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Studies\n                were eligible if genetic polymorphisms were compared with suspected ADR(s) in a\n                patient with asthma, as either a primary or secondary outcome. Five studies met the\n                inclusion criteria. The ADRs and polymorphisms identified were change in lung\n                function tests (rs1042713), adrenal suppression (rs591118), and decreased bone\n                mineral density (rs6461639) and accretion (rs9896933, rs2074439). Two of these\n                polymorphisms were replicated within the paper, but none had external replication.\n                Priorities from PiCA consortia members (representing 15 institution in eight\n                countries) for future studies were tachycardia (SABA\/LABA), adrenal\n                suppression\/crisis and growth suppression (corticosteroids), sleep\/behaviour\n                disturbances (leukotriene receptor antagonists), and nausea and vomiting\n                (theophylline). Future pharmacogenomic studies in asthma should collect relevant ADR\n                data as well as markers of efficacy.<\/jats:p>","DOI":"10.1038\/s41397-019-0140-y","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T00:03:03Z","timestamp":1579219383000},"page":"621-628","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Pharmacogenomic associations of adverse drug reactions in\n            asthma: systematic review and research prioritisation"],"prefix":"10.1038","volume":"20","author":[{"given":"Charlotte","family":"King","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"McKenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niloufar","family":"Farzan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne J.","family":"Vijverberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc P.","family":"van der Schee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke H.","family":"Maitland-van der Zee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lambang","family":"Arianto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4131-7592","authenticated-orcid":false,"given":"Hans","family":"Bisgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"B\u00d8nnelykke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vojko","family":"Berce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uros","family":"PotoC\u030cnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Repnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Carleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Daley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fook Tim","family":"Chew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Chin","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang Yie","family":"Sio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Cloutier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman T.","family":"Den Dekker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbeth","family":"Duijts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan C.","family":"de Jongste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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Celed\u00f3n,\n                        Erick Forno and Glorisa Canino in the list of authors and incorrectly cited\n                        Gerard H. Koppelman, Maria Pino-Yanes and Steve Turner as authors. This has\n                        now been corrected in both the PDF and HTML versions of the Article.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2021","order":8,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":9,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41397-020-0178-x","URL":"https:\/\/doi.org\/10.1038\/s41397-020-0178-x","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}