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The dynamic changes in secreted metabolites that occur during interactions between bacteria and fungi are complicated. Pyochelin is a siderophore produced by many Pseudomonas and Burkholderia species that induces systemic resistance in plants and has been identified as an antifungal agent. Through imaging mass spectrometry and metabolomics analysis, we found that Phellinus noxius, a plant pathogen, can modify pyochelin and ent-pyochelin to an esterification product, resulting in reduced iron-chelation and loss of antifungal activity. We also observed that dehydroergosterol peroxide, the fungal metabolite, is only accumulated in the presence of pyochelin produced through bacteria\u2013fungi interactions. For the first time, we show the fungal transformation of pyochelin in the microbial interaction. Our findings highlight the importance of understanding the dynamic changes of metabolites in microbial interactions and their influences on microbial communities.<\/jats:p>","DOI":"10.1038\/s41396-020-00871-0","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T22:19:29Z","timestamp":1614032369000},"page":"1858-1861","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Specific inactivation of an antifungal bacterial siderophore by a fungal plant pathogen"],"prefix":"10.1093","volume":"15","author":[{"given":"Ying-Ning","family":"Ho","sequence":"first","affiliation":[{"name":"Agricultural Biotechnology Research Center, Academia Sinica , Taipei 11529, Taiwan"},{"name":"Institute of Marine Biology and Center of Excellence for the Oceans, National Taiwan Ocean University , 2 Pei-Ning Road, Keelung 20224, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin Yong","family":"Hoo","sequence":"additional","affiliation":[{"name":"Agricultural Biotechnology Research Center, Academia Sinica , Taipei 11529, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Agricultural Biotechnology Research Center, Academia Sinica , Taipei 11529, Taiwan"},{"name":"Doctor Degree Program in Marine Biotechnology, National Sun Yat-sen University\/Academia Sinica , Kaohsiung 80424, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Ting","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Agricultural Biotechnology Research Center, Academia Sinica , Taipei 11529, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Chih","family":"Lin","sequence":"additional","affiliation":[{"name":"Agricultural Biotechnology Research Center, Academia Sinica , Taipei 11529, 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