{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:57:16Z","timestamp":1792843036265,"version":"4.5.0"},"reference-count":134,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mangrove sediment is a crucial component in the global mercury (Hg) cycling and acts as a hotspot for methylmercury (MeHg) production. Early evidence has documented the ubiquity of well-studied Hg methylators in mangrove superficial sediments; however, their diversity and metabolic adaptation in the more anoxic and highly reduced subsurface sediments are lacking. Through MeHg biogeochemical assay and metagenomic sequencing, we found that mangrove subsurface sediments (20\u2013100\u2009cm) showed a less hgcA gene abundance but higher diversity of Hg methylators than superficial sediments (0\u201320\u2009cm). Regional-scale investigation of mangrove subsurface sediments spanning over 1500\u2009km demonstrated a prevalence and family-level novelty of Hg-methylating microbial lineages (i.e., those affiliated to Anaerolineae, Phycisphaerae, and Desulfobacterales). We proposed the candidate phylum Zixibacteria lineage with sulfate-reducing capacity as a currently understudied Hg methylator across anoxic environments. Unlike other Hg methylators, the Zixibacteria lineage does not use the Wood\u2013Ljungdahl pathway but has unique capabilities of performing methionine synthesis to donate methyl groups. The absence of cobalamin biosynthesis pathway suggests that this Hg-methylating lineage may depend on its syntrophic partners (i.e., Syntrophobacterales members) for energy in subsurface sediments. Our results expand the diversity of subsurface Hg methylators and uncover their unique ecophysiological adaptations in mangrove sediments.<\/jats:p>","DOI":"10.1038\/s41396-023-01544-4","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T03:02:28Z","timestamp":1698202948000},"page":"2313-2325","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Phylogenetic and ecophysiological novelty of subsurface mercury methylators in mangrove sediments"],"prefix":"10.1093","volume":"17","author":[{"given":"Songfeng","family":"Liu","sequence":"first","affiliation":[{"name":"Environmental Microbiomics Research Center, School of Environmental Science and Engineering, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen University , Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiwen","family":"Hu","sequence":"additional","affiliation":[{"name":"Environmental Microbiomics Research Center, School of Environmental Science and Engineering, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen University , Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nenglong","family":"Peng","sequence":"additional","affiliation":[{"name":"Environmental Microbiomics Research Center, School of Environmental Science and Engineering, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen University , Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Environmental Microbiomics Research Center, School of Environmental Science and Engineering, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen University , Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihan","family":"Chen","sequence":"additional","affiliation":[{"name":"Environmental Microbiomics Research Center, School of Environmental Science and Engineering, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen University , Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhili","family":"He","sequence":"additional","affiliation":[{"name":"Environmental Microbiomics Research Center, School of Environmental Science and Engineering, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen University , Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6340-246X","authenticated-orcid":false,"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Environmental Microbiomics Research Center, School of Environmental Science and Engineering, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen University , Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,25]]},"reference":[{"key":"2024011017534456500_CR1","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1126\/science.1230667","article-title":"The genetic basis for bacterial mercury methylation","volume":"339","author":"Parks","year":"2013","journal-title":"Science"},{"key":"2024011017534456500_CR2","doi-asserted-by":"publisher","first-page":"11810","DOI":"10.1021\/es403075t","article-title":"Mercury methylation by novel microorganisms from new environments","volume":"47","author":"Gilmour","year":"2013","journal-title":"Environ Sci Technol"},{"key":"2024011017534456500_CR3","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1021\/acs.estlett.0c00409","article-title":"Tracing the uptake of Hg(II) in an iron-reducing bacterium using mercury stable isotopes","volume":"7","author":"Wang","year":"2020","journal-title":"Environ Sci Technol Lett"},{"key":"2024011017534456500_CR4","doi-asserted-by":"publisher","first-page":"e02403","DOI":"10.1128\/mBio.02403-17","article-title":"Robust mercury methylation across diverse methanogenic Archaea","volume":"9","author":"Gilmour","year":"2018","journal-title":"mBio"},{"key":"2024011017534456500_CR5","doi-asserted-by":"publisher","first-page":"e1500675","DOI":"10.1126\/sciadv.1500675","article-title":"Global prevalence and distribution of genes and microorganisms involved in mercury methylation","volume":"1","author":"Podar","year":"2015","journal-title":"Sci Adv"},{"key":"2024011017534456500_CR6","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1038\/s41396-020-00889-4","article-title":"Mercury methylation by metabolically versatile and cosmopolitan