{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:36:25Z","timestamp":1777538185201,"version":"3.51.4"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T00:00:00Z","timestamp":1747440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T00:00:00Z","timestamp":1747440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Hunan Provincial Natural Science Foundation Youth Project"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharmacogenomics J"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1038\/s41397-025-00374-1","type":"journal-article","created":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T16:11:17Z","timestamp":1747498277000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["KHSRP promotes the malignant behavior and cisplatin resistance of bladder cancer cells through the CLASP2\/MAPRE1 axis"],"prefix":"10.1038","volume":"25","author":[{"given":"Ruizhe","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyu","family":"Ou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9570-0115","authenticated-orcid":false,"given":"Lingxiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,17]]},"reference":[{"key":"374_CR1","doi-asserted-by":"publisher","first-page":"749","DOI":"10.3390\/medicina57080749","volume":"57","author":"J Dobruch","year":"2021","unstructured":"Dobruch J, Oszczud\u0142owski M. Bladder cancer: current challenges and future directions. Medicina. 2021;57:749.","journal-title":"Medicina"},{"key":"374_CR2","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1016\/S0140-6736(22)01188-6","volume":"400","author":"E Comp\u00e9rat","year":"2022","unstructured":"Comp\u00e9rat E, Amin MB, Cathomas R, Choudhury A, De Santis M, Kamat A, et al. Current best practice for bladder cancer: a narrative review of diagnostics and treatments. Lancet. 2022;400:1712\u201321.","journal-title":"Lancet"},{"key":"374_CR3","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1097\/SPC.0000000000000505","volume":"14","author":"A Desilets","year":"2020","unstructured":"Desilets A, Adam JP, Souli\u00e8res D. Management of cisplatin-associated toxicities in bladder cancer patients. Curr Opin Support Palliat Care. 2020;14:286\u201392.","journal-title":"Curr Opin Support Palliat Care"},{"key":"374_CR4","doi-asserted-by":"publisher","first-page":"br3","DOI":"10.1091\/mbc.E22-05-0149","volume":"34","author":"NC Rodgers","year":"2023","unstructured":"Rodgers NC, Lawrence EJ, Sawant AV, Efimova N, Gonzalez-Vasquez G, Hickman TT, et al. CLASP2 facilitates dynamic actin filament organization along the microtubule lattice. Mol Biol Cell. 2023;34:br3.","journal-title":"Mol Biol Cell"},{"key":"374_CR5","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1083\/jcb.201306019","volume":"203","author":"MN Shahbazi","year":"2013","unstructured":"Shahbazi MN, Megias D, Epifano C, Akhmanova A, Gundersen GG, Fuchs E, et al. CLASP2 interacts with p120-catenin and governs microtubule dynamics at adherens junctions. J Cell Biol. 2013;203:1043\u201361.","journal-title":"J Cell Biol"},{"key":"374_CR6","doi-asserted-by":"publisher","first-page":"39245","DOI":"10.1074\/jbc.M112.394148","volume":"287","author":"P Langlais","year":"2012","unstructured":"Langlais P, Dillon JL, Mengos A, Baluch DP, Ardebili R, Miranda DN, et al. Identification of a role for CLASP2 in insulin action. J Biol Chem. 2012;287:39245\u201353.","journal-title":"J Biol Chem"},{"key":"374_CR7","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1016\/j.urolonc.2019.05.003","volume":"37","author":"L Chen","year":"2019","unstructured":"Chen L, Xiong W, Guo W, Su S, Qi L, Zhu B, et al. Significance of CLASP2 expression in prognosis for muscle-invasive bladder cancer patients: a propensity score-based analysis. Urol Oncol. 2019;37:800\u20137.","journal-title":"Urol Oncol"},{"key":"374_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3101-3","volume":"17","author":"B Zhu","year":"2017","unstructured":"Zhu B, Qi L, Liu S, Liu W, Ou Z, Chen M, et al. CLASP2 is involved in the EMT and early progression after transurethral resection of the bladder tumor. BMC Cancer. 