{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T20:33:02Z","timestamp":1783629182423,"version":"3.55.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T00:00:00Z","timestamp":1537401600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T00:00:00Z","timestamp":1537401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["U01-GM074492"],"award-info":[{"award-number":["U01-GM074492"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["NIH R01 HL074730"],"award-info":[{"award-number":["NIH R01 HL074730"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS073346"],"award-info":[{"award-number":["R01 NS073346"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["U01GM074492-05S109"],"award-info":[{"award-number":["U01GM074492-05S109"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["1 KL2 TR001429"],"award-info":[{"award-number":["1 KL2 TR001429"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["U01HG04603"],"award-info":[{"award-number":["U01HG04603"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["U01HG006378"],"award-info":[{"award-number":["U01HG006378"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"INVEST was supported by grants from the University of Florida Opportunity Fund and Abbott Pharmaceuticals"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharmacogenomics J"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1038\/s41397-018-0049-x","type":"journal-article","created":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T15:38:20Z","timestamp":1537457900000},"page":"295-304","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Genome-wide association analysis of common genetic variants of resistant hypertension"],"prefix":"10.1038","volume":"19","author":[{"name":"on behalf of eMERGE network","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihal","family":"El Rouby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitrin W.","family":"McDonough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie A.","family":"McClure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Braxton D.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Horenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Talbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana C.","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Gitzendanner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6201-9784","authenticated-orcid":false,"given":"Toshihiro","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiaki","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6011-681X","authenticated-orcid":false,"given":"Carl J.","family":"Pepine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhonda M.","family":"Cooper-DeHoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar R.","family":"Benavente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R.","family":"Shuldiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,9,20]]},"reference":[{"key":"49_CR1","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1001\/jama.2010.650","volume":"303","author":"BM Egan","year":"2010","unstructured":"Egan BM, Zhao Y, Axon RN. US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008. JAMA. 2010;303:2043\u201350.","journal-title":"JAMA"},{"key":"49_CR2","doi-asserted-by":"publisher","first-page":"e510","DOI":"10.1161\/CIRCULATIONAHA.108.189141","volume":"117","author":"DA Calhoun","year":"2008","unstructured":"Calhoun DA, Jones D, Textor S, Goff DC, Murphy TP, Toto RD, et al. Resistant hypertension: diagnosis, evaluation, and treatment: a scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Circulation. 2008;117:e510\u201326.","journal-title":"Circulation"},{"key":"49_CR3","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1161\/HYPERTENSIONAHA.111.170308","volume":"57","author":"SD Persell","year":"2011","unstructured":"Persell SD. Prevalence of resistant hypertension in the United States, 2003-2008. Hypertension. 2011;57:1076\u201380.","journal-title":"Hypertension"},{"key":"49_CR4","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/nrneph.2012.260","volume":"9","author":"PA Sarafidis","year":"2013","unstructured":"Sarafidis PA, Georgianos P, Bakris GL. Resistant hypertension\u2014its identification and epidemiology. Nat Rev Nephrol. 