marine bacteria","volume":"15","author":"Lin","year":"2021","journal-title":"ISME J"},{"key":"2024011017534456500_CR7","doi-asserted-by":"publisher","first-page":"e00299","DOI":"10.1128\/mSystems.00299-20","article-title":"Expanded phylogenetic diversity and metabolic flexibility of mercury-methylating microorganisms","volume":"5","author":"McDaniel","year":"2020","journal-title":"mSystems"},{"key":"2024011017534456500_CR8","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/s41396-023-01360-w","article-title":"Potential for mercury methylation by Asgard archaea in mangrove sediments","volume":"17","author":"Zhang","year":"2023","journal-title":"ISME J"},{"key":"2024011017534456500_CR9","doi-asserted-by":"publisher","first-page":"5497","DOI":"10.1038\/ncomms6497","article-title":"Biology of a widespread uncultivated archaeon that contributes to carbon fixation in the subsurface","volume":"5","author":"Probst","year":"2014","journal-title":"Nat Commun"},{"key":"2024011017534456500_CR10","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.scitotenv.2019.04.451","article-title":"A review on mercury biogeochemistry in mangrove sediments: hotspots of methylmercury production?","volume":"680","author":"Lei","year":"2019","journal-title":"Sci Total Environ"},{"key":"2024011017534456500_CR11","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/j.1574-6941.2008.00501.x","article-title":"Acclimation of subsurface microbial communities to mercury","volume":"65","author":"De Lipthay","year":"2008","journal-title":"FEMS Microbiol Ecol"},{"key":"2024011017534456500_CR12","doi-asserted-by":"publisher","first-page":"493","DOI":"10.5194\/bg-9-493-2012","article-title":"Biogeochemical factors affecting mercury methylation rate in two contaminated floodplain soils","volume":"9","author":"Frohne","year":"2012","journal-title":"Biogeosciences"},{"key":"2024011017534456500_CR13","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1186\/s40168-021-01164-0","article-title":"Depth-dependent variability of biological nitrogen fixation and diazotrophic communities in mangrove sediments","volume":"9","author":"Luo","year":"2021","journal-title":"Microbiome"},{"key":"2024011017534456500_CR14","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3389\/fmars.2016.00271","article-title":"Nutrient limitation in central Red Sea mangroves","volume":"3","author":"Almahasheer","year":"2016","journal-title":"Front Mar Sci"},{"key":"2024011017534456500_CR15","doi-asserted-by":"publisher","first-page":"e03674","DOI":"10.1002\/ecs2.3674","article-title":"Buried hurricane legacies: increased nutrient limitation and decreased root biomass in coastal wetlands","volume":"12","author":"Kuhn","year":"2021","journal-title":"Ecosphere"},{"key":"2024011017534456500_CR16","doi-asserted-by":"publisher","first-page":"5772","DOI":"10.1016\/j.scitotenv.2009.07.034","article-title":"Vertical distribution and anaerobic biodegradation of polycyclic aromatic hydrocarbons in mangrove sediments in Hong Kong, South China","volume":"407","author":"Li","year":"2009","journal-title":"Sci Total Environ"},{"key":"2024011017534456500_CR17","doi-asserted-by":"publisher","first-page":"2564","DOI":"10.1016\/j.scib.2022.11.016","article-title":"Eco-engineering approaches for ocean negative carbon emission","volume":"67","author":"Zhang","year":"2022","journal-title":"Sci Bull"},{"key":"2024011017534456500_CR18","doi-asserted-by":"publisher","first-page":"13219","DOI":"10.1038\/ncomms13219","article-title":"Thousands of microbial genomes shed light on interconnected biogeochemical processes in an aquifer system","volume":"7","author":"Anantharaman","year":"2016","journal-title":"Nat Commun"},{"key":"2024011017534456500_CR19","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/1462-2920.12930","article-title":"Critical biogeochemical functions in the subsurface are associated with bacteria from new phyla and little studied lineages","volume":"18","author":"Hug","year":"2016","journal-title":"Environ Microbiol"},{"key":"2024011017534456500_CR20","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1111\/1462-2920.12817","article-title":"Metagenomic analysis of a high carbon dioxide subsurface microbial community populated by chemolithoautotrophs and bacteria and archaea from candidate phyla","volume":"18","author":"Emerson","year":"2016","journal-title":"Environ Microbiol"},{"key":"2024011017534456500_CR21","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1038\/s41396-021-01167-7","article-title":"Diverse ecophysiological adaptations of subsurface Thaumarchaeota in floodplain sediments revealed through genome-resolved metagenomics","volume":"16","author":"Reji","year":"2022","journal-title":"ISME J"},{"key":"2024011017534456500_CR22","doi-asserted-by":"crossref","DOI":"10.1101\/2022.11.23.517749","article-title":"Physiological adaptation of sulfate reducing bacteria in syntrophic partnership with anaerobic methanotrophic archaea","volume-title":"bioRxiv","author":"Murali"},{"key":"2024011017534456500_CR23","doi-asserted-by":"publisher","first-page":"7052","DOI":"10.1073\/pnas.0711303105","article-title":"Diverse syntrophic partnerships from deep-sea methane vents revealed by direct cell capture and metagenomics","volume":"105","author":"Pernthaler","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024011017534456500_CR24","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1038\/s41396-018-0106-0","article-title":"Syntrophic pathways for microbial mercury methylation","volume":"12","author":"Yu","year":"2018","journal-title":"ISME