{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:08:55Z","timestamp":1791857335089,"version":"4.3.4"},"reference-count":98,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000062","name":"U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P01 DK11479"],"award-info":[{"award-number":["P01 DK11479"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK113039"],"award-info":[{"award-number":["R01 DK113039"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK046718"],"award-info":[{"award-number":["R01 DK046718"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK113039"],"award-info":[{"award-number":["R01 DK113039"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK046718"],"award-info":[{"award-number":["R01 DK046718"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30 AR066261"],"award-info":[{"award-number":["P30 AR066261"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K21281"],"award-info":[{"award-number":["JP24K21281"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP25H01016"],"award-info":[{"award-number":["JP25H01016"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22ama121038"],"award-info":[{"award-number":["JP22ama121038"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22zf0127007"],"award-info":[{"award-number":["JP22zf0127007"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"MEXT | Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJFR215T"],"award-info":[{"award-number":["JPMJFR215T"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"MEXT | Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJMS2023"],"award-info":[{"award-number":["JPMJMS2023"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["Dean\u2019s Scholars Award from the Washington University Division of Physician-Scientists"],"award-info":[{"award-number":["Dean\u2019s Scholars Award from the Washington University Division of Physician-Scientists"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["535701562"],"award-info":[{"award-number":["535701562"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sig Transduct Target Ther"],"DOI":"10.1038\/s41392-026-02795-1","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T23:02:27Z","timestamp":1789081347000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Spatial control of parathyroid hormone receptor-1 signaling dictates ligand-specific biological outcomes"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9908-2066","authenticated-orcid":false,"given":"Jakob","family":"H\u00f6ppner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"J\u00fcppner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2213-5320","authenticated-orcid":false,"given":"Prem Swaroop","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Dean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Hanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Civitelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0805-4049","authenticated-orcid":false,"given":"Asuka","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernestina","family":"Schipani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Portales-Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Gardella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"2795_CR1","doi-asserted-by":"crossref","unstructured":"Rockman, H. A. & Lefkowitz, R. J. G protein-coupled receptors: from radioligand binding to cellular signaling. J. Clin. Investig. 134, e178109 (2024).","DOI":"10.1172\/JCI178109"},{"key":"2795_CR2","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1210\/endrev\/bnac033","volume":"44","author":"BP Cary","year":"2023","unstructured":"Cary, B. P. et al. New insights into the structure and function of Class B1 GPCRs. Endocr. Rev. 44, 492\u2013517 (2023).","journal-title":"Endocr. Rev."},{"key":"2795_CR3","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1126\/science.1658941","volume":"254","author":"H J\u00fcppner","year":"1991","unstructured":"J\u00fcppner, H. et al. A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254, 1024\u20131026 (1991).","journal-title":"Science"},{"key":"2795_CR4","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1124\/pr.114.009464","volume":"67","author":"TJ Gardella","year":"2015","unstructured":"Gardella, T. J. & Vilardaga, J. P. International union of basic and clinical pharmacology. XCIII. The parathyroid hormone receptors\u2014family B G protein-coupled receptors. Pharmacol. Rev. 67, 310\u2013337 (2015).","journal-title":"Pharmacol. Rev."