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High carriage rates of ESC-resistant E. coli were demonstrated in 2013 (86.6%) and 2014 (83.3%), compared to 2015 (22%) and 2016 (8.5%). ESC resistance identified among E. coli isolates was attributed to the carriage of an IncI1 ST-3 plasmid (pCTXM1-MU2) encoding blaCTXM-1. Genomic characterisation of selected E. coli isolates (n\u2009=\u200961) identified plasmid movement into multiple commensal E. coli (n\u2009=\u200922 STs). Major STs included ST10, ST5440, ST453, ST2514 and ST23. A subset of the isolates belong to the atypical enteropathogenic E. coli (aEPEC) pathotype that harboured multiple LEE pathogenic islands. pCTXM1-MU2 was similar (99% nt identity) to IncI1-ST3 plasmids reported from Europe, encoded resistance to aminoglycosides, sulphonamides and trimethoprim, and carried colicin Ib. pCTXM1-MU2 appears to be highly stable and readily transferable. This study demonstrates that ESC resistance may persist for a protracted period following removal of direct selection pressure, resulting in the emergence of ESC-resistance in both commensal E. coli and aEPEC isolates of potential significance to human and animal health.<\/jats:p>","DOI":"10.1038\/s41396-018-0200-3","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T14:42:32Z","timestamp":1528900952000},"page":"2352-2362","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Dissemination and persistence of extended-spectrum cephalosporin-resistance encoding IncI1-<i>bla<\/i>CTXM-1 plasmid among <i>Escherichia coli<\/i> in pigs"],"prefix":"10.1093","volume":"12","author":[{"given":"Sam","family":"Abraham","sequence":"first","affiliation":[{"name":"Antimicrobial Resistance and Infectious Diseases Laboratory, School of Veterinary and Life Sciences, Murdoch University , 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