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Previously, using data from the Genetic Association Information Network (GAIN) study of BD, we performed genome-wide association (GWA) analyses of BD with BE comorbidity. Here, utilizing data from the Mayo Clinic BD Biobank (969 BD cases, 777 controls), we performed a GWA analysis of a BD subtype defined by BE, and case-only analysis comparing BD subjects with and without BE. We then performed a meta-analysis of the Mayo and GAIN results. The meta-analysis provided genome-wide significant evidence of association between single nucleotide polymorphisms (SNPs) in <jats:italic>PRR5-ARHGAP8<\/jats:italic> and BE in BD cases (rs726170 OR\u2009=\u20091.91, <jats:italic>P<\/jats:italic>\u2009=\u20093.05E-08). In the meta-analysis comparing cases with BD with comorbid BE vs. non-BD controls, a genome-wide significant association was observed at SNP rs111940429 in an intergenic region near <jats:italic>PPP1R2P5<\/jats:italic> (<jats:italic>p<\/jats:italic>\u2009=\u20091.21E-08). <jats:italic>PRR5-ARHGAP8<\/jats:italic> is a read-through transcript resulting in a fusion protein of <jats:italic>PRR5<\/jats:italic> and <jats:italic>ARHGAP8<\/jats:italic>. <jats:italic>PRR5<\/jats:italic> encodes a subunit of mTORC2, a serine\/threonine kinase that participates in food intake regulation, while <jats:italic>ARHGAP8<\/jats:italic> encodes a member of the RhoGAP family of proteins that mediate cross-talk between Rho GTPases and other signaling pathways. Without BE information in controls, it is not possible to determine whether the observed association reflects a risk factor for BE in general, risk for BE in individuals with BD, or risk of a subtype of BD with BE. The effect of <jats:italic>PRR5-ARHGAP8<\/jats:italic> on BE risk thus warrants further investigation.<\/jats:p>","DOI":"10.1038\/s41398-017-0085-3","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T10:28:13Z","timestamp":1517480893000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Bipolar disorder with binge eating behavior: a genome-wide association study implicates PRR5-ARHGAP8"],"prefix":"10.1038","volume":"8","author":[{"given":"Susan L.","family":"McElroy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey J.","family":"Winham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo B.","family":"Cuellar-Barboza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin L.","family":"Colby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4989-8782","authenticated-orcid":false,"given":"Ada Man-Choi","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"Sicotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth R.","family":"Larrabee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Crow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Frye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9350-4440","authenticated-orcid":false,"given":"Joanna M.","family":"Biernacka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,2]]},"reference":[{"key":"85_CR1","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.biopsych.2006.03.040","volume":"61","author":"JI Hudson","year":"2007","unstructured":"Hudson, J. 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L. Mc. E has been a consultant to or member of the scientific advisory board of Avanir, Bracket, F. Hoffmann-La Roche Ltd., MedAvante, Mitsubishi Tanabe Pharma Corporation, Myriad, Naurex, Novo Nordisk, Shire, and Sunovion. She has also been a principal or coinvestigatoron studies sponsored by Alkermes, Allergan, Azevan Pharmaceuticals, Forest, Marriott Foundation, Myriad, National Institute of Mental Health, Naurex, Novo Nordisk, Shire, Sunovion, and Takeda Pharmaceutical Company Limited. She is also an inventor on United States Patent No. 6,323,236 B2, Use of Sulfamate Derivatives for Treating Impulse ControlDisorders, and along with the patent\u2019s assignee, University of Cincinnati, Cincinnati, Ohio, hasreceived payments from Johnson and Johnson, which has exclusive rights under the patent. Dr. M. A. F. has received grant support from Assurex Health, Myriad, Pfizer, Marriott Foundationand Mayo Foundation; has been a consultant to Janssen Global Services, LLC, Mitsubishi Tanabe Pharma Corporation, Myriad, Sunovion, and Teva Pharmaceuticals; has received CME\/Travel Support\/presentation from CME Outfitters Inc. and Sunovion. The remaining authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"40"}}