J"},{"key":"2024011017534456500_CR25","doi-asserted-by":"publisher","first-page":"137142","DOI":"10.1016\/j.scitotenv.2020.137142","article-title":"Changes of ecosystem carbon stock following the plantation of exotic mangrove Sonneratia apetala in Qi\u2019ao Island, China","volume":"717","author":"Yu","year":"2020","journal-title":"Sci Total Environ"},{"key":"2024011017534456500_CR26","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1007\/s00248-015-0615-6","article-title":"Comparison of archaeal and bacterial diversity in methane seep carbonate nodules and host sediments, Eel River Basin and Hydrate Ridge, USA","volume":"70","author":"Mason","year":"2015","journal-title":"Micro Ecol"},{"key":"2024011017534456500_CR27","doi-asserted-by":"publisher","first-page":"8721","DOI":"10.1038\/ncomms9721","article-title":"Engineering intracellular biomineralization and biosensing by a magnetic protein","volume":"6","author":"Matsumoto","year":"2015","journal-title":"Nat Commun"},{"key":"2024011017534456500_CR28","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1038\/s41467-022-28577-1","article-title":"Mantle Hg isotopic heterogeneity and evidence of oceanic Hg recycling into the mantle","volume":"13","author":"Yin","year":"2022","journal-title":"Nat Commun"},{"key":"2024011017534456500_CR29","doi-asserted-by":"publisher","first-page":"11418","DOI":"10.1021\/acs.est.2c03261","article-title":"Mass budget of mercury (Hg) in the seawater of Eastern China Marginal Seas: importance of the sediment\u2013water transport processes","volume":"56","author":"Chen","year":"2022","journal-title":"Environ Sci Technol"},{"key":"2024011017534456500_CR30","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1038\/s41467-020-15495-3","article-title":"Anomalous fractionation of mercury isotopes in the Late Archean atmosphere","volume":"11","author":"Zerkle","year":"2020","journal-title":"Nat Commun"},{"key":"2024011017534456500_CR31","volume-title":"Method 1631, Revision E: mercury in water by oxidation, purge and trap, and cold vapor atomic fluorescence spectrometry","author":"Telliard","year":"2002"},{"key":"2024011017534456500_CR32","volume-title":"Telliard WA Method 1630: methyl mercury in water by distillation, aqueous ethylation, purge and trap, and cold vapor atomic fluorescence spectrometry","year":"1998"},{"key":"2024011017534456500_CR33","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s00216-007-1236-9","article-title":"Reporting of variations in the natural isotopic composition of mercury","volume":"388","author":"Blum","year":"2007","journal-title":"Anal Bioanal Chem"},{"key":"2024011017534456500_CR34","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.aca.2018.12.026","article-title":"Rapid pre-concentration of mercury in solids and water for isotopic analysis","volume":"1054","author":"Janssen","year":"2019","journal-title":"Anal Chim Acta"},{"key":"2024011017534456500_CR35","first-page":"229","article-title":"Applications of stable mercury isotopes to biogeochemistry","volume":"I","author":"Blum","year":"2012","journal-title":"Handb Environ Isot Geochem"},{"key":"2024011017534456500_CR36","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.1093\/molbev\/msn190","article-title":"Recurrent positive selection of the Drosophila hybrid incompatibility gene Hmr","volume":"25","author":"Maheshwari","year":"2008","journal-title":"Mol Biol Evol"},{"key":"2024011017534456500_CR37","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/s40168-018-0541-1","article-title":"MetaWRAP-a flexible pipeline for genome-resolved metagenomic data analysis","volume":"6","author":"Uritskiy","year":"2018","journal-title":"Microbiome"},{"key":"2024011017534456500_CR38","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ymeth.2016.02.020","article-title":"MEGAHIT v1.0: a fast and scalable metagenome assembler driven by advanced methodologies and community practices","volume":"102","author":"Li","year":"2016","journal-title":"Methods"},{"key":"2024011017534456500_CR39","doi-asserted-by":"publisher","first-page":"e7359","DOI":"10.7717\/peerj.7359","article-title":"MetaBAT 2: an adaptive binning algorithm for robust and efficient genome reconstruction from metagenome assemblies","volume":"7","author":"Kang","year":"2019","journal-title":"PeerJ"},{"key":"2024011017534456500_CR40","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1093\/bioinformatics\/btv638","article-title":"MaxBin 2.0: an automated binning algorithm to recover genomes from multiple metagenomic datasets","volume":"32","author":"Wu","year":"2015","journal-title":"Bioinformatics"},{"key":"2024011017534456500_CR41","doi-asserted-by":"publisher","first-page":"2864","DOI":"10.1038\/ismej.2017.126","article-title":"dRep: a tool for fast and accurate genomic comparisons that enables improved genome recovery from metagenomes through de-replication","volume":"11","author":"Olm","year":"2017","journal-title":"ISME J"},{"key":"2024011017534456500_CR42","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1101\/gr.186072.114","article-title":"CheckM: assessing the quality of microbial genomes recovered from isolates, single cells, and metagenomes","volume":"25","author":"Parks","year":"2015","journal-title":"Genome Res"},{"key":"2024011017534456500_CR43","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1093\/bioinformatics\/btz848","article-title":"GTDB-Tk: a toolkit to classify genomes with the genome taxonomy database","volume":"36","author":"Chaumeil","year":"2019","journal-title":"Bioinformatics"},{"key":"2024011017534456500_CR44","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/1755-0998.13687","article-title":"A consensus protocol for the recovery