{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:43:10Z","timestamp":1772754190369,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006576","name":"Civilingeni\u00f8r Frode V. Nyegaard og Hustrus Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006576","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Region Midt, Research Fund"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Spinal Cord"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Study design<\/jats:title>\n                <jats:p>1-year prospective RCT.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>Examine the effect of implantable pulse generator and low-frequency stimulation of the pelvic nerves using laparoscopic implantation of neuroprosthesis (LION) compared with neuromuscular electrical stimulation (NMES) in SCI.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Inclusion criteria: traumatic spinal cord injury (SCI), age 18\u201355 years, neurological level-of-injury Th4\u2013L1, time-since-injury &gt;1 year, and AIS-grades A\u2013B. Participants were randomized to (A) LION procedure or (B) control group receiving NMES. Primary outcome measure: Walking Index for Spinal Cord Injury (WISCI-II), which is a SCI specific outcome measure assessing ability to ambulate. Secondary outcome measures: Spinal Cord Independence Measure III (SCIM III), Patient Global Impression of Change (PGIC), Penn Spasm Frequency Scale (PSFS), severity of spasticity measured by Numeric Rating Scale (NRS-11); International Spinal Cord Injury data sets-Quality of Life Basic Data Set (QoLBDS), and Brief Pain Inventory (BPI).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Seventeen SCI individuals, AIS grade A, neurological level ranging from Th4\u2013L1, were randomized to the study. One individual was excluded prior to intervention. Eight participants (7 males) with a mean age (SD) of 35.5 (12.4) years were allocated to the LION procedure, 8 participants (7 males) with age of 38.8 (15.1) years were allocated to NMES. Significantly, 5 LION group participants gained 1 point on the WISCI II scale, (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.013; Fisher\u00b4s exact test). WISCI II scale score did not change in controls. No significant changes were observed in the secondary outcome measures.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The LION procedure is a promising new treatment for individuals with SCI with significant one-year improvement in walking ability.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1038\/s41393-021-00693-7","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T08:03:26Z","timestamp":1629792206000},"page":"251-255","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of pelvic laparoscopic implantation of neuroprosthesis in spinal cord injured subjects: a 1-year prospective randomized controlled study"],"prefix":"10.1038","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9302-4946","authenticated-orcid":false,"given":"Helge","family":"Kasch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2409-0499","authenticated-orcid":false,"given":"Uffe Schou","family":"L\u00f8ve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anette Bach","family":"J\u00f8nsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaare Eg","family":"Severinsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0697-3394","authenticated-orcid":false,"given":"Marc","family":"Possover","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren Bruno","family":"Elmgreen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Forman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,24]]},"reference":[{"key":"693_CR1","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1038\/sc.2016.46","volume":"54","author":"SR Andresen","year":"2016","unstructured":"Andresen SR, Biering-Sorensen F, Hagen EM, Nielsen JF, Bach FW, Finnerup NB. 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The study and technical devices were also approved and surveilled by the Danish Medicines Agency (J.nr. 2017080415, CIV-17-08-020985).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}]}}