil activation and thrombosis in cardiac hypertrophy and heart failure progression. J. Clin. Investig. 132, e147191 (2022).","journal-title":"J. Clin. Investig."},{"key":"2782_CR161","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.immuni.2021.01.007","volume":"54","author":"Y Tang","year":"2021","unstructured":"Tang, Y. et al. Heparin prevents caspase-11-dependent septic lethality independent of anticoagulant properties. Immunity 54, 454\u2013467.e456 (2021).","journal-title":"Immunity"},{"key":"2782_CR162","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1016\/j.clnu.2024.04.020","volume":"43","author":"W Zhang","year":"2024","unstructured":"Zhang, W. et al. Polyunsaturated fatty acid-derived lipid mediator Resolvin D1 alleviates sepsis-induced disseminated intravascular coagulation via Caspase-1\/Gasdermin D pyroptotic pathway. Clin. Nutr. 43, 1372\u20131383 (2024).","journal-title":"Clin. Nutr."},{"key":"2782_CR163","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.trsl.2020.04.005","volume":"222","author":"L Luo","year":"2020","unstructured":"Luo, L. et al. PECAM-1 protects against DIC by dampening inflammatory responses via inhibiting macrophage pyroptosis and restoring vascular barrier integrity. Transl. Res. 222, 1\u201316 (2020).","journal-title":"Transl. Res."},{"key":"2782_CR164","doi-asserted-by":"publisher","first-page":"2702","DOI":"10.1182\/blood.2021011525","volume":"138","author":"CMS Silva","year":"2021","unstructured":"Silva, C. M. S. et al. Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blocking NET formation. Blood 138, 2702\u20132713 (2021).","journal-title":"Blood"},{"key":"2782_CR165","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-020-00603-z","volume":"18","author":"S Xu","year":"2020","unstructured":"Xu, S. et al. Phospho-Tyr705 of STAT3 is a therapeutic target for sepsis through regulating inflammation and coagulation. Cell Commun. Signal. 18, 104 (2020).","journal-title":"Cell Commun. Signal."},{"key":"2782_CR166","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.immuni.2019.11.005","volume":"51","author":"X Yang","year":"2019","unstructured":"Yang, X. et al. Bacterial endotoxin activates the coagulation cascade through gasdermin D-dependent phosphatidylserine exposure. Immunity 51, 983\u2013996.e986 (2019).","journal-title":"Immunity"},{"key":"2782_CR167","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s11658-023-00423-2","volume":"28","author":"A Janaszak-Jasiecka","year":"2023","unstructured":"Janaszak-Jasiecka, A. et al. Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets. Cell Mol. Biol. Lett. 28, 21 (2023).","journal-title":"Cell Mol. Biol. Lett."},{"key":"2782_CR168","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-04875-6","volume":"28","author":"RR McMullan","year":"2024","unstructured":"McMullan, R. R., McAuley, D. F., O\u2019Kane, C. M. & Silversides, J. A. Vascular leak in sepsis: physiological basis and potential therapeutic advances. Crit. Care 28, 97 (2024).","journal-title":"Crit. Care"},{"key":"2782_CR169","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1111\/jth.14371","volume":"17","author":"T Iba","year":"2019","unstructured":"Iba, T. & Levy, J. H. Derangement of the endothelial glycocalyx in sepsis. J. Thromb. Haemost. 17, 283\u2013294 (2019).","journal-title":"J. Thromb. Haemost."},{"key":"2782_CR170","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1159195","volume":"14","author":"N Peng","year":"2023","unstructured":"Peng, N. et al. Endothelial glycocalyx injury is involved in heatstroke-associated coagulopathy and protected by N-acetylcysteine. Front. Immunol. 14, 1159195 (2023).","journal-title":"Front. Immunol."},{"key":"2782_CR171","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2315898120","volume":"121","author":"S Kang","year":"2024","unstructured":"Kang, S. et al. Gp130-HIF1alpha axis-induced vascular damage is prevented by the short-term inhibition of IL-6 receptor signaling. Proc. Natl. Acad. Sci. USA 121, e2315898120 (2024).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2782_CR172","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1038\/s41423-024-01217-y","volume":"21","author":"X Wu","year":"2024","unstructured":"Wu, X. et al. MLKL-mediated endothelial necroptosis drives vascular damage and mortality in systemic inflammatory response syndrome. Cell Mol. Immunol. 21, 1309\u20131321 (2024).","journal-title":"Cell Mol. Immunol."},{"key":"2782_CR173","doi-asserted-by":"publisher","first-page":"6820","DOI":"10.1158\/0008-5472.CAN-05-0522","volume":"65","author":"S Kanda","year":"2005","unstructured":"Kanda, S. et al. Angiopoietin 1 is mitogenic for cultured endothelial cells. Cancer Res. 65, 6820\u20136827 (2005).","journal-title":"Cancer Res."},{"key":"2782_CR174","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1161\/ATVBAHA.107.150482","volume":"27","author":"CM Findley","year":"2007","unstructured":"Findley, C. M., Cudmore, M. J., Ahmed, A. & Kontos, C. D. VEGF induces Tie2 shedding via a phosphoinositide 3-kinase\/Akt dependent pathway to modulate Tie2 signaling. Arterioscler Thromb. Vasc. Biol. 27, 2619\u20132626 (2007).","journal-title":"Arterioscler Thromb. Vasc. Biol."},{"key":"2782_CR175","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03474-z","volume":"25","author":"WK Yu","year":"2021","unstructured":"Yu, W. K. et al. Angiopoietin-2 outperforms other endothelial biomarkers associated with severe acute kidney injury in patients with severe sepsis and respiratory failure. Crit. Care 25, 48 (2021).","journal-title":"Crit. Care"},{"key":"2782_CR176","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ads1796","volume":"11","author":"R Wang","year":"2025","unstructured":"Wang, R. et al. Development of a recombinant Ang1 variant with enhanced Tie2 binding and its application to attenuate sepsis in mice. Sci. Adv. 11, eads1796 (2025).","journal-title":"Sci. Adv."},{"key":"2782_CR177","doi-asserted-by":"publisher","first-page":"3495","DOI":"10.1172\/JCI84923","volume":"126","author":"EA Korhonen","year":"2016","unstructured":"Korhonen, E. A. et al. Tie1 controls angiopoietin function in vascular remodeling and inflammation. J. Clin. Investig. 126, 3495\u20133510 (2016).","journal-title":"J. Clin. Investig."},{"key":"2782_CR178","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1681\/ASN.0000000000000098","volume":"34","author":"Y Li","year":"2023","unstructured":"Li, Y. et al. Activation of Angiopoietin-Tie2 signaling protects the kidney from ischemic injury by modulation of endothelial-specific pathways. J. Am. Soc. Nephrol. 34, 969\u2013987 (2023).","journal-title":"J. Am. Soc. Nephrol."},{"key":"2782_CR179","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02342-8","volume":"18","author":"S Ruiz","year":"2020","unstructured":"Ruiz, S. et al. Kinin B1 receptor: a potential therapeutic target in sepsis-induced vascular hyperpermeability. J. Transl. Med. 18, 174 (2020).","journal-title":"J. Transl. Med."},{"key":"2782_CR180","doi-asserted-by":"publisher","first-page":"e499","DOI":"10.1097\/CCM.0000000000001268","volume":"43","author":"S Nasseri","year":"2015","unstructured":"Nasseri, S. et al. Kinin B1 receptor antagonist BI113823 reduces acute lung injury. Crit. Care Med. 43, e499\u2013e507 (2015).","journal-title":"Crit. Care Med."},{"key":"2782_CR181","doi-asserted-by":"publisher","first-page":"732690","DOI":"10.3389\/fimmu.2021.732690","volume":"12","author":"K Kuba","year":"2021","unstructured":"Kuba, K., Yamaguchi, T. & Penninger, J. M. Angiotensin-converting Enzyme 2 (ACE2) in the Pathogenesis of ARDS in COVID-19. Front. Immunol. 12, 732690 (2021).","journal-title":"Front. Immunol."},{"key":"2782_CR182","doi-asserted-by":"crossref","unstructured":"Tran, N. M. P., Truong, A. T. H., Nguyen, D. T. & Dang, T. T. Profiling pro-inflammatory proteases as biomolecular signatures of material-induced subcutaneous host response in immuno-competent mice. Adv. Sci. 12, e2309709 (2024).","DOI":"10.1002\/advs.202309709"},{"key":"2782_CR183","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.775267","volume":"12","author":"T Chen","year":"2021","unstructured":"Chen, T. et al. Receptor-mediated NETosis on neutrophils. Front. Immunol. 12, 775267 (2021).","journal-title":"Front. Immunol."},{"key":"2782_CR184","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1182\/blood.2023020484","volume":"143","author":"S van der Velden","year":"2024","unstructured":"van der Velden, S. et al. Complement activation drives antibody-mediated transfusion-related acute lung injury via macrophage trafficking and formation of NETs. Blood 143, 79\u201391 (2024).","journal-title":"Blood"},{"key":"2782_CR185","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/nm1753","volume":"14","author":"D Rittirsch","year":"2008","unstructured":"Rittirsch, D. et al. Functional roles for C5a receptors in sepsis. Nat. Med. 14, 551\u2013557 (2008).","journal-title":"Nat. Med."},{"key":"2782_CR186","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-022-04062-5","volume":"26","author":"CMS Silva","year":"2022","unstructured":"Silva, C. M. S. et al. Gasdermin-D activation by SARS-CoV-2 triggers NET and mediate COVID-19 immunopathology. Crit. Care 26, 206 (2022).","journal-title":"Crit. Care"},{"key":"2782_CR187","doi-asserted-by":"publisher","first-page":"3234","DOI":"10.1111\/bph.16175","volume":"180","author":"X Xiao","year":"2023","unstructured":"Xiao, X. et al. SerpinB1 is required for Rev-erbalpha-mediated protection against acute lung injury induced by lipopolysaccharide-in mice. Br. J. Pharm. 180, 3234\u20133253 (2023).","journal-title":"Br. J. Pharm."},{"key":"2782_CR188","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.4103\/1673-5374.389625","volume":"19","author":"J Lou","year":"2024","unstructured":"Lou, J., Zhang, J., Deng, Q. & Chen, X. Neutrophil extracellular traps mediate neuro-immunothrombosis. Neural Regen. Res. 19, 1734\u20131740 (2024).","journal-title":"Neural Regen. Res."},{"key":"2782_CR189","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.jconrel.2025.02.050","volume":"380","author":"X Li","year":"2025","unstructured":"Li, X. et al. Archaea-inspired deoxyribonuclease I liposomes prevent multiple organ dysfunction in sepsis. J. Control Release 380, 1109\u20131126 (2025).","journal-title":"J. Control Release"},{"key":"2782_CR190","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202308771","volume":"11","author":"T Zhao","year":"2024","unstructured":"Zhao, T. et al. Pregnane X receptor activation in liver macrophages protects against endotoxin-induced liver injury. Adv. Sci. 11, e2308771 (2024).","journal-title":"Adv. Sci."},{"key":"2782_CR191","doi-asserted-by":"publisher","first-page":"2694","DOI":"10.1021\/acs.jmedchem.4c02032","volume":"68","author":"W Xie","year":"2025","unstructured":"Xie, W. et al. Design and synthesis of hederagenin derivatives for the treatment of sepsis by targeting TAK1 and regulating the TAK1-NF-kappaB\/MAPK signaling. J. Med. Chem. 68, 2694\u20132719 (2025).","journal-title":"J. Med. Chem."},{"key":"2782_CR192","doi-asserted-by":"publisher","first-page":"3986","DOI":"10.1016\/j.apsb.2021.10.008","volume":"12","author":"Q Hu","year":"2022","unstructured":"Hu, Q. et al. Emodin attenuates severe acute pancreatitis-associated acute lung injury by suppressing pancreatic exosome-mediated alveolar macrophage activation. Acta Pharm. Sin. B 12, 3986\u20134003 (2022).","journal-title":"Acta Pharm. Sin. B"},{"key":"2782_CR193","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1681\/ASN.2021121548","volume":"33","author":"NS Shin","year":"2022","unstructured":"Shin, N. S. et al. Arginase-1 is required for macrophage-mediated renal tubule regeneration. J. Am. Soc. Nephrol. 33, 1077\u20131086 (2022).","journal-title":"J. Am. Soc. Nephrol."},{"key":"2782_CR194","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1002\/hep.32184","volume":"75","author":"J Rao","year":"2022","unstructured":"Rao, J. et al. Macrophage nuclear factor erythroid 2-related factor 2 deficiency promotes innate immune activation by tissue inhibitor of metalloproteinase 3-mediated RhoA\/ROCK pathway in the ischemic liver. Hepatology 75, 1429\u20131445 (2022).","journal-title":"Hepatology"},{"key":"2782_CR195","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/s41423-025-01263-0","volume":"22","author":"Y Chang","year":"2025","unstructured":"Chang, Y. et al. Gut-derived macrophages link intestinal damage to brain injury after cardiac arrest through TREM1 signaling. Cell Mol. Immunol. 22, 437\u2013455 (2025).","journal-title":"Cell Mol. Immunol."},{"key":"2782_CR196","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm0142","volume":"8","author":"A Lau","year":"2022","unstructured":"Lau, A. et al. Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury. Sci. Adv. 8, eabm0142 (2022).","journal-title":"Sci. Adv."},{"key":"2782_CR197","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1016\/j.cell.2019.07.017","volume":"178","author":"SR Choudhury","year":"2019","unstructured":"Choudhury, S. R. et al. Dipeptidase-1 is an adhesion receptor for neutrophil recruitment in lungs and liver. Cell 178, 1205\u20131221.e1217 (2019).","journal-title":"Cell"},{"key":"2782_CR198","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1038\/s41564-020-00795-7","volume":"5","author":"B Zhou","year":"2020","unstructured":"Zhou, B. et al. Extracellular SQSTM1 mediates bacterial septic death in mice through insulin receptor signalling. Nat. Microbiol. 5, 1576\u20131587 (2020).","journal-title":"Nat. Microbiol."},{"key":"2782_CR199","doi-asserted-by":"publisher","first-page":"15517","DOI":"10.1021\/acsnano.4c00162","volume":"18","author":"A Sheridan","year":"2024","unstructured":"Sheridan, A. et al. Clot-targeted nanogels for dual-delivery of AntithrombinIII and tissue plasminogen activator to mitigate disseminated intravascular coagulation complications. ACS Nano 18, 15517\u201315528 (2024).","journal-title":"ACS Nano"},{"key":"2782_CR200","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s00134-023-06980-6","volume":"49","author":"J Helms","year":"2023","unstructured":"Helms, J. et al. How to manage coagulopathies in critically ill patients. Intensive Care Med. 49, 273\u2013290 (2023).","journal-title":"Intensive Care Med."},{"key":"2782_CR201","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1016\/j.immuni.2019.04.003","volume":"50","author":"C Wu","year":"2019","unstructured":"Wu, C. et al. Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis. Immunity 50, 1401\u20131411 (2019).","journal-title":"Immunity"},{"key":"2782_CR202","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103956","volume":"89","author":"CY Han","year":"2025","unstructured":"Han, C. Y. et al. Inflammation contributes to trauma-induced coagulopathy by oxidation of multiple clotting factors. Redox Biol. 89, 103956 (2025).","journal-title":"Redox Biol."},{"key":"2782_CR203","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1182\/blood.2020009345","volume":"138","author":"R Silasi","year":"2021","unstructured":"Silasi, R. et al. Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus. Blood 138, 178\u2013189 (2021).","journal-title":"Blood"},{"key":"2782_CR204","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1182\/blood.2023019940","volume":"142","author":"P Burkard","year":"2023","unstructured":"Burkard, P. et al. A key role for platelet GPVI in neutrophil recruitment, migration, and NETosis in the early stages of acute lung injury. Blood 142, 1463\u20131477 (2023).","journal-title":"Blood"},{"key":"2782_CR205","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1210219","volume":"14","author":"D Cox","year":"2023","unstructured":"Cox, D. Sepsis - it is all about the platelets. Front. Immunol. 14, 1210219 (2023).","journal-title":"Front. Immunol."},{"key":"2782_CR206","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1111\/bph.16191","volume":"181","author":"D Pan","year":"2024","unstructured":"Pan, D., Ladds, G., Rahman, K. M. & Pitchford, S. C. Exploring bias in platelet P2Y(1) signalling: Host defence versus haemostasis. Br. J. Pharm. 181, 580\u2013592 (2024).","journal-title":"Br. J. Pharm."},{"key":"2782_CR207","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.immuni.2023.02.015","volume":"56","author":"M Yang","year":"2023","unstructured":"Yang, M. et al. STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion. Immunity 56, 1013\u20131026.e1016 (2023).","journal-title":"Immunity"},{"key":"2782_CR208","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1002\/art.41926","volume":"74","author":"AA Manfredi","year":"2022","unstructured":"Manfredi, A. A. et al. Platelet phagocytosis via P-selectin glycoprotein ligand 1 and accumulation of microparticles in systemic sclerosis. Arthritis Rheumatol. 74, 318\u2013328 (2022).","journal-title":"Arthritis Rheumatol."},{"key":"2782_CR209","doi-asserted-by":"publisher","first-page":"e133","DOI":"10.1161\/CIRCRESAHA.124.324924","volume":"135","author":"J Ge","year":"2024","unstructured":"Ge, J. et al. Prostacyclin synthase deficiency leads to exacerbation or occurrence of endothelium-dependent contraction and causes cardiovascular disorders mainly via the Non-TxA(2) prostanoids\/TP axis. Circ. Res. 135, e133\u2013e149 (2024).","journal-title":"Circ. Res."},{"key":"2782_CR210","doi-asserted-by":"publisher","first-page":"4087","DOI":"10.1111\/bph.13939","volume":"174","author":"G Ozen","year":"2017","unstructured":"Ozen, G. et al. Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI(2) : a safer alternative to COX-2 inhibition. Br. J. Pharm. 174, 4087\u20134098 (2017).","journal-title":"Br. J. Pharm."},{"key":"2782_CR211","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1093\/cvr\/cvae254","volume":"121","author":"S Talabieke","year":"2025","unstructured":"Talabieke, S. et al. Arachidonic acid synergizes with aspirin preventing myocardial ischemia-reperfusion injury and mitigates bleeding risk. Cardiovasc Res. 121, 775\u2013787 (2025).","journal-title":"Cardiovasc Res."},{"key":"2782_CR212","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41467-025-66978-0","volume":"17","author":"HW Choi","year":"2025","unstructured":"Choi, H. W. et al. Platelet-mediated activation of perivascular mast cells triggers progression of sepsis to septic shock in mice. Nat Commun. 17, 270 (2025).","journal-title":"Nat Commun."},{"key":"2782_CR213","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1182\/blood.2025028739","volume":"146","author":"H Jiang","year":"2025","unstructured":"Jiang, H. et al. Platelet NLRP6 protects against microvascular thrombosis in sepsis. Blood 146, 382\u2013395 (2025).","journal-title":"Blood"},{"key":"2782_CR214","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.jconrel.2025.01.053","volume":"379","author":"S Chen","year":"2025","unstructured":"Chen, S. et al. Disrupting the dangerous alliance: Dual anti-inflammatory and anticoagulant strategy targets platelet-neutrophil crosstalk in sepsis. J. Control Release 379, 814\u2013831 (2025).","journal-title":"J. Control Release"},{"key":"2782_CR215","doi-asserted-by":"publisher","first-page":"S35","DOI":"10.1097\/CCM.0b013e3181c9e31d","volume":"38","author":"S Gando","year":"2010","unstructured":"Gando, S. Microvascular thrombosis and multiple organ dysfunction syndrome. Crit. Care Med. 38, S35\u2013S42 (2010).","journal-title":"Crit. Care Med."},{"key":"2782_CR216","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1182\/blood.2021015280","volume":"139","author":"N Mackman","year":"2022","unstructured":"Mackman, N. & Hisada, Y. Therapeutic potential of granulocyte microvesicles in sepsis. Blood 139, 2269\u20132271 (2022).","journal-title":"Blood"},{"key":"2782_CR217","doi-asserted-by":"publisher","first-page":"8076","DOI":"10.7150\/thno.61810","volume":"11","author":"Z Qin","year":"2021","unstructured":"Qin, Z. et al. Endothelial cell infection and dysfunction, immune activation in severe COVID-19. Theranostics 11, 8076\u20138091 (2021).","journal-title":"Theranostics"},{"key":"2782_CR218","doi-asserted-by":"publisher","first-page":"2311","DOI":"10.1016\/j.immuni.2023.08.001","volume":"56","author":"T Fu","year":"2023","unstructured":"Fu, T. et al. Mechanotransduction via endothelial adhesion molecule CD31 initiates transmigration and reveals a role for VEGFR2 in diapedesis. Immunity 56, 2311\u20132324.e2316 (2023).","journal-title":"Immunity"},{"key":"2782_CR219","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1161\/ATVBAHA.123.320157","volume":"44","author":"M Kespohl","year":"2024","unstructured":"Kespohl, M. et al. TF-FVIIa PAR2-beta-arrestin signaling sustains organ dysfunction in Coxsackievirus B3 Infection Of Mice. Arterioscler Thromb. Vasc. Biol. 44, 843\u2013865 (2024).","journal-title":"Arterioscler Thromb. Vasc. Biol."},{"key":"2782_CR220","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1182\/blood.2023021149","volume":"143","author":"H Zelaya","year":"2024","unstructured":"Zelaya, H. et al. Nucleic acid sensing promotes inflammatory monocyte migration through biased coagulation factor VIIa signaling. Blood 143, 845\u2013857 (2024).","journal-title":"Blood"},{"key":"2782_CR221","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1038\/s41423-020-00630-3","volume":"18","author":"D Bertheloot","year":"2021","unstructured":"Bertheloot, D., Latz, E. & Franklin, B. S. Necroptosis, pyroptosis and apoptosis: an intricate game of cell death. Cell Mol. Immunol. 18, 1106\u20131121 (2021).","journal-title":"Cell Mol. Immunol."},{"key":"2782_CR222","doi-asserted-by":"publisher","first-page":"2748","DOI":"10.4049\/jimmunol.1701492","volume":"200","author":"M Brault","year":"2018","unstructured":"Brault, M. et al. Intracellular nucleic acid sensing triggers necroptosis through synergistic type I IFN and TNF signaling. J. Immunol. 200, 2748\u20132756 (2018).","journal-title":"J. Immunol."},{"key":"2782_CR223","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1126\/science.abg5251","volume":"376","author":"F Yuan","year":"2022","unstructured":"Yuan, F. et al. Z-DNA binding protein 1 promotes heatstroke-induced cell death. Science 376, 609\u2013615 (2022).","journal-title":"Science"},{"key":"2782_CR224","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.tcb.2016.01.006","volume":"26","author":"N Peltzer","year":"2016","unstructured":"Peltzer, N., Darding, M. & Walczak, H. Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling. Trends Cell Biol. 26, 445\u2013461 (2016).","journal-title":"Trends Cell Biol."},{"key":"2782_CR225","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.neo.2021.03.003","volume":"23","author":"A Koch","year":"2021","unstructured":"Koch, A. et al. Smac mimetics and TRAIL cooperate to induce MLKL-dependent necroptosis in Burkitt\u2019s lymphoma cell lines. Neoplasia 23, 539\u2013550 (2021).","journal-title":"Neoplasia"},{"key":"2782_CR226","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aay7066","volume":"13","author":"K Moriwaki","year":"2020","unstructured":"Moriwaki, K., Balaji, S. & Ka-Ming Chan, F. The death-inducing activity of RIPK1 is regulated by the pH environment. Sci. Signal 13, eaay7066 (2020).","journal-title":"Sci. Signal"},{"key":"2782_CR227","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.tips.2020.01.002","volume":"41","author":"S Martens","year":"2020","unstructured":"Martens, S. et al. Inhibitors Targeting RIPK1\/RIPK3: Old and New Drugs. Trends Pharm. Sci. 41, 209\u2013224 (2020).","journal-title":"Trends Pharm. Sci."},{"key":"2782_CR228","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.99692","volume":"3","author":"KC Ma","year":"2018","unstructured":"Ma, K. C. et al. Circulating RIPK3 levels are associated with mortality and organ failure during critical illness. JCI Insight 3, e99692 (2018).","journal-title":"JCI Insight"},{"key":"2782_CR229","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/s41418-024-01279-5","volume":"31","author":"K Lai","year":"2024","unstructured":"Lai, K. et al. Sensing of mitochondrial DNA by ZBP1 promotes RIPK3-mediated necroptosis and ferroptosis in response to diquat poisoning. Cell Death Differ. 31, 635\u2013650 (2024).","journal-title":"Cell Death Differ."},{"key":"2782_CR230","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/nm.4017","volume":"22","author":"T Zhang","year":"2016","unstructured":"Zhang, T. et al. CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis. Nat. Med. 22, 175\u2013182 (2016).","journal-title":"Nat. Med."},{"key":"2782_CR231","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.immuni.2019.01.007","volume":"50","author":"X Li","year":"2019","unstructured":"Li, X. et al. O-GlcNAc transferase suppresses inflammation and necroptosis by targeting receptor-interacting serine\/threonine-protein kinase 3. Immunity 50, 576\u2013590.e576 (2019).","journal-title":"Immunity"},{"key":"2782_CR232","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-02770-w","volume":"11","author":"Y Zhang","year":"2020","unstructured":"Zhang, Y. et al. Catalytically inactive RIP1 and RIP3 deficiency protect against acute ischemic stroke by inhibiting necroptosis and neuroinflammation. Cell Death Dis. 11, 565 (2020).","journal-title":"Cell Death Dis."},{"key":"2782_CR233","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0936-8","volume":"9","author":"H Chen","year":"2018","unstructured":"Chen, H. et al. RIPK3-MLKL-mediated necroinflammation contributes to AKI progression to CKD. Cell Death Dis. 9, 878 (2018).","journal-title":"Cell Death Dis."},{"key":"2782_CR234","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.kint.2022.12.023","volume":"103","author":"D Yang","year":"2023","unstructured":"Yang, D. et al. Downregulation of G protein-coupled receptor kinase 4 protects against kidney ischemia-reperfusion injury. Kidney Int. 103, 719\u2013734 (2023).","journal-title":"Kidney Int."},{"key":"2782_CR235","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175037","volume":"926","author":"F He","year":"2022","unstructured":"He, F. et al. Necrosulfonamide improves post-resuscitation myocardial dysfunction via inhibiting pyroptosis and necroptosis in a rat model of cardiac arrest. Eur. J. Pharm. 926, 175037 (2022).","journal-title":"Eur. J. Pharm."},{"key":"2782_CR236","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1016\/j.kint.2018.11.043","volume":"95","author":"H Fu","year":"2019","unstructured":"Fu, H. et al. Matrix metalloproteinase-7 protects against acute kidney injury by priming renal tubules for survival and regeneration. Kidney Int. 95, 1167\u20131180 (2019).","journal-title":"Kidney Int."},{"key":"2782_CR237","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1053\/gast.2002.30304","volume":"122","author":"HA Rudiger","year":"2002","unstructured":"Rudiger, H. A. & Clavien, P. A. Tumor necrosis factor alpha, but not Fas, mediates hepatocellular apoptosis in the murine ischemic liver. Gastroenterology 122, 202\u2013210 (2002).","journal-title":"Gastroenterology"},{"key":"2782_CR238","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1046\/j.1523-1755.2003.00709.x","volume":"63","author":"K Tsuruya","year":"2003","unstructured":"Tsuruya, K. et al. Direct involvement of the receptor-mediated apoptotic pathways in cisplatin-induced renal tubular cell death. Kidney Int. 63, 72\u201382 (2003).","journal-title":"Kidney Int."},{"key":"2782_CR239","doi-asserted-by":"publisher","first-page":"5056","DOI":"10.1172\/JCI97912","volume":"128","author":"M Armacki","year":"2018","unstructured":"Armacki, M. et al. Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure. J. Clin. Investig. 128, 5056\u20135072 (2018).","journal-title":"J. Clin. Investig."},{"key":"2782_CR240","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/s41418-022-01091-z","volume":"30","author":"MM Diaz","year":"2023","unstructured":"Diaz, M. M. et al. DCC\/netrin-1 regulates cell death in oligodendrocytes after brain injury. Cell Death Differ. 30, 397\u2013406 (2023).","journal-title":"Cell Death Differ."},{"key":"2782_CR241","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1152\/physrev.00058.2021","volume":"103","author":"JS Harrington","year":"2023","unstructured":"Harrington, J. S. et al. Mitochondria in health, disease, and aging. Physiol. Rev. 103, 2349\u20132422 (2023).","journal-title":"Physiol. Rev."},{"key":"2782_CR242","doi-asserted-by":"publisher","first-page":"998","DOI":"10.3390\/biom10070998","volume":"10","author":"M Bonora","year":"2020","unstructured":"Bonora, M. et al. Physiopathology of the permeability transition pore: molecular mechanisms in human pathology. Biomolecules 10, 998\u20131023 (2020).","journal-title":"Biomolecules"},{"key":"2782_CR243","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.7150\/thno.92650","volume":"14","author":"R Zou","year":"2024","unstructured":"Zou, R. et al. The DNA-dependent protein kinase catalytic subunit exacerbates endotoxemia-induced myocardial microvascular injury by disrupting the MOTS-c\/JNK pathway and inducing profilin-mediated lamellipodia degradation. Theranostics 14, 1561\u20131582 (2024).","journal-title":"Theranostics"},{"key":"2782_CR244","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154283","volume":"104","author":"H Zhu","year":"2022","unstructured":"Zhu, H. et al. Tetrahydrocurcumin improves lipopolysaccharide-induced myocardial dysfunction by inhibiting oxidative stress and inflammation via JNK\/ERK signaling pathway regulation. Phytomedicine 104, 154283 (2022).","journal-title":"Phytomedicine"},{"key":"2782_CR245","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1038\/s41401-020-00597-x","volume":"42","author":"SN Chen","year":"2021","unstructured":"Chen, S. N. et al. Deletion of TLR4 attenuates lipopolysaccharide-induced acute liver injury by inhibiting inflammation and apoptosis. Acta Pharm. Sin. 42, 1610\u20131619 (2021).","journal-title":"Acta Pharm. Sin."},{"key":"2782_CR246","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jhazmat.2016.05.063","volume":"317","author":"H Kuang","year":"2016","unstructured":"Kuang, H. et al. Size dependent effect of ZnO nanoparticles on endoplasmic reticulum stress signaling pathway in murine liver. J. Hazard Mater. 317, 119\u2013126 (2016).","journal-title":"J. Hazard Mater."