{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T15:28:30Z","timestamp":1776439710366,"version":"3.51.2"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Spinal Cord"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1038\/s41393-025-01077-x","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T14:03:56Z","timestamp":1744639436000},"page":"263-269","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["BDNF-GABA signaling in astrocytes: enhancing neural repair after SCI through MSC therapies"],"prefix":"10.1038","volume":"63","author":[{"given":"Qingsheng","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiongxuan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5052-2638","authenticated-orcid":false,"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7561-9367","authenticated-orcid":false,"given":"Yifeng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"1077_CR1","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1089\/neu.2011.2226","volume":"29","author":"LA Simpson","year":"2012","unstructured":"Simpson LA, Eng JJ, Hsieh JT, Wolfe DL. the Spinal Cord Injury Rehabilitation Evidence Research Team. The health and life priorities of individuals with spinal cord injury: a systematic review. J Neurotrauma. 2012;29:1548\u201355.","journal-title":"J Neurotrauma"},{"key":"1077_CR2","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1007\/s13311-018-0630-7","volume":"15","author":"AD Gaudet","year":"2018","unstructured":"Gaudet AD, Fonken LK. Glial cells shape pathology and repair after spinal cord injury. Neurotherapeutics. 2018;15:554\u201377.","journal-title":"Neurotherapeutics"},{"key":"1077_CR3","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s13311-018-0631-6","volume":"15","author":"MB Orr","year":"2018","unstructured":"Orr MB, Gensel JC. Spinal cord injury scarring and inflammation: therapies targeting glial and inflammatory responses. Neurotherapeutics. 2018;15:541\u201353.","journal-title":"Neurotherapeutics"},{"key":"1077_CR4","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1177\/1073858413504999","volume":"19","author":"TM Pirttimaki","year":"2013","unstructured":"Pirttimaki TM, Parri HR. Astrocyte plasticity: implications for synaptic and neuronal activity. Neuroscientist. 2013;19:604\u201315.","journal-title":"Neuroscientist"},{"key":"1077_CR5","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1152\/physrev.1956.36.4.427","volume":"36","author":"WF Windle","year":"1956","unstructured":"Windle WF. Regeneration of axons in the vertebrate central nervous system. Physiol Rev. 1956;36:427\u201340.","journal-title":"Physiol Rev"},{"key":"1077_CR6","doi-asserted-by":"publisher","first-page":"155","DOI":"10.5607\/en.2018.27.3.155","volume":"27","author":"H Chun","year":"2018","unstructured":"Chun H, An H, Lim J, Woo J, Lee J, Ryu H, et al. Astrocytic proBDNF and tonic GABA distinguish active versus reactive astrocytes in hippocampus. Exp Neurobiol. 2018;27:155.","journal-title":"Exp Neurobiol"},{"key":"1077_CR7","doi-asserted-by":"publisher","first-page":"3057","DOI":"10.7150\/thno.72015","volume":"12","author":"T Cao","year":"2022","unstructured":"Cao T, Chen H, Huang W, Xu S, Liu P, Zou W, et al. hUC-MSC-mediated recovery of subacute spinal cord injury through enhancing the pivotal subunits \u03b23 and \u03b32 of the GABAA receptor. Theranostics. 2022;12:3057.","journal-title":"Theranostics"},{"key":"1077_CR8","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1007\/s00018-017-2676-9","volume":"75","author":"N Nagoshi","year":"2018","unstructured":"Nagoshi N, Okano H. iPSC-derived neural precursor cells: potential for cell transplantation therapy in spinal cord injury. Cell Mol Life Sci. 2018;75:989\u20131000.","journal-title":"Cell Mol Life Sci"},{"key":"1077_CR9","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab579","volume":"23","author":"M Dai","year":"2022","unstructured":"Dai M, Pei X, Wang X-J. Accurate and fast cell marker gene identification with COSG. Brief Bioinform. 