{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T08:47:14Z","timestamp":1787993234732,"version":"build-2784847793"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100004702","name":"Baxter International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004702","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007064","name":"NuVasive","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007064","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001773","name":"University of New South Wales","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001773","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Spinal Cord"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Degenerative Cervical Myelopathy (DCM) is a chronic progressive condition of the cervical spine that leads to compression of the spinal cord. It is the most common cause of spinal cord dysfunction in adults, and it occurs due to age-related changes or genetically associated pathologies. DCM is a clinical and radiological diagnosis and presents with a spectrum of symptoms ranging from neck pain and stiffness to paralysis. While neck pain is prevalent amongst patients attending specialist clinics, its predictive value for DCM is limited. This paper focuses on elucidating the relationship between DCM and chronic neck pain, and we discuss the underlying aetiology and broader neurological implications in the context of the literature. The progression of DCM can be slow and insidious with symptoms worsening gradually over time. Neck pain should not be discounted in the evaluation of DCM.<\/jats:p>","DOI":"10.1038\/s41393-024-01041-1","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T18:02:14Z","timestamp":1728928934000},"page":"718-720","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Is neck pain a marker for something serious? Like myelopathy"],"prefix":"10.1038","volume":"62","author":[{"given":"Alisha W.","family":"Sial","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stone","family":"Sima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajpal","family":"Narulla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nashwa","family":"Najib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1037-8421","authenticated-orcid":false,"given":"Ashish D.","family":"Diwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"key":"1041_CR1","doi-asserted-by":"crossref","unstructured":"Davies BM, Khan DZ, Barzangi K, Ali A, Mowforth OD, Nouri A et al. We Choose to Call it \u2018Degenerative Cervical Myelopathy\u2019: Findings of AO Spine RECODE-DCM, an International and Multi-Stakeholder Partnership to Agree a Standard Unifying Term and Definition for a Disease. Global Spine J. 2024:14(2):503\u201312.","DOI":"10.1177\/21925682221111780"},{"key":"1041_CR2","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.jocn.2024.05.033","volume":"126","author":"AW Sial","year":"2024","unstructured":"Sial AW, Sima S, Chen X, Saulys C, Kuan J, Davies M, et al. Spinal column radiological factors associated with increased spinal cord intramedullary signal intensity\u2212 A study evaluating aging spinal cord\u2019s relation to spinal disc degeneration. J Clin Neurosci. 2024;126:86\u201394.","journal-title":"J Clin Neurosci"},{"key":"1041_CR3","doi-asserted-by":"crossref","unstructured":"Nouri A, Tessitore E, Molliqaj G, Meling T, Schaller K, Nakashima H, et al. Degenerative Cervical Myelopathy: Development and Natural History [AO Spine RECODE-DCM Research Priority Number 2]. Global Spine J. 2022;12:39s\u201354s.","DOI":"10.1177\/21925682211036071"},{"key":"1041_CR4","doi-asserted-by":"publisher","first-page":"494","DOI":"10.14245\/ns.1938314.157","volume":"16","author":"JR Wilson","year":"2019","unstructured":"Wilson JR, Badhiwala JH, Moghaddamjou A, Martin AR, Fehlings MG. Degenerative cervical myelopathy; a review of the latest advances and future directions in management. Neurospine. 