{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:33:23Z","timestamp":1778841203410,"version":"3.51.4"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T00:00:00Z","timestamp":1537920000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Spinal Cord"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1038\/s41393-018-0195-7","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T13:20:59Z","timestamp":1537968059000},"page":"1207-1211","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Effect of early treatment with zoledronic acid on prevention of bone loss in patients with acute spinal cord injury: a randomized controlled trial"],"prefix":"10.1038","volume":"56","author":[{"given":"Sunil","family":"Goenka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satyaranjan","family":"Sethi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitin","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mrinal","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajeswari","family":"Jindal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,9,26]]},"reference":[{"key":"195_CR1","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1007\/s00198-005-2028-8","volume":"17","author":"J Sheng-Dan","year":"2006","unstructured":"Sheng-Dan J, Li-Yang D, Lei-Sheng J. Osteoporosis after spinal cord injury. Osteoporos Int. 2006;17:180\u201392.","journal-title":"Osteoporos Int"},{"key":"195_CR2","first-page":"225","volume":"37","author":"BJ Kiratli","year":"2000","unstructured":"Kiratli BJ, Smith AE, Nauenberg T, Kallfelz CF, Perkash I. Bone mineral and geometric changes through the femur with immobilization due to spinal cord injury. J Rehabil Res Dev. 2000;37:225\u201333.","journal-title":"J Rehabil Res Dev"},{"key":"195_CR3","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1111\/j.1365-2265.2006.02683.x","volume":"65","author":"J Sheng-Dan","year":"2006","unstructured":"Sheng-Dan J, Lei-Sheng J, Li-Yang D. Mechanisms of osteoporosis in spinal cord injury. Clin Endocrinol. 2006;65:555\u201365.","journal-title":"Clin Endocrinol"},{"key":"195_CR4","doi-asserted-by":"crossref","unstructured":"Shapiro J, Smith B, Beck T, Ballard P, Dapthary M, BrintzenhofeSzoc K, et al. Treatment with zoledronic acid ameliorates negative geometric changes in the proximal femur following acute spinal cord injury. Calcified Tissue Int. 2007; 80:316\u201322.","DOI":"10.1007\/s00223-007-9012-6"},{"key":"195_CR5","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s00198-004-1665-7","volume":"16","author":"JM Slade","year":"2005","unstructured":"Slade JM, Bickel CS, Modlesky CM, Majumdar S, Dudley GA. Trabecular bone is more deteriorated in spinal cord injured versus estrogen-free postmenopausal women. Osteoporos Int. 2005;16:263\u201372.","journal-title":"Osteoporos Int"},{"key":"195_CR6","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1359\/jbmr.0301208","volume":"19","author":"CM Modlesky","year":"2004","unstructured":"Modlesky CM, Majumdar S, Narasimhan A, Dudley GA. Trabecular bone microarchitecture is deteriorated in men with spinal cord injury. J Bone Miner Res. 2004;19:48\u201355.","journal-title":"J Bone Miner Res"},{"key":"195_CR7","doi-asserted-by":"crossref","unstructured":"Nottage W. A review of long bone fractures in patients with spinal cord injuries. Clin Orthop Relat Res. 1981;155:65\u201370.","DOI":"10.1097\/00003086-198103000-00012"},{"key":"195_CR8","doi-asserted-by":"crossref","unstructured":"Vestergaard P, Krogh K, Rejnmark L, Mosekilde L. Fracture rates and risk factors for fractures in patients with spinal cord injury. Spinal Cord. 1998;36:790\u20136.","DOI":"10.1038\/sj.sc.3100648"},{"key":"195_CR9","doi-asserted-by":"crossref","unstructured":"Dauty M, Perrouin Verbe B, Maugars Y, Dubois C, Mathe J. Supralesional and sublesional bone mineral density in spinal cord injured patients. Bone. 2000;27:305\u20139.","DOI":"10.1016\/S8756-3282(00)00326-4"},{"key":"195_CR10","first-page":"669","volume":"33","author":"D \u00dcbelhart","year":"1995","unstructured":"\u00dcbelhart D, Demiaux-Domenech B, Roth M, Chantraine A. Bone metabolism in spinal cord injured individuals and in others who have prolonged immobilisation. A review. Paraplegia. 