of mercury methylation genes from metagenomes","volume":"23","author":"Capo","year":"2023","journal-title":"Mol Ecol Resour"},{"key":"2024011017534456500_CR45","doi-asserted-by":"publisher","first-page":"e1002195","DOI":"10.1371\/journal.pcbi.1002195","article-title":"Accelerated profile HMM searches","volume":"7","author":"Eddy","year":"2011","journal-title":"PLoS Comput Biol"},{"key":"2024011017534456500_CR46","doi-asserted-by":"publisher","first-page":"3150","DOI":"10.1093\/bioinformatics\/bts565","article-title":"CD-HIT: accelerated for clustering the next-generation sequencing data","volume":"28","author":"Fu","year":"2012","journal-title":"Bioinformatics"},{"key":"2024011017534456500_CR47","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon provides fast and bias-aware quantification of transcript expression","volume":"14","author":"Patro","year":"2017","journal-title":"Nat Methods"},{"key":"2024011017534456500_CR48","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/s41564-020-00840-5","article-title":"Genome-resolved metagenomics reveals site-specific diversity of episymbiotic CPR bacteria and DPANN archaea in groundwater ecosystems","volume":"6","author":"He","year":"2021","journal-title":"Nat Microbiol"},{"key":"2024011017534456500_CR49","doi-asserted-by":"publisher","first-page":"e00095","DOI":"10.1128\/mSystems.00095-16","article-title":"Impact of sample type and DNA isolation procedure on genomic inference of microbiome composition","volume":"1","author":"Knudsen","year":"2016","journal-title":"mSystems"},{"key":"2024011017534456500_CR50","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1128\/MMBR.00009-08","article-title":"A bioinformatician\u2019s guide to metagenomics","volume":"72","author":"Kunin","year":"2008","journal-title":"Microbiol Mol Biol Rev"},{"key":"2024011017534456500_CR51","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1093\/molbev\/mst010","article-title":"MAFFT multiple sequence alignment software version 7: improvements in performance and usability","volume":"30","author":"Katoh","year":"2013","journal-title":"Mol Biol Evol"},{"key":"2024011017534456500_CR52","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.1093\/bioinformatics\/btp348","article-title":"trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses","volume":"25","author":"Capella-Guti\u00e9rrez","year":"2009","journal-title":"Bioinformatics"},{"key":"2024011017534456500_CR53","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1093\/molbev\/msaa015","article-title":"IQ-TREE 2: new models and efficient methods for phylogenetic inference in the genomic era","volume":"37","author":"Minh","year":"2020","journal-title":"Mol Biol Evol"},{"key":"2024011017534456500_CR54","doi-asserted-by":"publisher","first-page":"W242","DOI":"10.1093\/nar\/gkw290","article-title":"Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees","volume":"44","author":"Letunic","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"2024011017534456500_CR55","doi-asserted-by":"publisher","first-page":"5114","DOI":"10.1038\/s41467-018-07641-9","article-title":"High throughput ANI analysis of 90K prokaryotic genomes reveals clear species boundaries","volume":"9","author":"Jain","year":"2018","journal-title":"Nat Commun"},{"key":"2024011017534456500_CR56","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/1471-2105-11-119","article-title":"Prodigal: prokaryotic gene recognition and translation initiation site identification","volume":"11","author":"Hyatt","year":"2010","journal-title":"BMC Bioinform"},{"key":"2024011017534456500_CR57","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1111\/1755-0998.13589","article-title":"MCycDB: a curated database for comprehensively profiling methane cycling processes of environmental microbiomes","volume":"22","author":"Qian","year":"2022","journal-title":"Mol Ecol Resour"},{"key":"2024011017534456500_CR58","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1111\/1755-0998.13306","article-title":"SCycDB: a curated functional gene database for metagenomic profiling of sulphur cycling pathways","volume":"21","author":"Yu","year":"2021","journal-title":"Mol Ecol Resour"},{"key":"2024011017534456500_CR59","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3389\/fmicb.2020.00037","article-title":"FeGenie: a comprehensive tool for the identification of iron genes and iron gene neighborhoods in genome and metagenome assemblies","volume":"11","author":"Garber","year":"2020","journal-title":"Front Microbiol"},{"key":"2024011017534456500_CR60","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s40168-021-01213-8","article-title":"Metabolic: high-throughput profiling of microbial genomes for functional traits, metabolism, biogeochemistry, and community-scale functional networks","volume":"10","author":"Zhou","year":"2022","journal-title":"Microbiome"},{"key":"2024011017534456500_CR61","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/s41592-021-01101-x","article-title":"Sensitive protein alignments at tree-of-life scale using DIAMOND","volume":"18","author":"Buchfink","year":"2021","journal-title":"Nat Methods"},{"key":"2024011017534456500_CR62","doi-asserted-by":"publisher","first-page":"34212","DOI":"10.1038\/srep34212","article-title":"HydDB: a web tool for hydrogenase classification and analysis","volume":"6","author":"S\u00f8ndergaard","year":"2016","journal-title":"Sci Rep"},{"key":"2024011017534456500_CR63","article-title":"AnHyDeg: a curated database of anaerobic hydrocarbon degradation genes","volume-title":"GitHub","author":"Callaghan","year":"2016"},{"key":"2024011017534456500_CR64","doi-asserted-by":"publisher","first-page":"682605","DOI":"10.3389\/fmicb.2021.682605","article-title":"Expanded