{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:28:57Z","timestamp":1792002537345,"version":"4.4.0"},"reference-count":132,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":386,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The substrates of the Brazilian campos rupestres, a grassland ecosystem, have extremely low concentrations of phosphorus and nitrogen, imposing restrictions to plant growth. Despite that, this ecosystem harbors almost 15% of the Brazilian plant diversity, raising the question of how plants acquire nutrients in such a harsh environment. Here, we set out to uncover the taxonomic profile, the compositional and functional differences and similarities, and the nutrient turnover potential of microbial communities associated with two plant species of the campos rupestres-dominant family Velloziaceae that grow over distinct substrates (soil and rock). Using amplicon sequencing data, we show that, despite the pronounced composition differentiation, the plant-associated soil and rock communities share a core of highly efficient colonizers that tend to be highly abundant and is enriched in 21 bacterial families. Functional investigation of metagenomes and 522 metagenome-assembled genomes revealed that the microorganisms found associated to plant roots are enriched in genes involved in organic compound intake, and phosphorus and nitrogen turnover. We show that potential for phosphorus transport, mineralization, and solubilization are mostly found within bacterial families of the shared microbiome, such as Xanthobacteraceae and Bryobacteraceae. We also detected the full repertoire of nitrogen cycle-related genes and discovered a lineage of Isosphaeraceae that acquired nitrogen-fixing potential via horizontal gene transfer and might be also involved in nitrification via a metabolic handoff association with Binataceae. We highlight that plant-associated microbial populations in the campos rupestres harbor a genetic repertoire with potential to increase nutrient availability and that the microbiomes of biodiversity hotspots can reveal novel mechanisms of nutrient turnover.<\/jats:p>","DOI":"10.1038\/s41396-022-01345-1","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T21:02:35Z","timestamp":1671483755000},"page":"354-370","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Plant microbiomes harbor potential to promote nutrient turnover in impoverished substrates of a Brazilian biodiversity hotspot"],"prefix":"10.1093","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3913-2484","authenticated-orcid":false,"given":"Antonio P","family":"Camargo","sequence":"first","affiliation":[{"name":"Centro de Biologia Molecular e Engenharia Gen\u00e9tica, Universidade Estadual de Campinas (UNICAMP) , 13083-875 Campinas, SP, Brazil"},{"name":"Departamento de Gen\u00e9tica e Evolu\u00e7\u00e3o, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP) , 13083-970 Campinas, SP, Brazil"},{"name":"Genomics for Climate Change Research Center (GCCRC), Universidade Estadual de Campinas (UNICAMP) , 13083-875 Campinas, SP, Brazil"},{"name":"US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory , Berkeley, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5399-3590","authenticated-orcid":false,"given":"Rafael S C","family":"de Souza","sequence":"additional","affiliation":[{"name":"Genomics for Climate Change Research Center (GCCRC), Universidade Estadual de Campinas (UNICAMP) , 13083-875 Campinas, SP, Brazil"},{"name":"Symbiomics Microbiome Solutions , Florian\u00f3polis, SC 88050-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8259-6519","authenticated-orcid":false,"given":"Juliana","family":"Jose","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica e Evolu\u00e7\u00e3o, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP) , 13083-970 Campinas, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1397-0199","authenticated-orcid":false,"given":"Isabel R","family":"Gerhardt","sequence":"additional","affiliation":[{"name":"Centro de Biologia Molecular e Engenharia Gen\u00e9tica, Universidade Estadual de Campinas (UNICAMP) , 13083-875 Campinas, SP, Brazil"},{"name":"Genomics for Climate Change Research Center (GCCRC), Universidade Estadual de Campinas (UNICAMP) , 13083-875 Campinas, SP, Brazil"},{"name":"Embrapa Agricultura Digital , 13083-886 Campinas, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2738-4433","authenticated-orcid":false,"given":"Ricardo A","family":"Dante","sequence":"additional","affiliation":[{"name":"Centro de Biologia Molecular e Engenharia Gen\u00e9tica, Universidade Estadual de Campinas (UNICAMP) , 13083-875 Campinas, SP, Brazil"},{"name":"Genomics for Climate Change Research Center (GCCRC), Universidade Estadual de Campinas (UNICAMP) , 13083-875 Campinas, SP, Brazil"},{"name":"Embrapa Agricultura Digital , 13083-886 Campinas, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6322-2271","authenticated-orcid":false,"given":"Supratim","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory , Berkeley, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1284-3748","authenticated-orcid":false,"given":"Marcel","family":"Huntemann","sequence":"additional","affiliation":[{"name":"US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory , Berkeley, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6131-0462","authenticated-orcid":false,"given":"Nikos