},{"key":"2782_CR247","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/cdd.2015.101","volume":"23","author":"L Gomez","year":"2016","unstructured":"Gomez, L. et al. The SR\/ER-mitochondria calcium crosstalk is regulated by GSK3beta during reperfusion injury. Cell Death Differ. 23, 313\u2013322 (2016).","journal-title":"Cell Death Differ."},{"key":"2782_CR248","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.jare.2021.01.016","volume":"33","author":"B Pan","year":"2021","unstructured":"Pan, B. et al. Longxuetongluo Capsule protects against cerebral ischemia\/reperfusion injury through endoplasmic reticulum stress and MAPK-mediated mechanisms. J. Adv. Res 33, 215\u2013225 (2021).","journal-title":"J. Adv. Res"},{"key":"2782_CR249","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/j.jare.2025.07.009","volume":"82","author":"M Jin","year":"2026","unstructured":"Jin, M. et al. Endothelial cells secrete small extracellular vesicles to promote neuron endoplasmic reticulum stress injury via miR-146a-5p\/Eif4g2 axis in ischemic stroke. J. Adv. Res. 82, 1099\u20131114 (2026).","journal-title":"J. Adv. Res."},{"key":"2782_CR250","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1136\/gutjnl-2014-308506","volume":"65","author":"CY Han","year":"2016","unstructured":"Han, C. Y. et al. PHLDA3 overexpression in hepatocytes by endoplasmic reticulum stress via IRE1-Xbp1s pathway expedites liver injury. Gut 65, 1377\u20131388 (2016).","journal-title":"Gut"},{"key":"2782_CR251","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02142-4","volume":"23","author":"S Huang","year":"2024","unstructured":"Huang, S. et al. Anti irradiation nanoparticles shelter immune organ from radio-damage via preventing the IKK\/IkappaB\/NF-kappaB activation. Mol. Cancer 23, 234 (2024).","journal-title":"Mol. Cancer"},{"key":"2782_CR252","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1084\/jem.20172024","volume":"215","author":"A Kimura","year":"2018","unstructured":"Kimura, A. et al. NQO1 inhibits the TLR-dependent production of selective cytokines by promoting IkappaB-zeta degradation. J. Exp. Med. 215, 2197\u20132209 (2018).","journal-title":"J. Exp. Med."},{"key":"2782_CR253","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-06504-0","volume":"15","author":"X Zhao","year":"2024","unstructured":"Zhao, X. et al. HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia\/reperfusion. Cell Death Dis. 15, 154 (2024).","journal-title":"Cell Death Dis."},{"key":"2782_CR254","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02392-3","volume":"19","author":"T Lu","year":"2022","unstructured":"Lu, T. et al. Neuroprotective effects of alisol A 24-acetate on cerebral ischaemia-reperfusion injury are mediated by regulating the PI3K\/AKT pathway. J. Neuroinflamm. 19, 37 (2022).","journal-title":"J. Neuroinflamm."},{"key":"2782_CR255","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/ki.2014.226","volume":"87","author":"J Peng","year":"2015","unstructured":"Peng, J. et al. Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in the susceptibility of diabetic models to ischemic acute kidney injury. Kidney Int. 87, 137\u2013150 (2015).","journal-title":"Kidney Int."},{"key":"2782_CR256","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.1681\/ASN.2013080902","volume":"25","author":"D Zhang","year":"2014","unstructured":"Zhang, D. et al. Tubular p53 regulates multiple genes to mediate AKI. J. Am. Soc. Nephrol. 25, 2278\u20132289 (2014).","journal-title":"J. Am. Soc. Nephrol."},{"key":"2782_CR257","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/s41418-022-01089-7","volume":"30","author":"D Wang","year":"2023","unstructured":"Wang, D. et al. SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1. Cell Death Differ. 30, 369\u2013382 (2023).","journal-title":"Cell Death Differ."},{"key":"2782_CR258","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28718-6","volume":"13","author":"S Van Coillie","year":"2022","unstructured":"Van Coillie, S. et al. Targeting ferroptosis protects against experimental (multi)organ dysfunction and death. Nat. Commun. 13, 1046 (2022).","journal-title":"Nat. Commun."},{"key":"2782_CR259","doi-asserted-by":"publisher","first-page":"1951340","DOI":"10.1183\/13993003.01340-2019","volume":"55","author":"MK Ali","year":"2020","unstructured":"Ali, M. K. et al. Crucial role for lung iron level and regulation in the pathogenesis and severity of asthma. Eur. Respir. J. 55, 1951340 (2020).","journal-title":"Eur. Respir. J."},{"key":"2782_CR260","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1161\/CIRCULATIONAHA.123.066110","volume":"149","author":"F Zhang","year":"2024","unstructured":"Zhang, F. et al. Ganglioside GM3 protects against abdominal aortic aneurysm by suppressing ferroptosis. Circulation 149, 843\u2013859 (2024).","journal-title":"Circulation"},{"key":"2782_CR261","doi-asserted-by":"publisher","first-page":"2062","DOI":"10.1080\/15548627.2023.2170960","volume":"19","author":"H Wu","year":"2023","unstructured":"Wu, H. et al. ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4. Autophagy 19, 2062\u20132077 (2023).","journal-title":"Autophagy"},{"key":"2782_CR262","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1080\/15548627.2025.2504792","volume":"21","author":"S Xue","year":"2025","unstructured":"Xue, S. et al. SENP2-mediated deSUMOylation of NCOA4 protects against ferritinophagy-dependent ferroptosis in myocardial ischemia-reperfusion injury. Autophagy 21, 2367\u20132384 (2025).","journal-title":"Autophagy"},{"key":"2782_CR263","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.freeradbiomed.2023.08.025","volume":"208","author":"L Jin","year":"2023","unstructured":"Jin, L. et al. STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury. Free Radic. Biol. Med. 208, 348\u2013360 (2023).","journal-title":"Free Radic. Biol. Med."},{"key":"2782_CR264","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103353","volume":"78","author":"Y Liu","year":"2024","unstructured":"Liu, Y. et al. Role of Hippo\/ACSL4 axis in ferroptosis-induced pericyte loss and vascular dysfunction in sepsis. Redox Biol. 78, 103353 (2024).","journal-title":"Redox Biol."},{"key":"2782_CR265","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adk1200","volume":"10","author":"Q Huang","year":"2024","unstructured":"Huang, Q. et al. Identification of a targeted ACSL4 inhibitor to treat ferroptosis-related diseases. Sci. Adv. 10, eadk1200 (2024).","journal-title":"Sci. Adv."},{"key":"2782_CR266","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/j.tcb.2023.05.003","volume":"33","author":"LE Pope","year":"2023","unstructured":"Pope, L. E. & Dixon, S. J. Regulation of ferroptosis by lipid metabolism. Trends Cell Biol. 33, 1077\u20131087 (2023).","journal-title":"Trends Cell Biol."},{"key":"2782_CR267","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1038\/s42003-024-07377-x","volume":"7","author":"Y Ma","year":"2024","unstructured":"Ma, Y. et al. Chemerin attenuates acute kidney injury by inhibiting ferroptosis via the AMPK\/NRF2\/SLC7A11 axis. Commun. Biol. 7, 1679 (2024).","journal-title":"Commun. Biol."},{"key":"2782_CR268","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.3390\/antiox12061173","volume":"12","author":"F Zhang","year":"2023","unstructured":"Zhang, F. et al. Melatonin alleviates retinal ischemia-reperfusion injury by inhibiting p53-mediated ferroptosis. Antioxidants 12, 1173 (2023).","journal-title":"Antioxidants"},{"key":"2782_CR269","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","volume":"575","author":"K Bersuker","year":"2019","unstructured":"Bersuker, K. et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature 575, 688\u2013692 (2019).","journal-title":"Nature"},{"key":"2782_CR270","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","volume":"575","author":"S Doll","year":"2019","unstructured":"Doll, S. et al. FSP1 is a glutathione-independent ferroptosis suppressor. Nature 575, 693\u2013698 (2019).","journal-title":"Nature"},{"key":"2782_CR271","doi-asserted-by":"publisher","first-page":"4223","DOI":"10.7150\/ijbs.82287","volume":"19","author":"Z Qi","year":"2023","unstructured":"Qi, Z. et al. microRNA-130b-3p attenuates septic cardiomyopathy by regulating the AMPK\/mTOR signaling pathways and directly targeting ACSL4 against ferroptosis. Int. J. Biol. Sci. 19, 4223\u20134241 (2023).","journal-title":"Int. J. Biol. Sci."},{"key":"2782_CR272","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103417","volume":"78","author":"Q Zheng","year":"2024","unstructured":"Zheng, Q. et al. PRDM16 suppresses ferroptosis to protect against sepsis-associated acute kidney injury by targeting the NRF2\/GPX4 axis. Redox Biol. 78, 103417 (2024).","journal-title":"Redox Biol."},{"key":"2782_CR273","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2024.2430929","volume":"29","author":"J Huang","year":"2024","unstructured":"Huang, J. et al. Dexmedetomidine inhibits ferroptosis and attenuates sepsis-induced acute kidney injury via activating the Nrf2\/SLC7A11\/FSP1\/CoQ10 pathway. Redox Rep. 29, 2430929 (2024).","journal-title":"Redox Rep."},{"key":"2782_CR274","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202400441","volume":"13","author":"W Xin","year":"2024","unstructured":"Xin, W. et al. Self-assembling P38 peptide inhibitor nanoparticles ameliorate the transition from acute to chronic kidney disease by suppressing ferroptosis. Adv. Health. Mater. 13, e2400441 (2024).","journal-title":"Adv. Health. Mater."},{"key":"2782_CR275","doi-asserted-by":"publisher","first-page":"5290","DOI":"10.1002\/ptr.8315","volume":"38","author":"Y Jin","year":"2024","unstructured":"Jin, Y. et al. Oroxylin A alleviates myocardial ischemia-reperfusion injury by quelling ferroptosis via activating the DUSP10\/MAPK-Nrf2 pathway. Phytother. Res. 38, 5290\u20135308 (2024).","journal-title":"Phytother. Res."},{"key":"2782_CR276","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155989","volume":"134","author":"G Shu","year":"2024","unstructured":"Shu, G. et al. Galangin alleviated Doxorubicin-induced cardiotoxicity by inhibiting ferroptosis through GSTP1\/JNK pathway. Phytomedicine 134, 155989 (2024).","journal-title":"Phytomedicine"},{"key":"2782_CR277","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1016\/j.jcmgh.2022.02.009","volume":"13","author":"S Huang","year":"2022","unstructured":"Huang, S. et al. Hepatic TGFbetar1 deficiency attenuates lipopolysaccharide\/D-galactosamine-induced acute liver failure through inhibiting GSK3beta-Nrf2-Mediated Hepatocyte Apoptosis And Ferroptosis. Cell Mol. Gastroenterol. Hepatol. 13, 1649\u20131672 (2022).","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"2782_CR278","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3389\/fimmu.2019.00131","volume":"10","author":"A Zarjou","year":"2019","unstructured":"Zarjou, A. et al. Ferritin light chain confers protection against sepsis-induced inflammation and organ injury. Front. Immunol. 10, 131 (2019).","journal-title":"Front. Immunol."},{"key":"2782_CR279","doi-asserted-by":"publisher","first-page":"3196","DOI":"10.7150\/thno.71029","volume":"12","author":"W Jin","year":"2022","unstructured":"Jin, W. et al. Neuronal STAT3\/HIF-1alpha\/PTRF axis-mediated bioenergetic disturbance exacerbates cerebral ischemia-reperfusion injury via PLA2G4A. Theranostics 12, 3196\u20133216 (2022).","journal-title":"Theranostics"},{"key":"2782_CR280","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/nature18590","volume":"535","author":"J Ding","year":"2016","unstructured":"Ding, J. et al. Pore-forming activity and structural autoinhibition of the gasdermin family. Nature 535, 111\u2013116 (2016).","journal-title":"Nature"},{"key":"2782_CR281","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/nature18629","volume":"535","author":"X Liu","year":"2016","unstructured":"Liu, X. et al. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature 535, 153\u2013158 (2016).","journal-title":"Nature"},{"key":"2782_CR282","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-54826-6","volume":"16","author":"W Xu","year":"2025","unstructured":"Xu, W. et al. Methylcobalamin protects against liver failure via engaging gasdermin E. Nat. Commun. 16, 1233 (2025).","journal-title":"Nat. Commun."},{"key":"2782_CR283","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1142\/S0192415X24500198","volume":"52","author":"W Tian","year":"2024","unstructured":"Tian, W. et al. Astragaloside IV alleviates doxorubicin-induced cardiotoxicity by inhibiting cardiomyocyte pyroptosis through the SIRT1\/NLRP3 pathway. Am. J. Chin. Med. 52, 453\u2013469 (2024).","journal-title":"Am. J. Chin. Med."},{"key":"2782_CR284","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/s41420-022-00859-z","volume":"8","author":"T Li","year":"2022","unstructured":"Li, T. et al. Downregulation of macrophage migration inhibitory factor attenuates NLRP3 inflammasome mediated pyroptosis in sepsis-induced AKI. Cell Death Discov. 8, 61 (2022).","journal-title":"Cell Death Discov."},{"key":"2782_CR285","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153586","volume":"87","author":"X Wang","year":"2021","unstructured":"Wang, X. et al. Luteolin ameliorates LPS-induced acute liver injury by inhibiting TXNIP-NLRP3 inflammasome in mice. Phytomedicine 87, 153586 (2021).","journal-title":"Phytomedicine"},{"key":"2782_CR286","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.781003","volume":"13","author":"X Shi","year":"2022","unstructured":"Shi, X. et al. HSF1 protects sepsis-induced acute lung injury by inhibiting NLRP3 inflammasome activation. Front. Immunol. 13, 781003 (2022).","journal-title":"Front. Immunol."},{"key":"2782_CR287","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.3389\/fphar.2020.01060","volume":"11","author":"J Lin","year":"2020","unstructured":"Lin, J. et al. The rCC16 protein protects against LPS-induced cell apoptosis and inflammatory responses in human lung pneumocytes. Front. Pharm. 11, 1060 (2020).","journal-title":"Front. Pharm."},{"key":"2782_CR288","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.594071","volume":"11","author":"S Chen","year":"2020","unstructured":"Chen, S. et al. Maf1 ameliorates sepsis-associated encephalopathy by suppressing the NF-kB\/NLRP3 inflammasome signaling pathway. Front .Immunol. 11, 594071 (2020).","journal-title":"Front .Immunol."},{"key":"2782_CR289","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.609319","volume":"12","author":"L Chen","year":"2021","unstructured":"Chen, L. et al. JQ1 as a BRD4 inhibitor blocks inflammatory pyroptosis-related acute colon injury induced by LPS. Front .Immunol. 12, 609319 (2021).","journal-title":"Front .Immunol."},{"key":"2782_CR290","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1340405","volume":"15","author":"JR Yaron","year":"2024","unstructured":"Yaron, J. R. et al. Inflammasome modulation with P2X7 inhibitor A438079-loaded dressings for diabetic wound healing. Front. Immunol. 15, 1340405 (2024).","journal-title":"Front. Immunol."},{"key":"2782_CR291","doi-asserted-by":"publisher","first-page":"1405622","DOI":"10.3389\/fimmu.2024.1405622","volume":"15","author":"T Lin","year":"2024","unstructured":"Lin, T., Peng, M., Zhu, Q. & Pan, X. S1PR2 participates in intestinal injury in severe acute pancreatitis by regulating macrophage pyroptosis. Front. Immunol. 