{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T10:21:17Z","timestamp":1783592477654,"version":"3.55.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Spinal Cord"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1038\/s41393-021-00747-w","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T16:04:13Z","timestamp":1641830653000},"page":"510-515","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A prospective multi-center study comparing the complication profile of modest systemic hypothermia versus normothermia for acute cervical spinal cord injury"],"prefix":"10.1038","volume":"60","author":[{"given":"Aditya","family":"Vedantam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Jimsheleishvili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0943-3406","authenticated-orcid":false,"given":"James S.","family":"Harrop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda R.","family":"Alberga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiz U.","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory K.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"J. Benjamin","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Rodgers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan D.","family":"Levi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"747_CR1","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.resuscitation.2006.01.017","volume":"70","author":"AG Alzaga","year":"2006","unstructured":"Alzaga AG, Cerdan M, Varon J. Therapeutic hypothermia. Resuscitation. 2006;70:369\u201380.","journal-title":"Resuscitation"},{"key":"747_CR2","doi-asserted-by":"publisher","first-page":"339","DOI":"10.3171\/jns.1999.90.2.0339","volume":"90","author":"T Kaibara","year":"1999","unstructured":"Kaibara T, Sutherland GR, Colbourne F, Tyson RL. Hypothermia: depression of tricarboxylic acid cycle flux and evidence for pentose phosphate shunt upregulation. J Neurosurg. 1999;90:339\u201347.","journal-title":"J Neurosurg"},{"key":"747_CR3","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/sj.sc.3102163","volume":"46","author":"T Morino","year":"2008","unstructured":"Morino T, Ogata T, Takeba J, Yamamoto H. Microglia inhibition is a target of mild hypothermic treatment after the spinal cord injury. Spinal Cord. 2008;46:425\u201331.","journal-title":"Spinal Cord"},{"key":"747_CR4","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/S0169-328X(00)00252-7","volume":"86","author":"LK Friedman","year":"2001","unstructured":"Friedman LK, Ginsberg MD, Belayev L, Busto R, Alonso OF, Lin B, et al. Intraischemic but not postischemic hypothermia prevents non-selective hippocampal downregulation of AMPA and NMDA receptor gene expression after global ischemia. Brain Res Mol Brain Res. 2001;86:34\u201347.","journal-title":"Brain Res Mol Brain Res"},{"key":"747_CR5","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1089\/neu.2008.0745","volume":"26","author":"AD Levi","year":"2009","unstructured":"Levi AD, Green BA, Wang MY, Dietrich WD, Brindle T, Vanni S, et al. Clinical application of modest hypothermia after spinal cord injury. J Neurotrauma. 2009;26:407\u201315.","journal-title":"J Neurotrauma"},{"key":"747_CR6","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1227\/01.NEU.0000367557.77973.5F","volume":"66","author":"AD Levi","year":"2010","unstructured":"Levi AD, Casella G, Green BA, Dietrich WD, Vanni S, Jagid J, et al. Clinical outcomes using modest intravascular hypothermia after acute cervical spinal cord injury. Neurosurgery. 2010;66:670\u20137.","journal-title":"Neurosurgery"},{"key":"747_CR7","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/sc.2012.161","volume":"51","author":"M Dididze","year":"2013","unstructured":"Dididze M, Green BA, Dietrich WD, Vanni S, Wang MY, Levi AD. Systemic hypothermia in acute cervical spinal cord injury: a case-controlled study. Spinal Cord. 2013;51:395\u2013400.","journal-title":"Spinal Cord"},{"key":"747_CR8","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3171\/2012.5.AOSPINE12127","volume":"17","author":"RG Grossman","year":"2012","unstructured":"Grossman RG, Frankowski RF, Burau KD. Incidence and severity of acute complications after spinal cord injury. J Neurosurg Spine. 2012;17:119\u201328.","journal-title":"J Neurosurg Spine"},{"key":"747_CR9","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1089\/neu.2007.0395","volume":"25","author":"M Boakye","year":"2008","unstructured":"Boakye M, Patil CG, Santarelli J, Ho C, Tian W, Lad SP. Laminectomy and fusion after spinal cord injury: national inpatient complications and outcomes. J Neurotrauma. 2008;25:173\u201383.","journal-title":"J Neurotrauma"},{"key":"747_CR10","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1097\/BRS.0b013e3181be76f5","volume":"35","author":"PW New","year":"2010","unstructured":"New PW, Jackson T. The costs and adverse events associated with hospitalization of patients with spinal cord injury in Victoria, Australia. Spine. 2010;35:796\u2013802.","journal-title":"Spine"},{"key":"747_CR11","first-page":"700","volume":"31","author":"CH Tator","year":"1993","unstructured":"Tator CH, Duncan EG, Edmonds VE, Lapczak LI, Andrews DF. Complications and costs of management of acute spinal cord injury. Paraplegia. 1993;31:700\u201314.","journal-title":"Paraplegia"},{"key":"747_CR12","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1089\/089771503765172345","volume":"20","author":"AV Krassioukov","year":"2003","unstructured":"Krassioukov AV, Furlan JC, Fehlings MG. Medical co-morbidities, secondary complications, and mortality in elderly with acute spinal cord injury. J Neurotrauma. 