},{"key":"2795_CR5","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1210\/endrev\/bnab005","volume":"42","author":"TJ Martin","year":"2021","unstructured":"Martin, T. J., Sims, N. A. & Seeman, E. Physiological and pharmacological roles of PTH and PTHrP in bone using their shared receptor, PTH1R. Endocr. Rev. 42, 383\u2013406 (2021).","journal-title":"Endocr. Rev."},{"key":"2795_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-59665-7","volume":"16","author":"J H\u00f6ppner","year":"2025","unstructured":"H\u00f6ppner, J. et al. Prolonging parathyroid hormone analog action in vitro and in vivo through peptide lipidation. Nat. Commun. 16, 4487 (2025).","journal-title":"Nat. Commun."},{"key":"2795_CR7","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/nrendo.2015.139","volume":"11","author":"RW Cheloha","year":"2015","unstructured":"Cheloha, R. W., Gellman, S. H., Vilardaga, J.-P. & Gardella, T. J. PTH receptor-1 signalling\u2014mechanistic insights and therapeutic prospects. Nat. Rev. Endocrinol. 11, 712\u2013724 (2015).","journal-title":"Nat. Rev. Endocrinol."},{"key":"2795_CR8","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.str.2023.04.002","volume":"31","author":"BP Cary","year":"2023","unstructured":"Cary, B. P. et al. Molecular insights into peptide agonist engagement with the PTH receptor. Structure 31, 668\u2013676.e5 (2023).","journal-title":"Structure"},{"key":"2795_CR9","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1210\/en.2015-1726","volume":"157","author":"G Hattersley","year":"2016","unstructured":"Hattersley, G., Dean, T., Corbin, B. A., Bahar, H. & Gardella, T. J. Binding selectivity of abaloparatide for PTH-type-1-receptor conformations and effects on downstream signaling. Endocrinology 157, 141\u2013149 (2016).","journal-title":"Endocrinology"},{"key":"2795_CR10","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1210\/me.2007-0274","volume":"22","author":"T Dean","year":"2008","unstructured":"Dean, T., Vilardaga, J. P., Potts, J. T. & Gardella, T. J. Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH\/PTHrP receptor. Mol. Endocrinol. 22, 156\u2013166 (2008).","journal-title":"Mol. Endocrinol."},{"key":"2795_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fendo.2022.992666","volume":"13","author":"I Portales-Castillo","year":"2022","unstructured":"Portales-Castillo, I. & Simic, P. PTH, FGF-23, Klotho and Vitamin D as regulators of calcium and phosphorus: genetics, epigenetics and beyond. Front. Endocrinol. 13, 1\u201312 (2022).","journal-title":"Front. Endocrinol."},{"key":"2795_CR12","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1002\/bdrc.10028","volume":"69","author":"E Schipani","year":"2003","unstructured":"Schipani, E. & Provot, S. PTHrP, PTH, and the PTH\/PTHrP receptor in endochondral bone development. Birth Defects Res. C Embryo Today 69, 352\u2013362 (2003).","journal-title":"Birth Defects Res. C Embryo Today"},{"key":"2795_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1196\/annals.1346.002","volume":"1068","author":"HM Kronenberg","year":"2006","unstructured":"Kronenberg, H. M. PTHrP and skeletal development. Ann. N. Y. Acad. Sci. 1068, 1\u201313 (2006).","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2795_CR14","doi-asserted-by":"crossref","unstructured":"Senevirathne, G. et al. The evolution of hominin bipedalism in two steps. Nature 645, 952\u2013963 (2025).","DOI":"10.1038\/s41586-025-09399-9"},{"key":"2795_CR15","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.chembiol.2021.05.020","volume":"29","author":"D Liang","year":"2022","unstructured":"Liang, D., Cheloha, R. W., Watanabe, T., Gardella, T. J. & Baskin, J. M. Activity-based, bioorthogonal imaging of phospholipase D reveals spatiotemporal dynamics of GPCR-Gq signaling. Cell Chem. Biol. 29, 67\u201373.e3 (2022).","journal-title":"Cell Chem. Biol."},{"key":"2795_CR16","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1038\/nchembio.206","volume":"5","author":"S Ferrandon","year":"2009","unstructured":"Ferrandon, S. et al. Sustained cyclic AMP production by parathyroid hormone receptor endocytosis. Nat. Chem. Biol. 5, 734\u2013742 (2009).","journal-title":"Nat. Chem. Biol."},{"key":"2795_CR17","doi-asserted-by":"publisher","unstructured":"Zhao, J. et al. Inhibitory probes for spatiotemporal analysis of G\u03b1s protein signaling. Nat. Chem. Biol. https:\/\/doi.org\/10.1038\/s41589-025-02138-1 (2026).","DOI":"10.1038\/s41589-025-02138-1"},{"key":"2795_CR18","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/7355_2017_1","volume":"30","author":"I Sutkeviciute","year":"2019","unstructured":"Sutkeviciute, I., Jean-Alphonse, F. G. & Vilardaga, J. P. Endosomal PTH receptor signaling through cAMP and its consequence for human medicine. Top. Med. Chem. 30, 181\u2013193 (2019).","journal-title":"Top. Med. Chem."