15, 1405622 (2024).","journal-title":"Front. Immunol."},{"key":"2782_CR292","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1023-x","volume":"9","author":"Z Zhang","year":"2018","unstructured":"Zhang, Z. et al. Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury. Cell Death Dis. 9, 983 (2018).","journal-title":"Cell Death Dis."},{"key":"2782_CR293","doi-asserted-by":"publisher","first-page":"406","DOI":"10.3389\/fcimb.2019.00406","volume":"9","author":"RKS Malireddi","year":"2019","unstructured":"Malireddi, R. K. S., Kesavardhana, S. & Kanneganti, T. D. ZBP1 and TAK1: master regulators of NLRP3 inflammasome\/pyroptosis, apoptosis, and necroptosis (PAN-optosis). Front. Cell Infect. Microbiol. 9, 406 (2019).","journal-title":"Front. Cell Infect. Microbiol."},{"key":"2782_CR294","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.kint.2021.10.021","volume":"101","author":"S Minami","year":"2022","unstructured":"Minami, S. & Nakamura, S. Therapeutic potential of Beclin1 for transition from AKI to CKD: autophagy-dependent and autophagy-independent functions. Kidney Int. 101, 13\u201315 (2022).","journal-title":"Kidney Int."},{"key":"2782_CR295","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1080\/15548627.2020.1767371","volume":"17","author":"B Mathew","year":"2021","unstructured":"Mathew, B. et al. Autophagy and post-ischemic conditioning in retinal ischemia. Autophagy 17, 1479\u20131499 (2021).","journal-title":"Autophagy"},{"key":"2782_CR296","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1161\/CIRCULATIONAHA.117.032821","volume":"138","author":"Y Sun","year":"2018","unstructured":"Sun, Y. et al. Beclin-1-dependent autophagy protects the heart during sepsis. Circulation 138, 2247\u20132262 (2018).","journal-title":"Circulation"},{"key":"2782_CR297","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1080\/15548627.2016.1203483","volume":"12","author":"J Wang","year":"2016","unstructured":"Wang, J. et al. Role for DUSP1 (dual-specificity protein phosphatase 1) in the regulation of autophagy. Autophagy 12, 1791\u20131803 (2016).","journal-title":"Autophagy"},{"key":"2782_CR298","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1172\/JCI97712","volume":"129","author":"W Wang","year":"2019","unstructured":"Wang, W. et al. MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT\/mTOR signaling. J. Clin. Investig. 129, 1015\u20131029 (2019).","journal-title":"J. Clin. Investig."},{"key":"2782_CR299","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2025.109285","volume":"196","author":"W Zhang","year":"2025","unstructured":"Zhang, W. et al. Activation of autophagy with PF-06409577 alleviates heatstroke-induced organ injury. Environ. Int. 196, 109285 (2025).","journal-title":"Environ. Int."},{"key":"2782_CR300","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1080\/15548627.2023.2281156","volume":"20","author":"MJ Livingston","year":"2024","unstructured":"Livingston, M. J. et al. Autophagy activates EGR1 via MAPK\/ERK to induce FGF2 in renal tubular cells for fibroblast activation and fibrosis during maladaptive kidney repair. Autophagy 20, 1032\u20131053 (2024).","journal-title":"Autophagy"},{"key":"2782_CR301","doi-asserted-by":"publisher","first-page":"736","DOI":"10.7150\/thno.79876","volume":"13","author":"Y Lu","year":"2023","unstructured":"Lu, Y. et al. Cellular mitophagy: mechanism, roles in diseases and small molecule pharmacological regulation. Theranostics 13, 736\u2013766 (2023).","journal-title":"Theranostics"},{"key":"2782_CR302","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/s41392-023-01503-7","volume":"8","author":"S Wang","year":"2023","unstructured":"Wang, S. et al. The mitophagy pathway and its implications in human diseases. Signal Transduct. Target Ther. 8, 304 (2023).","journal-title":"Signal Transduct. Target Ther."},{"key":"2782_CR303","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101767","volume":"38","author":"Y Wang","year":"2021","unstructured":"Wang, Y. et al. The PINK1\/PARK2\/optineurin pathway of mitophagy is activated for protection in septic acute kidney injury. Redox Biol. 38, 101767 (2021).","journal-title":"Redox Biol."},{"key":"2782_CR304","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102305","volume":"52","author":"Z Liu","year":"2022","unstructured":"Liu, Z. et al. XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury. Redox Biol. 52, 102305 (2022).","journal-title":"Redox Biol."},{"key":"2782_CR305","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jcmgh.2023.09.004","volume":"17","author":"Y Zhang","year":"2024","unstructured":"Zhang, Y. et al. Blockade of hepatocyte PCSK9 ameliorates hepatic ischemia-reperfusion injury by promoting Pink1-parkin-mediated mitophagy. Cell Mol. Gastroenterol. Hepatol. 17, 149\u2013169 (2024).","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"2782_CR306","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103511","volume":"80","author":"XT Li","year":"2025","unstructured":"Li, X. T. et al. The UCP2\/PINK1\/LC3b-mediated mitophagy is involved in the protection of NRG1 against myocardial ischemia\/reperfusion injury. Redox Biol. 80, 103511 (2025).","journal-title":"Redox Biol."},{"key":"2782_CR307","doi-asserted-by":"publisher","first-page":"2975","DOI":"10.1080\/15548627.2020.1848971","volume":"17","author":"Q Lin","year":"2021","unstructured":"Lin, Q. et al. Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy. Autophagy 17, 2975\u20132990 (2021).","journal-title":"Autophagy"},{"key":"2782_CR308","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1080\/15548627.2017.1357792","volume":"13","author":"Y Yuan","year":"2017","unstructured":"Yuan, Y. et al. BNIP3L\/NIX-mediated mitophagy protects against ischemic brain injury independent of PARK2. Autophagy 13, 1754\u20131766 (2017).","journal-title":"Autophagy"},{"key":"2782_CR309","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1080\/15548627.2024.2395799","volume":"21","author":"TL Lee","year":"2025","unstructured":"Lee, T. L. et al. Mir221- and Mir222-enriched adsc-exosomes mitigate PM exposure-exacerbated cardiac ischemia-reperfusion injury through the modulation of the BNIP3-MAP1LC3B-BBC3\/PUMA pathway. Autophagy 21, 374\u2013393 (2025).","journal-title":"Autophagy"},{"key":"2782_CR310","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1080\/15548627.2024.2414386","volume":"21","author":"DS Sankar","year":"2025","unstructured":"Sankar, D. S. & Dengjel, J. Interactors and neighbors of ULK1 complex members. Autophagy 21, 243\u2013245 (2025).","journal-title":"Autophagy"},{"key":"2782_CR311","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.kint.2021.10.028","volume":"101","author":"H Ma","year":"2022","unstructured":"Ma, H. et al. Dephosphorylation of AMP-activated protein kinase exacerbates ischemia\/reperfusion-induced acute kidney injury via mitochondrial dysfunction. Kidney Int. 101, 315\u2013330 (2022).","journal-title":"Kidney Int."},{"key":"2782_CR312","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102288","volume":"52","author":"C Cai","year":"2022","unstructured":"Cai, C. et al. Empagliflozin attenuates cardiac microvascular ischemia\/reperfusion through activating the AMPKalpha1\/ULK1\/FUNDC1\/mitophagy pathway. Redox Biol. 52, 102288 (2022).","journal-title":"Redox Biol."},{"key":"2782_CR313","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1126\/science.abf0529","volume":"375","author":"P Tsvetkov","year":"2022","unstructured":"Tsvetkov, P. et al. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science 375, 1254\u20131261 (2022).","journal-title":"Science"},{"key":"2782_CR314","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2024.110943","volume":"393","author":"Z Qiu","year":"2024","unstructured":"Qiu, Z. et al. The copper transporter, SLC31A1, transcriptionally activated by ELF3, imbalances copper homeostasis to exacerbate cisplatin-induced acute kidney injury through mitochondrial dysfunction. Chem. Biol. Interact. 393, 110943 (2024).","journal-title":"Chem. Biol. Interact."},{"key":"2782_CR315","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48227-y","volume":"15","author":"N Chen","year":"2024","unstructured":"Chen, N. et al. Sleep fragmentation exacerbates myocardial ischemia\u2012reperfusion injury by promoting copper overload in cardiomyocytes. Nat. Commun. 15, 3834 (2024).","journal-title":"Nat. Commun."},{"key":"2782_CR316","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2022.100510","volume":"4","author":"PR Angelova","year":"2022","unstructured":"Angelova, P. R. et al. Hyperammonaemia induces mitochondrial dysfunction and neuronal cell death. JHEP Rep. 4, 100510 (2022).","journal-title":"JHEP Rep."},{"key":"2782_CR317","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.169036","volume":"912","author":"B Chen","year":"2024","unstructured":"Chen, B. et al. Inhalation of ammonia promotes apoptosis and induces autophagy in hepatocytes via Bax\/BCl-2 and m-TOR\/ATG5\/LC-3bII axes. Sci. Total Environ. 912, 169036 (2024).","journal-title":"Sci. Total Environ."},{"key":"2782_CR318","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1038\/s41556-024-01503-x","volume":"26","author":"H Zhang","year":"2024","unstructured":"Zhang, H. et al. Ammonia-induced lysosomal and mitochondrial damage causes cell death of effector CD8(+) T cells. Nat. Cell Biol. 26, 1892\u20131902 (2024).","journal-title":"Nat. Cell Biol."},{"key":"2782_CR319","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1016\/j.apsb.2021.02.006","volume":"11","author":"BE Burdette","year":"2021","unstructured":"Burdette, B. E., Esparza, A. N., Zhu, H. & Wang, S. Gasdermin D in pyroptosis. Acta Pharm. Sin. B 11, 2768\u20132782 (2021).","journal-title":"Acta Pharm. Sin. B"},{"key":"2782_CR320","doi-asserted-by":"publisher","first-page":"3084","DOI":"10.1016\/j.ymthe.2023.07.026","volume":"31","author":"L Gao","year":"2023","unstructured":"Gao, L. et al. STING\/ACSL4 axis-dependent ferroptosis and inflammation promote hypertension-associated chronic kidney disease. Mol. Ther. 31, 3084\u20133103 (2023).","journal-title":"Mol. Ther."},{"key":"2782_CR321","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1038\/s41423-024-01222-1","volume":"21","author":"YJ Kim","year":"2024","unstructured":"Kim, Y. J. et al. Ubiquitin regulatory X (UBX) domain-containing protein 6 is essential for autophagy induction and inflammation control in macrophages. Cell Mol. Immunol. 21, 1441\u20131458 (2024).","journal-title":"Cell Mol. Immunol."},{"key":"2782_CR322","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03961-9","volume":"12","author":"Q Liu","year":"2021","unstructured":"Liu, Q. et al. Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury. Cell Death Dis. 12, 673 (2021).","journal-title":"Cell Death Dis."},{"key":"2782_CR323","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.1038\/s41418-020-0528-x","volume":"27","author":"Y Li","year":"2020","unstructured":"Li, Y. et al. Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia\/reperfusion-induced acute lung injury. Cell Death Differ. 27, 2635\u20132650 (2020).","journal-title":"Cell Death Differ."},{"key":"2782_CR324","doi-asserted-by":"publisher","first-page":"861","DOI":"10.7150\/thno.48436","volume":"11","author":"Y Cheng","year":"2021","unstructured":"Cheng, Y. et al. Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury. Theranostics 11, 861\u2013877 (2021).","journal-title":"Theranostics"},{"key":"2782_CR325","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202410410","volume":"12","author":"Q Xia","year":"2025","unstructured":"Xia, Q. et al. SENP6-Mediated deSUMOylation of Nrf2 exacerbates neuronal oxidative stress following cerebral ischemia and reperfusion injury. Adv. Sci. 12, e2410410 (2025).","journal-title":"Adv. Sci."},{"key":"2782_CR326","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103406","volume":"77","author":"X Lan","year":"2024","unstructured":"Lan, X. et al. Isoliquiritigenin alleviates cerebral ischemia-reperfusion injury by reducing oxidative stress and ameliorating mitochondrial dysfunction via activating the Nrf2 pathway. Redox Biol. 77, 103406 (2024).","journal-title":"Redox Biol."},{"key":"2782_CR327","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101215","volume":"24","author":"N Li","year":"2019","unstructured":"Li, N. et al. STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3. Redox Biol. 24, 101215 (2019).","journal-title":"Redox Biol."},{"key":"2782_CR328","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154922","volume":"117","author":"G Fang","year":"2023","unstructured":"Fang, G. et al. Amentoflavone mitigates doxorubicin-induced cardiotoxicity by suppressing cardiomyocyte pyroptosis and inflammation through inhibition of the STING\/NLRP3 signalling pathway. Phytomedicine 117, 154922 (2023).","journal-title":"Phytomedicine"},{"key":"2782_CR329","doi-asserted-by":"publisher","first-page":"4959","DOI":"10.1073\/pnas.1916427117","volume":"117","author":"MG Naito","year":"2020","unstructured":"Naito, M. G. et al. Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke. Proc. Natl. Acad. Sci. USA 117, 4959\u20134970 (2020).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2782_CR330","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1080\/15548627.2022.2084862","volume":"19","author":"L Su","year":"2023","unstructured":"Su, L. et al. Mitochondria ROS and mitophagy in acute kidney injury. Autophagy 19, 401\u2013414 (2023).","journal-title":"Autophagy"},{"key":"2782_CR331","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05191-z","volume":"13","author":"KTK Giuliani","year":"2022","unstructured":"Giuliani, K. T. K. et al. Hypoxic human proximal tubular epithelial cells undergo ferroptosis and elicit an NLRP3 inflammasome response in CD1c(+) dendritic cells. Cell Death Dis. 13, 739 (2022).","journal-title":"Cell Death Dis."},{"key":"2782_CR332","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03362-4","volume":"12","author":"C Chen","year":"2021","unstructured":"Chen, C. et al. Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI. Cell Death Dis. 12, 65 (2021).","journal-title":"Cell Death Dis."},{"key":"2782_CR333","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.1073\/pnas.1819728116","volume":"116","author":"Z Wu","year":"2019","unstructured":"Wu, Z. et al. Chaperone-mediated autophagy is involved in the execution of ferroptosis. Proc. Natl. Acad. Sci. USA 116, 2996\u20133005 (2019).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2782_CR334","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.cmet.2024.02.013","volume":"36","author":"K Willmann","year":"2024","unstructured":"Willmann, K. & Moita, L. F. Physiologic disruption and metabolic reprogramming in infection and sepsis. Cell Metab. 36, 927\u2013946 (2024).","journal-title":"Cell Metab."},{"key":"2782_CR335","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42659-8","volume":"14","author":"A McNelly","year":"2023","unstructured":"McNelly, A. et al. A pilot study of alternative substrates in the critically Ill subject using a ketogenic feed. Nat. Commun. 