2013;9:51\u20138.","journal-title":"Nat Rev Nephrol"},{"key":"49_CR5","doi-asserted-by":"crossref","unstructured":"Whelton PK, Carey RM, Aronow WS, Casey DE, Collins KJ, Dennison Himmelfarb C, et al. 2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2018;71:1269\u2013324.","DOI":"10.1161\/HYP.0000000000000066"},{"key":"49_CR6","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1161\/CIRCULATIONAHA.111.068064","volume":"125","author":"SL Daugherty","year":"2012","unstructured":"Daugherty SL, Powers JD, Magid DJ, Tavel HM, Masoudi FA, Margolis KL, et al. Incidence and prognosis of resistant hypertension in hypertensive patients. Circulation. 2012;125:1635\u201342.","journal-title":"Circulation"},{"key":"49_CR7","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1097\/HJH.0000000000000051","volume":"32","author":"SM Smith","year":"2014","unstructured":"Smith SM, Gong Y, Handberg E, Messerli FH, Bakris GL, Ahmed A, et al. Predictors and outcomes of resistant hypertension among patients with coronary artery disease and hypertension. J Hypertens. 2014;32:635\u201343.","journal-title":"J Hypertens"},{"key":"49_CR8","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s11906-015-0583-8","volume":"17","author":"N El Rouby","year":"2015","unstructured":"El Rouby N, Cooper-DeHoff RM. Genetics of resistant hypertension: a novel pharmacogenomics phenotype. Curr Hypertens Rep. 2015;17:583.","journal-title":"Curr Hypertens Rep"},{"key":"49_CR9","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.1001\/jama.290.21.2805","volume":"290","author":"CJ Pepine","year":"2003","unstructured":"Pepine CJ, Handberg EM, Cooper-DeHoff RM, Marks RG, Kowey P, Messerli FH, et al. A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial. JAMA. 2003;290:2805\u201316.","journal-title":"JAMA"},{"key":"49_CR10","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1111\/j.1747-4949.2010.00573.x","volume":"6","author":"OR Benavente","year":"2011","unstructured":"Benavente OR, White CL, Pearce L, Pergola P, Roldan A, Benavente MF, et al. The secondary prevention of small subcortical strokes (SPS3) study. Int J Stroke. 2011;6:164\u201375.","journal-title":"Int J Stroke"},{"key":"49_CR11","doi-asserted-by":"publisher","first-page":"e0171745","DOI":"10.1371\/journal.pone.0171745","volume":"12","author":"L Dumitrescu","year":"2017","unstructured":"Dumitrescu L, Ritchie MD, Denny JC, El Rouby NM, McDonough CW, Bradford Y, et al. Genome-wide study of resistant hypertension identified from electronic health records. PLoS ONE. 2017;12:e0171745.","journal-title":"PLoS ONE"},{"key":"49_CR12","doi-asserted-by":"publisher","first-page":"e001398","DOI":"10.1161\/JAHA.114.001398","volume":"3","author":"V Fontana","year":"2014","unstructured":"Fontana V, McDonough CW, Gong Y, El Rouby NM, Sa AC, Taylor KD, et al. Large-scale gene-centric analysis identifies polymorphisms for resistant hypertension. J Am Heart Assoc. 2014;3:e001398.","journal-title":"J Am Heart Assoc"},{"key":"49_CR13","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","volume":"81","author":"S Purcell","year":"2007","unstructured":"Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81:559\u201375.","journal-title":"Am J Hum Genet"},{"key":"49_CR14","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","volume":"26","author":"CJ Willer","year":"2010","unstructured":"Willer CJ, Li Y, Abecasis GR. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics. 2010;26:2190\u20131.","journal-title":"Bioinformatics"},{"key":"49_CR15","doi-asserted-by":"crossref","unstructured":"DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium; South Asian Type 2 Diabetes (SAT2D) Consortium, Mexican American Type 2 Diabetes (MAT2D) Consortium, Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in muylti-Ethnic Samples (T2D-GENES) Consortium, et al. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet. 2014;46:234\u201344.","DOI":"10.1038\/ng.2897"},{"key":"49_CR16","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1007\/s00439-014-1493-6","volume":"133","author":"IP Gorlov","year":"2014","unstructured":"Gorlov IP, Moore JH, Peng B, Jin JL, Gorlova OY, Amos CI. SNP characteristics predict replication success in association studies. Hum Genet. 2014;133:1477\u201386.","journal-title":"Hum Genet"},{"key":"49_CR17","doi-asserted-by":"publisher","first-page":"280","DOI":"10.3389\/fgene.2013.00280","volume":"4","author":"L Hou","year":"2013","unstructured":"Hou L, Zhao H. A review of post-GWAS prioritization approaches. Front Genet. 