2003;20:391\u20139.","journal-title":"J Neurotrauma"},{"key":"747_CR13","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1089\/neu.2008.0764","volume":"26","author":"JC Furlan","year":"2009","unstructured":"Furlan JC, Kattail D, Fehlings MG. The impact of co-morbidities on age-related differences in mortality after acute traumatic spinal cord injury. J Neurotrauma. 2009;26:1361\u20137.","journal-title":"J Neurotrauma"},{"key":"747_CR14","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3171\/2012.4.AOSPINE1295","volume":"17","author":"B Aarabi","year":"2012","unstructured":"Aarabi B, Harrop JS, Tator CH, Alexander M, Dettori JR, Grossman RG, et al. Predictors of pulmonary complications in blunt traumatic spinal cord injury. J Neurosurg Spine. 2012;17:38\u201345.","journal-title":"J Neurosurg Spine"},{"key":"747_CR15","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/0003-9993(94)90027-2","volume":"75","author":"AB Jackson","year":"1994","unstructured":"Jackson AB, Groomes TE. Incidence of respiratory complications following spinal cord injury. Arch Phys Med Rehabil. 1994;75:270\u20135.","journal-title":"Arch Phys Med Rehabil"},{"key":"747_CR16","first-page":"197","volume":"71","author":"MJ Fishburn","year":"1990","unstructured":"Fishburn MJ, Marino RJ, Ditunno JF. Atelectasis and pneumonia in acute spinal cord injury. Arch Phys Med Rehabil. 1990;71:197\u2013200.","journal-title":"Arch Phys Med Rehabil"},{"key":"747_CR17","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1016\/j.echo.2013.06.021","volume":"26","author":"A Espinoza","year":"2013","unstructured":"Espinoza A, Kerans V, Opdahl A, Skulstad H, Halvorsen PS, Bugge JF, et al. Effects of therapeutic hypothermia on left ventricular function assessed by ultrasound imaging. J Am Soc Echocardiogr Publ Am Soc Echocardiogr. 2013;26:1353\u201363.","journal-title":"J Am Soc Echocardiogr Publ Am Soc Echocardiogr"},{"key":"747_CR18","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1111\/apha.12003","volume":"207","author":"RM Wold","year":"2013","unstructured":"Wold RM, Kondratiev T, Tveita T. Myocardial calcium overload during graded hypothermia and after rewarming in an in vivo rat model. Acta Physiol Oxf Engl. 2013;207:460\u20139.","journal-title":"Acta Physiol Oxf Engl"},{"key":"747_CR19","first-page":"39","volume":"82","author":"MA MacKenzie","year":"1992","unstructured":"MacKenzie MA, Aengevaeren WR, Hermus AR, Van Der Werf T, Pieters GF, Smals AG, et al. Electrocardiographic changes during steady mild hypothermia and normothermia in patients with poikilothermia. Clin Sci Lond Engl 1979. 1992;82:39\u201345.","journal-title":"Clin Sci Lond Engl 1979"},{"key":"747_CR20","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/BF02279888","volume":"9","author":"R Ilia","year":"1988","unstructured":"Ilia R, Ovsyshcher I, Rudnik L, Gueron M. Atypical ventricular tachycardia and alternating Osborn waves induced by spontaneous mild hypothermia. Pediatr Cardiol. 1988;9:63\u20135.","journal-title":"Pediatr Cardiol"},{"key":"747_CR21","doi-asserted-by":"publisher","first-page":"S186","DOI":"10.1097\/CCM.0b013e3181aa5241","volume":"37","author":"KH Polderman","year":"2009","unstructured":"Polderman KH. Mechanisms of action, physiological effects, and complications of hypothermia. Crit Care Med. 2009;37:S186\u2013202.","journal-title":"Crit Care Med"},{"key":"747_CR22","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1016\/j.resuscitation.2014.05.029","volume":"85","author":"R Maze","year":"2014","unstructured":"Maze R, Le May MR, Froeschl M, Hazra SK, Wells PS, Osborne C, et al. Endovascular cooling catheter related thrombosis in patients undergoing therapeutic hypothermia for out of hospital cardiac arrest. Resuscitation. 2014;85:1354\u20138.","journal-title":"Resuscitation"},{"key":"747_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.resuscitation.2017.12.014","volume":"124","author":"O Andremont","year":"2018","unstructured":"Andremont O, du Cheyron D, Terzi N, Daubin C, Seguin A, Valette X, et al. Endovascular cooling versus standard femoral catheters and intravascular complications: a propensity-matched cohort study. Resuscitation. 2018;124:1\u20136.","journal-title":"Resuscitation"},{"key":"747_CR24","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/S0039-6109(16)44585-8","volume":"68","author":"A Patt","year":"1988","unstructured":"Patt A, McCroskey BL, Moore EE. Hypothermia-induced coagulopathies in trauma. Surg Clin North Am. 1988;68:775\u201385.","journal-title":"Surg Clin North Am"},{"key":"747_CR25","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/00008506-199504000-00021","volume":"7","author":"A Schubert","year":"1995","unstructured":"Schubert A. Side effects of mild hypothermia. J Neurosurg Anesthesiol. 1995;7:139\u201347.","journal-title":"J Neurosurg Anesthesiol"}],"container-title":["Spinal Cord"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41393-021-00747-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41393-021-00747-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41393-021-00747-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T12:06:55Z","timestamp":1655726815000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41393-021-00747-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,10]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["747"],"URL":"https:\/\/doi.org\/10.1038\/s41393-021-00747-w","relation":{},"ISSN":["1362-4393","1476-5624"],"issn-type":[{"value":"1362-4393","type":"print"},{"value":"1476-5624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,10]]},"assertion":[{"value":"1 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 December 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"We certify that all applicable institutional regulations concerning the ethical use of human volunteers were followed during the course of this research.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}