{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:25:16Z","timestamp":1784820316091,"version":"3.55.0"},"reference-count":141,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":498,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sponge microbiomes contribute to host health, nutrition, and defense through the production of secondary metabolites. Chlamydiae, a phylum of obligate intracellular bacteria ranging from animal pathogens to endosymbionts of microbial eukaryotes, are frequently found associated with sponges. However, sponge-associated chlamydial diversity has not yet been investigated at the genomic level and host interactions thus far remain unexplored. Here, we sequenced the microbiomes of three sponge species and found high, though variable, Chlamydiae relative abundances of up to 18.7% of bacteria. Using genome-resolved metagenomics 18 high-quality sponge-associated chlamydial genomes were reconstructed, covering four chlamydial families. Among these, Candidatus Sororchlamydiaceae shares a common ancestor with Chlamydiaceae animal pathogens, suggesting long-term co-evolution with animals. Based on gene content, sponge-associated chlamydiae resemble members from the same family more than sponge-associated chlamydiae of other families, and have greater metabolic versatility than known chlamydial animal pathogens. Sponge-associated chlamydiae are also enriched in genes for degrading diverse compounds found in sponges. Unexpectedly, we identified widespread genetic potential for secondary metabolite biosynthesis across Chlamydiae, which may represent an unexplored source of novel natural products. This finding suggests that\u00a0Chlamydiae members\u00a0may partake in defensive symbioses and that secondary metabolites play a wider role in mediating intracellular interactions. Furthermore, sponge-associated chlamydiae relatives were found in other marine invertebrates, pointing towards wider impacts of the Chlamydiae phylum on marine ecosystems.<\/jats:p>","DOI":"10.1038\/s41396-022-01305-9","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T14:14:48Z","timestamp":1661868888000},"page":"2725-2740","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Genomic diversity and biosynthetic capabilities of sponge-associated chlamydiae"],"prefix":"10.1093","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4563-3939","authenticated-orcid":false,"given":"Jennah E","family":"Dharamshi","sequence":"first","affiliation":[{"name":"Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University , SE-75123 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Gaarslev","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University , SE-75123 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0499-1430","authenticated-orcid":false,"given":"Karin","family":"Steffen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biosciences, Biomedical Center, Uppsala University , SE-75123 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University , SE-75123 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detmer","family":"Sipkema","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Wageningen University and Research , 6708 WE Wageningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6898-6377","authenticated-orcid":false,"given":"Thijs J G","family":"Ettema","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Wageningen University and Research , 6708 WE Wageningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,30]]},"reference":[{"key":"2024011018292383000_CR1","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/nrmicro2839","article-title":"Genomic insights into the marine sponge microbiome","volume":"10","author":"Hentschel","year":"2012","journal-title":"Nat Rev Microbiol"},{"key":"2024011018292383000_CR2","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1038\/ismej.2013.227","article-title":"Host-specificity among abundant and rare taxa in the sponge 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