},{"key":"2795_CR19","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/nchembio.1611","volume":"10","author":"JP Vilardaga","year":"2014","unstructured":"Vilardaga, J. P., Jean-Alphonse, F. G. & Gardella, T. J. Endosomal generation of cAMP in GPCR signaling. Nat. Chem. Biol. 10, 700\u2013706 (2014).","journal-title":"Nat. Chem. Biol."},{"key":"2795_CR20","doi-asserted-by":"crossref","unstructured":"White, A. D. et al. Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation. Sci. Signal. 14, eabc5944 (2021).","DOI":"10.1126\/scisignal.abc5944"},{"key":"2795_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1083\/jcb.202409027","volume":"224","author":"L Ripoll","year":"2025","unstructured":"Ripoll, L., von Zastrow, M. & Blythe, E. E. Intersection of GPCR trafficking and cAMP signaling at endomembranes. J. Cell Biol. 224, 1\u201316 (2025).","journal-title":"J. Cell Biol."},{"key":"2795_CR22","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1074\/jbc.270.1.151","volume":"270","author":"Z Huang","year":"1995","unstructured":"Huang, Z., Chen, Y. & Nissenson, R. A. The cytoplasmic tail of the G-protein-coupled receptor for parathyroid hormone and parathyroid hormone-related protein contains positive and negative signals for endocytosis. J. Biol. Chem. 270, 151\u2013156 (1995).","journal-title":"J. Biol. Chem."},{"key":"2795_CR23","first-page":"1240","volume":"9","author":"Z Huang","year":"1995","unstructured":"Huang, Z. et al. Mutational analysis of the cytoplasmic tail of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein: Effects on receptor expression and signaling. Mol. Endocrinol. 9, 1240\u20131249 (1995).","journal-title":"Mol. Endocrinol."},{"key":"2795_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/hmg\/ddi001","volume":"14","author":"S Duchatelet","year":"2005","unstructured":"Duchatelet, S., Ostergaard, E., Cortes, D., Lemainque, A. & Julier, C. Recessive mutations in PTHR1 cause constrasting skeletal dysplasias in Eiken and Blomstrand syndromes. Hum. Mol. Genet. 14, 1\u20135 (2005).","journal-title":"Hum. Mol. Genet."},{"key":"2795_CR25","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/BF00572767","volume":"141","author":"M Eiken","year":"1984","unstructured":"Eiken, M., Prag, J., Petersen, K. E. & Kaufmann, H. J. A new familial skeletal dysplasia with severely retarded ossification and abnormal modeling of bones especially of the epiphyses, the hands, and feet. Eur. J. Pediatr. 141, 231\u2013235 (1984).","journal-title":"Eur. J. Pediatr."},{"key":"2795_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1172\/jci.insight.97903","volume":"4","author":"S Nishimori","year":"2019","unstructured":"Nishimori, S. et al. PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy. JCI Insight 4, 1\u201317 (2019).","journal-title":"JCI Insight"},{"key":"2795_CR27","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1111\/cge.13601","volume":"96","author":"P Jacob","year":"2019","unstructured":"Jacob, P., Soni, J. P., Mortier, G. & Girisha, K. M. The third family with Eiken syndrome. Clin. Genet. 96, 378\u2013379 (2019).","journal-title":"Clin. Genet."},{"key":"2795_CR28","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/cge.13413","volume":"94","author":"A Moirangthem","year":"2018","unstructured":"Moirangthem, A. et al. Report of second case and clinical and molecular characterization of Eiken syndrome. Clin. Genet. 94, 457\u2013460 (2018).","journal-title":"Clin. Genet."},{"key":"2795_CR29","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1093\/jbmr\/zjae148","volume":"39","author":"AD Calder","year":"2024","unstructured":"Calder, A. D. et al. Eiken syndrome with parathyroid hormone resistance due to a novel parathyroid hormone receptor type 1 mutation: clinical features and functional analysis. J. Bone Miner. Res. 39, 1596\u20131605 (2024).","journal-title":"J. Bone Miner. Res."},{"key":"2795_CR30","doi-asserted-by":"publisher","first-page":"1641292","DOI":"10.3389\/fendo.2025.1641292","volume":"16","author":"I Portales-Castillo","year":"2025","unstructured":"Portales-Castillo, I., H\u00f6ppner, J., J\u00fcppner, H. & Gardella, T. J. Human diseases caused by homozygous PTH1R mutations. Front. Endocrinol. 16, 1641292 (2025).","journal-title":"Front. Endocrinol."},{"key":"2795_CR31","doi-asserted-by":"crossref","unstructured":"H\u00f6ppner, J. & J\u00fcppner, H. Rare genetic disorders that impair parathyroid hormone synthesis, secretion, or bioactivity provide insights into the diagnostic utility of different parathyroid hormone assays. Curr. Opin. Nephrol. Hypertens. 