{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T20:07:25Z","timestamp":1783627645090,"version":"3.55.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Spinal Cord"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1038\/s41393-023-00905-2","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T11:02:26Z","timestamp":1687950146000},"page":"447-452","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["D-dimer\/fibrinogen ratio for the prediction of deep venous thrombosis after traumatic spinal cord injury"],"prefix":"10.1038","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3153-9458","authenticated-orcid":false,"given":"Changyi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfu","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyu","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,28]]},"reference":[{"key":"905_CR1","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1056\/NEJM199412153312401","volume":"331","author":"WH Geerts","year":"1994","unstructured":"Geerts WH, Code KI, Jay RM, Chen E, Szalai JP. A prospective study of venous thromboembolism after major trauma. N. Engl J Med. 1994;331:1601\u20136.","journal-title":"N. Engl J Med"},{"key":"905_CR2","first-page":"8","volume":"29","author":"WP Waring","year":"1991","unstructured":"Waring WP, Karunas RS. Acute spinal cord injuries and the incidence of clinically occurring thromboembolic disease. Paraplegia 1991;29:8\u201316.","journal-title":"Paraplegia"},{"key":"905_CR3","first-page":"606","volume":"31","author":"S G\u00fcnd\u00fcz","year":"1993","unstructured":"G\u00fcnd\u00fcz S, O\u011fur E, M\u00f6h\u00fcr H, Somuncu I, A\u00e7jks\u00f6z E, Ust\u00fcns\u00f6z B. Deep vein thrombosis in spinal cord injured patients. Paraplegia 1993;31:606\u201310.","journal-title":"Paraplegia"},{"key":"905_CR4","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/sj.sc.3102170","volume":"46","author":"MF Rathore","year":"2008","unstructured":"Rathore MF, Hanif S, New PW, Butt AW, Aasi MH, Khan SU. The prevalence of deep vein thrombosis in a cohort of patients with spinal cord injury following the Pakistan earthquake of October 2005. Spinal Cord. 2008;46:523\u20136.","journal-title":"Spinal Cord"},{"key":"905_CR5","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/S0003-9993(99)90058-8","volume":"80","author":"M Powell","year":"1999","unstructured":"Powell M, Kirshblum S, O'Connor KC. Duplex ultrasound screening for deep vein thrombosis in spinal cord injured patients at rehabilitation admission. Arch Phys Med Rehabil. 1999;80:1044\u20136.","journal-title":"Arch Phys Med Rehabil"},{"key":"905_CR6","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1097\/00005373-198506000-00013","volume":"25","author":"P Myllynen","year":"1985","unstructured":"Myllynen P, Kammonen M, Rokkanen P, B\u00f6stman O, Lalla M, Laasonen E. Deep venous thrombosis and pulmonary embolism in patients with acute spinal cord injury: a comparison with nonparalyzed patients immobilized due to spinal fractures. J Trauma. 1985;25:541\u20133.","journal-title":"J Trauma"},{"key":"905_CR7","doi-asserted-by":"publisher","first-page":"972","DOI":"10.4184\/asj.2016.10.5.972","volume":"10","author":"S Alabed","year":"2016","unstructured":"Alabed S, Belci M, Van Middendorp JJ, Al Halabi A, Meagher TM. Thromboembolism in the sub-acute phase of spinal cord injury: a systematic review of the lite. Asian Spine J. 2016;10:972\u201381.","journal-title":"Asian Spine J"},{"key":"905_CR8","doi-asserted-by":"publisher","first-page":"194","DOI":"10.4103\/0019-5413.33681","volume":"41","author":"SK Saraf","year":"2007","unstructured":"Saraf SK, Rana RJ, Sharma OP. Venous thromboembolism in acute spinal cord injury patients. Indian J Orthop. 2007;41:194\u20137.","journal-title":"Indian J Orthop"},{"key":"905_CR9","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.3346\/jkms.2013.28.9.1382","volume":"28","author":"JG Do","year":"2013","unstructured":"Do JG, Kim du H, Sung DH. Incidence of deep vein thrombosis after spinal cord injury in Korean patients at acute rehabilitation unit. J Korean Med Sci. 2013;28:1382\u20137.","journal-title":"J Korean Med Sci"},{"key":"905_CR10","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1373\/clinchem.2011.166249","volume":"57","author":"A Tripodi","year":"2011","unstructured":"Tripodi A. D-dimer testing in laboratory practice. Clin Chem. 2011;57:1256\u201362.","journal-title":"Clin