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Bile acids (BAs) play a central role in modulating intestinal immune responses, and changes in gut bacterial communities can profoundly alter the intestinal BA pool. The liver synthesizes and conjugates primary bile acids (priBAs) that are then deconjugated, epimerized, and dehydroxylated by gut bacteria to produce secondary bile acids (secBAs). We investigated the relationship between the gut microbiome and the fecal BA pool in stool samples obtained from a well-characterized cohort of pediatric CD patients undergoing nutritional therapy to induce disease remission. We found that fecal BA composition was altered in a sub-group of CD patients who did not sustain remission. The microbial community structures associated with priBA and secBA-dominant profiles were distinct. In addition, the fecal BA concentrations were correlated with the abundance of distinct bacterial taxonomic groups. Finally, priBA dominant samples were associated with community-level decreases in enzymes for dehydroxylation but not deconjugation.<\/jats:p>","DOI":"10.1038\/s41396-019-0560-3","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T13:03:19Z","timestamp":1575378199000},"page":"702-713","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["The relationship between fecal bile acids and microbiome community structure in pediatric Crohn\u2019s disease"],"prefix":"10.1093","volume":"14","author":[{"given":"Jessica","family":"Connors","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology & Nutrition, IWK Health Centre , Halifax, NS, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A","family":"Dunn","sequence":"additional","affiliation":[{"name":"Department of Biology, Dalhousie University , Halifax, NS, 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The other authors have no conflicts to report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}