2017;17:105.","journal-title":"BMC Cancer"},{"key":"374_CR9","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1007\/s00018-017-2476-2","volume":"74","author":"A Nehlig","year":"2017","unstructured":"Nehlig A, Molina A, Rodrigues-Ferreira S, Honor\u00e9 S, Nahmias C. Regulation of end-binding protein EB1 in the control of microtubule dynamics. Cell Mol Life Sci. 2017;74:2381\u201393.","journal-title":"Cell Mol Life Sci"},{"key":"374_CR10","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/s41388-020-01531-5","volume":"40","author":"L Tang","year":"2021","unstructured":"Tang L, Xiong W, Zhang L, Wang D, Wang Y, Wu Y, et al. circSETD3 regulates MAPRE1 through miR-615-5p and miR-1538 sponges to promote migration and invasion in nasopharyngeal carcinoma. Oncogene. 2021;40:307\u201321.","journal-title":"Oncogene"},{"key":"374_CR11","doi-asserted-by":"publisher","first-page":"2402212","DOI":"10.1155\/2022\/2402212","volume":"2022","author":"L Qiu","year":"2022","unstructured":"Qiu L, Xing S, Lang F, Bao Q. MiR-526b-3p inhibits the resistance of glioma cells to adriamycin by targeting MAPRE1. J Oncol. 2022;2022:2402212.","journal-title":"J Oncol"},{"key":"374_CR12","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1002\/wrna.1327","volume":"7","author":"P Briata","year":"2016","unstructured":"Briata P, Bordo D, Puppo M, Gorlero F, Rossi M, Perrone-Bizzozero N, et al. Diverse roles of the nucleic acid-binding protein KHSRP in cell differentiation and disease. Wiley Interdiscip Rev RNA. 2016;7:227\u201340.","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"374_CR13","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1186\/s13046-019-1479-2","volume":"38","author":"M Yan","year":"2019","unstructured":"Yan M, Sun L, Li J, Yu H, Lin H, Yu T, et al. RNA-binding protein KHSRP promotes tumor growth and metastasis in non-small cell lung cancer. J Exp Clin Cancer Res. 2019;38:478.","journal-title":"J Exp Clin Cancer Res"},{"key":"374_CR14","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1002\/jcp.29076","volume":"235","author":"R Pan","year":"2020","unstructured":"Pan R, Cai W, Sun J, Yu C, Li P, Zheng M. Inhibition of KHSRP sensitizes colorectal cancer to 5-fluoruracil through miR-501-5p-mediated ERRFI1 mRNA degradation. J Cell Physiol. 2020;235:1576\u201387.","journal-title":"J Cell Physiol"},{"key":"374_CR15","first-page":"412","volume":"36","author":"L Chen","year":"2021","unstructured":"Chen L, Zhao T. Identification of KHSRP-Regulated RNAs in esophageal cancer by integrated bioinformatics analysis. Cancer Biother Radiopharm. 2021;36:412\u201324.","journal-title":"Cancer Biother Radiopharm"},{"key":"374_CR16","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.molcel.2020.03.011","volume":"78","author":"M Corley","year":"2020","unstructured":"Corley M, Burns MC, Yeo GW. How RNA-binding proteins interact with RNA: molecules and mechanisms. Mol Cell. 2020;78:9\u201329.","journal-title":"Mol Cell"},{"key":"374_CR17","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.1001\/jama.2020.17598","volume":"324","author":"AT Lenis","year":"2020","unstructured":"Lenis AT, Lec PM, Chamie K, Mshs MD. Bladder cancer: a review. JAMA. 2020;324:1980\u201391.","journal-title":"JAMA"},{"key":"374_CR18","doi-asserted-by":"publisher","first-page":"100938","DOI":"10.1016\/j.drup.2023.100938","volume":"68","author":"F Li","year":"2023","unstructured":"Li F, Zheng Z, Chen W, Li D, Zhang H, Zhu Y, et al. Regulation of cisplatin resistance in bladder cancer by epigenetic mechanisms. Drug Resist Updat. 