4, 375\u2013382 (2024).","DOI":"10.1097\/MNH.0000000000000999"},{"key":"2795_CR32","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/s42003-023-04966-0","volume":"6","author":"I Portales-Castillo","year":"2023","unstructured":"Portales-Castillo, I. et al. Altered signaling and desensitization responses in PTH1R mutants associated with Eiken syndrome. Commun. Biol. 6, 599 (2023).","journal-title":"Commun. Biol."},{"key":"2795_CR33","doi-asserted-by":"publisher","first-page":"4173","DOI":"10.1042\/BCJ20160740","volume":"473","author":"D Zindel","year":"2016","unstructured":"Zindel, D. et al. Identification of key phosphorylation sites in PTH1R that determine arrestin3 binding and fine-tune receptor signaling. Biochem. J. 473, 4173\u20134192 (2016).","journal-title":"Biochem. J."},{"key":"2795_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-022-33307-8","volume":"13","author":"RS Haider","year":"2022","unstructured":"Haider, R. S. et al. \u03b2-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the same GPCR in living cells. Nat. Commun. 13, 1\u201317 (2022).","journal-title":"Nat. Commun."},{"key":"2795_CR35","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1126\/science.2163110","volume":"248","author":"MJ Lohse","year":"1990","unstructured":"Lohse, M. J., Benovic, J. L., Codina, J., Caron, M. G. & Lefkowitz, R. J. \u03b2-arrestin: a protein that regulates \u03b2-adrenergic receptor function. Science 248, 1547\u20131550 (1990).","journal-title":"Science"},{"key":"2795_CR36","doi-asserted-by":"crossref","unstructured":"Gesty-Palmer, D. et al. A \u03b2-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation. Sci. Transl. Med. 1, 1ra1(2009).","DOI":"10.1126\/scitranslmed.3000071"},{"key":"2795_CR37","doi-asserted-by":"publisher","first-page":"10856","DOI":"10.1074\/jbc.M513380200","volume":"281","author":"D Gesty-Palmer","year":"2006","unstructured":"Gesty-Palmer, D. et al. Distinct \u03b2-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1\/2 activation. J. Biol. Chem. 281, 10856\u201310864 (2006).","journal-title":"J. Biol. Chem."},{"key":"2795_CR38","doi-asserted-by":"crossref","unstructured":"Pakharukova, N. et al. Mechanism of beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy. Nat. Commun. 17, 2973 (2026).","DOI":"10.1038\/s41467-026-69884-1"},{"key":"2795_CR39","doi-asserted-by":"publisher","first-page":"2562","DOI":"10.1073\/pnas.1701529114","volume":"114","author":"TJ Cahill","year":"2017","unstructured":"Cahill, T. J. et al. Distinct conformations of GPCR-\u03b2-arrestin complexes mediate desensitization, signaling, and endocytosis. Proc. Natl. Acad. Sci. USA 114, 2562\u20132567 (2017).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2795_CR40","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.cell.2016.07.004","volume":"166","author":"ARB Thomsen","year":"2016","unstructured":"Thomsen, A. R. B. et al. GPCR-G protein-\u03b2-arrestin super-complex mediates sustained G protein signaling. Cell 166, 907\u2013919 (2016).","journal-title":"Cell"},{"key":"2795_CR41","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1038\/s41594-019-0330-y","volume":"26","author":"AH Nguyen","year":"2019","unstructured":"Nguyen, A. H. et al. Structure of an endosomal signaling GPCR-G protein-\u03b2-arrestin megacomplex. Nat. Struct. Mol. Biol. 26, 1123\u20131131 (2019).","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2795_CR42","doi-asserted-by":"crossref","unstructured":"Calebiro, D. et al. Persistent cAMP-signals triggered by internalized G-protein-coupled receptors. PLoS Biol. 7, e1000172 (2009).","DOI":"10.1371\/journal.pbio.1000172"},{"key":"2795_CR43","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1038\/nature12000","volume":"495","author":"R Irannejad","year":"2013","unstructured":"Irannejad, R. et al. Conformational biosensors reveal GPCR signalling from endosomes. Nature 495, 534\u2013538 (2013).","journal-title":"Nature"},{"key":"2795_CR44","doi-asserted-by":"crossref","unstructured":"He, G. et al. A GPCR-G protein-\u03b2-arrestin megacomplex enabled by a versatile allosteric modulator. Cell 189, 1434\u20131450.e22 (2026).","DOI":"10.1016\/j.cell.2025.12.023"},{"key":"2795_CR45","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.tibs.2024.03.006","volume":"49","author":"E Flores-Espinoza","year":"2024","unstructured":"Flores-Espinoza, E. & Thomsen, A. R. B. Beneath the surface: endosomal GPCR signaling. Trends Biochem. Sci. 49, 520\u2013531 (2024).","journal-title":"Trends Biochem. Sci."