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The SCBF was measured with laser doppler flowmetry, motor function was assessed using modified Tarlov grading system, and neurophysiological integrity was detected with motor-evoked potential (MEP), followed by histological observation on the seventh day after operation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Lumbar arteries ligation at 3 levels led to average 40% decrease of SCBF, and spinal cord remained functional, electrophysiological and histological normal. Lumbar arteries ligation at 4 levels resulted in average 50% decrease of SCBF, slight motor dysfunction, prolonged latency of MEP and decreased cell volume of neuron, rabbits presented mild spinal cord injury. Lumbar arteries ligation at 5 levels caused average 60% decrease of SCBF, complete paraplegia, loss of MEP waveform and neuron karyopyknosis, rabbits presented severe SCI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>More ligation of bilateral lumbar arteries leads to lower SCBF and increase the risk of SCI in rabbits, SCBF decreased by more than 50% could cause SCI. MEP associated significantly with SCBF, suggesting the usefulness of MEP to monitoring SCBF in surgery.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1038\/s41393-025-01071-3","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T19:06:26Z","timestamp":1742324786000},"page":"233-238","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The critical threshold of blood flow associated with spinal cord ischemia in a modified rabbit model developed by ligation of lumbar arteries"],"prefix":"10.1038","volume":"63","author":[{"given":"Li-Feng","family":"Xing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding-Wen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Song","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Cai","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6009-6803","authenticated-orcid":false,"given":"Wei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"1071_CR1","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.ejvs.2024.03.014","volume":"68","author":"M Ando","year":"2024","unstructured":"Ando M, Kise Y, Kuniyoshi Y, Higa S, Nagano T, Furukawa K. 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