Chem"},{"key":"905_CR11","doi-asserted-by":"publisher","first-page":"253","DOI":"10.7326\/M16-0031","volume":"165","author":"N van Es","year":"2016","unstructured":"van Es N, van der Hulle T, van Es J, den Exter PL, Douma RA, Goekoop RJ, et al. Wells rule and d-Dimer testing to rule out pulmonary embolism: a systematic review and individual-patient data meta-analysis. Ann Intern Med. 2016;165:253\u201361.","journal-title":"Ann Intern Med"},{"key":"905_CR12","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/s41393-021-00647-z","volume":"60","author":"J Zhang","year":"2022","unstructured":"Zhang J, Fang Y, Pang H, Tao Y, Zhou J, Zhu S, et al. Association of age-adjusted D-dimer with deep vein thrombosis risk in patients with spinal cord injury: a cross-sectional study. Spinal Cord. 2022;60:90\u20138.","journal-title":"Spinal Cord"},{"key":"905_CR13","doi-asserted-by":"publisher","first-page":"689","DOI":"10.3390\/jcm10040689","volume":"10","author":"M Mackiewicz-Milewska","year":"2021","unstructured":"Mackiewicz-Milewska M, Cisowska-Adamiak M, Pyskir J, \u015awi\u0105tkiewicz I. Usefulness of D-dimer and ultrasonography screening for detecting deep vein thrombosis in patients with spinal cord injury undergoing rehabilitation. J Clin Med. 2021;10:689.","journal-title":"J Clin Med"},{"key":"905_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-82147-x","volume":"11","author":"J Ma","year":"2021","unstructured":"Ma J, Du P, Qin J, Zhou Y, Liang N, Hu J, et al. Incidence and risk factors predicting deep venous thrombosis of lower extremity following spinal fractures. Sci Rep. 2021;11:2441.","journal-title":"Sci Rep"},{"key":"905_CR15","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1080\/10790268.2018.1518765","volume":"43","author":"G Kumagai","year":"2020","unstructured":"Kumagai G, Wada K, Kudo H, Asari T, Ichikawa N, Ishibashi Y. D-dimer monitoring combined with ultrasonography improves screening for asymptomatic venous thromboembolism in acute spinal cord injury. J Spinal Cord Med. 2020;43:353\u20137.","journal-title":"J Spinal Cord Med"},{"key":"905_CR16","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1097\/PHM.0000000000001383","volume":"99","author":"JH Cho","year":"2020","unstructured":"Cho JH, Kim JB, Lee DG. Correlation between D-Dimer level and deep venous thrombosis in patients with acute spinal cord injuries. Am J Phys Med Rehabil. 2020;99:613\u20136.","journal-title":"Am J Phys Med Rehabil"},{"key":"905_CR17","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1016\/j.spinee.2015.06.060","volume":"15","author":"M Masuda","year":"2015","unstructured":"Masuda M, Ueta T, Shiba K, Iwamoto Y. D-dimer screening for deep venous thrombosis in traumatic cervical spinal injuries. Spine J. 2015;15:2338\u201344.","journal-title":"Spine J"},{"key":"905_CR18","doi-asserted-by":"crossref","unstructured":"Marcian\u00f2 T, Franchini S. Could a D-dimer\/fibrinogen ratio have a role in ruling-out venous thromboembolism? Emerg Med J. 2022;39:941\u20134.","DOI":"10.1136\/emermed-2020-210688"},{"key":"905_CR19","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1046\/j.1538-7836.2003.00145.x","volume":"1","author":"N Kucher","year":"2003","unstructured":"Kucher N, Kohler HP, Dornh\u00f6fer T, Wallmann D, L\u00e4mmle B. Accuracy of D-dimer\/fibrinogen ratio to predict pulmonary embolism: a prospective diagnostic study. J Thromb Haemost. 2003;1:708\u201313.","journal-title":"J Thromb Haemost"},{"key":"905_CR20","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1111\/j.1538-7836.2004.01121.x","volume":"3","author":"WA Wuillemin","year":"2005","unstructured":"Wuillemin WA, Korte W, Waser G, L\u00e4mmle B. Usefulness of the D-dimer\/fibrinogen ratio to predict deep venous thrombosis. J Thromb Haemost. 2005;3:385\u20137.","journal-title":"J Thromb Haemost"},{"key":"905_CR21","doi-asserted-by":"publisher","first-page":"131","DOI":"10.14336\/AD.2016.0715","volume":"8","author":"J Liu","year":"2017","unstructured":"Liu J, Wang D, Xiong Y, Liu B, Lin J, Zhang S, et al. Association between coagulation function and cerebral microbleeds in ischemic stroke patients with atrial fibrillation and\/or rheumatic heart disease. Aging Dis. 2017;8:131\u20135.","journal-title":"Aging Dis"},{"key":"905_CR22","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1161\/CIRCULATIONAHA.113.002966","volume":"129","author":"HL Gornik","year":"2014","unstructured":"Gornik HL, Sharma