},{"key":"2795_CR46","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/s41589-023-01412-4","volume":"20","author":"EE Blythe","year":"2024","unstructured":"Blythe, E. E. & von Zastrow, M. \u03b2-Arrestin-independent endosomal cAMP signaling by a polypeptide hormone GPCR. Nat. Chem. Biol. 20, 323\u2013332 (2024).","journal-title":"Nat. Chem. Biol."},{"key":"2795_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s42003-024-06512-y","volume":"7","author":"B Sokrat","year":"2024","unstructured":"Sokrat, B. et al. Role of the V2R-\u03b2arrestin-G\u03b2\u03b3 complex in promoting G protein translocation to endosomes. Commun. Biol. 7, 1\u201314 (2024).","journal-title":"Commun. Biol."},{"key":"2795_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1210\/endocr\/bqac054","volume":"163","author":"EJ Daley","year":"2022","unstructured":"Daley, E. J. et al. Actions of parathyroid hormone ligand analogues in humanized PTH1R knockin mice. Endocrinology 163, 1\u201314 (2022).","journal-title":"Endocrinology"},{"key":"2795_CR49","doi-asserted-by":"publisher","first-page":"e2500176122","DOI":"10.1073\/pnas.2500176122","volume":"122","author":"J H\u00f6ppner","year":"2025","unstructured":"H\u00f6ppner, J. et al. A mouse model of Jansen\u2019s metaphyseal chondrodysplasia for investigating disease mechanisms and candidate therapeutics. Proc. Natl. Acad. Sci. USA 122, e2500176122 (2025).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2795_CR50","doi-asserted-by":"publisher","first-page":"2452","DOI":"10.1038\/s41596-019-0187-x","volume":"14","author":"CB Gurumurthy","year":"2019","unstructured":"Gurumurthy, C. B. et al. Creation of CRISPR-based germline-genome-engineered mice without ex vivo handling of zygotes by i-GONAD. Nat. Protoc. 14, 2452\u20132482 (2019).","journal-title":"Nat. Protoc."},{"key":"2795_CR51","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/nature01657","volume":"423","author":"HM Kronenberg","year":"2003","unstructured":"Kronenberg, H. M. Developmental regulation of the growth plate. Nature 423, 332\u2013336 (2003).","journal-title":"Nature"},{"key":"2795_CR52","doi-asserted-by":"publisher","first-page":"10240","DOI":"10.1073\/pnas.93.19.10240","volume":"93","author":"EC Weir","year":"1996","unstructured":"Weir, E. C. et al. Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation. Proc. Natl. Acad. Sci. USA 93, 10240\u201310245 (1996).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2795_CR53","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1016\/j.cell.2024.01.028","volume":"187","author":"R Janicot","year":"2024","unstructured":"Janicot, R. et al. Direct interrogation of context-dependent GPCR activity with a universal biosensor platform. Cell 187, 1527\u20131546.e25 (2024).","journal-title":"Cell"},{"key":"2795_CR54","doi-asserted-by":"crossref","unstructured":"Liu, J. et al. Multi-faceted roles of \u03b2-arrestins in G protein-coupled receptor endocytosis. Nat. Commun. 17, 463 (2026).","DOI":"10.1038\/s41467-025-67156-y"},{"key":"2795_CR55","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36797-2","volume":"14","author":"Y Aydin","year":"2023","unstructured":"Aydin, Y. et al. Structural details of a Class B GPCR-arrestin complex revealed by genetically encoded crosslinkers in living cells. Nat. Commun. 14, 1151 (2023).","journal-title":"Nat. Commun."},{"key":"2795_CR56","doi-asserted-by":"publisher","first-page":"115709","DOI":"10.1016\/j.bone.2020.115709","volume":"142","author":"S Nishimori","year":"2021","unstructured":"Nishimori, S., Wein, M. N. & Kronenberg, H. M. PTHrP targets salt-inducible kinases, HDAC4 and HDAC5, to repress chondrocyte hypertrophy in the growth plate. Bone 142, 115709 (2021).","journal-title":"Bone"},{"key":"2795_CR57","doi-asserted-by":"crossref","unstructured":"Lanske, B. et al. PTH\/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science 273, 663\u2013666 (1996).","DOI":"10.1126\/science.273.5275.663"},{"key":"2795_CR58","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1126\/science.273.5275.613","volume":"273","author":"A Vortkamp","year":"1996","unstructured":"Vortkamp, A. et al. Regulation of rate of cartilage differentiation by Indian Hedgehog and PTH-related protein. Science 273, 613\u2013622 (1996).","journal-title":"Science"},{"key":"2795_CR59","doi-asserted-by":"publisher","first-page":"6522","DOI":"10.1021\/jacs.3c09694","volume":"146","author":"S Liu","year":"2024","unstructured":"Liu, S. et al. Backbone modification provides a long-acting inverse agonist of pathogenic, constitutively active PTH1R variants. J. Am. Chem. Soc. 146, 6522\u20136529 (2024).","journal-title":"J. Am. Chem. Soc."