2022;23:bbab579.","journal-title":"Brief Bioinform"},{"key":"1077_CR10","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-03961-7","volume":"21","author":"Y Sun","year":"2023","unstructured":"Sun Y, Zhang C, Fang Q, Zhang W, Liu W. Abnormal signal pathways and tumor heterogeneity in osteosarcoma. J Transl Med. 2023;21:99.","journal-title":"J Transl Med"},{"key":"1077_CR11","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/nature17623","volume":"532","author":"MA Anderson","year":"2016","unstructured":"Anderson MA, Burda JE, Ren Y, Ao Y, O\u2019Shea TM, Kawaguchi R, et al. Astrocyte scar formation aids central nervous system axon regeneration. Nature. 2016;532:195\u2013200.","journal-title":"Nature"},{"key":"1077_CR12","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1111\/cns.14085","volume":"29","author":"S Xiao","year":"2023","unstructured":"Xiao S, Zhang Y, Liu Z, Li A, Tong W, Xiong X, et al. Alpinetin inhibits neuroinflammation and neuronal apoptosis via targeting the JAK2\/STAT3 signaling pathway in spinal cord injury. CNS Neurosci Ther. 2023;29:1094\u2013108.","journal-title":"CNS Neurosci Ther"},{"key":"1077_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2023.114576","volume":"370","author":"JY Lee","year":"2023","unstructured":"Lee JY, Park CS, Seo KJ, Kim IY, Han S, Youn I, et al. IL-6\/JAK2\/STAT3 axis mediates neuropathic pain by regulating astrocyte and microglia activation after spinal cord injury. Exp Neurol. 2023;370:114576.","journal-title":"Exp Neurol"},{"key":"1077_CR14","doi-asserted-by":"publisher","first-page":"853","DOI":"10.3390\/cells12060853","volume":"12","author":"T Clifford","year":"2023","unstructured":"Clifford T, Finkel Z, Rodriguez B, Joseph A, Cai L. Current advancements in spinal cord injury research-glial scar formation and neural regeneration. Cells. 2023;12:853.","journal-title":"Cells"},{"key":"1077_CR15","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41536-022-00241-8","volume":"7","author":"D Kamiya","year":"2022","unstructured":"Kamiya D, Takenaka-Ninagawa N, Motoike S, Kajiya M, Akaboshi T, Zhao C, et al. Induction of functional xeno-free MSCs from human iPSCs via a neural crest cell lineage. NPJ Regen Med. 2022;7:47.","journal-title":"NPJ Regen Med"},{"key":"1077_CR16","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1002\/sctm.20-0269","volume":"10","author":"Y Kamata","year":"2021","unstructured":"Kamata Y, Isoda M, Sanosaka T, Shibata R, Ito S, Okubo T, et al. A robust culture system to generate neural progenitors with gliogenic competence from clinically relevant induced pluripotent stem cells for treatment of spinal cord injury. Stem Cells Transl Med. 2021;10:398\u2013413.","journal-title":"Stem Cells Transl Med"},{"key":"1077_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.844497","volume":"13","author":"R Wang","year":"2022","unstructured":"Wang R, Zhou R, Chen Z, Gao S, Zhou F. The glial cells respond to spinal cord injury. Front Neurol. 2022;13:844497.","journal-title":"Front Neurol"},{"key":"1077_CR18","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/s41386-021-01116-0","volume":"47","author":"T Tomoda","year":"2022","unstructured":"Tomoda T, Sumitomo A, Shukla R, Hirota-Tsuyada Y, Miyachi H, Oh H, et al. BDNF controls GABAAR trafficking and related cognitive processes via autophagic regulation of p62. Neuropsychopharmacology. 2022;47:553\u201363.","journal-title":"Neuropsychopharmacology"},{"key":"1077_CR19","doi-asserted-by":"publisher","first-page":"40464","DOI":"10.1074\/jbc.M111.232009","volume":"286","author":"SH Vaz","year":"2011","unstructured":"Vaz SH, J\u00f8rgensen TN, Crist\u00f3v\u00e3o-Ferreira S, Duflot S, Ribeiro JA, Gether U, et al. Brain-derived neurotrophic factor (BDNF) enhances GABA transport by modulating the trafficking of GABA transporter-1 (GAT-1) from the plasma membrane of rat cortical astrocytes. J Biol Chem. 2011;286:40464\u201376.","journal-title":"J Biol Chem"},{"key":"1077_CR20","doi-asserted-by":"crossref","unstructured":"Liu J, Feng X, Wang Y, Xia X, Zheng JC: Astrocytes: GABAceptive and GABAergic Cells in the Brain. Front Cell Neurosci.2022;16:892497.","DOI":"10.3389\/fncel.2022.892497"},{"key":"1077_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13572","volume":"7","author":"K Boddum","year":"2016","unstructured":"Boddum K, Jensen TP, Magloire V, Kristiansen U, Rusakov DA, Pavlov I, et al. Astrocytic GABA transporter activity modulates excitatory neurotransmission. Nat Commun. 