C","family":"Kyrpides","sequence":"additional","affiliation":[{"name":"US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory , Berkeley, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5474-2830","authenticated-orcid":false,"given":"Marcelo F","family":"Carazzolle","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica e Evolu\u00e7\u00e3o, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP) , 13083-970 Campinas, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8365-731X","authenticated-orcid":false,"given":"Paulo","family":"Arruda","sequence":"additional","affiliation":[{"name":"Centro de Biologia Molecular e Engenharia Gen\u00e9tica, Universidade Estadual de Campinas (UNICAMP) , 13083-875 Campinas, SP, Brazil"},{"name":"Departamento de Gen\u00e9tica e Evolu\u00e7\u00e3o, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP) , 13083-970 Campinas, SP, Brazil"},{"name":"Genomics for Climate Change Research Center (GCCRC), Universidade Estadual de Campinas (UNICAMP) , 13083-875 Campinas, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,12,20]]},"reference":[{"key":"2024011017300221100_CR1","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/978-3-319-29808-5_11","volume-title":"Ecology and Conservation of Mountaintop grasslands in Brazil","author":"Oliveira","year":"2016"},{"key":"2024011017300221100_CR2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/978-3-319-29808-5_2","volume-title":"Ecology and Conservation of Mountaintop grasslands in Brazil","author":"Schaefer","year":"2016"},{"key":"2024011017300221100_CR3","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s11104-015-2637-8","article-title":"Ecology and evolution of plant diversity in the endangered campo rupestre: a neglected conservation priority","volume":"403","author":"Silveira","year":"2016","journal-title":"Plant Soil"},{"key":"2024011017300221100_CR4","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1093\/biolinnean\/blaa179","article-title":"An escape-to-radiate model for explaining the high plant diversity and endemism in campos rupestres","volume":"133","author":"Rapini","year":"2021","journal-title":"Biol J Linn Soc"},{"key":"2024011017300221100_CR5","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s11258-014-0302-6","article-title":"CSR analysis of plant functional types in highly diverse tropical grasslands of harsh environments","volume":"215","author":"Negreiros","year":"2014","journal-title":"Plant Ecol"},{"key":"2024011017300221100_CR6","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1111\/1365-2435.13324","article-title":"Specialized roots of Velloziaceae weather quartzite rock while mobilizing phosphorus using carboxylates","volume":"33","author":"Teodoro","year":"2019","journal-title":"Funct Ecol"},{"key":"2024011017300221100_CR7","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1111\/1365-2745.13111","article-title":"Soil types select for plants with matching nutrient-acquisition and -use traits in hyperdiverse and severely nutrient-impoverished campos rupestres and cerrado in Central Brazil","volume":"107","author":"Abrah\u00e3o","year":"2019","journal-title":"J Ecol"},{"key":"2024011017300221100_CR8","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1111\/1365-2435.13479","article-title":"Vellozioid roots allow for habitat specialization among rock- and soil-dwelling Velloziaceae in campos rupestres","volume":"34","author":"Abrah\u00e3o","year":"2020","journal-title":"Funct Ecol"},{"key":"2024011017300221100_CR9","doi-asserted-by":"publisher","first-page":"103345","DOI":"10.1016\/j.apsoil.2019.08.007","article-title":"The plant microbiome: A missing link for the understanding of community dynamics and multifunctionality in forest ecosystems","volume":"145","author":"Mishra","year":"2020","journal-title":"Applied Soil Ecology"},{"key":"2024011017300221100_CR10","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1111\/nph.13312","article-title":"The importance of the microbiome of the plant holobiont","volume":"206","author":"Vandenkoornhuyse","year":"2015","journal-title":"N Phytol"},{"key":"2024011017300221100_CR11","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/s41588-017-0012-9","article-title":"Genomic features of bacterial adaptation to plants","volume":"50","author":"Levy","year":"2018","journal-title":"Nat Genet"},{"key":"2024011017300221100_CR12","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1111\/nph.14979","article-title":"Out of sight, but no longer out of mind - towards an increased recognition of the role of soil microbes in plant speciation","volume":"217","author":"Geml","year":"2018","journal-title":"New Phytol"},{"key":"2024011017300221100_CR13","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1111\/j.1461-0248.2007.01139.x","article-title":"The unseen majority: soil microbes as drivers of plant diversity and productivity in terrestrial ecosystems","volume":"11","author":"van der Heijden","year":"2008","journal-title":"Ecol Letters"},{"key":"2024011017300221100_CR14","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1890\/0012-9658(2006)87[816:NISFAP]2.0.CO;2","article-title":"15N in symbiotic fungi and plants estimates nitrogen and carbon flux rates in Arctic tundra","volume":"87","author":"Hobbie","year":"2006","journal-title":"Ecology"},{"key":"2024011017300221100_CR15","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1111\/nph.14979","article-title":"Out