14, 8345 (2023).","journal-title":"Nat. Commun."},{"key":"2782_CR336","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1161\/CIRCRESAHA.123.321872","volume":"132","author":"TR Matsuura","year":"2023","unstructured":"Matsuura, T. R., Puchalska, P., Crawford, P. A. & Kelly, D. P. Ketones and the Heart: metabolic principles and therapeutic implications. Circ. Res. 132, 882\u2013898 (2023).","journal-title":"Circ. Res."},{"key":"2782_CR337","doi-asserted-by":"publisher","first-page":"e65","DOI":"10.1161\/CIRCRESAHA.124.325708","volume":"137","author":"TN Zhang","year":"2025","unstructured":"Zhang, T. N. et al. Lactylation of HADHA promotes sepsis-induced myocardial depression. Circ. Res 137, e65\u2013e87 (2025).","journal-title":"Circ. Res"},{"key":"2782_CR338","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70344","volume":"6","author":"X Liu","year":"2025","unstructured":"Liu, X. et al. Global lactylome reveals lactylation-dependent mechanisms underlying CXC motif chemokine ligand 12 expression in pulmonary endothelium during acute respiratory distress syndrome. MedComm 6, e70344 (2025).","journal-title":"MedComm"},{"key":"2782_CR339","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202411943","volume":"12","author":"J Li","year":"2025","unstructured":"Li, J. et al. Aldehyde dehydrogenase 2 lactylation aggravates mitochondrial dysfunction by disrupting PHB2 mediated mitophagy in acute kidney injury. Adv. Sci. 12, e2411943 (2025).","journal-title":"Adv. Sci."},{"key":"2782_CR340","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102755","volume":"63","author":"M Semenzato","year":"2023","unstructured":"Semenzato, M. et al. Oxidization of optic atrophy 1 cysteines occurs during heart ischemia-reperfusion and amplifies cell death by oxidative stress. Redox Biol. 63, 102755 (2023).","journal-title":"Redox Biol."},{"key":"2782_CR341","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103047","volume":"70","author":"C Tabata Fukushima","year":"2024","unstructured":"Tabata Fukushima, C. et al. Reactive oxygen species generation by reverse electron transfer at mitochondrial complex I under simulated early reperfusion conditions. Redox Biol. 70, 103047 (2024).","journal-title":"Redox Biol."},{"key":"2782_CR342","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103660","volume":"83","author":"Y Ju","year":"2025","unstructured":"Ju, Y. et al. Protein S-glutathionylation confers cellular resistance to ferroptosis induced by glutathione depletion. Redox Biol. 83, 103660 (2025).","journal-title":"Redox Biol."},{"key":"2782_CR343","doi-asserted-by":"publisher","first-page":"609","DOI":"10.3389\/fimmu.2017.00609","volume":"8","author":"N Raulien","year":"2017","unstructured":"Raulien, N. et al. Fatty acid oxidation compensates for lipopolysaccharide-induced warburg effect in glucose-deprived monocytes. Front. Immunol. 8, 609 (2017).","journal-title":"Front. Immunol."},{"key":"2782_CR344","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155353","volume":"125","author":"P Guo","year":"2024","unstructured":"Guo, P. et al. Isolation of Calenduloside E from Achyranthes bidentata Blume and its effects on LPS\/D-GalN-induced acute liver injury in mice by regulating the AMPK-SIRT3 signaling pathway. Phytomedicine 125, 155353 (2024).","journal-title":"Phytomedicine"},{"key":"2782_CR345","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02818-6","volume":"20","author":"L Wang","year":"2023","unstructured":"Wang, L. et al. Microglia-derived TNF-alpha contributes to RVLM neuronal mitochondrial dysfunction via blocking the AMPK-Sirt3 pathway in stress-induced hypertension. J. Neuroinflamm. 20, 137 (2023).","journal-title":"J. Neuroinflamm."},{"key":"2782_CR346","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1038\/s41374-018-0176-7","volume":"99","author":"Z Liu","year":"2019","unstructured":"Liu, Z. et al. STC-1 ameliorates renal injury in diabetic nephropathy by inhibiting the expression of BNIP3 through the AMPK\/SIRT3 pathway. Lab Investig. 99, 684\u2013697 (2019).","journal-title":"Lab Investig."},{"key":"2782_CR347","doi-asserted-by":"publisher","first-page":"4637","DOI":"10.7150\/thno.56082","volume":"11","author":"W Xiong","year":"2021","unstructured":"Xiong, W. et al. Relieving lipid accumulation through UCP1 suppresses the progression of acute kidney injury by promoting the AMPK\/ULK1\/autophagy pathway. Theranostics 11, 4637\u20134654 (2021).","journal-title":"Theranostics"},{"key":"2782_CR348","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1126\/science.abn1725","volume":"380","author":"T Zhang","year":"2023","unstructured":"Zhang, T. et al. Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. Science 380, 1372\u20131380 (2023).","journal-title":"Science"},{"key":"2782_CR349","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04745-7","volume":"27","author":"JM Wider","year":"2023","unstructured":"Wider, J. M. et al. Modulation of mitochondrial function with near-infrared light reduces brain injury in a translational model of cardiac arrest. Crit. Care 27, 491 (2023).","journal-title":"Crit. Care"},{"key":"2782_CR350","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70297","volume":"31","author":"D Li","year":"2025","unstructured":"Li, D. et al. Exploring the therapeutic mechanism of Xinbao Pill in brain injury after cardiopulmonary resuscitation based on network pharmacology, metabolomics, and experimental verification. CNS Neurosci. Ther. 31, e70297 (2025).","journal-title":"CNS Neurosci. Ther."},{"key":"2782_CR351","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1093\/cvr\/cvae252","volume":"121","author":"AM Darwesh","year":"2025","unstructured":"Darwesh, A. M. et al. Cardioprotective effect of 19,20-epoxydocosapentaenoic acid (19,20-EDP) in ischaemic injury involves direct activation of mitochondrial sirtuin 3. Cardiovasc. Res. 121, 267\u2013282 (2025).","journal-title":"Cardiovasc. Res."},{"key":"2782_CR352","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102984","volume":"69","author":"M Carlstrom","year":"2024","unstructured":"Carlstrom, M. et al. Dimethyl malonate preserves renal and mitochondrial functions following ischemia-reperfusion via inhibition of succinate dehydrogenase. Redox Biol. 69, 102984 (2024).","journal-title":"Redox Biol."},{"key":"2782_CR353","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.freeradbiomed.2023.09.007","volume":"208","author":"X Yi","year":"2023","unstructured":"Yi, X. et al. LPS induces SGPP2 to participate metabolic reprogramming in endothelial cells. Free Radic. Biol. Med. 208, 780\u2013793 (2023).","journal-title":"Free Radic. Biol. Med."},{"key":"2782_CR354","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05854-5","volume":"14","author":"ZL Li","year":"2023","unstructured":"Li, Z. L. et al. Activation of HIF-1alpha C-terminal transactivation domain protects against hypoxia-induced kidney injury through hexokinase 2-mediated mitophagy. Cell Death Dis. 14, 339 (2023).","journal-title":"Cell Death Dis."},{"key":"2782_CR355","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112880","volume":"141","author":"J Gao","year":"2024","unstructured":"Gao, J. et al. Suppressing nuclear translocation of microglial PKM2 confers neuroprotection via downregulation of neuroinflammation after mouse cerebral ischemia-reperfusion injury. Int Immunopharmacol. 141, 112880 (2024).","journal-title":"Int Immunopharmacol."},{"key":"2782_CR356","doi-asserted-by":"publisher","first-page":"e159400","DOI":"10.1172\/JCI159400","volume":"135","author":"S Ming","year":"2024","unstructured":"Ming, S. et al. TREM2 aggravates sepsis by inhibiting fatty acid oxidation via the SHP1\/BTK axis. J. Clin. Investig. 135, e159400 (2024).","journal-title":"J. Clin. Investig."},{"key":"2782_CR357","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.131021","volume":"449","author":"L Dong","year":"2023","unstructured":"Dong, L. et al. Investigating the adverse outcome pathways (AOP) of neurotoxicity induced by DBDPE with a combination of in vitro and in silico approaches. J. Hazard Mater. 449, 131021 (2023).","journal-title":"J. Hazard Mater."},{"key":"2782_CR358","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.actbio.2021.12.023","volume":"140","author":"J Sun","year":"2022","unstructured":"Sun, J. et al. Targeted delivery of PARP inhibitors to neuronal mitochondria via biomimetic engineered nanosystems in a mouse model of traumatic brain injury. Acta Biomater. 140, 573\u2013585 (2022).","journal-title":"Acta Biomater."},{"key":"2782_CR359","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/nature14156","volume":"520","author":"AP West","year":"2015","unstructured":"West, A. P. et al. Mitochondrial DNA stress primes the antiviral innate immune response. Nature 520, 553\u2013557 (2015).","journal-title":"Nature"},{"key":"2782_CR360","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.cmet.2015.05.019","volume":"21","author":"TD Kanneganti","year":"2015","unstructured":"Kanneganti, T. D., Kundu, M. & Green, D. R. Innate immune recognition of mtDNA-an undercover signal? Cell Metab. 21, 793\u2013794 (2015).","journal-title":"Cell Metab."},{"key":"2782_CR361","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1126\/science.aab3291","volume":"350","author":"L Lau","year":"2015","unstructured":"Lau, L., Gray, E. E., Brunette, R. L. & Stetson, D. B. DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway. Science 350, 568\u2013571 (2015).","journal-title":"Science"},{"key":"2782_CR362","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/nature23449","volume":"548","author":"KJ Mackenzie","year":"2017","unstructured":"Mackenzie, K. J. et al. cGAS surveillance of micronuclei links genome instability to innate immunity. Nature 548, 461\u2013465 (2017).","journal-title":"Nature"},{"key":"2782_CR363","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.228","volume":"10","author":"L Ning","year":"2020","unstructured":"Ning, L. et al. Cytosolic DNA-STING-NLRP3 axis is involved in murine acute lung injury induced by lipopolysaccharide. Clin. Transl. Med. 10, e228 (2020).","journal-title":"Clin. Transl. Med."},{"key":"2782_CR364","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s10020-023-00769-5","volume":"29","author":"H Liu","year":"2023","unstructured":"Liu, H. et al. ALDH2 mitigates LPS-induced cardiac dysfunction, inflammation, and apoptosis through the cGAS\/STING pathway. Mol. Med. 29, 171 (2023).","journal-title":"Mol. Med."},{"key":"2782_CR365","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1093\/cvr\/cvae218","volume":"121","author":"W Zhang","year":"2024","unstructured":"Zhang, W. et al. Double-stranded DNA enhances platelet activation, thrombosis, and myocardial injury via cyclic GMP-AMP synthase. Cardiovasc Res. 121, 353\u2013366 (2024).","journal-title":"Cardiovasc Res."},{"key":"2782_CR366","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20220759","volume":"219","author":"N Kessler","year":"2022","unstructured":"Kessler, N. et al. Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS\/STING\/IFN-mediated nucleic acid sensing. J. Exp. Med. 219, e20220759 (2022).","journal-title":"J. Exp. Med."},{"key":"2782_CR367","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1097\/CCM.0000000000004132","volume":"48","author":"PA Prasad","year":"2020","unstructured":"Prasad, P. A. et al. Time to recognition of sepsis in the emergency department using electronic health record data: a comparative analysis of systemic inflammatory response syndrome, sequential organ failure assessment, and quick sequential organ failure assessment. Crit. Care Med. 48, 200\u2013209 (2020).","journal-title":"Crit. Care Med."},{"key":"2782_CR368","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.jvs.2023.06.011","volume":"78","author":"MS Hafeez","year":"2023","unstructured":"Hafeez, M. S. et al. Characterization of multiple organ failure after ruptured abdominal aortic aneurysm repair. J. Vasc. Surg. 78, 945\u2013953.e943 (2023).","journal-title":"J. Vasc. Surg."},{"key":"2782_CR369","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1097\/CCM.0000000000004774","volume":"49","author":"LN Sanchez-Pinto","year":"2021","unstructured":"Sanchez-Pinto, L. N. et al. Evaluation of organ dysfunction scores for allocation of scarce resources in critically Ill children and adults during a healthcare crisis. Crit. Care Med. 49, 271\u2013281 (2021).","journal-title":"Crit. Care Med."},{"key":"2782_CR370","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-2109-7","volume":"22","author":"Y Maruchi","year":"2018","unstructured":"Maruchi, Y. et al. Plasma myeloperoxidase-conjugated DNA level predicts outcomes and organ dysfunction in patients with septic shock. Crit. Care 22, 176 (2018).","journal-title":"Crit. Care"},{"key":"2782_CR371","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1002\/bjs.10538","volume":"104","author":"T Liu","year":"2017","unstructured":"Liu, T. et al. Accuracy of circulating histones in predicting persistent organ failure and mortality in patients with acute pancreatitis. Br. J. Surg. 104, 1215\u20131225 (2017).","journal-title":"Br. J. Surg."},{"key":"2782_CR372","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1097\/CCM.0000000000002949","volume":"46","author":"L Pruinelli","year":"2018","unstructured":"Pruinelli, L. et al. Delay within the 3-hour surviving sepsis campaign guideline on mortality for patients with severe sepsis and septic shock. Crit. Care Med. 46, 500\u2013505 (2018).","journal-title":"Crit. Care Med."},{"key":"2782_CR373","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.jpeds.2020.12.035","volume":"233","author":"J Sankar","year":"2021","unstructured":"Sankar, J. et al. Delayed Administration Of Antibiotics Beyond The First Hour Of Recognition Is Associated With Increased Mortality Rates In Children With Sepsis\/severe Sepsis And Septic Shock. J. Pediatr. 233, 183\u2013190.e183 (2021).","journal-title":"J. Pediatr."},{"key":"2782_CR374","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.3390\/microorganisms9071401","volume":"9","author":"P Povoa","year":"2021","unstructured":"Povoa, P., Moniz, P., Pereira, J. G. & Coelho, L. Optimizing antimicrobial drug dosing in critically Ill patients. Microorganisms 9, 1401 (2021).","journal-title":"Microorganisms"},{"key":"2782_CR375","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1097\/CCM.0000000000002069","volume":"45","author":"CS Scheer","year":"2017","unstructured":"Scheer, C. S. et al. Quality improvement initiative for severe sepsis and septic shock reduces 90-day mortality: a 7.5-year observational study. Crit. Care Med. 45, 241\u2013252 (2017).","journal-title":"Crit. Care Med."