diversity and phylogeny of mer genes broadens mercury resistance paradigms and reveals an origin for MerA among thermophilic archaea","volume":"12","author":"Christakis","year":"2021","journal-title":"Front Microbiol"},{"key":"2024011017534456500_CR65","doi-asserted-by":"publisher","first-page":"913","DOI":"10.3389\/fmicb.2016.00913","article-title":"Isolation and genomic characterization of Desulfuromonas soudanensis WTL, a metal-and electrode-respiring bacterium from anoxic deep subsurface brine","volume":"7","author":"Badalamenti","year":"2016","journal-title":"Front Microbiol"},{"key":"2024011017534456500_CR66","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1038\/ismej.2017.39","article-title":"Potential for microbial H2 and metal transformations associated with novel bacteria and archaea in deep terrestrial subsurface sediments","volume":"11","author":"Hernsdorf","year":"2017","journal-title":"ISME J"},{"key":"2024011017534456500_CR67","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1038\/s41564-019-0534-2","article-title":"An archaeal origin of the Wood\u2013Ljungdahl H4MPT branch and the emergence of bacterial methylotrophy","volume":"4","author":"Adam","year":"2019","journal-title":"Nat Microbiol"},{"key":"2024011017534456500_CR68","doi-asserted-by":"publisher","first-page":"E1166","DOI":"10.1073\/pnas.1716667115","article-title":"Evolutionary history of carbon monoxide dehydrogenase\/acetyl-CoA synthase, one of the oldest enzymatic complexes","volume":"115","author":"Adam","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024011017534456500_CR69","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1099\/mic.0.077826-0","article-title":"Bacterial methionine biosynthesis","volume":"160","author":"Ferla","year":"2014","journal-title":"Microbiology"},{"key":"2024011017534456500_CR70","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1038\/s41396-020-00890-x","article-title":"Newly discovered Asgard archaea Hermodarchaeota potentially degrade alkanes and aromatics via alkyl\/benzyl-succinate synthase and benzoyl-CoA pathway","volume":"15","author":"Zhang","year":"2021","journal-title":"ISME J"},{"key":"2024011017534456500_CR71","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.1093\/bioinformatics\/btz859","article-title":"KofamKOALA: KEGG ortholog assignment based on profile HMM and adaptive score threshold","volume":"36","author":"Aramaki","year":"2019","journal-title":"Bioinformatics"},{"key":"2024011017534456500_CR72","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/j.sbi.2008.11.005","article-title":"Cobalamin-dependent and cobamide-dependent methyltransferases","volume":"18","author":"Matthews","year":"2008","journal-title":"Curr Opin Struct Biol"},{"key":"2024011017534456500_CR73","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"2024011017534456500_CR74","doi-asserted-by":"publisher","first-page":"W408","DOI":"10.1093\/nar\/gkv451","article-title":"CCTOP: a consensus constrained topology prediction web server","volume":"43","author":"Dobson","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2024011017534456500_CR75","first-page":"W380","article-title":"mTM-align: a server for fast protein structure database search and multiple protein structure alignment","volume":"46","author":"Dong","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2024011017534456500_CR76","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/nature10916","article-title":"Visualizing molecular juggling within a B12-dependent methyltransferase complex","volume":"484","author":"Kung","year":"2012","journal-title":"Nature"},{"key":"2024011017534456500_CR77","first-page":"16065","article-title":"Atomic resolution (0.94 \u00c5) structure of Clostridium acidurici ferredoxin","volume":"36","author":"Dauter","year":"1997","journal-title":"Detailed geometry of [4Fe-4S] clusters in a protein. Biochemistry"},{"key":"2024011017534456500_CR78","doi-asserted-by":"crossref","DOI":"10.1038\/s41396-023-01484-z","article-title":"Candidatus Nemesobacterales is a sponge-specific clade of the candidate phylum Desulfobacterota adapted to a symbiotic lifestyle","volume-title":"ISME J","author":"Gavriilidou"},{"key":"2024011017534456500_CR79","doi-asserted-by":"publisher","first-page":"D723","DOI":"10.1093\/nar\/gkac976","article-title":"The IMG\/M data management and analysis system v.7: content updates and new features","volume":"51","author":"Chen","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"2024011017534456500_CR80","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/nrmicro3330","article-title":"Uniting the classification of cultured and uncultured bacteria and archaea using 16S rRNA gene sequences","volume":"12","author":"Yarza","year":"2014","journal-title":"Nat Rev Microbiol"},{"key":"2024011017534456500_CR81","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1038\/s41596-020-0312-x","article-title":"The HDOCK server for integrated protein\u2013protein docking","volume":"15","author":"Yan","year":"2020","journal-title":"Nat Protoc"},{"key":"2024011017534456500_CR82","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1002\/prot.25234","article-title":"Addressing recent docking challenges: a hybrid strategy to integrate template-based and free protein-protein docking","volume":"85","author":"Yan","year":"2017","journal-title":"Proteins"},{"key":"2024011017534456500_CR83","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1002\/prot.21949","article-title":"An iterative knowledge-based scoring function for protein-protein