of sight, but no longer out of mind - towards an increased recognition of the role of soil microbes in plant speciation","volume":"217","author":"Geml","year":"2018","journal-title":"N Phytol"},{"key":"2024011017300221100_CR16","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1111\/nph.13175","article-title":"Mineral nutrition of campos rupestres plant species on contrasting nutrient-impoverished soil types","volume":"205","author":"Oliveira","year":"2015","journal-title":"N Phytol"},{"key":"2024011017300221100_CR17","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1038\/s41597-019-0141-3","article-title":"Microbiomes of Velloziaceae from phosphorus-impoverished soils of the campos rupestres, a biodiversity hotspot","volume":"6","author":"Camargo","year":"2019","journal-title":"Sci Data"},{"key":"2024011017300221100_CR18","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/nrmicro.2017.87","article-title":"Embracing the unknown: disentangling the complexities of the soil microbiome","volume":"15","author":"Fierer","year":"2017","journal-title":"Nat Rev Microbiol"},{"key":"2024011017300221100_CR19","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1126\/science.aap9516","article-title":"A global atlas of the dominant bacteria found in soil","volume":"359","author":"Delgado-Baquerizo","year":"2018","journal-title":"Science"},{"key":"2024011017300221100_CR20","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1038\/s41579-020-0412-1","article-title":"Plant\u2013microbiome interactions: from community assembly to plant health","volume":"18","author":"Trivedi","year":"2020","journal-title":"Nat Rev Microbiol"},{"key":"2024011017300221100_CR21","doi-asserted-by":"publisher","first-page":"5114","DOI":"10.1038\/s41467-018-07641-9","article-title":"High throughput ANI analysis of 90K prokaryotic genomes reveals clear species boundaries","volume":"9","author":"Jain","year":"2018","journal-title":"Nat Commun"},{"key":"2024011017300221100_CR22","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/nrmicro3330","article-title":"Uniting the classification of cultured and uncultured bacteria and archaea using 16S rRNA gene sequences","volume":"12","author":"Yarza","year":"2014","journal-title":"Nat Rev Microbiol"},{"key":"2024011017300221100_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/mBio.01718-20","article-title":"The role of phosphorus limitation in shaping soil bacterial communities and their metabolic capabilities","volume":"11","author":"Oliverio","year":"2020","journal-title":"MBio"},{"key":"2024011017300221100_CR24","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/0022-5193(66)90013-0","article-title":"The measurement of diversity in different types of biological collections","volume":"13","author":"PE","year":"1966","journal-title":"J Theor Biol"},{"key":"2024011017300221100_CR25","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/s41564-018-0129-3","article-title":"Dynamic root exudate chemistry and microbial substrate preferences drive patterns in rhizosphere microbial community assembly","volume":"3","author":"Zhalnina","year":"2018","journal-title":"Nat Microbiol"},{"key":"2024011017300221100_CR26","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.tplants.2017.09.003","article-title":"Feed your friends: do plant exudates shape the root microbiome?","volume":"23","author":"Sasse","year":"2018","journal-title":"Trends Plant Sci"},{"key":"2024011017300221100_CR27","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1038\/s41396-020-0632-4","article-title":"Novel phosphate-solubilizing bacteria enhance soil phosphorus cycling following ecological restoration of land degraded by mining","volume":"14","author":"Liang","year":"2020","journal-title":"ISME J"},{"key":"2024011017300221100_CR28","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1111\/nph.16924","article-title":"Phosphate-solubilising microorganisms for improved crop productivity: a critical assessment","volume":"229","author":"Raymond","year":"2021","journal-title":"N Phytol"},{"key":"2024011017300221100_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2017.00971","article-title":"Microbial phosphorus solubilization and its potential for use in sustainable agriculture","volume":"8","author":"Alori","year":"2017","journal-title":"Front Microbiol"},{"key":"2024011017300221100_CR30","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/S0021-9258(18)54198-3","article-title":"An exopolyphosphatase of Escherichia coli. The enzyme and its ppx gene in a polyphosphate operon","volume":"268","author":"Akiyama","year":"1993","journal-title":"J Biol Chem"},{"key":"2024011017300221100_CR31","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1128\/br.30.4.772-794.1966","article-title":"Inorganic polyphosphates in biology: structure, metabolism, and function","volume":"30","author":"Harold","year":"1966","journal-title":"Bacteriol Rev"},{"key":"2024011017300221100_CR32","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1111\/1751-7915.12117","article-title":"Siderophores in environmental research: Roles and applications","volume":"7","author":"Ahmed","year":"2014","journal-title":"Micro Biotechnol"},{"key":"2024011017300221100_CR33","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1039\/b906679a","article-title":"Chemistry