},{"key":"2782_CR376","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1001\/jama.2023.7560","volume":"329","author":"FG Zampieri","year":"2023","unstructured":"Zampieri, F. G., Bagshaw, S. M. & Semler, M. W. Fluid therapy for critically Ill adults with sepsis: a review. JAMA 329, 1967\u20131980 (2023).","journal-title":"JAMA"},{"key":"2782_CR377","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-2819-5","volume":"24","author":"B Hu","year":"2020","unstructured":"Hu, B. et al. Effect of initial infusion rates of fluid resuscitation on outcomes in patients with septic shock: a historical cohort study. Crit. Care 24, 137 (2020).","journal-title":"Crit. Care"},{"key":"2782_CR378","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1097\/CCM.0000000000000223","volume":"42","author":"G Tachon","year":"2014","unstructured":"Tachon, G. et al. Microcirculatory alterations in traumatic hemorrhagic shock. Crit. Care Med. 42, 1433\u20131441 (2014).","journal-title":"Crit. Care Med."},{"key":"2782_CR379","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-2728-7","volume":"24","author":"J Scheuzger","year":"2020","unstructured":"Scheuzger, J. et al. Sublingual microcirculation does not reflect red blood cell transfusion thresholds in the intensive care unit-a prospective observational study in the intensive care unit. Crit. Care 24, 18 (2020).","journal-title":"Crit. Care"},{"key":"2782_CR380","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1097\/CCM.0000000000005851","volume":"51","author":"W Huang","year":"2023","unstructured":"Huang, W. et al. Association of sublingual microcirculation parameters and capillary refill time in the early phase of ICU admission. Crit. Care Med. 51, 913\u2013923 (2023).","journal-title":"Crit. Care Med."},{"key":"2782_CR381","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1164\/rccm.202305-0896OC","volume":"209","author":"G Martucci","year":"2024","unstructured":"Martucci, G. et al. Anticoagulation and bleeding during veno-venous extracorporeal membrane oxygenation: insights from the PROTECMO Study. Am. J. Respir. Crit. Care Med. 209, 417\u2013426 (2024).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2782_CR382","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1056\/NEJMoa1705835","volume":"378","author":"B Venkatesh","year":"2018","unstructured":"Venkatesh, B. et al. Adjunctive glucocorticoid therapy in patients with septic shock. N. Engl. J. Med. 378, 797\u2013808 (2018).","journal-title":"N. Engl. J. Med."},{"key":"2782_CR383","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1007\/s00134-015-3899-6","volume":"41","author":"M Volbeda","year":"2015","unstructured":"Volbeda, M. et al. Glucocorticosteroids for sepsis: systematic review with meta-analysis and trial sequential analysis. Intensive Care Med. 41, 1220\u20131234 (2015).","journal-title":"Intensive Care Med."},{"key":"2782_CR384","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1207-7","volume":"20","author":"X Wan","year":"2016","unstructured":"Wan, X. et al. Ulinastatin administration is associated with a lower incidence of acute kidney injury after cardiac surgery: a propensity score matched study. Crit. Care 20, 42 (2016).","journal-title":"Crit. Care"},{"key":"2782_CR385","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1164\/rccm.202212-2293OC","volume":"208","author":"D Rudym","year":"2023","unstructured":"Rudym, D. et al. Mortality in patients with obesity and acute respiratory distress syndrome receiving extracorporeal membrane oxygenation: the multicenter ECMObesity study. Am. J. Respir. Crit. Care Med. 208, 685\u2013694 (2023).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2782_CR386","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1164\/rccm.202309-1688OC","volume":"210","author":"E Spinelli","year":"2024","unstructured":"Spinelli, E. et al. Physiologic effects of extracorporeal membrane oxygenation in patients with severe acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 210, 629\u2013638 (2024).","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"2782_CR387","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1007\/s00134-024-07564-8","volume":"50","author":"A Burrell","year":"2024","unstructured":"Burrell, A. et al. Conservative or liberal oxygen targets in patients on venoarterial extracorporeal membrane oxygenation. Intensive Care Med. 50, 1470\u20131483 (2024).","journal-title":"Intensive Care Med."},{"key":"2782_CR388","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.32444","volume":"7","author":"MH Bestle","year":"2024","unstructured":"Bestle, M. H. et al. Iloprost and organ dysfunction in adults with septic shock and endotheliopathy: a randomized clinical trial. JAMA Netw. Open 7, e2432444 (2024).","journal-title":"JAMA Netw. Open"},{"key":"2782_CR389","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1097\/SHK.0000000000001978","volume":"58","author":"AC Rydz","year":"2022","unstructured":"Rydz, A. C. et al. Early initiation of vasopressin reduces organ failure and mortality in septic shock. Shock 58, 269\u2013274 (2022).","journal-title":"Shock"},{"key":"2782_CR390","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s00134-017-4935-5","volume":"44","author":"F Depret","year":"2018","unstructured":"Depret, F. et al. Intravenous iloprost to recruit the microcirculation in septic shock patients? Intensive Care Med. 44, 121\u2013122 (2018).","journal-title":"Intensive Care Med."},{"key":"2782_CR391","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1097\/CCM.0b013e318236edb8","volume":"40","author":"AA Igonin","year":"2012","unstructured":"Igonin, A. A. et al. C1-esterase inhibitor infusion increases survival rates for patients with sepsis*. Crit. Care Med. 40, 770\u2013777 (2012).","journal-title":"Crit. Care Med."},{"key":"2782_CR392","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-024-08006-y","volume":"25","author":"Z Kiani","year":"2024","unstructured":"Kiani, Z. et al. Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial. Trials 25, 160 (2024).","journal-title":"Trials"},{"key":"2782_CR393","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1177\/0148607114529994","volume":"39","author":"DK Heyland","year":"2015","unstructured":"Heyland, D. K. et al. Glutamine and antioxidants in the critically ill patient: a post hoc analysis of a large-scale randomized trial. JPEN J. Parenter. Enter. Nutr. 39, 401\u2013409 (2015).","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"2782_CR394","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-021-00417-4","volume":"9","author":"K Stahl","year":"2021","unstructured":"Stahl, K. et al. Effects of therapeutic plasma exchange on the endothelial glycocalyx in septic shock. Intensive Care Med. Exp. 9, 57 (2021).","journal-title":"Intensive Care Med. Exp."},{"key":"2782_CR395","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-2799-5","volume":"24","author":"K Stahl","year":"2020","unstructured":"Stahl, K. et al. Effect of therapeutic plasma exchange on endothelial activation and coagulation-related parameters in septic shock. Crit. Care 24, 71 (2020).","journal-title":"Crit. Care"},{"key":"2782_CR396","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1007\/s00134-020-06339-1","volume":"47","author":"S David","year":"2021","unstructured":"David, S. et al. Adjuvant therapeutic plasma exchange in septic shock. Intensive Care Med. 47, 352\u2013354 (2021).","journal-title":"Intensive Care Med."},{"key":"2782_CR397","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.1001\/jama.2009.856","volume":"301","author":"DN Cruz","year":"2009","unstructured":"Cruz, D. N. et al. Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial. JAMA 301, 2445\u20132452 (2009).","journal-title":"JAMA"},{"key":"2782_CR398","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1001\/jama.2009.1608","volume":"302","author":"Y Kida","year":"2009","unstructured":"Kida, Y. Polymyxin B hemoperfusion and mortality in abdominal septic shock. JAMA 302, 1969\u20131970 (2009).","journal-title":"JAMA"},{"key":"2782_CR399","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03476-x","volume":"25","author":"N Lumlertgul","year":"2021","unstructured":"Lumlertgul, N. et al. Clearance of inflammatory cytokines in patients with septic acute kidney injury during renal replacement therapy using the EMiC2 filter (Clic-AKI study). Crit. Care 25, 39 (2021).","journal-title":"Crit. Care"},{"key":"2782_CR400","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1097\/CCM.0000000000000043","volume":"42","author":"GR Bernard","year":"2014","unstructured":"Bernard, G. R. et al. Evaluating the efficacy and safety of two doses of the polyclonal anti-tumor necrosis factor-alpha fragment antibody AZD9773 in adult patients with severe sepsis and\/or septic shock: randomized, double-blind, placebo-controlled phase IIb study*. Crit. Care Med. 42, 504\u2013511 (2014).","journal-title":"Crit. Care Med."},{"key":"2782_CR401","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1097\/CCM.0000000000001402","volume":"44","author":"B Shakoory","year":"2016","unstructured":"Shakoory, B. et al. Interleukin-1 receptor blockade is associated with reduced mortality in sepsis patients with features of macrophage activation syndrome: reanalysis of a prior phase III trial. Crit. Care Med. 44, 275\u2013281 (2016).","journal-title":"Crit. Care Med."},{"key":"2782_CR402","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202407705","volume":"11","author":"R Liu","year":"2024","unstructured":"Liu, R. et al. Unfractionated heparin enhances sepsis prognosis through inhibiting Drp1-mediated mitochondrial quality imbalance. Adv. Sci. 11, e2407705 (2024).","journal-title":"Adv. Sci."},{"key":"2782_CR403","doi-asserted-by":"publisher","first-page":"891","DOI":"10.3389\/fimmu.2018.00891","volume":"9","author":"A Aswani","year":"2018","unstructured":"Aswani, A. et al. Scavenging circulating mitochondrial DNA as a potential therapeutic option for multiple organ dysfunction in trauma hemorrhage. Front. Immunol. 9, 891 (2018).","journal-title":"Front. Immunol."},{"key":"2782_CR404","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s10020-019-0081-6","volume":"25","author":"H Yang","year":"2019","unstructured":"Yang, H. et al. Inhibition of HMGB1\/RAGE-mediated endocytosis by HMGB1 antagonist box A, anti-HMGB1 antibodies, and cholinergic agonists suppresses inflammation. Mol. Med. 25, 13 (2019).","journal-title":"Mol. Med."},{"key":"2782_CR405","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.pharmthera.2018.12.005","volume":"196","author":"L Pellegrini","year":"2019","unstructured":"Pellegrini, L. et al. HMGB1 and repair: focus on the heart. Pharm. Ther. 196, 160\u2013182 (2019).","journal-title":"Pharm. Ther."},{"key":"2782_CR406","doi-asserted-by":"publisher","first-page":"e677","DOI":"10.1097\/CCM.0000000000003839","volume":"47","author":"Z Cheng","year":"2019","unstructured":"Cheng, Z. et al. Circulating histones are major mediators of multiple organ dysfunction syndrome in acute critical illnesses. Crit. Care Med. 47, e677\u2013e684 (2019).","journal-title":"Crit. Care Med."},{"key":"2782_CR407","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1001\/jama.2024.6096","volume":"332","author":"R Pirracchio","year":"2024","unstructured":"Pirracchio, R., Venkatesh, B. & Legrand, M. Low-dose corticosteroids for critically Ill Adults With Severe Pulmonary Infections: A Review. JAMA 332, 318\u2013328 (2024).","journal-title":"JAMA"},{"key":"2782_CR408","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-019-0501-3","volume":"9","author":"J Cui","year":"2019","unstructured":"Cui, J. et al. The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis. Ann. Intensive Care 9, 27 (2019).","journal-title":"Ann. Intensive Care"},{"key":"2782_CR409","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1093\/cid\/ciaa022","volume":"71","author":"H Bergsten","year":"2020","unstructured":"Bergsten, H. et al. Correlation Between Immunoglobulin Dose Administered And Plasma Neutralization Of Streptococcal Superantigens In Patients With Necrotizing Soft Tissue Infections. Clin. Infect. Dis. 71, 1772\u20131775 (2020).","journal-title":"Clin. Infect. Dis."},{"key":"2782_CR410","doi-asserted-by":"publisher","first-page":"1069444","DOI":"10.3389\/fimmu.2022.1069444","volume":"13","author":"HM Lazarus","year":"2022","unstructured":"Lazarus, H. M. et al. Recombinant GM-CSF for diseases of GM-CSF insufficiency: correcting dysfunctional mononuclear phagocyte disorders. Front. Immunol. 13, 1069444 (2022).","journal-title":"Front. Immunol."},{"key":"2782_CR411","doi-asserted-by":"publisher","first-page":"1130214","DOI":"10.3389\/fimmu.2023.1130214","volume":"14","author":"I Joshi","year":"2023","unstructured":"Joshi, I., Carney, W. P. & Rock, E. P. Utility of monocyte HLA-DR and rationale for therapeutic GM-CSF in sepsis immunoparalysis. Front. Immunol. 14, 1130214 (2023).","journal-title":"Front. Immunol."},{"key":"2782_CR412","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1016\/j.ymthe.2020.05.014","volume":"28","author":"Z Li","year":"2020","unstructured":"Li, Z. et al. Antibacterial fusion protein BPI21\/LL-37 modification enhances the therapeutic efficacy of hUC-MSCs in sepsis. Mol. Ther. 28, 1806\u20131817 (2020).","journal-title":"Mol. Ther."},{"key":"2782_CR413","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-01913-3","volume":"21","author":"L Lu","year":"2023","unstructured":"Lu, L. et al. Bioengineered stem cell membrane functionalized nanoparticles combine anti-inflammatory and antimicrobial properties for sepsis treatment. J. Nanobiotechnol. 21, 170 (2023).","journal-title":"J. Nanobiotechnol."},{"key":"2782_CR414","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.737","volume":"5","author":"X Li","year":"2024","unstructured":"Li, X. et al. Overexpression of PRDM16 attenuates acute kidney injury progression: genetic and pharmacological approaches. MedComm 5, e737 (2024).","journal-title":"MedComm"},{"key":"2782_CR415","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-023-00773-1","volume":"18","author":"J Yang","year":"2023","unstructured":"Yang, J. et al. Formononetin alleviates acute pancreatitis by reducing oxidative stress and modulating intestinal barrier. Chin. Med. 18, 78 (2023).","journal-title":"Chin. Med."},{"key":"2782_CR416","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155325","volume":"125","author":"L Dao","year":"2024","unstructured":"Dao, L. et al. Gramine improves sepsis-induced myocardial dysfunction by binding to NF-kappaB p105 and inhibiting its ubiquitination. Phytomedicine 125, 155325 (2024).","journal-title":"Phytomedicine"},{"key":"2782_CR417","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.bcp.2016.05.003","volume":"112","author":"ME Shaker","year":"2016","unstructured":"Shaker, M. E., Trawick, B. N. & Mehal, W. Z. The novel TLR9 antagonist COV08-0064 protects from ischemia\/reperfusion injury in non-steatotic and steatotic mice livers. Biochem. Pharm. 112, 90\u2013101 (2016).","journal-title":"Biochem. Pharm."},{"key":"2782_CR418","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.kint.2020.01.036","volume":"98","author":"SJ Han","year":"2020","unstructured":"Han, S. J. et al. Selective nanoparticle-mediated targeting of renal tubular Toll-like receptor 9 attenuates ischemic acute kidney injury. Kidney Int. 98, 76\u201387 (2020).","journal-title":"Kidney Int."