2023;68:100938.","journal-title":"Drug Resist Updat"},{"key":"374_CR19","first-page":"e201905080","volume":"219","author":"H Gir\u00e3o","year":"2020","unstructured":"Gir\u00e3o H, Okada N, Rodrigues TA, Silva AO, Figueiredo AC, Garcia Z, et al. CLASP2 binding to curved microtubule tips promotes flux and stabilizes kinetochore attachments. J Cell Biol. 2020;219:e201905080.","journal-title":"J Cell Biol"},{"key":"374_CR20","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0724-6","volume":"16","author":"H Yuan","year":"2017","unstructured":"Yuan H, Deng R, Zhao X, Chen R, Hou G, Zhang H, et al. SUMO1 modification of KHSRP regulates tumorigenesis by preventing the TL-G-Rich miRNA biogenesis. Mol Cancer. 2017;16:157.","journal-title":"Mol Cancer"},{"key":"374_CR21","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.celrep.2016.06.055","volume":"16","author":"M Puppo","year":"2016","unstructured":"Puppo M, Bucci G, Rossi M, Giovarelli M, Bordo D, Moshiri A, et al. miRNA-mediated KHSRP Silencing rewires distinct post-transcriptional programs during TGF-\u03b2-induced epithelial-to-mesenchymal transition. Cell Rep. 2016;16:967\u201378.","journal-title":"Cell Rep"},{"key":"374_CR22","doi-asserted-by":"publisher","first-page":"3507","DOI":"10.21873\/anticanres.15837","volume":"42","author":"P Prathaphan","year":"2022","unstructured":"Prathaphan P, Reamtong O, Ngaokrajang U, Janvilisri T, Swainson NM, Kiatwuthinon. Comparative proteomic profiling of cisplatin-resistant nasopharyngeal carcinoma cell lines: novel biomarkers for improving chemotherapy of NPC. Anticancer Res. 2022;42:3507\u201322.","journal-title":"Anticancer Res"},{"key":"374_CR23","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/s42003-022-03594-4","volume":"5","author":"SL Olguin","year":"2022","unstructured":"Olguin SL, Patel P, Buchanan CN, Dell\u2019Orco M, Gardiner AS, Cole R, et al. KHSRP loss increases neuronal growth and synaptic transmission and alters memory consolidation through RNA stabilization. Commun Biol. 2022;5:672.","journal-title":"Commun Biol"},{"key":"374_CR24","doi-asserted-by":"publisher","first-page":"3851","DOI":"10.1016\/j.cub.2023.07.052","volume":"33","author":"J Park","year":"2023","unstructured":"Park J, Xie Y, Miller KG, De Camilli P, Yogev S. End-binding protein 1 promotes specific motor-cargo association in the cell body prior to axonal delivery of dense core vesicles. Curr Biol. 2023;33:3851\u201364.e7.","journal-title":"Curr Biol"},{"key":"374_CR25","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.1080\/21655979.2021.1997223","volume":"13","author":"L Zhang","year":"2022","unstructured":"Zhang L, Peng H, Xu Z, Yang Q, Wang Y, Wang H, et al. Circular RNA SOX13 promotes malignant behavior and cisplatin resistance in non-small cell lung cancer through targeting microRNA-3194-3p\/microtubule-associated protein RP\/EB family member 1. Bioengineered. 2022;13:1814\u201327.","journal-title":"Bioengineered"}],"container-title":["The Pharmacogenomics Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41397-025-00374-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41397-025-00374-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41397-025-00374-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T15:02:49Z","timestamp":1751036569000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41397-025-00374-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,17]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["374"],"URL":"https:\/\/doi.org\/10.1038\/s41397-025-00374-1","relation":{},"ISSN":["1470-269X","1473-1150"],"issn-type":[{"value":"1470-269X","type":"print"},{"value":"1473-1150","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,17]]},"assertion":[{"value":"23 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was approved by the Ethics Committee of Xiangya Hospital Central South University (No. SYXK2020-0019). Written informed consent was obtained from the patients prior to the investigation. The study was performed in strict accordance with the Declaration of Helsinki, Ethical Principles for Medical Research Involving Human Subjects.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"14"}}