and biology of siderophores","volume":"27","author":"Hider","year":"2010","journal-title":"Nat Prod Rep"},{"key":"2024011017300221100_CR34","doi-asserted-by":"crossref","DOI":"10.1093\/femsec\/fix086","article-title":"Actinobacteria phylogenomics, selective isolation from an iron oligotrophic environment and siderophore functional characterization, unveil new desferrioxamine traits","volume":"93","author":"Cruz-Morales","year":"2017","journal-title":"FEMS Microbiology Ecology"},{"key":"2024011017300221100_CR35","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1038\/ismej.2017.137","article-title":"Function-related replacement of bacterial siderophore pathways","volume":"12","author":"Bruns","year":"2018","journal-title":"ISME J"},{"key":"2024011017300221100_CR36","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s11104-008-9877-9","article-title":"Mycorrhizal associations and other means of nutrition of vascular plants: Understanding the global diversity of host plants by resolving conflicting information and developing reliable means of diagnosis","volume":"320","author":"Brundrett","year":"2009","journal-title":"Plant Soil"},{"key":"2024011017300221100_CR37","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s11104-017-3503-7","article-title":"High abundance of non-mycorrhizal plant species in severely phosphorus-impoverished Brazilian campos rupestres","volume":"424","author":"Zemunik","year":"2018","journal-title":"Plant Soil"},{"key":"2024011017300221100_CR38","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.tplants.2019.06.004","article-title":"Phosphorus transport in mycorrhiza: how far are we?","volume":"24","author":"Plassard","year":"2019","journal-title":"Trends Plant Sci"},{"key":"2024011017300221100_CR39","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1016\/j.molp.2016.08.011","article-title":"Arbuscular mycorrhizal symbiosis requires a phosphate transceptor in the Gigaspora margarita fungal symbiont","volume":"9","author":"Xie","year":"2016","journal-title":"Mol Plant"},{"key":"2024011017300221100_CR40","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.funbio.2015.06.008","article-title":"Fungal endophytic communities on twigs of fast and slow growing Scots pine (Pinus sylvestris L.) in northern Spain","volume":"119","author":"Sanz-Ros","year":"2015","journal-title":"Fungal Biol"},{"key":"2024011017300221100_CR41","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-94-007-1599-8_1","volume-title":"Endophytes of Forest Trees","author":"Gr\u00fcnig","year":"2011"},{"key":"2024011017300221100_CR42","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.3389\/fmicb.2019.02565","article-title":"Root-Colonizing Endophytic Fungi of the Dominant Grass Stipa krylovii From a Mongolian Steppe Grassland","volume":"10","author":"Knapp","year":"2019","journal-title":"Front Microbiol"},{"key":"2024011017300221100_CR43","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1017\/S0953756201005196","article-title":"A new fungal phylum, the Glomeromycota: phylogeny and evolution","volume":"105","author":"Sch\u00fc\u00dfler","year":"2001","journal-title":"Mycol Res"},{"key":"2024011017300221100_CR44","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1093\/molbev\/msh047","article-title":"The natural history of nitrogen fixation","volume":"21","author":"Raymond","year":"2004","journal-title":"Mol Biol Evol"},{"key":"2024011017300221100_CR45","doi-asserted-by":"publisher","first-page":"7564","DOI":"10.1073\/pnas.0801093105","article-title":"Nitrogen fixation island and rhizosphere competence traits in the genome of root-associated Pseudomonas stutzeri A1501","volume":"105","author":"Yan","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024011017300221100_CR46","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1475-2859-5-7","article-title":"Rhizobial exopolysaccharides: genetic control and symbiotic functions","volume":"5","author":"Skorupska","year":"2006","journal-title":"Microb Cell Fact"},{"key":"2024011017300221100_CR47","doi-asserted-by":"publisher","first-page":"D764","DOI":"10.1093\/nar\/gkaa946","article-title":"IMG\/VR v3: an integrated ecological and evolutionary framework for interrogating genomes of uncultivated viruses","volume":"49","author":"Roux","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2024011017300221100_CR48","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1146\/annurev.micro.55.1.485","article-title":"Ammonia-oxidizing bacteria: a model for molecular microbial ecology","volume":"55","author":"George","year":"2001","journal-title":"Annu Rev Microbiol"},{"key":"2024011017300221100_CR49","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1073\/pnas.1214272110","article-title":"Hydroxylamine as an intermediate in ammonia oxidation by globally abundant marine archaea","volume":"110","author":"Vajrala","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024011017300221100_CR50","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.3389\/fmicb.2017.01901","article-title":"Ammonia Oxidation and Nitrite Reduction in the Verrucomicrobial Methanotroph Methylacidiphilum fumariolicum SolV","volume":"8","author":"Mohammadi","year":"2017","journal-title":"Front Microbiol"},{"key":"2024011017300221100_CR51"},{"key":"2024011017300221100_CR52","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.3389\/fpls.2017.02223","article-title":"Drought Stress and Root-Associated Bacterial Communities","volume":"8","author":"Naylor","year":"2018","journal-title":"Front Plant Sci"},{"key":"2024011017300221100_CR53","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1023\/A:1022367312851","article-title":"Chickpea and white lupin rhizosphere carboxylates vary with soil properties and enhance phosphorus uptake","volume":"248","author":"Veneklaas","year":"2003","journal-title":"Plant and Soil"},{"key":"2024011017300221100_CR54","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1099\/ijsem.0.001687","article-title":"Defining the taxonomic status of described subdivision 3 acidobacteria: proposal of Bryobacteraceae fam. nov","volume":"67","author":"Dedysh","year":"2017","journal-title":"Int J Syst Evol Microbiol"},{"key":"2024011017300221100_CR55","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1038\/s41579-020-0379-y","article-title":"Ecology and genomics of Actinobacteria: new concepts for natural product discovery","volume":"18","author":"van Bergeijk","year":"2020","journal-title":"Nat Rev Microbiol"},{"key":"2024011017300221100_CR56","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1111\/nph.14967","article-title":"Costs of acquiring phosphorus by vascular land plants: patterns and implications for plant coexistence","volume":"217","author":"Raven","year":"2018","journal-title":"N Phytol"},{"key":"2024011017300221100_CR57","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1038\/s41467-018-03861-1","article-title":"Unifying the global phylogeny and environmental distribution of ammonia-oxidising archaea based on amoA genes","volume":"9","author":"Alves","year":"2018","journal-title":"Nat Commun"},{"key":"2024011017300221100_CR58","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1038\/ismej.2012.70","article-title":"Nitrification expanded: Discovery, physiology and genomics of a nitrite-oxidizing bacterium from the phylum","volume":"6","author":"Sorokin","year":"2012","journal-title":"Chloroflexi ISME J"},{"key":"2024011017300221100_CR59","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1038\/s41564-018-0176-9","article-title":"Nitrogen-fixing populations of Planctomycetes and Proteobacteria are abundant in surface ocean metagenomes","volume":"3","author":"Delmont","year":"2018","journal-title":"Nat Microbiol"},{"key":"2024011017300221100_CR60","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/ismej.2009.99","article-title":"Horizontal transfer of the nitrogen fixation gene cluster in the cyanobacterium Microcoleus chthonoplastes","volume":"4","author":"Bolhuis","year":"2010","journal-title":"ISME J"},{"key":"2024011017300221100_CR61","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/gbi.12419","article-title":"Radiation of nitrogen-metabolizing enzymes across the tree of life tracks environmental transitions in Earth history","volume":"19","author":"Parsons","year":"2021","journal-title":"Geobiology"},{"key":"2024011017300221100_CR62","doi-asserted-by":"publisher","first-page":"9584","DOI":"10.1073\/pnas.0603534103","article-title":"Quantitative exploration of the occurence of lateral gene transfer by using nitrogen fixation gene as a case study","volume":"103","author":"Kechris","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024011017300221100_CR63","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1051\/agro\/2010008","article-title":"Models of biological nitrogen fixation of legumes. A review","volume":"31","author":"Liu","year":"2011","journal-title":"Agron Sustain Dev"},{"key":"2024011017300221100_CR64","doi-asserted-by":"publisher","first-page":"135","DOI":"10.5670\/oceanog.2007.58","article-title":"Exploring the vast diversity of marine viruses","volume":"20","author":"Breitbart","year":"2007","journal-title":"Oceanography"},{"key":"2024011017300221100_CR65","doi-asserted-by":"publisher","first-page":"E757","DOI":"10.1073\/pnas.1102164108","article-title":"Phage auxiliary metabolic genes and the redirection of cyanobacterial host carbon metabolism","volume":"108","author":"Thompson","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024011017300221100_CR66","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12985-019-1120-1","article-title":"Host-hijacking and planktonic piracy: how phages command the microbial high seas","volume":"16","author":"Warwick-Dugdale","year":"2019","journal-title":"Virol J"},{"key":"2024011017300221100_CR67"},{"key":"2024011017300221100_CR68","doi-asserted-by":"publisher","first-page":"e00152","DOI":"10.1128\/mSystems.00152-17","article-title":"It Takes a Village: Microbial Communities Thrive through Interactions and Metabolic Handoffs","volume":"3","author":"Hug","year":"2018","journal-title":"mSystems"},{"key":"2024011017300221100_CR69","doi-asserted-by":"publisher","first-page":"4442","DOI":"10.1093\/nar\/gkz246","article-title":"AnnoTree: visualization and exploration of a functionally annotated microbial tree of life","volume":"47","author":"Mendler","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2024011017300221100_CR70","doi-asserted-by":"publisher","first-page":"5879","DOI":"10.1128\/jb.176.19.5879-5887.1994","article-title":"Oxidation of hydroxylamine by cytochrome P-460 of the obligate methylotroph Methylococcus capsulatus Bath","volume":"176","author":"Zahn","year":"1994","journal-title":"J