},{"key":"2782_CR419","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.kint.2020.04.024","volume":"98","author":"ZH Endre","year":"2020","unstructured":"Endre, Z. H. & Erlich, J. H. Targeted protection of proximal tubular cells by nanoparticle-enhanced delivery of a TLR9-antagonist. Kidney Int. 98, 48\u201350 (2020).","journal-title":"Kidney Int."},{"key":"2782_CR420","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3390\/antiox11020177","volume":"11","author":"G Veres","year":"2022","unstructured":"Veres, G. et al. Aspirin reduces ischemia-reperfusion injury induced endothelial cell damage of arterial grafts in a rodent model. Antioxidants 11, 177 (2022).","journal-title":"Antioxidants"},{"key":"2782_CR421","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.jacc.2015.05.012","volume":"66","author":"C Patrono","year":"2015","unstructured":"Patrono, C. The multifaceted clinical readouts of platelet inhibition by low-dose aspirin. J. Am. Coll. Cardiol. 66, 74\u201385 (2015).","journal-title":"J. Am. Coll. Cardiol."},{"key":"2782_CR422","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.801337","volume":"13","author":"Y Zhang","year":"2022","unstructured":"Zhang, Y. et al. Metformin alleviates LPS-induced acute lung injury by regulating the SIRT1\/NF-kappaB\/NLRP3 pathway and inhibiting endothelial cell pyroptosis. Front. Pharm. 13, 801337 (2022).","journal-title":"Front. Pharm."},{"key":"2782_CR423","doi-asserted-by":"publisher","first-page":"3785","DOI":"10.2147\/JIR.S460413","volume":"17","author":"SY Fan","year":"2024","unstructured":"Fan, S. Y. et al. Metformin mitigates sepsis-induced acute lung injury and inflammation in young mice by suppressing the S100A8\/A9-NLRP3-IL-1beta signaling pathway. J. Inflamm. Res. 17, 3785\u20133799 (2024).","journal-title":"J. Inflamm. Res."},{"key":"2782_CR424","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155728","volume":"132","author":"J Cai","year":"2024","unstructured":"Cai, J. et al. Integration of network pharmacology and proteomics analysis to identify key target pathways of Ginsenoside Re for myocardial ischemia. Phytomedicine 132, 155728 (2024).","journal-title":"Phytomedicine"},{"key":"2782_CR425","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202310227","volume":"11","author":"J Cui","year":"2024","unstructured":"Cui, J. et al. Protosappanin A Protects DOX-induced myocardial injury and cardiac dysfunction by targeting ACSL4\/FTH1 Axis-dependent ferroptosis. Adv. Sci. 11, e2310227 (2024).","journal-title":"Adv. Sci."},{"key":"2782_CR426","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-1180-6","volume":"20","author":"K Doenyas-Barak","year":"2016","unstructured":"Doenyas-Barak, K., Beberashvili, I., Marcus, R. & Efrati, S. Lactic acidosis and severe septic shock in metformin users: a cohort study. Crit. Care 20, 10 (2016).","journal-title":"Crit. Care"},{"key":"2782_CR427","doi-asserted-by":"publisher","first-page":"103266","DOI":"10.1016\/j.redox.2024.103266","volume":"75","author":"KA Akter","year":"2024","unstructured":"Akter, K. A. et al. Metformin ameliorates neuroinflammatory environment for neurons and astrocytes during in vitro and in vivo stroke and tobacco smoke chemical exposure: Role of Nrf2 activation. Redox Biol. 75, 103266 (2024).","journal-title":"Redox Biol."},{"key":"2782_CR428","first-page":"235","volume":"11","author":"A Soltanian","year":"2020","unstructured":"Soltanian, A. et al. Comparative evaluation of therapeutic effects of silymarin and hydrocortisone on clinical and hematological alterations, and organ injury (liver and heart) in a low-dose canine lipopolysaccharide-induced sepsis model. Vet. Res Forum 11, 235\u2013241 (2020).","journal-title":"Vet. Res Forum"},{"key":"2782_CR429","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2024.2431632","volume":"46","author":"L Chen","year":"2024","unstructured":"Chen, L. et al. Vitamin D supplementation can improve the 28-day mortality rate in patients with sepsis-associated acute kidney injury. Ren. Fail 46, 2431632 (2024).","journal-title":"Ren. Fail"},{"key":"2782_CR430","volume":"10","author":"I Anjum","year":"2018","unstructured":"Anjum, I. et al. The role of Vitamin D in brain health: a mini literature review. Cureus 10, e2960 (2018).","journal-title":"Cureus"},{"key":"2782_CR431","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.acthis.2008.09.010","volume":"111","author":"K Erbuyun","year":"2009","unstructured":"Erbuyun, K. et al. Effects of levosimendan and dobutamine on experimental acute lung injury in rats. Acta Histochem. 111, 404\u2013414 (2009).","journal-title":"Acta Histochem."},{"key":"2782_CR432","doi-asserted-by":"publisher","first-page":"34375","DOI":"10.1021\/acsnano.4c13404","volume":"18","author":"C Zhang","year":"2024","unstructured":"Zhang, C. et al. Prevent and reverse metabolic dysfunction-associated steatohepatitis and hepatic fibrosis via mRNA-mediated liver-specific antibody therapy. ACS Nano 18, 34375\u201334390 (2024).","journal-title":"ACS Nano"},{"key":"2782_CR433","doi-asserted-by":"publisher","first-page":"2326","DOI":"10.1111\/ajt.14266","volume":"17","author":"Z Solhjou","year":"2017","unstructured":"Solhjou, Z. et al. Novel application of localized nanodelivery of anti-interleukin-6 protects organ transplant from ischemia-reperfusion injuries. Am. J. Transpl. 17, 2326\u20132337 (2017).","journal-title":"Am. J. Transpl."},{"key":"2782_CR434","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302320","volume":"13","author":"Y Zhang","year":"2024","unstructured":"Zhang, Y. et al. An Erythrocyte Membrane-derived Nanosystem For Efficient Reversal Of Endothelial Injury In Sepsis. Adv. Health. Mater. 13, e2302320 (2024).","journal-title":"Adv. Health. Mater."},{"key":"2782_CR435","doi-asserted-by":"publisher","first-page":"29535","DOI":"10.1021\/acsnano.4c05902","volume":"18","author":"YG Kim","year":"2024","unstructured":"Kim, Y. G. et al. Co-delivery of renal clearable cerium complex and synergistic antioxidant iron complex for treating sepsis. ACS Nano 18, 29535\u201329549 (2024).","journal-title":"ACS Nano"},{"key":"2782_CR436","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02439-y","volume":"22","author":"E Wen","year":"2024","unstructured":"Wen, E. et al. The mitochondria-targeted Kaempferol nanoparticle ameliorates severe acute pancreatitis. J. Nanobiotechnol. 22, 148 (2024).","journal-title":"J. Nanobiotechnol."},{"key":"2782_CR437","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02615-0","volume":"22","author":"S Zhang","year":"2024","unstructured":"Zhang, S. et al. Advances in nanomaterial-targeted treatment of acute lung injury after burns. J. Nanobiotechnol. 22, 342 (2024).","journal-title":"J. Nanobiotechnol."},{"key":"2782_CR438","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1038\/s41392-024-01852-x","volume":"9","author":"P Lu","year":"2024","unstructured":"Lu, P. et al. Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions. Signal Transduct. Target Ther. 9, 166 (2024).","journal-title":"Signal Transduct. Target Ther."},{"key":"2782_CR439","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1080\/10717544.2018.1440445","volume":"25","author":"M Zhao","year":"2018","unstructured":"Zhao, M. et al. Control release of mitochondria-targeted antioxidant by injectable self-assembling peptide hydrogel ameliorated persistent mitochondrial dysfunction and inflammation after acute kidney injury. Drug Deliv. 25, 546\u2013554 (2018).","journal-title":"Drug Deliv."},{"key":"2782_CR440","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.821070","volume":"13","author":"MK Shin","year":"2022","unstructured":"Shin, M. K. et al. Designing a novel functional peptide with dual antimicrobial and anti-inflammatory activities via in silico methods. Front. Immunol. 13, 821070 (2022).","journal-title":"Front. Immunol."},{"key":"2782_CR441","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02503-7","volume":"22","author":"Y Xia","year":"2024","unstructured":"Xia, Y. et al. Comprehensive dry eye therapy: overcoming ocular surface barrier and combating inflammation, oxidation, and mitochondrial damage. J. Nanobiotechnol. 22, 233 (2024).","journal-title":"J. Nanobiotechnol."},{"key":"2782_CR442","doi-asserted-by":"publisher","DOI":"10.1172\/JCI176758","volume":"134","author":"Y Zhao","year":"2024","unstructured":"Zhao, Y. et al. Inhibition of endothelial histone deacetylase 2 shifts endothelial-mesenchymal transitions in cerebral arteriovenous malformation models. J. Clin. Investig. 134, e176758 (2024).","journal-title":"J. Clin. Investig."},{"key":"2782_CR443","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.tips.2024.05.008","volume":"45","author":"GAF Nicolaes","year":"2024","unstructured":"Nicolaes, G. A. F. & Soehnlein, O. Targeting extranuclear histones to alleviate acute and chronic inflammation. Trends Pharm. Sci. 45, 651\u2013662 (2024).","journal-title":"Trends Pharm. Sci."},{"key":"2782_CR444","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1093\/cvr\/cvab198","volume":"118","author":"LS Dunaway","year":"2022","unstructured":"Dunaway, L. S. & Pollock, J. S. HDAC1: an environmental sensor regulating endothelial function. Cardiovasc Res. 118, 1885\u20131903 (2022).","journal-title":"Cardiovasc Res."},{"key":"2782_CR445","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.118246","volume":"297","author":"Z Chen","year":"2025","unstructured":"Chen, Z. et al. Single-cell analysis of diquat-induced oxidative stress and its impact on organ-specific toxicity. Ecotoxicol. Environ. Saf. 297, 118246 (2025).","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"2782_CR446","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1007\/s00018-025-05721-w","volume":"82","author":"Y Feng","year":"2025","unstructured":"Feng, Y. et al. Inflammatory metabolite 7alpha,25-OHC promotes TIMP1 expression in COVID-19 monocytes through synergy effect of SMARCC1\/JUND\/H3K27ac. Cell Mol. Life Sci. 82, 208 (2025).","journal-title":"Cell Mol. Life Sci."},{"key":"2782_CR447","doi-asserted-by":"publisher","first-page":"159","DOI":"10.7150\/thno.88678","volume":"14","author":"Y Wang","year":"2024","unstructured":"Wang, Y. et al. LCP1 knockdown in monocyte-derived macrophages: mitigating ischemic brain injury and shaping immune cell signaling and metabolism. Theranostics 14, 159\u2013175 (2024).","journal-title":"Theranostics"},{"key":"2782_CR448","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1681\/ASN.0000000000000191","volume":"34","author":"J Ren","year":"2023","unstructured":"Ren, J. et al. Divergent actions of renal tubular and endothelial Type 1 IL-1 receptor signaling in toxin-induced AKI. J. Am. Soc. Nephrol. 34, 1629\u20131646 (2023).","journal-title":"J. Am. Soc. Nephrol."},{"key":"2782_CR449","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.147703","volume":"6","author":"R Melo Ferreira","year":"2021","unstructured":"Melo Ferreira, R. et al. Integration of spatial and single-cell transcriptomics localizes epithelial cell-immune cross-talk in kidney injury. JCI Insight 6, e147703 (2021).","journal-title":"JCI Insight"},{"key":"2782_CR450","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202309752","volume":"11","author":"YL Zhang","year":"2024","unstructured":"Zhang, Y. L. et al. Identification of a novel ECM remodeling macrophage subset in AKI to CKD transition by integrative spatial and single-cell analysis. Adv. Sci. 11, e2309752 (2024).","journal-title":"Adv. Sci."},{"key":"2782_CR451","doi-asserted-by":"publisher","first-page":"F1136","DOI":"10.1152\/ajprenal.00100.2016","volume":"310","author":"S Rao","year":"2016","unstructured":"Rao, S. et al. Early lipid changes in acute kidney injury using SWATH lipidomics coupled with MALDI tissue imaging. Am. J. Physiol. Ren. Physiol. 310, F1136\u2013F1147 (2016).","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"2782_CR452","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-023-01257-5","volume":"15","author":"H Li","year":"2023","unstructured":"Li, H. et al. Acute ischemia induces spatially and transcriptionally distinct microglial subclusters. Genome Med. 15, 109 (2023).","journal-title":"Genome Med."},{"key":"2782_CR453","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2404203121","volume":"121","author":"D Zucha","year":"2024","unstructured":"Zucha, D. et al. Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia. Proc. Natl. Acad. Sci. USA 121, e2404203121 (2024).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2782_CR454","doi-asserted-by":"publisher","first-page":"F971","DOI":"10.1152\/ajprenal.00597.2019","volume":"318","author":"JLM Digby","year":"2020","unstructured":"Digby, J. L. M. et al. Evaluation of cisplatin-induced injury in human kidney organoids. Am. J. Physiol. Ren. Physiol. 318, F971\u2013F978 (2020).","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"2782_CR455","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/s41581-022-00539-2","volume":"18","author":"NA Hukriede","year":"2022","unstructured":"Hukriede, N. A. et al. Experimental models of acute kidney injury for translational research. Nat. Rev. Nephrol. 18, 277\u2013293 (2022).","journal-title":"Nat. Rev. Nephrol."},{"key":"2782_CR456","doi-asserted-by":"publisher","first-page":"31569","DOI":"10.1021\/acsnano.4c13262","volume":"18","author":"T Zhang","year":"2024","unstructured":"Zhang, T. et al. Unveiling the heart\u2019s hidden enemy: dynamic insights into polystyrene nanoplastic-induced cardiotoxicity based on cardiac organoid-on-a-chip. ACS Nano 18, 31569\u201331585 (2024).","journal-title":"ACS Nano"},{"key":"2782_CR457","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1146\/annurev-bioeng-072623-044010","volume":"26","author":"S Musah","year":"2024","unstructured":"Musah, S., Bhattacharya, R. & Himmelfarb, J. Kidney disease modeling with organoids and organs-on-chips. Annu Rev. Biomed. Eng. 26, 383\u2013414 (2024).","journal-title":"Annu Rev. Biomed. Eng."},{"key":"2782_CR458","doi-asserted-by":"publisher","first-page":"19370","DOI":"10.1021\/acs.analchem.4c03552","volume":"96","author":"Y Hou","year":"2024","unstructured":"Hou, Y. et al. Establishment of an idiosyncratic drug-induced liver injury model on a stacked array chip for identification of CCL5-mediated paracrine dynamics. Anal. Chem. 96, 19370\u201319377 (2024).","journal-title":"Anal. Chem."},{"key":"2782_CR459","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1126\/science.1188302","volume":"328","author":"D Huh","year":"2010","unstructured":"Huh, D. et al. Reconstituting organ-level lung functions on a chip. Science 328, 1662\u20131668 (2010).","journal-title":"Science"},{"key":"2782_CR460","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1016\/j.drudis.2016.11.002","volume":"21","author":"MR Somayaji","year":"2016","unstructured":"Somayaji, M. R., Das, D. & Przekwas, A. Computational approaches for modeling and analysis of human-on-chip systems for drug testing and characterization. Drug Discov. Today 21, 1859\u20131862 (2016).","journal-title":"Drug Discov. Today"},{"key":"2782_CR461","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/s41551-019-0497-x","volume":"4","author":"R Novak","year":"2020","unstructured":"Novak, R. et al. Robotic fluidic coupling and interrogation of multiple vascularized organ chips. Nat. Biomed. Eng. 4, 407\u2013420 (2020).","journal-title":"Nat. Biomed. Eng."