recognition","volume":"72","author":"Huang","year":"2008","journal-title":"Proteins"},{"key":"2024011017534456500_CR84","doi-asserted-by":"publisher","first-page":"2778","DOI":"10.1021\/ci200227u","article-title":"LigPlot+: multiple ligand\u2013protein interaction diagrams for drug discovery","volume":"51","author":"Laskowski","year":"2011","journal-title":"J Chem Inf Model"},{"key":"2024011017534456500_CR85","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: high-resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat Methods"},{"key":"2024011017534456500_CR86","doi-asserted-by":"publisher","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA ribosomal RNA gene database project: improved data processing and web-based tools","volume":"41","author":"Quast","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"2024011017534456500_CR87","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1093\/bioinformatics\/bty734","article-title":"FastSpar: rapid and scalable correlation estimation for compositional data","volume":"35","author":"Watts","year":"2018","journal-title":"Bioinformatics"},{"key":"2024011017534456500_CR88","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1609\/icwsm.v3i1.13937","article-title":"Gephi: an open source software for exploring and manipulating networks","volume":"3","author":"Bastian","year":"2009","journal-title":"Proc Int AAAI Conf Web Soc Media"},{"key":"2024011017534456500_CR89","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/wics.147","volume":"3","author":"Wickham","year":"2011","journal-title":"ggplot2. Wiley Interdiscip Rev Comput Stat"},{"key":"2024011017534456500_CR90","first-page":"165","article-title":"spaa: an R package for computing species association and niche overlap","volume":"10","author":"Zhang","year":"2014","journal-title":"Res Prog Biodivers Conserv China"},{"key":"2024011017534456500_CR91","first-page":"719","article-title":"The vegan package","volume":"10","author":"Oksanen","year":"2007","journal-title":"Community Ecol package"},{"key":"2024011017534456500_CR92","doi-asserted-by":"publisher","first-page":"bbac222","DOI":"10.1093\/bib\/bbac222","article-title":"ggmsa: a visual exploration tool for multiple sequence alignment and associated data","volume":"23","author":"Zhou","year":"2022","journal-title":"Brief Bioinform"},{"key":"2024011017534456500_CR93","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/S1001-0742(10)60368-3","article-title":"Methylmercury and sulfate-reducing bacteria in mangrove sediments from Jiulong River Estuary, China","volume":"23","author":"Wu","year":"2011","journal-title":"J Environ Sci"},{"key":"2024011017534456500_CR94","doi-asserted-by":"publisher","first-page":"2684","DOI":"10.1021\/es2033718","article-title":"Contribution of coexisting sulfate and iron reducing bacteria to methylmercury production in freshwater river sediments","volume":"46","author":"Yu","year":"2012","journal-title":"Environ Sci Technol"},{"key":"2024011017534456500_CR95","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1146\/annurev-earth-050212-124107","article-title":"Mercury isotopes in earth and environmental sciences","volume":"42","author":"Blum","year":"2014","journal-title":"Annu Rev Earth Planet Sci"},{"key":"2024011017534456500_CR96","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/gbc.20021","article-title":"Mercury isotopes in a forested ecosystem: Implications for air-surface exchange dynamics and the global mercury cycle","volume":"27","author":"Demers","year":"2013","journal-title":"Glob Biogeochem Cy"},{"key":"2024011017534456500_CR97","doi-asserted-by":"publisher","first-page":"8303","DOI":"10.1021\/es801444b","article-title":"Natural mercury isotope variation in coal deposits and organic soils","volume":"42","author":"Biswas","year":"2008","journal-title":"Environ Sci Technol"},{"key":"2024011017534456500_CR98","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1002\/2015GB005323","article-title":"Mercury isotope compositions across North American forests","volume":"30","author":"Zheng","year":"2016","journal-title":"Glob Biogeochem Cy"},{"key":"2024011017534456500_CR99","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1039\/C7EM00245A","article-title":"Source tracing of natural organic matter bound mercury in boreal forest runoff with mercury stable isotopes","volume":"19","author":"Jiskra","year":"2017","journal-title":"Environ Sci Process Impacts"},{"key":"2024011017534456500_CR100","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.crte.2015.04.001","article-title":"The mercury isotope composition of Arctic coastal seawater","volume":"347","author":"\u0160trok","year":"2015","journal-title":"CR Geosci"},{"key":"2024011017534456500_CR101","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.chemgeo.2017.08.010","article-title":"Anomalous mercury enrichment in Early Cambrian black shales of South China: mercury isotopes indicate a seawater source","volume":"467","author":"Yin","year":"2017","journal-title":"Chem Geol"},{"key":"2024011017534456500_CR102","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1130\/G38487.1","article-title":"Isotopic signatures of mercury contamination in latest Permian oceans","volume":"45","author":"Grasby","year":"2017","journal-title":"Geology"},{"key":"2024011017534456500_CR103","doi-asserted-by":"publisher","first-page":"112725","DOI":"10.1016\/j.envres.2022.112725","article-title":"Study of microplastics pollution in sediments and organisms in mangrove forests: a review","volume":"208","author":"Maghsodian","year":"2022","journal-title":"Environ Res"},{"key":"2024011017534456500_CR104","doi-asserted-by":"publisher","first-page":"9171","DOI":"10.1021\/es801591k","article-title":"Mercury stable isotope fractionation during reduction of Hg(II) by different microbial pathways","volume":"42","author":"Kritee","year":"2008","journal-title":"Environ Sci Technol"},{"key":"2024011017534456500_CR105","doi-asserted-by":"publisher","first-page":"17284","DOI":"10.1038\/srep17284","article-title":"Impact of a wastewater treatment plant on microbial community composition and function in a hyporheic zone of a eutrophic river","volume":"5","author":"Atashgahi","year":"2015","journal-title":"Sci Rep"},{"key":"2024011017534456500_CR106","doi-asserted-by":"publisher","first-page":"601705","DOI":"10.3389\/fmicb.2021.601705","article-title":"Assessment of biological contribution to natural recovery of anthropized freshwater sediments from Argentina: autochthonous microbiome structure and functional prediction","volume":"12","author":"Madue\u00f1o","year":"2021","journal-title":"Front Microbiol"},{"key":"2024011017534456500_CR107","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1016\/j.bbabio.2011.06.016","article-title":"The cytochrome bd respiratory oxygen reductases","volume":"1807","author":"Borisov","year":"2011","journal-title":"Biochim Biophys Acta Bioenerg"},{"key":"2024011017534456500_CR108","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/j.1574-6968.1997.tb10231.x","article-title":"cbb3-type cytochrome oxidase in the obligately chemolithoautotrophic Thiobacillus sp. W5","volume":"147","author":"Visser","year":"1997","journal-title":"FEMS Microbiol Lett"},{"key":"2024011017534456500_CR109","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1021\/acs.est.8b02709","article-title":"Microbial mercury methylation in aquatic environments: a critical review of published field and laboratory studies","volume":"53","author":"Regnell","year":"2018","journal-title":"Environ Sci Technol"},{"key":"2024011017534456500_CR110","doi-asserted-by":"publisher","first-page":"506","DOI":"10.3390\/v13030506","article-title":"A roadmap for genome-based phage taxonomy","volume":"13","author":"Turner","year":"2021","journal-title":"Viruses"},{"key":"2024011017534456500_CR111","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s40168-018-0421-8","article-title":"\u201cCandidatus Paraporphyromonas polyenzymogenes\u201d encodes multi-modular cellulases linked to the type IX secretion system","volume":"6","author":"Naas","year":"2018","journal-title":"Microbiome"},{"key":"2024011017534456500_CR112","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1186\/s40168-022-01421-w","article-title":"Microbial active functional modules derived from network analysis and metabolic interactions decipher the complex microbiome assembly in mangrove sediments","volume":"10","author":"Du","year":"2022","journal-title":"Microbiome"},{"key":"2024011017534456500_CR113","doi-asserted-by":"publisher","first-page":"7919","DOI":"10.1128\/AEM.01602-06","article-title":"Mercury methylation by dissimilatory iron-reducing bacteria","volume":"72","author":"Kerin","year":"2006","journal-title":"Appl Environ Microbiol"},{"key":"2024011017534456500_CR114","doi-asserted-by":"publisher","first-page":"3938","DOI":"10.1128\/AEM.02993-10","article-title":"Sulfate-reducing bacterium Desulfovibrio desulfuricans ND132 as a model for understanding bacterial mercury methylation","volume":"77","author":"Gilmour","year":"2011","journal-title":"Appl Environ Microbiol"},{"key":"2024011017534456500_CR115","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1128\/JB.00170-11","article-title":"Genome sequence of the mercury-methylating strain Desulfovibrio desulfuricans ND132","volume":"193","author":"Brown","year":"2011","journal-title":"J Bacteriol"},{"key":"2024011017534456500_CR116","doi-asserted-by":"publisher","first-page":"7337","DOI":"10.1128\/AEM.01792-12","article-title":"Detailed assessment of the kinetics of Hg-cell association, Hg methylation, and methylmercury degradation in several Desulfovibrio species","volume":"78","author":"Graham","year":"2012","journal-title":"Appl Environ Microbiol"},{"key":"2024011017534456500_CR117","doi-asserted-by":"publisher","first-page":"2430","DOI":"10.1128\/AEM.66.6.2430-2437.2000","article-title":"Sulfate-reducing bacteria methylate mercury at variable rates in pure culture and in marine sediments","volume":"66","author":"King","year":"2000","journal-title":"Appl Environ Microbiol"},{"key":"2024011017534456500_CR118","doi-asserted-by":"publisher","first-page":"11137","DOI":"10.1016\/S0021-9258(19)68568-6","article-title":"Purification of five components from Clostridium thermoaceticum which catalyze synthesis of acetate from pyruvate and methyltetrahydrofolate. Properties of phosphotransacetylase","volume":"256","author":"Drake","year":"1981","journal-title":"J Biol Chem"},{"key":"2024011017534456500_CR119","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/S0969-2126(00)00172-6","article-title":"Crystal structure of a methyltetrahydrofolate-and corrinoid-dependent methyltransferase","volume":"8","author":"Doukov","year":"2000","journal-title":"Structure"},{"key":"2024011017534456500_CR120","doi-asserted-by":"publisher","first-page":"16570","DOI":"10.1074\/jbc.272.26.16570","article-title":"Reconstitution of monomethylamine: coenzyme M methyl transfer with a corrinoid protein and two methyltransferases purified from Methanosarcina barkeri","volume":"272","author":"Burke","year":"1997","journal-title":"J Biol Chem"},{"key":"2024011017534456500_CR121","doi-asserted-by":"publisher","first-page":"3432","DOI":"10.1128\/JB.180.13.3432-3440.1998","article-title":"Clustered