Bacteriol"},{"key":"2024011017300221100_CR71","doi-asserted-by":"publisher","first-page":"13122","DOI":"10.1021\/acs.est.7b02360","article-title":"Abiotic conversion of extracellular NH2OH contributes to N2O emission during ammonia oxidation","volume":"51","author":"Liu","year":"2017","journal-title":"Environ Sci Technol"},{"key":"2024011017300221100_CR72","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1038\/s41598-018-20170-1","article-title":"Hydroxylamine released by nitrifying microorganisms is a precursor for HONO emission from drying soils","volume":"8","author":"Ermel","year":"2018","journal-title":"Sci Rep"},{"key":"2024011017300221100_CR73","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/0022-1902(59)80250-5","article-title":"The autoxidation of hydroxylamine","volume":"11","author":"Moews","year":"1959","journal-title":"J Inorg Nucl Chem"},{"key":"2024011017300221100_CR74","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/ejss.12306","article-title":"A review of chemical reactions of nitrification intermediates and their role in nitrogen cycling and nitrogen trace gas formation in soil","volume":"67","author":"Heil","year":"2016","journal-title":"Eur J Soil Sci"},{"key":"2024011017300221100_CR75","doi-asserted-by":"publisher","first-page":"4516","DOI":"10.1073\/pnas.1000080107","article-title":"Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample","volume":"108","author":"Caporaso","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024011017300221100_CR76","first-page":"315","volume-title":"PCR Protocols","author":"White","year":"1990"},{"key":"2024011017300221100_CR77","first-page":"10","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Marcel","year":"2013","journal-title":"EMBnet J"},{"key":"2024011017300221100_CR78","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: High-resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat Methods"},{"key":"2024011017300221100_CR79","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.12688\/f1000research.8986.2","article-title":"Bioconductor workflow for microbiome data analysis: from raw reads to community analyses","volume":"5","author":"Callahan","year":"2016","journal-title":"F1000Research"},{"key":"2024011017300221100_CR80","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s40168-018-0521-5","article-title":"IDTAXA: a novel approach for accurate taxonomic classification of microbiome sequences","volume":"6","author":"Murali","year":"2018","journal-title":"Microbiome"},{"key":"2024011017300221100_CR81","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/nbt.4229","article-title":"A standardized bacterial taxonomy based on genome phylogeny substantially revises the tree of life","volume":"36","author":"Parks","year":"2018","journal-title":"Nat Biotechnol"},{"key":"2024011017300221100_CR82","doi-asserted-by":"publisher","first-page":"D259","DOI":"10.1093\/nar\/gky1022","article-title":"The UNITE database for molecular identification of fungi: Handling dark taxa and parallel taxonomic classifications","volume":"47","author":"Nilsson","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2024011017300221100_CR83","doi-asserted-by":"publisher","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA ribosomal RNA gene database project: improved data processing and web-based tools","volume":"41","author":"Quast","year":"2012","journal-title":"Nucleic Acids Research"},{"key":"2024011017300221100_CR84","doi-asserted-by":"publisher","first-page":"e61217","DOI":"10.1371\/journal.pone.0061217","article-title":"phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census Data","volume":"8","author":"McMurdie","year":"2013","journal-title":"PLoS ONE"},{"key":"2024011017300221100_CR85"},{"key":"2024011017300221100_CR86","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1093\/molbev\/mst010","article-title":"MAFFT multiple sequence alignment software version 7: Improvements in performance and usability","volume":"30","author":"Katoh","year":"2013","journal-title":"Mol Biol Evol"},{"key":"2024011017300221100_CR87","first-page":"1","volume-title":"Wiley StatsRef: Statistics Reference Online","author":"Anderson","year":"2017","edition":"1st"},{"key":"2024011017300221100_CR88","doi-asserted-by":"crossref","DOI":"10.1186\/2049-2618-2-15","article-title":"Unifying the analysis of high-throughput sequencing datasets: characterizing RNA-seq, 16S rRNA gene sequencing and selective growth experiments by compositional data analysis","volume":"2","author":"Fernandes","year":"2014","journal-title":"Microbiome"},{"key":"2024011017300221100_CR89","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1093\/bioinformatics\/btz700","article-title":"HypeR: an R package for geneset enrichment workflows","volume":"36","author":"Federico","year":"2020","journal-title":"Bioinformatics"},{"key":"2024011017300221100_CR90","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J Mol Biol"},{"key":"2024011017300221100_CR91","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1093\/bioinformatics\/btv033","article-title":"MEGAHIT: An ultra-fast single-node solution for large and complex metagenomics assembly via succinct de Bruijn graph","volume":"31","author":"Li","year":"2015","journal-title":"Bioinformatics"},{"key":"2024011017300221100_CR92","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/s41592-019-0437-4","article-title":"Protein-level