},{"key":"2795_CR60","doi-asserted-by":"publisher","first-page":"102332","DOI":"10.1016\/j.jbc.2022.102332","volume":"298","author":"KA Pe\u00f1a","year":"2022","unstructured":"Pe\u00f1a, K. A. et al. Biased GPCR signaling by the native parathyroid hormone\u2013related protein 1 to 141 relative to its N-terminal fragment 1 to 36. J. Biol. Chem. 298, 102332 (2022).","journal-title":"J. Biol. Chem."},{"key":"2795_CR61","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1073\/pnas.1205756110","volume":"110","author":"VL Wehbi","year":"2013","unstructured":"Wehbi, V. L. et al. Noncanonical GPCR signaling arising from a PTH receptor-arrestin- G\u03b2\u03b3 complex. Proc. Natl. Acad. Sci. USA 110, 1530\u20131535 (2013).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2795_CR62","doi-asserted-by":"publisher","first-page":"132","DOI":"10.4236\/abb.2011.23021","volume":"2","author":"MJ Mahon","year":"2011","unstructured":"Mahon, M. J. pHluorin2: an enhanced, ratiometric, pH-sensitive green florescent protein. Adv. Biosci. Biotechnol. 2, 132\u2013137 (2011).","journal-title":"Adv. Biosci. Biotechnol."},{"key":"2795_CR63","doi-asserted-by":"publisher","first-page":"7466","DOI":"10.1074\/jbc.RA118.001975","volume":"293","author":"Q Wan","year":"2018","unstructured":"Wan, Q. et al. Mini G protein probes for active G protein-coupled receptors (GPCRs) in live cells. J. Biol. Chem. 293, 7466\u20137473 (2018).","journal-title":"J. Biol. Chem."},{"key":"2795_CR64","doi-asserted-by":"crossref","unstructured":"Robleto, V. L., Zhuo, Y., Crecelius, J. M., Benzow, S. & Marchese, A. SNX9 family mediates \u03b2arrestin-independent GPCR endocytosis. Commun. Biol. 7, 1455 (2024).","DOI":"10.1038\/s42003-024-07157-7"},{"key":"2795_CR65","doi-asserted-by":"publisher","first-page":"116119","DOI":"10.1016\/j.bcp.2024.116119","volume":"222","author":"SM McNeill","year":"2024","unstructured":"McNeill, S. M. et al. The role of G protein-coupled receptor kinases in GLP-1R \u03b2-arrestin recruitment and internalisation. Biochem. Pharmacol. 222, 116119 (2024).","journal-title":"Biochem. Pharmacol."},{"key":"2795_CR66","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1124\/molpharm.120.000192","volume":"99","author":"E Von Moo","year":"2021","unstructured":"Von Moo, E., van Senten, J. R., Br\u00e4uner-Osborne, H. & M\u00f8ller, T. C. Arrestin-dependent and -independent internalization of G protein-coupled receptors: methods, mechanisms, and implications on cell signaling. Mol. Pharmacol. 99, 242\u2013255 (2021).","journal-title":"Mol. Pharmacol."},{"key":"2795_CR67","first-page":"149","volume":"15","author":"SL Ferrari","year":"2001","unstructured":"Ferrari, S. L. & Bisello, A. Cellular distribution of constitutively active mutant parathyroid hormone (PTH)\/PTH-related protein receptors and regulation of cyclic adenosine 3\u2032,5\u2032-monophosphate signaling by \u03b2-arrestin2. Mol. Endocrinol. 15, 149\u2013163 (2001).","journal-title":"Mol. Endocrinol."},{"key":"2795_CR68","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/nchembio.545","volume":"7","author":"TN Feinstein","year":"2011","unstructured":"Feinstein, T. N. et al. Retromer terminates the generation of cAMP by internalized PTH receptors. Nat. Chem. Biol. 7, 278\u2013284 (2011).","journal-title":"Nat. Chem. Biol."},{"key":"2795_CR69","doi-asserted-by":"crossref","unstructured":"Yoon, S. H. et al. A parathyroid hormone\/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis. J. Clin. Investig. 133, e163627 (2023).","DOI":"10.1172\/JCI163627"},{"key":"2795_CR70","doi-asserted-by":"crossref","unstructured":"Reno, P. L., Wallace, S., Doelp, S. N., Biancaniello, M. & Kjosness, K. M. The role of the PTHrP\/Ihh feedback loop in the unusual growth plate location in mammalian metatarsals and pisiforms. Dev. Dyn. 254, 1307\u20131324 (2025).","DOI":"10.1002\/dvdy.70013"},{"key":"2795_CR71","doi-asserted-by":"crossref","unstructured":"Monahan, G. et al. A novel brachydactyly type E syndrome caused by variants in helix 8 of the PTH1R. J. Bone Miner. Res. 5, 521\u2013536 (2026)","DOI":"10.1093\/jbmr\/zjaf134"},{"key":"2795_CR72","unstructured":"H\u00f6ppner, J., J\u00fcppner, H. & Gardella, T. J. Mutations in Helix 8 of the PTH1R cause a novel skeletal dysplasia syndrome by altering receptor engagement with effector proteins. In Proc. ASBMR 2025 Annual Meeting (ASBMR, 2025)."},{"key":"2795_CR73","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1038\/nchembio.1665","volume":"10","author":"NG Tsvetanova","year":"2014","unstructured":"Tsvetanova, N. G. & von Zastrow, M. Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis. Nat. Chem. Biol. 10, 1061\u20131065 (2014).","journal-title":"Nat. Chem. Biol."