2016;7:13572.","journal-title":"Nat Commun"},{"key":"1077_CR22","doi-asserted-by":"publisher","first-page":"7623","DOI":"10.1523\/JNEUROSCI.1999-04.2004","volume":"24","author":"AJ Bolteus","year":"2004","unstructured":"Bolteus AJ, Bordey A. GABA release and uptake regulate neuronal precursor migration in the postnatal subventricular zone. J Neurosci. 2004;24:7623\u201331.","journal-title":"J Neurosci"},{"key":"1077_CR23","doi-asserted-by":"publisher","first-page":"2964","DOI":"10.3390\/ijms20122964","volume":"20","author":"M Ishibashi","year":"2019","unstructured":"Ishibashi M, Egawa K, Fukuda A. Diverse actions of astrocytes in GABAergic signaling. Int J Mol Sci. 2019;20:2964.","journal-title":"Int J Mol Sci"},{"key":"1077_CR24","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1007\/s11064-022-03545-9","volume":"47","author":"J Kang","year":"2022","unstructured":"Kang J, Guo Y. Human umbilical cord mesenchymal stem cells derived exosomes promote neurological function recovery in a rat spinal cord injury model. Neurochem Res. 2022;47:1532\u201340.","journal-title":"Neurochem Res"},{"key":"1077_CR25","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s12015-019-09934-y","volume":"16","author":"F Nishida","year":"2020","unstructured":"Nishida F, Zappa Villar MF, Zanuzzi CN, Sisti MS, Cami\u00f1a AE, Reggiani PC, et al. Intracerebroventricular delivery of human umbilical cord mesenchymal stem cells as a promising therapy for repairing the spinal cord injury induced by kainic acid. Stem Cell Rev Rep. 2020;16:167\u201380.","journal-title":"Stem Cell Rev Rep"},{"key":"1077_CR26","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3390\/jcm4010037","volume":"4","author":"M Khazaei","year":"2014","unstructured":"Khazaei M, Siddiqui AM, Fehlings MG. The potential for iPS-derived stem cells as a therapeutic strategy for spinal cord injury: opportunities and challenges. J Clin Med. 2014;4:37\u201365.","journal-title":"J Clin Med"},{"key":"1077_CR27","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.4103\/1673-5374.303013","volume":"16","author":"Y Li","year":"2021","unstructured":"Li Y, Shen P-P, Wang B. Induced pluripotent stem cell technology for spinal cord injury: a promising alternative therapy. Neural Regen Res. 2021;16:1500.","journal-title":"Neural Regen Res"},{"key":"1077_CR28","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1098\/rstb.2009.0149","volume":"365","author":"FM Watt","year":"2010","unstructured":"Watt FM, Driskell RR. The therapeutic potential of stem cells. Philos Trans R Soc Lond B Biol Sci. 2010;365:155\u201363.","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"1077_CR29","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.4103\/1673-5374.274347","volume":"15","author":"Y Yang","year":"2020","unstructured":"Yang Y, Pang M, Chen YY, Zhang LM, Liu H, Tan J, et al. Human umbilical cord mesenchymal stem cells to treat spinal cord injury in the early chronic phase: study protocol for a prospective, multicenter, randomized, placebo-controlled, single-blinded clinical trial. Neural Regen Res. 2020;15:1532\u20138.","journal-title":"Neural Regen Res"},{"key":"1077_CR30","volume":"13","author":"M Kawai","year":"2023","unstructured":"Kawai M, Nagoshi N, Okano H, Nakamura M. A review of regenerative therapy for spinal cord injury using human iPS cells. N Am Spine Soc J. 2023;13:100184.","journal-title":"N Am Spine Soc J"}],"container-title":["Spinal Cord"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41393-025-01077-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41393-025-01077-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41393-025-01077-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T13:21:50Z","timestamp":1747142510000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41393-025-01077-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,14]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["1077"],"URL":"https:\/\/doi.org\/10.1038\/s41393-025-01077-x","relation":{},"ISSN":["1362-4393","1476-5624"],"issn-type":[{"value":"1362-4393","type":"print"},{"value":"1476-5624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,14]]},"assertion":[{"value":"8 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This is a bioinformatic analysis; therefore, ethics approval and consent to participate are not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}