{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T15:17:53Z","timestamp":1794496673199,"version":"4.9.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T00:00:00Z","timestamp":1544486400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Am J Gastroenterol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Portal vein thrombosis (PVT) is a frequent complication of cirrhosis. Benefit, safety, and duration of anticoagulant treatment in this setting are controversial issues. The aim of this study was to analyze the course of PVT in a large cohort of cirrhotic patients undergoing or not anticoagulation therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The data of 182 patients who presented between January 2008 and March 2016 with cirrhosis and PVT with at least 3 months of follow-up after the first PVT detection were analyzed. Eighty-one patients received anticoagulants and 101 were untreated per physician discretion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The extension of the thrombosis decreased by &gt;50% in 46 (56.8%, with complete recanalization in 31\/46) patients under anticoagulation and in 26 (25.7%) untreated patients. Of the 46 patients who underwent recanalization, 17 (36%) suffered recurrent thrombosis after stopping anticoagulation therapy. Kaplan\u2013Meier analysis showed a higher survival rate in the treated group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.010). At multivariate analysis, anticoagulation was an independent factor associated with longer survival (HR:0.30, CI:0.10\u20130.91,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.014). The Child\u2013Turcotte\u2013Pugh classes B\/C negatively influenced survival (hazard ratio, (HR):3.09, confidence interval (CI):1.14\u20138.36,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.027 for Child\u2013Turcotte\u2013Pugh B and HR:9.27, CI:2.67\u201332.23,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001 for Child\u2013Turcotte\u2013Pugh C). Bleeding complications occurred in 22 (21.8%) untreated and 16 (19.7%) treated patients, but in only four cases was it judged to be related to the anticoagulant treatment. No death was reported as a consequence of the bleeding events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Anticoagulant treatment is a safe and effective treatment leading to partial or complete recanalization of the portal venous system in 56.8% of cases, improving the survival of patients with cirrhosis and PVT. Discontinuation of the therapy is associated with a high rate of PVT recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41395-018-0421-0","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T08:24:50Z","timestamp":1544516690000},"page":"258-266","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":117,"title":["Clinical Impact and Safety of Anticoagulants for Portal Vein Thrombosis in Cirrhosis"],"prefix":"10.14309","volume":"114","author":[{"given":"I.","family":"Pettinari","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, Azienda Ospedaliero Universitaria S.Orsola Malpighi, Bologna, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Vukotic","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, Azienda Ospedaliero Universitaria S.Orsola Malpighi, Bologna, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Stefanescu","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, University of Medicine and Pharmacy \u201cIuliu Hatieganu\", Cluj-Napoca, Romania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pecorelli","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, Azienda Ospedaliero Universitaria S.Orsola Malpighi, Bologna, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mc","family":"Morelli","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine, Azienda Ospedaliero Universitaria S.Orsola Malpighi, Bologna, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Grigoras","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, University of Medicine and Pharmacy \u201cIuliu Hatieganu\", Cluj-Napoca, Romania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Sparchez","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, University of Medicine and Pharmacy \u201cIuliu Hatieganu\", Cluj-Napoca, Romania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Andreone","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, Azienda Ospedaliero Universitaria S.Orsola Malpighi, Bologna, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Piscaglia","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, Azienda Ospedaliero Universitaria S.Orsola Malpighi, Bologna, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the BO-LIVES (BOlogna LIVEr vascular 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