{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:29:14Z","timestamp":1786548554172,"version":"build-2736575974"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Am J Gastroenterol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES:<\/jats:title>\n                    <jats:p>In order to screen for gastric cancer effectively, its interval should be set according to the risk. This study aimed to determine whether risk stratification is possible using the data obtained from medical examination or endoscopic findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      First, subjects who underwent both cancer screening and medical examination from 2009 to 2015 and underwent cancer screening once more by 2016 were studied. Data such as the lipid profile and history of smoking obtained during the medical examination, and the grade of atrophy and presence of peptic ulcers were studied using multivariate analysis. Next, subjects who underwent cancer screening twice or more between 2009 and 2015 with or without medical examinations were studied to analyze any correlation between the grade of atrophy and cancer occurrence using univariate analysis. In both studies, the status of\n                      <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic>\n                      (HP) infection was determined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      In the multivariate analysis, 9378 subjects were included. Aging, advanced atrophy, presence of ulcers, and uric acid levels were identified as risk factors. Among subjects who underwent successful HP eradication therapy, advanced atrophy and aging were observed to be crucial risk factors. In the univariate analysis, there were 12,941 subjects. Gastric cancer occurred more frequently in the more severe atrophy group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The annual rate of cancer occurrence in the most severe atrophy group was 0.31%, which was approximately thrice as that in the less atrophy group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Risk stratification was possible based on endoscopic examination alone. The interval should be set depending on each case.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41395-018-0259-5","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T07:47:30Z","timestamp":1539330450000},"page":"71-79","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":68,"title":["Grading of Atrophic Gastritis is Useful for Risk Stratification in Endoscopic Screening for Gastric Cancer"],"prefix":"10.14309","volume":"114","author":[{"given":"Kyosuke","family":"Kaji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Hashiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chika","family":"Uotani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Takabatake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tokio","family":"Wakabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Doyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itasu","family":"Ninomiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Kiriyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigekazu","family":"Ohyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Yoneshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobu","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-20250611","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/ijc.2910560407","article-title":"Life-style and subsite of gastric cancer\u2013joint effect of smoking and drinking habits","volume":"56","author":"Inoue","year":"1994","journal-title":"Int J Cancer"},{"key":"R3-20250611","first-page":"6559","article-title":"A comparative case-control analysis of stomach cancer and atrophic gastritis","volume":"50","author":"Kato","year":"1990","journal-title":"Cancer Res"},{"key":"R4-20250611","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1002\/ijc.20518","article-title":"Cigarette smoking and the risk of gastric cancer: a pooled analysis of two prospective studies in Japan","volume":"112","author":"Koizumi","year":"2004","journal-title":"Int J Cancer"},{"key":"R5-20250611","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.cgh.2014.07.043","article-title":"A tool to predict risk for gastric cancer in patients with peptic ulcer disease on the basis of a nationwide cohort","volume":"13","author":"Lee","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R6-20250611","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/ijc.10649","article-title":"Cigarette smoking, alcohol consumption and subsequent gastric cancer risk by subsite and histologic type","volume":"101","author":"Sasazuki","year":"2002","journal-title":"Int J Cancer"},{"key":"R7-20250611","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/ijc.22157","article-title":"Smoking and alcohol drinking in relation to risk of gastric cancer: a population-based, prospective cohort study","volume":"120","author":"Sjodahl","year":"2007","journal-title":"Int J Cancer"},{"issue":"Suppl 17","key":"R8-20250611","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00535-006-1924-9","article-title":"Baseline gastric mucosal atrophy is a risk factor associated with the development of gastric cancer after Helicobacter pylori eradication therapy in patients with peptic ulcer diseases","volume":"42","author":"Take","year":"2007","journal-title":"J Gastroenterol"},{"key":"R9-20250611","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1055\/s-0028-1098086","article-title":"An endoscopic recognition of the atrophic border and its significance in chronic gastritis","volume":"3","author":"Kimura","year":"1969","journal-title":"Eodoscopy"},{"key":"R10-20250611","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1080\/003655298750027074","article-title":"Helicobacter pylori infection and progression of gastric atrophy and intestinal metaplasia","volume":"33","author":"Furuta","year":"1998","journal-title":"Scand J Gastroenterol"},{"key":"R12-20250611","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1572-0241.2006.01109.x","article-title":"Helicobacter pylori infection and the risk of gastric malignancy","volume":"102","author":"Hsu","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"R13-20250611","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.gie.2016.03.791","article-title":"Histologic intestinal metaplasia and endoscopic atrophy are predictors of gastric cancer development after Helicobacter pylori eradication","volume":"84","author":"Shichijo","year":"2016","journal-title":"Gastrointest Endosc"},{"key":"R14-20250611","doi-asserted-by":"crossref","first-page":"13113","DOI":"10.3748\/wjg.v21.i46.13113","article-title":"Can endoscopic atrophy predict histological atrophy? Historical study in United Kingdom and Japan","volume":"21","author":"Kono","year":"2015","journal-title":"World J Gastroenterol"},{"key":"R15-20250611","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1007\/s10620-010-1154-0","article-title":"Prescreening of a high-risk group for gastric cancer by serologically determined Helicobacter pylori infection and atrophic gastritis","volume":"55","author":"Mizuno","year":"2010","journal-title":"Dig Dis Sci"},{"key":"R16-20250611","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1111\/j.1349-7006.1995.tb03001.x","article-title":"Gastric cancer among the Japanese in Hawaii","volume":"86","author":"Nomura","year":"1995","journal-title":"Jpn J Cancer Res"},{"key":"R17-20250611","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/den.12471","article-title":"Helicobacter pylori-negative gastric cancer: characteristics and endoscopic findings","volume":"27","author":"Yamamoto","year":"2015","journal-title":"Dig Endosc"},{"key":"R18-20250611","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1111\/cas.12821","article-title":"Declining trends in prevalence of Helicobacter pylori infection by birth-year in a Japanese population","volume":"106","author":"Watanabe","year":"2015","journal-title":"Cancer Sci"},{"key":"R19-20250611","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1067\/mge.2001.114422","article-title":"Prospective evaluation of complications in outpatient GI endoscopy: a survey among German gastroenterologists","volume":"53","author":"Sieg","year":"2001","journal-title":"Gastrointest Endosc"}],"container-title":["American Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41395-018-0259-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41395-018-0259-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/00000434-201901000-00015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/s41395-018-0259-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:28:37Z","timestamp":1786544917000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000434-201901000-00015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1038\/s41395-018-0259-5","relation":{},"ISSN":["0002-9270","1572-0241"],"issn-type":[{"value":"0002-9270","type":"print"},{"value":"1572-0241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"2017-10-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-07","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}