{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:18:01Z","timestamp":1789391881687,"version":"build-2803163510"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["American Journal of Gastroenterology"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1038\/s41395-018-0026-7","type":"journal-article","created":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T22:11:18Z","timestamp":1522793478000},"page":"735-745","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":127,"title":["Efficacy, safety, and tolerability of plecanatide in patients with irritable bowel syndrome with constipation: results of two phase 3 randomized clinical trials"],"prefix":"10.14309","volume":"113","author":[{"given":"Darren M.","family":"Brenner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Fogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer D.","family":"Dorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Krause","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Eng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Kirshoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anhthu","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Crozier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Magnus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick H.","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-17-20190521","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1053\/j.gastro.2016.02.031","volume":"150","author":"Lacy","year":"2016","journal-title":"Gastroenterology"},{"key":"R2-17-20190521","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.cgh.2012.02.029","volume":"10","author":"Lovell","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R3-17-20190521","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1111\/j.1365-2036.2005.02463.x","volume":"21","author":"Hungin","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"R4-17-20190521","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/ajg.2016.574","volume":"112","author":"Sayuk","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"R5-17-20190521","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ajg.2015.67","volume":"110","author":"Heidelbaugh","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"R6-17-20190521","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1185\/03007995.2011.623157","volume":"27","author":"DiBonaventura","year":"2011","journal-title":"Curr Med Res Opin"},{"key":"R7-17-20190521","first-page":"382","volume":"20","author":"Doshi","year":"2014","journal-title":"J Manag Care Spec Pharm"},{"key":"R8-17-20190521","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1007\/s12325-017-0633-5","volume":"34","author":"Harris","year":"2017","journal-title":"Adv Ther"},{"key":"R9-17-20190521","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/MCG.0b013e318189a7f9","volume":"43","author":"Drossman","year":"2009","journal-title":"J Clin Gastroenterol"},{"key":"R10-17-20190521","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1586\/17474124.2013.820045","volume":"7","author":"Blackshaw","year":"2013","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"R11-17-20190521","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/nmo.12574","volume":"27","author":"Jarmuz","year":"2015","journal-title":"Neurogastroenterol Motil"},{"key":"R12-17-20190521","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1053\/j.gastro.2015.01.003","volume":"148","author":"Camilleri","year":"2015","journal-title":"Gastroenterology"},{"key":"R13-17-20190521","doi-asserted-by":"crossref","first-page":"e16139","DOI":"10.1371\/journal.pone.0016139","volume":"6","author":"Han","year":"2011","journal-title":"PLoS ONE"},{"key":"R14-17-20190521","doi-asserted-by":"crossref","first-page":"S700","DOI":"10.14309\/00000434-201210001-01725","volume":"107","author":"Comiskey","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"R15-17-20190521","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4292\/wjgpt.v6.i4.213","volume":"6","author":"Shailubhai","year":"2015","journal-title":"World J Gastrointest Pharmacol Ther"},{"key":"R16-17-20190521","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1073\/pnas.95.4.1466","volume":"95","author":"Vaandrager","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"R17-17-20190521","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1159\/000335767","volume":"28","author":"Toriano","year":"2011","journal-title":"Cell Physiol Biochem"},{"key":"R18-17-20190521","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.ejphar.2010.09.019","volume":"649","author":"Busby","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"R19-17-20190521","doi-asserted-by":"crossref","first-page":"S541","DOI":"10.14309\/00000434-201410002-01831","volume":"109","author":"Miner","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"R20-17-20190521","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1053\/j.gastro.2005.11.061","volume":"130","author":"Longstreth","year":"2006","journal-title":"Gastroenterology"},{"key":"R22-17-20190521","first-page":"8612189","volume":"2017","author":"Tse","year":"2017","journal-title":"J Gastroenterol Hepatol"},{"key":"R23-17-20190521","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1111\/j.1365-2036.2004.02256.x","volume":"20","author":"Whitehead","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"R24-17-20190521","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1097\/01.mcg.0000139029.00451.c7","volume":"38","author":"Lembo","year":"2004","journal-title":"J Clin Gastroenterol"},{"key":"R25-17-20190521","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/nmo.12758","volume":"28","author":"Neri","year":"2016","journal-title":"Neurogastroenterol Motil"},{"key":"R26-17-20190521","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13030-016-0070-8","volume":"10","author":"Kanazawa","year":"2016","journal-title":"Biopsychosoc Med"},{"key":"R27-17-20190521","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/ajg.2016.611","volume":"112","author":"Miner","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"R28-17-20190521","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1177\/1756283X17734697","volume":"10","author":"DeMicco","year":"2017","journal-title":"Ther Adv Gastroenterol"},{"key":"R29-17-20190521","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1038\/ajg.2011.257","volume":"106","author":"Bertiaux-Vandaele","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"R30-17-20190521","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1365-2982.2012.01921.x","volume":"24","author":"Camilleri","year":"2012","journal-title":"Neurogastroenterol Motil"},{"key":"R31-17-20190521","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/nmo.12315","volume":"26","author":"Piche","year":"2014","journal-title":"Neurogastroenterol Motil"},{"key":"R32-17-20190521","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/nmo.12262","volume":"26","author":"Wilcz-Villega","year":"2014","journal-title":"Neurogastroenterol Motil"},{"key":"R33-17-20190521","doi-asserted-by":"crossref","first-page":"S506","DOI":"10.1016\/S0016-5085(17)31872-3","volume":"152","author":"Thadi","year":"2017","journal-title":"Gastroenterology"}],"container-title":["American Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41395-018-0026-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41395-018-0026-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/00000434-201805000-00017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/s41395-018-0026-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:22:14Z","timestamp":1786548134000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000434-201805000-00017"}},"subtitle":[""],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":32,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.1038\/s41395-018-0026-7","relation":{},"ISSN":["0002-9270"],"issn-type":[{"value":"0002-9270","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]}}}