},{"key":"2795_CR74","doi-asserted-by":"publisher","first-page":"e2414738122","DOI":"10.1073\/pnas.2414738122","volume":"122","author":"MJ Klauer","year":"2025","unstructured":"Klauer, M. J., Hall, K. L., Jagla, C. A. D. & Tsvetanova, N. G. Extensive location bias of the GPCR-dependent translatome via site-selective activation of mTOR. Proc. Natl. Acad. Sci. USA 122, e2414738122 (2025).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2795_CR75","doi-asserted-by":"crossref","unstructured":"Calebiro, D., Miljus, T. & O\u2019Brien, S. Endomembrane GPCR signaling: 15 years on, the quest continues. Trends Biochem. Sci. 50, 46\u201360 (2025).","DOI":"10.1016\/j.tibs.2024.10.006"},{"key":"2795_CR76","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/s41589-023-01381-8","volume":"20","author":"TY Lin","year":"2024","unstructured":"Lin, T. Y. et al. Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools. Nat. Chem. Biol. 20, 62\u201373 (2024).","journal-title":"Nat. Chem. Biol."},{"key":"2795_CR77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7554\/eLife.87754.3","volume":"12","author":"C Daly","year":"2023","unstructured":"Daly, C. et al. \u03b2-arrestin-dependent and-independent endosomal G protein activation by the vasopressin type 2 receptor. eLife 12, 1\u201319 (2023).","journal-title":"eLife"},{"key":"2795_CR78","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-026-69329-9","volume":"17","author":"B Wysolmerski","year":"2026","unstructured":"Wysolmerski, B. et al. Conformational biosensors delineate endosomal G protein regulation by GPCRs. Nat. Commun. 17, 2911 (2026).","journal-title":"Nat. Commun."},{"key":"2795_CR79","doi-asserted-by":"publisher","first-page":"e10367","DOI":"10.1002\/jbm4.10367","volume":"4","author":"H Noda","year":"2020","unstructured":"Noda, H. et al. Optimization of PTH\/PTHrP hybrid peptides to derive a long-acting PTH analog (LA-PTH). JBMR Plus 4, e10367 (2020).","journal-title":"JBMR Plus"},{"key":"2795_CR80","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1002\/jbmr.2811","volume":"31","author":"M Shimizu","year":"2016","unstructured":"Shimizu, M. et al. Pharmacodynamic actions of a long-acting PTH analog (LA-PTH) in thyroparathyroidectomized (TPTX) rats and normal monkeys. J. Bone Miner. Res. 31, 1405\u20131412 (2016).","journal-title":"J. Bone Miner. Res."},{"key":"2795_CR81","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1210\/clinem\/dgae121","volume":"109","author":"I Takacs","year":"2024","unstructured":"Takacs, I. et al. An open-label phase 2 study of eneboparatide, a novel PTH receptor 1 agonist, in hypoparathyroidism. J. Clin. Endocrinol. Metab. 109, 2199\u20132209 (2024).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2795_CR82","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1126\/scisignal.ado7543","volume":"18","author":"T Redfern-Nichols","year":"2025","unstructured":"Redfern-Nichols, T. et al. Loss-of-function G\u03b1 s rare disease variants exert mutation-specific effects on GPCR signaling. Sci. Signal. 18, 1\u201312 (2025).","journal-title":"Sci. Signal."},{"key":"2795_CR83","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.tibs.2024.01.004","volume":"49","author":"A Bock","year":"2024","unstructured":"Bock, A., Irannejad, R. & Scott, J. D. cAMP signaling: a remarkably regional affair. Trends Biochem. Sci. 49, 305\u2013317 (2024).","journal-title":"Trends Biochem. Sci."},{"key":"2795_CR84","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1016\/j.cell.2022.02.011","volume":"185","author":"SE Anton","year":"2022","unstructured":"Anton, S. E. et al. Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling. Cell 185, 1130\u20131142.e11 (2022).","journal-title":"Cell"},{"key":"2795_CR85","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1021\/cb200248h","volume":"6","author":"BF Binkowski","year":"2011","unstructured":"Binkowski, B. F. et al. A luminescent biosensor with increased dynamic range for intracellular cAMP. ACS Chem. Biol. 6, 1193\u20131197 (2011).","journal-title":"ACS Chem. Biol."},{"key":"2795_CR86","doi-asserted-by":"publisher","first-page":"5864","DOI":"10.1073\/pnas.1301674110","volume":"110","author":"A Maeda","year":"2013","unstructured":"Maeda, A. et al. Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTH. Proc. Natl. Acad. Sci. USA 110, 5864\u20135869 (2013).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2795_CR87","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/nbt.2920","volume":"32","author":"RW Cheloha","year":"2014","unstructured":"Cheloha, R. W., Maeda, A., Dean, T., Gardella, T. J. & Gellman, S. H. Backbone modification of a polypeptide drug alters duration of action in vivo. Nat. Biotechnol. 