},{"key":"2782_CR462","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1053\/j.gastro.2020.10.002","volume":"160","author":"T Shinozawa","year":"2021","unstructured":"Shinozawa, T. et al. High-fidelity drug-induced liver injury screen using human pluripotent stem cell-derived organoids. Gastroenterology 160, 831\u2013846.e810 (2021).","journal-title":"Gastroenterology"},{"key":"2782_CR463","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1093\/procel\/pwad038","volume":"15","author":"Y Mao","year":"2024","unstructured":"Mao, Y. et al. Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids. Protein Cell 15, 285\u2013304 (2024).","journal-title":"Protein Cell"},{"key":"2782_CR464","doi-asserted-by":"publisher","DOI":"10.1172\/JCI175824","volume":"133","author":"PH Zushin","year":"2023","unstructured":"Zushin, P. H., Mukherjee, S. & Wu, J. C. FDA modernization Act 2.0: transitioning beyond animal models with human cells, organoids, and AI\/ML-based approaches. J. Clin. Investig. 133, e175824 (2023).","journal-title":"J. Clin. Investig."},{"key":"2782_CR465","volume":"4","author":"H Liu","year":"2023","unstructured":"Liu, H. et al. Inflammatory risk stratification individualizes anti-inflammatory pharmacotherapy for acute type A aortic dissection. Innovation 4, 100448 (2023).","journal-title":"Innovation"},{"key":"2782_CR466","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1038\/s41591-020-0789-4","volume":"26","author":"SL Hyland","year":"2020","unstructured":"Hyland, S. L. et al. Early prediction of circulatory failure in the intensive care unit using machine learning. Nat. Med. 26, 364\u2013373 (2020).","journal-title":"Nat. Med."},{"key":"2782_CR467","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1097\/CCM.0000000000004966","volume":"49","author":"PK Shah","year":"2021","unstructured":"Shah, P. K. et al. A simulated prospective evaluation of a deep learning model for real-time prediction of clinical deterioration among ward patients. Crit. Care Med. 49, 1312\u20131321 (2021).","journal-title":"Crit. Care Med."},{"key":"2782_CR468","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-022-03977-3","volume":"26","author":"Y Qin","year":"2022","unstructured":"Qin, Y. et al. Machine learning derivation of four computable 24-h pediatric sepsis phenotypes to facilitate enrollment in early personalized anti-inflammatory clinical trials. Crit. Care 26, 128 (2022).","journal-title":"Crit. Care"},{"key":"2782_CR469","unstructured":"Shams, P. & Collier, S. A. Acute Myocarditis. In: StatPearls [Internet] (StatPearls Publishing, 2025)."},{"key":"2782_CR470","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12072-024-10773-4","volume":"19","author":"A Choudhury","year":"2025","unstructured":"Choudhury, A. et al. Acute-on-chronic liver failure (ACLF): the \u2018Kyoto Consensus\u2019-steps from Asia. Hepatol. Int. 19, 1\u201369 (2025).","journal-title":"Hepatol. Int."},{"key":"2782_CR471","unstructured":"Schaefer, T. J. & John, S. in Acute Hepatitis(Archived). 2023 Jul 10. In: StatPearls [Internet] (StatPearls Publishing, 2025)."},{"key":"2782_CR472","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.kint.2020.02.010","volume":"97","author":"AS Levey","year":"2020","unstructured":"Levey, A. S. et al. Nomenclature for kidney function and disease: report of a Kidney Disease: Improving Global Outcomes (KDIGO) Consensus Conference. Kidney Int. 97, 1117\u20131129 (2020).","journal-title":"Kidney Int."},{"key":"2782_CR473","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1007\/s00134-011-2459-y","volume":"38","author":"A Reintam Blaser","year":"2012","unstructured":"Reintam Blaser, A. et al. Gastrointestinal function in intensive care patients: terminology, definitions and management. Recommendations of the ESICM Working Group on Abdominal Problems. Intensive Care Med. 38, 384\u2013394 (2012).","journal-title":"Intensive Care Med."},{"key":"2782_CR474","doi-asserted-by":"publisher","first-page":"2442","DOI":"10.1111\/aor.14324","volume":"46","author":"M Fang","year":"2022","unstructured":"Fang, M. et al. Evaluation of the revised ISTH overt DIC score (2018) for predicting 90-day mortality in critically ill adult patients undergoing extracorporeal membrane oxygenation. Artif. Organs 46, 2442\u20132452 (2022).","journal-title":"Artif. Organs"},{"key":"2782_CR475","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1007\/s00134-017-4919-5","volume":"43","author":"D Annane","year":"2017","unstructured":"Annane, D. et al. Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part I): society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017. Intensive Care Med. 43, 1751\u20131763 (2017).","journal-title":"Intensive Care Med."},{"key":"2782_CR476","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1111\/aas.13776","volume":"65","author":"PI Johansson","year":"2021","unstructured":"Johansson, P. I. et al. Efficacy and safety of iloprost in trauma patients with haemorrhagic shock-induced endotheliopathy-Protocol for the multicentre randomized, placebo-controlled, blinded, investigator-initiated shine-trauma trial. Acta Anaesthesiol. Scand. 65, 551\u2013557 (2021).","journal-title":"Acta Anaesthesiol. Scand."},{"key":"2782_CR477","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-020-04549-y","volume":"21","author":"M Legrand","year":"2020","unstructured":"Legrand, M. et al. The I-MICRO trial, Ilomedin for treatment of septic shock with persistent microperfusion defects: a double-blind, randomized controlled trial-study protocol for a randomized controlled trial. Trials 21, 601 (2020).","journal-title":"Trials"},{"key":"2782_CR478","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jcrc.2019.12.025","volume":"56","author":"ASP Meyer","year":"2020","unstructured":"Meyer, A. S. P. et al. Low dose Iloprost effect on platelet aggregation in comatose out-of-hospital cardiac arrest patients: a predefined sub-study of the ENDO-RCA randomized -phase 2- trial. J. Crit. Care 56, 197\u2013202 (2020).","journal-title":"J. Crit. Care"},{"key":"2782_CR479","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ahj.2019.10.002","volume":"219","author":"ASP Meyer","year":"2020","unstructured":"Meyer, A. S. P. et al. Endothelial Dysfunction in Resuscitated Cardiac Arrest (ENDO-RCA): safety and efficacy of low-dose Iloprost, a prostacyclin analogue, in addition to standard therapy, as compared to standard therapy alone, in post-cardiac-arrest-syndrome patients. Am. Heart J. 219, 9\u201320 (2020).","journal-title":"Am. Heart J."},{"key":"2782_CR480","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1182\/blood-2015-10-676924","volume":"127","author":"PG Richardson","year":"2016","unstructured":"Richardson, P. G. et al. Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure. Blood 127, 1656\u20131665 (2016).","journal-title":"Blood"},{"key":"2782_CR481","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-017-2234-7","volume":"18","author":"G Bellingan","year":"2017","unstructured":"Bellingan, G. et al. Comparison of the efficacy and safety of FP-1201-lyo (intravenously administered recombinant human interferon beta-1a) and placebo in the treatment of patients with moderate or severe acute respiratory distress syndrome: study protocol for a randomized controlled trial. Trials 18, 536 (2017).","journal-title":"Trials"},{"key":"2782_CR482","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1097\/CCM.0b013e31819598af","volume":"37","author":"S Heemskerk","year":"2009","unstructured":"Heemskerk, S. et al. Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients. Crit. Care Med. 37, 417\u2013423, e411 (2009).","journal-title":"Crit. Care Med."},{"key":"2782_CR483","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-04808-3","volume":"28","author":"LER Obling","year":"2024","unstructured":"Obling, L. E. R. et al. Effect of prehospital high-dose glucocorticoid on hemodynamics in patients resuscitated from out-of-hospital cardiac arrest: a sub-study of the STEROHCA trial. Crit. Care 28, 28 (2024).","journal-title":"Crit. Care"},{"key":"2782_CR484","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1007\/s00134-023-07135-3","volume":"49","author":"JM Shepherd","year":"2023","unstructured":"Shepherd, J. M. et al. Safety and efficacy of artesunate treatment in severely injured patients with traumatic hemorrhage. The TOP-ART randomized clinical trial. Intensive Care Med. 49, 922\u2013933 (2023).","journal-title":"Intensive Care Med."},{"key":"2782_CR485","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1182\/blood.2023022526","volume":"143","author":"S Jodele","year":"2024","unstructured":"Jodele, S. et al. A prospective multi-institutional study of eculizumab to treat high-risk stem cell transplantation-associated TMA. Blood 143, 1112\u20131123 (2024).","journal-title":"Blood"},{"key":"2782_CR486","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1097\/MPA.0000000000000344","volume":"44","author":"VA Gorsky","year":"2015","unstructured":"Gorsky, V. A., Agapov, M. A., Khoreva, M. V. & Leonenko, I. V. The effect of lornoxicam on TLR2 and TLR4 messenger RNA expression and tumor necrosis factor-alpha, interleukin-6, and interleukin-8 secretion in patients with systemic complications of acute pancreatitis. Pancreas 44, 824\u2013830 (2015).","journal-title":"Pancreas"},{"key":"2782_CR487","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/S2213-2600(19)30417-5","volume":"8","author":"J Villar","year":"2020","unstructured":"Villar, J. et al. Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial. Lancet Respir. Med. 8, 267\u2013276 (2020).","journal-title":"Lancet Respir. Med."},{"key":"2782_CR488","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1001\/jama.2017.2088","volume":"317","author":"Y Kawazoe","year":"2017","unstructured":"Kawazoe, Y. et al. Effect of dexmedetomidine on mortality and ventilator-free days in patients requiring mechanical ventilation with sepsis: a randomized clinical trial. JAMA 317, 1321\u20131328 (2017).","journal-title":"JAMA"},{"key":"2782_CR489","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jcrc.2015.11.013","volume":"32","author":"MM Zamani","year":"2016","unstructured":"Zamani, M. M. et al. Survival benefits of dexmedetomidine used for sedating septic patients in intensive care setting: a systematic review. J. Crit. Care 32, 93\u2013100 (2016).","journal-title":"J. Crit. Care"},{"key":"2782_CR490","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03207-8","volume":"24","author":"Y Ohta","year":"2020","unstructured":"Ohta, Y. et al. Effect of dexmedetomidine on inflammation in patients with sepsis requiring mechanical ventilation: a sub-analysis of a multicenter randomized clinical trial. Crit. Care 24, 493 (2020).","journal-title":"Crit. Care"},{"key":"2782_CR491","doi-asserted-by":"crossref","unstructured":"Nakashima, T. et al. Dexmedetomidine improved renal function in patients with severe sepsis: an exploratory analysis of a randomized controlled trial. J. Intensive Care. 8, 1 (2020).","DOI":"10.1186\/s40560-019-0415-z"},{"key":"2782_CR492","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1242551","volume":"14","author":"PV van Heerden","year":"2023","unstructured":"van Heerden, P. V. et al. Apoptotic cells for treatment of acute respiratory distress syndrome associated with COVID-19. Front. Immunol. 14, 1242551 (2023).","journal-title":"Front. Immunol."},{"key":"2782_CR493","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.718191","volume":"12","author":"PV van Heerden","year":"2021","unstructured":"van Heerden, P. V. et al. Apoptotic cells for therapeutic use in cytokine storm associated with sepsis- a phase Ib clinical trial. Front. Immunol. 12, 718191 (2021).","journal-title":"Front. Immunol."},{"key":"2782_CR494","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-022-06077-3","volume":"23","author":"M Keshani","year":"2022","unstructured":"Keshani, M. et al. The effects of L-carnitine supplementation on inflammatory factors, oxidative stress, and clinical outcomes in patients with sepsis admitted to the intensive care unit (ICU): study protocol for a double blind, randomized, placebo-controlled clinical trial. Trials 23, 170 (2022).","journal-title":"Trials"},{"key":"2782_CR495","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1161\/CIRCULATIONAHA.120.053318","volume":"143","author":"MAS Meyer","year":"2021","unstructured":"Meyer, M. A. S. et al. Treatment effects of interleukin-6 receptor antibodies for modulating the systemic inflammatory response after out-of-hospital cardiac arrest (The IMICA Trial): a double-blinded, placebo-controlled, single-center, randomized, clinical trial. Circulation 143, 1841\u20131851 (2021).","journal-title":"Circulation"},{"key":"2782_CR496","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2022.109676","volume":"184","author":"MAS Meyer","year":"2023","unstructured":"Meyer, M. A. S. et al. Modulation of inflammation by treatment with tocilizumab after out-of-hospital cardiac arrest and associations with clinical status, myocardial- and brain injury. Resuscitation 184, 109676 (2023).","journal-title":"Resuscitation"},{"key":"2782_CR497","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1007\/s00134-024-07733-9","volume":"51","author":"J Rynne","year":"2025","unstructured":"Rynne, J. et al. Sepsis subtypes and differential treatment response to vitamin C: biological sub-study of the LOVIT trial. Intensive Care Med. 51, 82\u201393 (2025).","journal-title":"Intensive Care Med."},{"key":"2782_CR498","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1007\/s40265-021-01547-5","volume":"81","author":"A Gulati","year":"2021","unstructured":"Gulati, A. et al. A multicentric, randomized, controlled phase iii study of centhaquine (Lyfaquin((R))) as a resuscitative agent in hypovolemic shock patients. Drugs 81, 1079\u20131100 (2021).","journal-title":"Drugs"},{"key":"2782_CR499","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-1047-x","volume":"19","author":"RP de Azevedo","year":"2015","unstructured":"de Azevedo, R. P. et al. Daily laxative therapy reduces organ dysfunction in mechanically ventilated patients: a phase II randomized controlled trial. Crit. Care 19, 329 (2015).","journal-title":"Crit. Care"}],"container-title":["Signal Transduction and Targeted Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41392-026-02782-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41392-026-02782-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41392-026-02782-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T23:01:38Z","timestamp":1783983698000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41392-026-02782-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,14]]},"references-count":499,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2782"],"URL":"https:\/\/doi.org\/10.1038\/s41392-026-02782-6","relation":{},"ISSN":["2059-3635"],"issn-type":[{"value":"2059-3635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,14]]},"assertion":[{"value":"28 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"274"}}