assembly increases protein sequence recovery from metagenomic samples manyfold","volume":"16","author":"Steinegger","year":"2019","journal-title":"Nat Methods"},{"key":"2024011017300221100_CR93","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat Methods"},{"key":"2024011017300221100_CR94","doi-asserted-by":"publisher","first-page":"e7359","DOI":"10.7717\/peerj.7359","article-title":"MetaBAT 2: an adaptive binning algorithm for robust and efficient genome reconstruction from metagenome assemblies","volume":"7","author":"Kang","year":"2019","journal-title":"PeerJ"},{"key":"2024011017300221100_CR95","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1093\/bioinformatics\/btv638","article-title":"MaxBin 2.0: an automated binning algorithm to recover genomes from multiple metagenomic datasets","volume":"32","author":"Wu","year":"2016","journal-title":"Bioinformatics"},{"key":"2024011017300221100_CR96","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1038\/nmeth.3103","article-title":"Binning metagenomic contigs by coverage and composition","volume":"11","author":"Alneberg","year":"2014","journal-title":"Nat Methods"},{"key":"2024011017300221100_CR97"},{"key":"2024011017300221100_CR98","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41564-018-0171-1","article-title":"Dereplication, aggregation and scoring strategy","volume":"3","author":"Sieber","year":"2018","journal-title":"Nat Microbiol"},{"key":"2024011017300221100_CR99","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1101\/gr.186072.114","article-title":"CheckM: assessing the quality of microbial genomes recovered from isolates, single cells, and metagenomes","volume":"25","author":"Parks","year":"2015","journal-title":"Genome Res"},{"key":"2024011017300221100_CR100","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/nbt.3893","article-title":"Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea","volume":"35","author":"Bowers","year":"2017","journal-title":"Nat Biotechnol"},{"key":"2024011017300221100_CR101"},{"key":"2024011017300221100_CR102","doi-asserted-by":"publisher","first-page":"e00731","DOI":"10.1128\/mSystems.00731-19","article-title":"Consistent metagenome-derived metrics verify and delineate bacterial species boundaries","volume":"5","author":"Olm","year":"2020","journal-title":"mSystems"},{"key":"2024011017300221100_CR103"},{"key":"2024011017300221100_CR104","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1038\/s41564-017-0012-7","article-title":"Recovery of nearly 8,000 metagenome-assembled genomes substantially expands the tree of life","volume":"2","author":"Parks","year":"2017","journal-title":"Nat Microbiol"},{"key":"2024011017300221100_CR105","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1093\/bioinformatics\/btq228","article-title":"DendroPy: a Python library for phylogenetic computing","volume":"26","author":"Sukumaran","year":"2010","journal-title":"Bioinformatics"},{"key":"2024011017300221100_CR106","doi-asserted-by":"publisher","first-page":"D457","DOI":"10.1093\/nar\/gkv1070","article-title":"KEGG as a reference resource for gene and protein annotation","volume":"44","author":"Kanehisa","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"2024011017300221100_CR107","doi-asserted-by":"publisher","first-page":"D427","DOI":"10.1093\/nar\/gky995","article-title":"The Pfam protein families database in 2019","volume":"47","author":"El-Gebali","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2024011017300221100_CR108","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1093\/nar\/gkg128","article-title":"The TIGRFAMs database of protein families","volume":"31","author":"Haft","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"2024011017300221100_CR109","doi-asserted-by":"publisher","first-page":"D666","DOI":"10.1093\/nar\/gky901","article-title":"IMG\/M v.5.0: an integrated data management and comparative analysis system for microbial genomes and microbiomes","volume":"47","author":"Chen","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2024011017300221100_CR110","doi-asserted-by":"publisher","first-page":"e00804","DOI":"10.1128\/mSystems.00804-20","article-title":"DOE JGI Metagenome Workflow","volume":"6","author":"Clum","year":"2021","journal-title":"mSystems"},{"key":"2024011017300221100_CR111"},{"key":"2024011017300221100_CR112","doi-asserted-by":"publisher","first-page":"D461","DOI":"10.1093\/nar\/gkaa1004","article-title":"The transporter classification database (TCDB): 2021 update","volume":"49","author":"Saier","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2024011017300221100_CR113","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1038\/nbt.3988","article-title":"MMseqs2 enables sensitive protein sequence searching for the analysis of massive data sets","volume":"35","author":"Steinegger","year":"2017","journal-title":"Nat Biotechnol"},{"key":"2024011017300221100_CR114","doi-asserted-by":"publisher","first-page":"W95","DOI":"10.1093\/nar\/gky418","article-title":"dbCAN2: a meta server for automated carbohydrate-active enzyme annotation","volume":"46","author":"Yohe","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2024011017300221100_CR115","doi-asserted-by":"publisher","first-page":"e59","DOI":"10.1093\/nar\/gky174","article-title":"GraftM: a tool for scalable, phylogenetically informed classification of