1995;33:669\u201373.","journal-title":"Paraplegia"},{"key":"195_CR11","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s004020000162","volume":"121","author":"D Sabo","year":"2001","unstructured":"Sabo D, Blaich S, Wenz W, Hohmann M, Loew M, Gerner HJ. Osteoporosis in patients with paralysis after spinal cord injury: a cross sectional study in 46 male patients with dual-energy X-ray absorptiometry. Arch Orthop Trauma Surg. 2001;121:75\u20138.","journal-title":"Arch Orthop Trauma Surg"},{"key":"195_CR12","doi-asserted-by":"crossref","unstructured":"Bubbear JS, Gall A, Middleton FR, Ferguson-Pell M, Swaminathan R, Keen RW. Early treatment with zoledronic acid prevents bone loss at the hip following acute spinal cord injury. Osteoporos Int. 2011;22:271\u20139.","DOI":"10.1007\/s00198-010-1221-6"},{"key":"195_CR13","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1002\/jbmr.5650090521","volume":"9","author":"JR Green","year":"1994","unstructured":"Green JR, Muller K, Jaeggi KA. Preclinical pharmacology of CGP 42\u2032446, a new, potent, heterocyclic bisphosphonate compound. J Bone Miner Res. 1994;9:745\u201351.","journal-title":"J Bone Miner Res"},{"key":"195_CR14","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1002\/ddr.10071","volume":"55","author":"RG Jonathan","year":"2002","unstructured":"Jonathan RG, Michael JR. Pharmacologic profile of zoledronic acid: a highly potent inhibitor of bone resorption. Drug Dev Res. 2002;55:210\u201324.","journal-title":"Drug Dev Res"},{"key":"195_CR15","doi-asserted-by":"publisher","first-page":"3721","DOI":"10.1021\/jm020819i","volume":"45","author":"L Widler","year":"2002","unstructured":"Widler L, Jaeggi K, Glatt M, M\u00fcller K, Bachmann R, Bisping M, et al. Highly potent geminal bisphosphonates from pamidronate disodium (Aredia) to zoledronic acid (Zometa). J Med Chem. 2002;45:3721\u201338.","journal-title":"J Med Chem"},{"key":"195_CR16","doi-asserted-by":"crossref","unstructured":"Gilchrist NL, Frampton CM, Acland RH, Nicholls MG, March RL, Maguire P, et al. Alendronate prevents bone loss in patients with acute spinal cord injury: a randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab. 2007;92:1385\u201390.","DOI":"10.1210\/jc.2006-2013"},{"key":"195_CR17","doi-asserted-by":"crossref","unstructured":"Zehnder Y, Risi S, Michel D, Knecht H, Perrelet R, Kraenzlin M, et al. Prevention of bone loss in paraplegics over 2 years with alendronate. J Bone Miner Res. 2004;19:1067\u201374.","DOI":"10.1359\/JBMR.040313"},{"key":"195_CR18","doi-asserted-by":"crossref","unstructured":"Nance P, Schryvers O, Leslie W, Ludwig S, Krahn J, Uebelhart D. Intravenous pamidronate attenuates bone density loss after acute spinal cord injury. Arch Phys Med Rehabil. 1999;80:243\u201351.","DOI":"10.1016\/S0003-9993(99)90133-8"},{"key":"195_CR19","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.pmrj.2016.01.012","volume":"8","author":"TJ Schnitzer","year":"2016","unstructured":"Schnitzer TJ, Kim K, Marks J, Yeasted R, Simonian N, Chen D. Zoledronic acid treatment after acute spinal cord injury: results of a randomized, placebo controlled pilot trial. PM R. 2016;8:833\u201343.","journal-title":"PM R"},{"key":"195_CR20","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1210\/er.2001-2002","volume":"23","author":"A Cranney","year":"2002","unstructured":"Cranney A, Wells G, Willan A, Griffith L, Zytaruk N, Robinson V, Black D, Adachi J, Shea B, Tugwell P, Guyatt G. Meta-analyses of therapies for postmenopausal osteoporosis. II. Meta-analysis of alendronate for the treatment of postmenopausal women. Endocr Rev. 2002;23:508\u201316.","journal-title":"Endocr Rev"}],"container-title":["Spinal Cord"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41393-018-0195-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41393-018-0195-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41393-018-0195-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:36:34Z","timestamp":1684618594000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41393-018-0195-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,26]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["195"],"URL":"https:\/\/doi.org\/10.1038\/s41393-018-0195-7","relation":{},"ISSN":["1362-4393","1476-5624"],"issn-type":[{"value":"1362-4393","type":"print"},{"value":"1476-5624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,26]]},"assertion":[{"value":"25 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}