32, 653\u2013655 (2014).","journal-title":"Nat. Biotechnol."},{"key":"2795_CR88","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1126\/scisignal.aal3395","volume":"10","author":"M O\u2019Hayre","year":"2017","unstructured":"O\u2019Hayre, M. et al. Genetic evidence that b-arrestins are dispensable for the initiation of b2-adrenergic receptor signaling to ERK. Sci. Signal. 10, 1\u201313 (2017).","journal-title":"Sci. Signal."},{"key":"2795_CR89","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-020-15884-8","volume":"11","author":"RW Cheloha","year":"2020","unstructured":"Cheloha, R. W. et al. Improved GPCR ligands from nanobody tethering. Nat. Commun. 11, 1\u201311 (2020).","journal-title":"Nat. Commun."},{"key":"2795_CR90","doi-asserted-by":"publisher","first-page":"e10802","DOI":"10.1002\/jbm4.10802","volume":"7","author":"M Reyes","year":"2023","unstructured":"Reyes, M. et al. Substantially delayed maturation of growth plate chondrocytes in \u2018humanized\u2019 PTH1R mice with the H223R mutation of Jansen\u2019s Disease. JBMR Plus 7, e10802 (2023).","journal-title":"JBMR Plus"},{"key":"2795_CR91","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<145::AID-GENE14>3.0.CO;2-C","volume":"26","author":"DA Ovchinnikov","year":"2000","unstructured":"Ovchinnikov, D. A., Deng, J. M., Ogunrinu, G. & Behringer, R. R. Col2a1-directed expression of Cre recombinase in differentiating chondrocytes in transgenic mice. Genesis 26, 145\u2013146 (2000).","journal-title":"Genesis"},{"key":"2795_CR92","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1210\/endo.142.5.8146","volume":"142","author":"B He","year":"2001","unstructured":"He, B. et al. Tissue-specific targeting of the PTHrP gene: the generation of mice with floxed alleles. Endocrinology 142, 2070\u20132077 (2001).","journal-title":"Endocrinology"},{"key":"2795_CR93","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1126\/science.286.5449.2495","volume":"286","author":"LM Bohn","year":"1999","unstructured":"Bohn, L. M. et al. Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science 286, 2495\u20132498 (1999).","journal-title":"Science"},{"key":"2795_CR94","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13395-018-0184-8","volume":"8","author":"J Kim","year":"2018","unstructured":"Kim, J. et al. \u0392-arrestin 1 regulates \u03922-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility. Skelet. Muscle 8, 1\u201313 (2018).","journal-title":"Skelet. Muscle"},{"key":"2795_CR95","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1097\/01.ASN.0000133023.89251.01","volume":"15","author":"I Rubera","year":"2004","unstructured":"Rubera, I. et al. Specific Cre\/Lox recombination in the mouse proximal tubule. J. Am. Soc. Nephrol. 15, 2050\u20132056 (2004).","journal-title":"J. Am. Soc. Nephrol."},{"key":"2795_CR96","doi-asserted-by":"publisher","first-page":"107548","DOI":"10.1016\/j.isci.2023.107548","volume":"26","author":"PS Yadav","year":"2023","unstructured":"Yadav, P. S., Papaioannou, G., Kobelski, M. M. & Demay, M. B. Phosphate-induced activation of VEGFR2 leads to caspase-9-mediated apoptosis of hypertrophic chondrocytes. iScience 26, 107548 (2023).","journal-title":"iScience"},{"key":"2795_CR97","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1093\/nar\/gkr1013","volume":"40","author":"X Wang","year":"2012","unstructured":"Wang, X., Spandidos, A., Wang, H. & Seed, B. PrimerBank: A PCR primer database for quantitative gene expression analysis, 2012 update. Nucleic Acids Res. 40, 1144\u20131149 (2012).","journal-title":"Nucleic Acids Res."},{"key":"2795_CR98","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak, K. J. & Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25, 402\u2013408 (2001).","journal-title":"Methods"}],"container-title":["Signal Transduction and Targeted Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41392-026-02795-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41392-026-02795-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41392-026-02795-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T23:02:32Z","timestamp":1789081352000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41392-026-02795-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":98,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2795"],"URL":"https:\/\/doi.org\/10.1038\/s41392-026-02795-1","relation":{},"ISSN":["2059-3635"],"issn-type":[{"value":"2059-3635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,11]]},"assertion":[{"value":"6 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"376"}}