AM. Duplex ultrasound in the diagnosis of lower-extremity deep venous thrombosis. Circulation 2014;129:917\u201321.","journal-title":"Circulation"},{"key":"905_CR23","doi-asserted-by":"publisher","first-page":"228","DOI":"10.7326\/M16-2472","volume":"167","author":"SY Park","year":"2017","unstructured":"Park SY, Freedman ND, Haiman CA, Le Marchand L, Wilkens LR, Setiawan VW. Association of coffee consumption with total and cause-specific mortality among nonwhite populations. Ann Intern Med. 2017;167:228\u201335.","journal-title":"Ann Intern Med"},{"key":"905_CR24","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1002\/sim.4780080504","volume":"8","author":"S Durrleman","year":"1989","unstructured":"Durrleman S, Simon R. Flexible regression models with cubic splines. Stat Med. 1989;8:551\u201361.","journal-title":"Stat Med"},{"key":"905_CR25","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1016\/j.jacc.2017.09.024","volume":"70","author":"JI Weitz","year":"2017","unstructured":"Weitz JI, Fredenburgh JC, Eikelboom JW. A test in context: D-Dimer. J Am Coll Cardiol. 2017;70:2411\u201320.","journal-title":"J Am Coll Cardiol"},{"key":"905_CR26","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.2217\/bmm-2020-0553","volume":"14","author":"TJ Zhao","year":"2020","unstructured":"Zhao TJ, Yang QK, Tan CY, Bi LD, Li J, Miao ZL. Prognostic value of D-dimer\/fibrinogen ratio in the adverse outcomes of patients hospitalized for heart failure. Biomark Med. 2020;14:1733\u201345.","journal-title":"Biomark Med"},{"key":"905_CR27","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.cca.2020.04.022","volume":"507","author":"DX Xu","year":"2020","unstructured":"Xu DX, Du WT, Li X, Wu ZX, Yu GF. D-dimer\/fibrinogen ratio for the prediction of progressive hemorrhagic injury after traumatic brain injury. Clin Chim Acta. 2020;507:143\u20138.","journal-title":"Clin Chim Acta"},{"key":"905_CR28","doi-asserted-by":"publisher","first-page":"104918","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.104918","volume":"29","author":"X Chen","year":"2020","unstructured":"Chen X, Li S, Chen W, Xu F, Wang Y, Zou G, et al. The potential value of D-Dimer to fibrinogen ratio in diagnosis of acute ischemic stroke. J Stroke Cerebrovasc Dis. 2020;29:104918.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"905_CR29","doi-asserted-by":"publisher","first-page":"107602962094858","DOI":"10.1177\/1076029620948586","volume":"26","author":"Y Bai","year":"2020","unstructured":"Bai Y, Zheng YY, Tang JN, Yang XM, Guo QQ, Zhang JC, et al. D-Dimer to fibrinogen ratio as a novel prognostic marker in patients after undergoing percutaneous coronary intervention: a retrospective cohort study. Clin Appl Thromb Hemost. 2020;26:1076029620948586.","journal-title":"Clin Appl Thromb Hemost"},{"key":"905_CR30","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.leukres.2019.02.007","volume":"79","author":"Y Bai","year":"2019","unstructured":"Bai Y, Shi M, Yang X, Zhang W, Yang R, Wei X, et al. The value of FDP\/FIB and D-dimer\/FIB ratios in predicting high-risk APL-related thrombosis. Leuk Res. 2019;79:34\u20137.","journal-title":"Leuk Res"},{"key":"905_CR31","first-page":"1241","volume":"71","author":"AA Maung","year":"2011","unstructured":"Maung AA, Schuster KM, Kaplan LJ, Maerz LL, Davis KA. Risk of venous thromboembolism after spinal cord injury: not all levels are the same. J Trauma. 2011;71:1241\u20135.","journal-title":"J Trauma"}],"container-title":["Spinal Cord"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41393-023-00905-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41393-023-00905-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41393-023-00905-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T07:02:36Z","timestamp":1692169356000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41393-023-00905-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,28]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["905"],"URL":"https:\/\/doi.org\/10.1038\/s41393-023-00905-2","relation":{},"ISSN":["1362-4393","1476-5624"],"issn-type":[{"value":"1362-4393","type":"print"},{"value":"1476-5624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,28]]},"assertion":[{"value":"29 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was approved by the Scientific Research Department of West China Hospital (approval no. 2021-1413).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}