2019;16:494.","journal-title":"Neurospine"},{"key":"1041_CR5","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jpain.2013.10.011","volume":"15","author":"MJ Barad","year":"2014","unstructured":"Barad MJ, Ueno T, Younger J, Chatterjee N, Mackey S. Complex regional pain syndrome is associated with structural abnormalities in pain-related regions of the human brain. J Pain. 2014;15:197\u2013203.","journal-title":"J Pain"},{"key":"1041_CR6","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-03143-3","volume":"19","author":"KJ Wirth","year":"2021","unstructured":"Wirth KJ, Scheibenbogen C, Paul F. An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome. J Transl Med. 2021;19:471.","journal-title":"J Transl Med"},{"key":"1041_CR7","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1007\/s11154-022-09742-9","volume":"23","author":"G Boehl","year":"2022","unstructured":"Boehl G, Raguindin PF, Valido E, Bertolo A, Itodo OA, Minder B, et al. Endocrinological and inflammatory markers in individuals with spinal cord injury: A systematic review and meta-analysis. Rev Endocr Metab Disord. 2022;23:1035\u201350.","journal-title":"Rev Endocr Metab Disord"},{"key":"1041_CR8","doi-asserted-by":"publisher","first-page":"197","DOI":"10.4055\/cios.2018.10.2.197","volume":"10","author":"C-Y Kim","year":"2018","unstructured":"Kim C-Y, Lee S-M, Lim S-A, Choi Y-S. Impact of fat infiltration in cervical extensor muscles on cervical lordosis and neck pain: a cross-sectional study. Clin Orthopedic Surg. 2018;10:197\u2013203.","journal-title":"Clin Orthopedic Surg"},{"key":"1041_CR9","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.2106\/00004623-200210000-00021","volume":"84","author":"R Rao","year":"2002","unstructured":"Rao R. Neck pain, cervical radiculopathy, and cervical myelopathy: pathophysiology, natural history, and clinical evaluation. JBJS. 2002;84:1872\u201381.","journal-title":"JBJS"},{"key":"1041_CR10","doi-asserted-by":"publisher","first-page":"326","DOI":"10.2174\/1874325001408010326","volume":"8","author":"D Steilen","year":"2014","unstructured":"Steilen D, Hauser R, Woldin B, Sawyer S. Chronic Neck Pain: Making the Connection Between Capsular Ligament Laxity and Cervical Instability. Open Orthop J. 2014;8:326\u201345.","journal-title":"Open Orthop J"},{"key":"1041_CR11","doi-asserted-by":"crossref","unstructured":"Tu J, Vargas Castillo J, Das A, Diwan AD. Degenerative Cervical Myelopathy: Insights into Its Pathobiology and Molecular Mechanisms. J Clin Med. 2021;10:1214.","DOI":"10.3390\/jcm10061214"},{"key":"1041_CR12","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1177\/21925682221124098","volume":"14","author":"MM Schneider","year":"2024","unstructured":"Schneider MM, Badhiwala JH, Alvi MA, Tetreault LA, Kalsi P, Idler RK, et al. Prevalence of neck pain in patients with degenerative cervical myelopathy and short-term response after operative treatment: a cohort study of 664 patients from 26 global sites. Glob Spine J. 2024;14:830\u20138.","journal-title":"Glob Spine J"},{"key":"1041_CR13","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1136\/bmj.39127.608299.80","volume":"334","author":"AI Binder","year":"2007","unstructured":"Binder AI. Cervical spondylosis and neck pain. BMJ. 2007;334:527\u201331.","journal-title":"BMJ"},{"key":"1041_CR14","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1097\/BRS.0000000000002308","volume":"42","author":"BF Stephens","year":"2017","unstructured":"Stephens BF, Rhee JM, Neustein TM, Arceo R. Laminoplasty does not lead to worsening axial neck pain in the properly selected patient with cervical myelopathy: a comparison with laminectomy and fusion. Spine. 2017;42:1844\u201350.","journal-title":"Spine"},{"key":"1041_CR15","first-page":"100232","volume":"15","author":"O Bakr","year":"2023","unstructured":"Bakr O, Soufi K, Jones Q, Bautista B, Van B, Booze Z, et al. Laminoplasty versus laminectomy with fusion for treating multilevel degenerative cervical myelopathy. North Am Spine Soc J. 2023;15:100232.","journal-title":"North Am Spine Soc J"}],"container-title":["Spinal Cord"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41393-024-01041-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41393-024-01041-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41393-024-01041-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T10:48:07Z","timestamp":1733395687000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41393-024-01041-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,14]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["1041"],"URL":"https:\/\/doi.org\/10.1038\/s41393-024-01041-1","relation":{},"ISSN":["1362-4393","1476-5624"],"issn-type":[{"value":"1362-4393","type":"print"},{"value":"1476-5624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,14]]},"assertion":[{"value":"21 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}