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Poissons Log-linear regression estimated the incidence rate ratio (IRR) for developing eight groups of autoimmune diseases. A dose-response relationship based on the cervical\/thoracic level of injury was assessed by stratification.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The cohort included 3,272 individuals with TSCI and 4.8 million background individuals, accounting for 50,865 and 140 million person-years respectively. The TSCI population had an overall IRR of 1.81 (95% CI, 1.59 to 2.05) of getting any autoimmune disease. Subgroup analysis found positive associations for; a) <jats:italic>Other neurologic<\/jats:italic> IRR 5.19 (95% CI, 2.79 to 9.65), b) <jats:italic>multiple sclerosis<\/jats:italic> IRR 3.70 (95% CI, 2.54 to 5.40), c) <jats:italic>Dermatologic<\/jats:italic> IRR 2.57 (95% CI, 1.86 to 3.55), d) Type 1 d<jats:italic>iabetes mellitus<\/jats:italic> IRR 2.01 (95% CI, 1.54 to 2.61), e) <jats:italic>Systemic<\/jats:italic> 1.92 (95% CI, 1.44 to 2.55), and f) <jats:italic>Gastroenterologic<\/jats:italic> IRR 1.42 (95% CI, 1.05 to 1.92). Cervical levels of TSCI showed an IRR of 1.70 (95% CI, 1.43 to 2.02), while thoracic levels had an IRR 1.98 (95% CI, 1.63 to 2.39).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>TSCI may be an individual risk factor of developing an autoimmune disease. There does not appear to exist a dose-response relationship from the level of injury.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Sponsorship<\/jats:title>\n                <jats:p>None.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1038\/s41393-024-01026-0","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T13:05:03Z","timestamp":1726059903000},"page":"642-650","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Traumatic spinal cord injury and its correlation to risk of autoimmune\/-inflammatory disease"],"prefix":"10.1038","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7359-5832","authenticated-orcid":false,"given":"Tim Damgaard","family":"Nielsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Munk","family":"Laursen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodil Hammer","family":"Bech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel Mylius","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"1026_CR1","doi-asserted-by":"publisher","first-page":"100171","DOI":"10.1016\/j.wnsx.2023.100171","volume":"18","author":"SB Jazayeri","year":"2023","unstructured":"Jazayeri SB, Maroufi SF, Mohammadi E, Dabbagh Ohadi MA, Hagen EM, Chalangari M, et al. 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All authors declare no actual or potential conflicts of interest with the funding source or other potential financial, professional, or personal relationships that may conflict with the study aims.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was approved by the Danish Data Protection Agency, and data access was granted by Statistics Denmark and the Danish Health Data Authority. According to Act no. 1338 of 1 September 2020, section 10 on research ethics for the administration of health scientific research projects and health data scientific research projects, approval by the Ethics Committee and written informed consent were not required for register-based projects. All data were de-identified and not recognizable at an individual level.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}