2013;4:280.","journal-title":"Front Genet"},{"key":"49_CR18","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/ng.175","volume":"40","author":"JC Barrett","year":"2008","unstructured":"Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn\u2019s disease. Nat Genet. 2008;40:955\u201362.","journal-title":"Nat Genet"},{"key":"49_CR19","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14355-3","volume":"7","author":"TH Lee","year":"2017","unstructured":"Lee TH, Ko TM, Chen CH, Chang YJ, Lu LS, Chang CH, et al. A genome-wide association study links small-vessel ischemic stroke to autophagy. Sci Rep. 2017;7:15229.","journal-title":"Sci Rep"},{"key":"49_CR20","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1161\/HYPERTENSIONAHA.111.00823","volume":"62","author":"CW McDonough","year":"2013","unstructured":"McDonough CW, Gong Y, Padmanabhan S, Burkley B, Langaee TY, Melander O, et al. Pharmacogenomic association of nonsynonymous SNPs in SIGLEC12, A1BG, and the selectin region and cardiovascular outcomes. Hypertension. 201362:48\u201354.","journal-title":"Hypertension"},{"issue":"Database issue","key":"49_CR21","doi-asserted-by":"publisher","first-page":"D930","DOI":"10.1093\/nar\/gkr917","volume":"40","author":"LD Ward","year":"2012","unstructured":"Ward LD, Kellis M. HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res. 2012;40(Database issue):D930\u20134.","journal-title":"Nucleic Acids Res"},{"key":"49_CR22","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1101\/gr.137323.112","volume":"22","author":"AP Boyle","year":"2012","unstructured":"Boyle AP, Hong EL, Hariharan M, Cheng Y, Schaub MA, Kasowski M, et al. Annotation of functional variation in personal genomes using RegulomeDB. Genome Res. 2012;22:1790\u20137.","journal-title":"Genome Res"},{"key":"49_CR23","first-page":"19","volume":"20","author":"MM Cohen Jr.","year":"2000","unstructured":"Cohen MM Jr. Craniofacial disorders caused by mutations in homeobox genes MSX1 and MSX2. J Craniofac Genet Dev Biol. 2000;20:19\u201325.","journal-title":"J Craniofac Genet Dev Biol"},{"key":"49_CR24","doi-asserted-by":"publisher","first-page":"30427","DOI":"10.1074\/jbc.273.46.30427","volume":"273","author":"DA Towler","year":"1998","unstructured":"Towler DA, Bidder M, Latifi T, Coleman T, Semenkovich CF. Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice. J Biol Chem. 1998;273:30427\u201334.","journal-title":"J Biol Chem"},{"key":"49_CR25","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1172\/JCI24140","volume":"115","author":"JS Shao","year":"2005","unstructured":"Shao JS, Cheng SL, Pingsterhaus JM, Charlton-Kachigian N, Loewy AP, Towler DA. Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals. J Clin Invest. 2005;115:1210\u201320.","journal-title":"J Clin Invest"},{"key":"49_CR26","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-8-S1-S18","volume":"8","author":"CS Fox","year":"2007","unstructured":"Fox CS, Heard-Costa N, Cupples LA, Dupuis J, Vasan RS, Atwood LD. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. BMC Med Genet. 2007;8:S18.","journal-title":"BMC Med Genet"},{"key":"49_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-8-S1-S3","volume":"8","author":"D Levy","year":"2007","unstructured":"Levy D, Larson MG, Benjamin EJ, Newton-Cheh C, Wang TJ, Hwang SJ, et al. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. BMC Med Genet. 2007;8:S3.","journal-title":"BMC Med Genet"},{"key":"49_CR28","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.1097\/HJH.0000000000000714","volume":"33","author":"Y Gong","year":"2015","unstructured":"Gong Y, McDonough CW, Beitelshees AL, El Rouby N, Hiltunen TP, O\u2019Connell JR, et al. PTPRD gene associated with blood pressure response to atenolol and resistant hypertension. J Hypertens. 2015;33:2278\u201385.","journal-title":"J Hypertens"},{"key":"49_CR29","doi-asserted-by":"publisher","first-page":"5750","DOI":"10.1093\/hmg\/ddu289","volume":"23","author":"M Visser","year":"2014","unstructured":"Visser M, Palstra RJ, Kayser M. Human skin color is influenced by an intergenic DNA polymorphism regulating transcription of the nearby BNC2 pigmentation gene. Hum Mol Genet. 