genes within metagenomes","volume":"46","author":"Boyd","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2024011017300221100_CR116","doi-asserted-by":"publisher","first-page":"4284","DOI":"10.1093\/bioinformatics\/bty510","article-title":"MetaPOAP: presence or absence of metabolic pathways in metagenome-assembled genomes","volume":"34","author":"Ward","year":"2018","journal-title":"Bioinformatics"},{"key":"2024011017300221100_CR117","doi-asserted-by":"publisher","first-page":"6211","DOI":"10.1021\/bi400960w","article-title":"Structural studies of hydroxylamine oxidoreductase reveal a unique heme cofactor and a previously unidentified interaction partner","volume":"52","author":"Cedervall","year":"2013","journal-title":"Biochemistry"},{"key":"2024011017300221100_CR118","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon provides fast and bias-aware quantification of transcript expression","volume":"14","author":"Patro","year":"2017","journal-title":"Nat Methods"},{"key":"2024011017300221100_CR119","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s13059-015-0611-7","article-title":"Average genome size estimation improves comparative metagenomics and sheds light on the functional ecology of the human microbiome","volume":"16","author":"Nayfach","year":"2015","journal-title":"Genome Biol"},{"key":"2024011017300221100_CR120","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.12688\/f1000research.7563.1","article-title":"Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences","volume":"4","author":"Soneson","year":"2015","journal-title":"F1000Research"},{"key":"2024011017300221100_CR121","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2024011017300221100_CR122","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1038\/ismej.2010.29","article-title":"Average genome size: a potential source of bias in comparative metagenomics","volume":"4","author":"Beszteri","year":"2010","journal-title":"ISME J"},{"key":"2024011017300221100_CR123"},{"key":"2024011017300221100_CR124","first-page":"1","article-title":"A linear-time algorithm for Gaussian and non-Gaussian trait evolution models","volume":"63","author":"Ho","year":"2014","journal-title":"Syst Biol"},{"key":"2024011017300221100_CR125","doi-asserted-by":"publisher","first-page":"W81","DOI":"10.1093\/nar\/gkz310","article-title":"antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline","volume":"47","author":"Blin","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2024011017300221100_CR126","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1038\/s41589-019-0400-9","article-title":"A computational framework to explore large-scale biosynthetic diversity","volume":"16","author":"Navarro-Mu\u00f1oz","year":"2020","journal-title":"Nat Chem Biol"},{"key":"2024011017300221100_CR127","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/s41592-019-0686-2","article-title":"SciPy 1.0: fundamental algorithms for scientific computing in Python","volume":"17","author":"Virtanen","year":"2020","journal-title":"Nat Methods"},{"key":"2024011017300221100_CR128","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.1093\/bioinformatics\/btp348","article-title":"trimAl: A tool for automated alignment trimming in large-scale phylogenetic analyses","volume":"25","author":"Capella-Guti\u00e9rrez","year":"2009","journal-title":"Bioinformatics"},{"key":"2024011017300221100_CR129"},{"key":"2024011017300221100_CR130","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/j.1747-0765.2005.tb00034.x","article-title":"Detection of nifH Sequences in Sugarcane (Saccharum officinarum L.) and Pineapple (Ananas comosus [L.] Merr.)","volume":"51","author":"Ando","year":"2005","journal-title":"Soil Sci Plant Nutr"},{"key":"2024011017300221100_CR131","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40168-020-00867-0","article-title":"VIBRANT: automated recovery, annotation and curation of microbial viruses, and evaluation of viral community function from genomic sequences","volume":"8","author":"Kieft","year":"2020","journal-title":"Microbiome"},{"key":"2024011017300221100_CR132"}],"container-title":["The ISME Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41396-022-01345-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41396-022-01345-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/ismej\/article-pdf\/17\/3\/354\/55250550\/41396_2022_article_1345.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.nature.com\/articles\/s41396-022-01345-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/academic.oup.com\/ismej\/article-pdf\/17\/3\/354\/55250550\/41396_2022_article_1345.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T13:15:07Z","timestamp":1707916507000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ismej\/article\/17\/3\/354-370\/7474055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,20]]},"references-count":132,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3,1]]}},"URL":"https:\/\/doi.org\/10.1038\/s41396-022-01345-1","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.07.30.454538","asserted-by":"object"}]},"ISSN":["1751-7362","1751-7370"],"issn-type":[{"value":"1751-7362","type":"print"},{"value":"1751-7370","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,3]]},"published":{"date-parts":[[2022,12,20]]},"assertion":[{"value":"7 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}