genes encoding the methyltransferases of methanogenesis from monomethylamine","volume":"180","author":"Burke","year":"1998","journal-title":"J Bacteriol"},{"key":"2024011017534456500_CR122","doi-asserted-by":"publisher","first-page":"29053","DOI":"10.1074\/jbc.M910218199","article-title":"Reconstitution of dimethylamine: coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri","volume":"275","author":"Ferguson","year":"2000","journal-title":"J Biol Chem"},{"key":"2024011017534456500_CR123","doi-asserted-by":"publisher","first-page":"3276","DOI":"10.1128\/JB.183.11.3276-3281.2001","article-title":"Characterization of a three-component vanillate O-demethylase from Moorella thermoacetica","volume":"183","author":"Naidu","year":"2001","journal-title":"J Bacteriol"},{"key":"2024011017534456500_CR124","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/S0005-2728(00)00274-7","article-title":"The Na+-translocating methyltransferase complex from methanogenic archaea","volume":"1505","author":"Gottschalk","year":"2001","journal-title":"Biochim Biophys Acta Bioenerg"},{"key":"2024011017534456500_CR125","doi-asserted-by":"publisher","first-page":"4485","DOI":"10.1074\/jbc.M007514200","article-title":"The MtsA subunit of the methylthiol: coenzyme M methyltransferase of Methanosarcina barkeri catalyses both half-reactions of corrinoid-dependent dimethylsulfide: coenzyme M methyl transfer","volume":"276","author":"Tallant","year":"2001","journal-title":"J Biol Chem"},{"key":"2024011017534456500_CR126","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1046\/j.1432-1327.1998.2530698.x","article-title":"Methanol: coenzyme M methyltransferase from Methanosarcina barkeri: identification of the active-site histidine in the corrinoid-harboring subunit MtaC by site-directed mutagenesis","volume":"253","author":"Sauer","year":"1998","journal-title":"Eur J Biochem"},{"key":"2024011017534456500_CR127","doi-asserted-by":"publisher","first-page":"2520","DOI":"10.1128\/JB.182.9.2520-2529.2000","article-title":"The trimethylamine methyltransferase gene and multiple dimethylamine methyltransferase genes of Methanosarcina barkeri contain in-frame and read-through amber codons","volume":"182","author":"Paul","year":"2000","journal-title":"J Bacteriol"},{"key":"2024011017534456500_CR128","doi-asserted-by":"publisher","first-page":"18527","DOI":"10.1073\/pnas.0906132106","article-title":"Insights into the reactivation of cobalamin-dependent methionine synthase","volume":"106","author":"Koutmos","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024011017534456500_CR129","doi-asserted-by":"publisher","first-page":"16127","DOI":"10.1038\/nmicrobiol.2016.127","article-title":"Microbial mercury methylation in Antarctic sea ice","volume":"1","author":"Gionfriddo","year":"2016","journal-title":"Nat Microbiol"},{"key":"2024011017534456500_CR130","doi-asserted-by":"publisher","first-page":"11973","DOI":"10.1073\/pnas.211429998","article-title":"Life on carbon monoxide: X-ray structure of Rhodospirillum rubrum Ni-Fe-S carbon monoxide dehydrogenase","volume":"98","author":"Drennan","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024011017534456500_CR131","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41522-021-00255-y","article-title":"Transcriptomic evidence for versatile metabolic activities of mercury cycling microorganisms in brackish microbial mats","volume":"7","author":"Vigneron","year":"2021","journal-title":"NPJ Biofilms Microb"},{"key":"2024011017534456500_CR132","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.orggeochem.2012.08.007","article-title":"Polycyclic aromatic hydrocarbon fingerprints in the Pichavaram mangrove\u2013estuarine sediments, southeastern India","volume":"53","author":"Ranjan","year":"2012","journal-title":"Org Geochem"},{"key":"2024011017534456500_CR133","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1038\/s41564-023-01400-3","article-title":"Candidatus Alkanophaga archaea from Guaymas Basin hydrothermal vent sediment oxidize petroleum alkanes","volume":"8","author":"Zehnle","year":"2023","journal-title":"Nat Microbiol"},{"key":"2024011017534456500_CR134","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1038\/s41396-023-01391-3","article-title":"Vitamin B12 is not shared by all marine prototrophic bacteria with their environment","volume":"17","author":"Sultana","year":"2023","journal-title":"ISME J"}],"container-title":["The ISME Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41396-023-01544-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41396-023-01544-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/ismej\/article-pdf\/17\/12\/2313\/55367786\/41396_2023_article_1544.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.nature.com\/articles\/s41396-023-01544-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/academic.oup.com\/ismej\/article-pdf\/17\/12\/2313\/55367786\/41396_2023_article_1544.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T13:16:40Z","timestamp":1707916600000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ismej\/article\/17\/12\/2313-2325\/7506669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,25]]},"references-count":134,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12,1]]}},"URL":"https:\/\/doi.org\/10.1038\/s41396-023-01544-4","relation":{},"ISSN":["1751-7362","1751-7370"],"issn-type":[{"value":"1751-7362","type":"print"},{"value":"1751-7370","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,12]]},"published":{"date-parts":[[2023,10,25]]},"assertion":[{"value":"24 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}