2014;23:5750\u201362.","journal-title":"Hum Mol Genet"},{"key":"49_CR30","doi-asserted-by":"publisher","first-page":"539","DOI":"10.2337\/db09-0653","volume":"59","author":"AD Paterson","year":"2010","unstructured":"Paterson AD, Waggott D, Boright AP, Hosseini SM, Shen E, Sylvestre MP, et al. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. Diabetes. 2010;59:539\u201349.","journal-title":"Diabetes"},{"key":"49_CR31","first-page":"AP253","volume":"133","author":"C Li","year":"2016","unstructured":"Li C, He J, Hixson JE, Gu D, Rao DC, Shimmin LC, et al. Abstract P253: genome-wide gene-potassium interaction analyses on blood pressure: The GenSalt Study. Circulation. 2016;133:AP253.","journal-title":"Circulation"},{"key":"49_CR32","first-page":"6","volume":"10","author":"C Li","year":"2017","unstructured":"Li C, He J, Chen J, Zhao J, Gu D, Hixson JE, et al. Genome-wide gene-potassium interaction analyses on blood pressure: the gensalt study (genetic epidemiology network of salt sensitivity). Circ Cardiovasc Genet. 2017;10:6.","journal-title":"Circ Cardiovasc Genet"},{"key":"49_CR33","doi-asserted-by":"publisher","first-page":"D56","DOI":"10.1093\/nar\/gks1172","volume":"41","author":"KR Rosenbloom","year":"2013","unstructured":"Rosenbloom KR, Sloan CA, Malladi VS, Dreszer TR, Learned K, Kirkup VM, et al. ENCODE data in the UCSC Genome Browser: year 5 update. Nucleic Acids Res. 2013;41:D56\u201363.","journal-title":"Nucleic Acids Res"},{"key":"49_CR34","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1016\/S0140-6736(15)00257-3","volume":"386","author":"B Williams","year":"2015","unstructured":"Williams B, MacDonald TM, Morant S, Webb DJ, Sever P, McInnes G, et al. Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial. Lancet. 2015;386:2059\u201368.","journal-title":"Lancet"},{"key":"49_CR35","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1056\/NEJMoa1511939","volume":"373","author":"JT Wright","year":"2015","unstructured":"Wright JT, Williamson JD, Whelton PK, Snyder JK, Sink KM, Rocco MV, et al. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med. 2015;373:2103\u201316.","journal-title":"N Engl J Med"},{"key":"49_CR36","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/S0140-6736(13)60852-1","volume":"382","author":"Benavente","year":"2013","unstructured":"Group SPSS, Benavente, Coffey OR, et al. Blood-pressure targets in patients with recent lacunar stroke: the SPS3 randomised trial. Lancet. 2013;382:507\u201315.","journal-title":"Lancet"},{"key":"49_CR37","doi-asserted-by":"publisher","first-page":"V14","DOI":"10.1002\/clc.4960240706","volume":"24","author":"R Cooper-DeHoff","year":"2001","unstructured":"Cooper-DeHoff R, Handberg E, Heissenberg C, Johnson K. Electronic prescribing via the internet for a coronary artery disease and hypertension megatrial. Clin Cardiol. 2001;24:V14\u20136.","journal-title":"Clin Cardiol"},{"key":"49_CR38","doi-asserted-by":"publisher","first-page":"e147","DOI":"10.1136\/amiajnl-2012-000896","volume":"20","author":"KM Newton","year":"2013","unstructured":"Newton KM, Peissig PL, Kho AN, Bielinski SJ, Berg RL, Choudhary V, et al. Validation of electronic medical record-based phenotyping algorithms: results and lessons learned from the eMERGE network. J Am Med Inform Assoc. 2013;20:e147\u201354.","journal-title":"J Am Med Inform Assoc"}],"container-title":["The Pharmacogenomics Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41397-018-0049-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41397-018-0049-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41397-018-0049-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T20:59:41Z","timestamp":1684616381000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41397-018-0049-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,20]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["49"],"URL":"https:\/\/doi.org\/10.1038\/s41397-018-0049-x","relation":{},"ISSN":["1470-269X","1473-1150"],"issn-type":[{"value":"1470-269X","type":"print"},{"value":"1473-1150","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,20]]},"assertion":[{"value":"11 August 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Dr. Shuldiner is employed by Regeneron Pharmaceuticals, Inc. The remaining authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}