{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:00:56Z","timestamp":1792555256924,"version":"4.5.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T00:00:00Z","timestamp":1539302400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Am J Gastroenterol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>\n                      Baveno-VI guidelines recommend that patients with compensated cirrhosis with liver stiffness by transient elastography (LSM-TE) &lt;20 kPa and platelets &gt;150,000\/mm\n                      <jats:sup>3<\/jats:sup>\n                      do not need an esophagogastroduodenoscopy (EGD) to screen for varices, since the risk of having varices needing treatment (VNT) is &lt;5%. It remains uncertain if this tool can be used in patients with cholestatic liver diseases (ChLDs): primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). These patients may have a pre-sinusoidal component of portal hypertension that could affect the performance of this rule. In this study we evaluated the performance of Baveno-VI, expanded Baveno-VI (LSM-TE &lt;25 kPa and platelets &gt;110,000\/mm\n                      <jats:sup>3<\/jats:sup>\n                      ), and other criteria in predicting the absence of VNT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      This was a multicenter cross-sectional study in four referral hospitals. We retrospectively analyzed data from 227 patients with compensated advanced chronic liver disease (cACLD) due to PBC (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 147) and PSC (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 80) that had paired EGD and LSM-TE. We calculated false negative rate (FNR) and number of saved endoscopies for each prediction rule.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Prevalence of VNT was 13%. Baveno-VI criteria had a 0% FNR in PBC and PSC, saving 39 and 30% of EGDs, respectively. In PBC the other LSM-TE-based criteria resulted in FNRs &gt;5%. In PSC the expanded Baveno criteria had an adequate performance. In both conditions LSM-TE-independent criteria resulted in an acceptable FNR but saved less EGDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Baveno-VI criteria can be applied in patients with cACLD due to ChLDs, which would result in saving 30\u201340% of EGDs. Expanded criteria in PBC would lead to FNRs &gt;5%.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41395-018-0265-7","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T05:10:03Z","timestamp":1539321003000},"page":"446-452","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":72,"title":["Non-Invasive Prediction of High-Risk Varices in Patients with Primary Biliary Cholangitis and Primary Sclerosing Cholangitis"],"prefix":"10.14309","volume":"114","author":[{"given":"Carlos","family":"Moctezuma-Velazquez","sequence":"first","affiliation":[{"name":"Liver Unit, Division of Gastroenterology, CEGIIR, University of Alberta, Edmonton, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Saffioti","sequence":"additional","affiliation":[{"name":"UCL Institute for Liver and Digestive Health and Sheila Sherlock Liver Unit, Royal Free Hospital, 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Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Roccarina","sequence":"additional","affiliation":[{"name":"UCL Institute for Liver and Digestive Health and Sheila Sherlock Liver Unit, Royal Free Hospital, London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Vargas","sequence":"additional","affiliation":[{"name":"Liver Unit, Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Institute of Research (VHIR), Universitat Autonoma de Barcelona, Barcelona, Spain;"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas, CIBERehd, Instituto de Salud Carlos III, Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Erick","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Liver Unit, Division of Gastroenterology, CEGIIR, University of Alberta, Edmonton, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Tsochatzis","sequence":"additional","affiliation":[{"name":"UCL Institute for Liver and Digestive Health and Sheila Sherlock Liver Unit, Royal Free Hospital, London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Augustin","sequence":"additional","affiliation":[{"name":"Liver Unit, Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Institute of Research (VHIR), Universitat Autonoma de Barcelona, Barcelona, Spain;"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas, CIBERehd, Instituto de Salud Carlos III, Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo J.","family":"Montano-Loza","sequence":"additional","affiliation":[{"name":"Liver Unit, Division of Gastroenterology, CEGIIR, University of Alberta, Edmonton, 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