{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:05:37Z","timestamp":1787497537247,"version":"build-2736575974"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    There is growing evidence that lithium used in the treatment of bipolar disorder (BD) affects molecular targets that are involved in neuronal growth, survival, and maturation, but it remains unclear if neuronal alterations in any of these molecules predict specific symptom changes in BD patients undergoing lithium monotherapy. The goals of this study were to (a) determine which molecular changes in the olfactory neurons of symptomatic patients receiving lithium are associated with antimanic or antidepressant response, and (b) uncover novel intraneuronal regulatory mechanisms of lithium therapy. Twenty-two treatment-na\u00efve non-smoking patients, with symptomatic BD underwent nasal biopsies for collection of olfactory tissues, prior to their treatment and following a 6-week course of lithium monotherapy. Sixteen healthy controls were also biopsied. Combining laser capture microdissection with real-time polymerase chain reaction, we investigated baseline and treatment-associated transcriptional changes in candidate molecular targets of lithium action in the olfactory neuroepithelium. Baseline mRNA levels of glycogen synthase kinase 3 beta (\n                    <jats:italic>GSK3\u03b2<\/jats:italic>\n                    ) and collapsin response mediator protein 1 (\n                    <jats:italic>CRMP1<\/jats:italic>\n                    ) genes were significantly associated with BD status and with severity of mood symptoms. Among BD subjects, treatment-associated downregulation of\n                    <jats:italic>CRMP1<\/jats:italic>\n                    expression was most predictive of decreases in both manic and depressive symptoms. This study provides a novel insight into the relevance of\n                    <jats:italic>CRMP1<\/jats:italic>\n                    , a key molecule in semaphorin-3A signaling during neurodevelopment, in the molecular mechanism of action of lithium, and in the pathophysiology of BD. It supports the use of human-derived olfactory neuronal tissues in the evaluation of treatment response of psychiatric disorders.\n                  <\/jats:p>","DOI":"10.1038\/s41398-018-0126-6","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T10:39:33Z","timestamp":1523961573000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Lithium-associated transcriptional regulation of CRMP1 in patient-derived olfactory neurons and symptom changes in bipolar disorder"],"prefix":"10.1038","volume":"8","author":[{"given":"Charlee K.","family":"McLean","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumya","family":"Narayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Y.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narayan","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youjin","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MariaMananita S.","family":"Hipolito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola G.","family":"Cascella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"John I","family":"Nurnberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koko","family":"Ishizuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira S.","family":"Sawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evaristus A.","family":"Nwulia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,18]]},"reference":[{"issue":"Suppl. 2","key":"126_CR1","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1111\/j.1399-5618.2009.00714.x","volume":"11","author":"R Machado-Vieira","year":"2009","unstructured":"Machado-Vieira, R., Manji, H. K. & Zarate, C. A. Jr. The role of lithium in the treatment of bipolar disorder: convergent evidence for neurotrophic effects as a unifying hypothesis. Bipolar Disord. 11(Suppl. 2), 92\u2013109 (2009).","journal-title":"Bipolar Disord."},{"key":"126_CR2","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1146\/annurev.pharmtox.41.1.789","volume":"41","author":"CJ Phiel","year":"2001","unstructured":"Phiel, C. J. & Klein, P. S. Molecular targets of lithium action. Annu. Rev. Pharmacol. Toxicol. 41, 789\u2013813 (2001).","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"126_CR3","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.neubiorev.2007.03.002","volume":"31","author":"MK Rowe","year":"2007","unstructured":"Rowe, M. K., Wiest, C. & Chuang, D. M. GSK-3 is a viable potential target for therapeutic intervention in bipolar disorder. Neurosci. Biobehav. Rev. 31, 920\u2013931 (2007).","journal-title":"Neurosci. Biobehav. Rev."},{"key":"126_CR4","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s00406-008-0828-5","volume":"259","author":"CT Mendes","year":"2009","unstructured":"Mendes, C. T. et al. Lithium reduces Gsk3b mRNA levels: implications for Alzheimer Disease. Eur. Arch. Psychiatry Clin. Neurosci. 259, 16\u201322 (2009).","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"126_CR5","doi-asserted-by":"publisher","first-page":"8745","DOI":"10.1073\/pnas.96.15.8745","volume":"96","author":"E Chalecka-Franaszek","year":"1999","unstructured":"Chalecka-Franaszek, E. & Chuang, D. M. Lithium activates the serine\/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons. Proc. Natl Acad. Sci. USA 96, 8745\u20138750 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"126_CR6","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/ng1296","volume":"36","author":"ES Emamian","year":"2004","unstructured":"Emamian, E. S., Hall, D., Birnbaum, M. J., Karayiorgou, M. & Gogos, J. A. Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nat. Genet. 36, 131\u2013137 (2004).","journal-title":"Nat. Genet."},{"key":"126_CR7","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1038\/npp.2011.24","volume":"36","author":"JQ Pan","year":"2011","unstructured":"Pan, J. Q. et al. AKT kinase activity is required for lithium to modulate mood-related behaviors in mice. Neuropsychopharmacology 36, 1397\u20131411 (2011).","journal-title":"Neuropsychopharmacology"},{"key":"126_CR8","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1016\/S0006-3223(99)00235-8","volume":"46","author":"HK Manji","year":"1999","unstructured":"Manji, H. K. & Lenox, R. H. Ziskind-Somerfeld Research Award. Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illness. Biol. Psychiatry 46, 1328\u20131351 (1999).","journal-title":"Biol. Psychiatry"},{"key":"126_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-11-589","volume":"11","author":"C Cai","year":"2010","unstructured":"Cai, C. et al. Is human blood a good surrogate for brain tissue in transcriptional studies? BMC Genomics 11, 589 (2010).","journal-title":"BMC Genomics"},{"key":"126_CR10","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1097\/YCO.0000000000000327","volume":"30","author":"J Lavoie","year":"2017","unstructured":"Lavoie, J., Sawa, A. & Ishizuka, K. Application of olfactory tissue and its neural progenitors to schizophrenia and psychiatric research. Curr. Opin. Psychiatry 30, 176\u2013183 (2017).","journal-title":"Curr. Opin. Psychiatry"},{"key":"126_CR11","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.molmed.2016.12.010","volume":"23","author":"J Lavoie","year":"2017","unstructured":"Lavoie, J. et al. The olfactory neural epithelium as a tool in neuroscience. Trends Mol. Med. 23, 100\u2013103 (2017).","journal-title":"Trends Mol. Med."},{"key":"126_CR12","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1176\/appi.ajp.2008.08111702","volume":"166","author":"A Sawa","year":"2009","unstructured":"Sawa, A. & Cascella, N. G. Peripheral olfactory system for clinical and basic psychiatry: a promising entry point to the mystery of brain mechanism and biomarker identification in schizophrenia. Am. J. Psychiatry 166, 137\u2013139 (2009).","journal-title":"Am. J. Psychiatry"},{"key":"126_CR13","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1097\/YPG.0b013e328341a2f0","volume":"21","author":"OV Evgrafov","year":"2011","unstructured":"Evgrafov, O. V. et al. Olfactory neuroepithelium-derived neural progenitor cells as a model system for investigating the molecular mechanisms of neuropsychiatric disorders. Psychiatr. Genet. 21, 217\u2013228 (2011).","journal-title":"Psychiatr. Genet."},{"key":"126_CR14","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.schres.2014.11.023","volume":"161","author":"A Minovi","year":"2015","unstructured":"Minovi, A., Dombrowski, T., Brune, M., Dazert, S. & Juckel, G. Olfactory function and morphology of olfactory epithelium in an adult population with schizophrenia. Schizophr. Res. 161, 513\u2013514 (2015).","journal-title":"Schizophr. Res."},{"key":"126_CR15","doi-asserted-by":"crossref","unstructured":"Girard SD, Dev\u00e9ze A, Nivet E, Gepner B, Roman FS, F\u00e9ron F. Isolating nasal olfactory stem cells from rodents or humans. J Vis Exp. 54, https:\/\/doi.org\/10.3791\/2762 (2011).","DOI":"10.3791\/2762"},{"key":"126_CR16","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/mp.2009.73","volume":"15","author":"K Tajinda","year":"2010","unstructured":"Tajinda, K. et al. Neuronal biomarkers from patients with mental illnesses: a novel method through nasal biopsy combined with laser-captured microdissection. Mol. Psychiatry 15, 231\u2013232 (2010).","journal-title":"Mol. Psychiatry"},{"key":"126_CR17","doi-asserted-by":"crossref","unstructured":"Narayan S, McLean C, Sawa A, Lin SY, Rai N, Hipolito MS, Cascella N, Nurnberger JJ Jr, Ishizuka K, Nwulia EA. Olfactory neurons obtained through nasal biopsy combined with laser-capture microdissection: a potential approach to study treatment response in mental disorders. J Vis Exp. 94, https:\/\/doi.org\/10.3791\/51853  (2014).","DOI":"10.3791\/51853"},{"key":"126_CR18","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1242\/dev.031377","volume":"136","author":"A Chiang","year":"2009","unstructured":"Chiang, A., Priya, R., Ramaswami, M., Vijayraghavan, K. & Rodrigues, V. Neuronal activity and Wnt signaling act through Gsk3-beta to regulate axonal integrity in mature Drosophila olfactory sensory neurons. Development 136, 1273\u20131282 (2009).","journal-title":"Development"},{"key":"126_CR19","doi-asserted-by":"publisher","first-page":"e63598","DOI":"10.1371\/journal.pone.0063598","volume":"8","author":"Z Xu","year":"2013","unstructured":"Xu, Z., Wang, L., Chen, G., Rao, X. & Xu, F. Roles of GSK3beta in odor habituation and spontaneous neural activity of the mouse olfactory bulb. PLoS ONE 8, e63598 (2013).","journal-title":"PLoS ONE"},{"key":"126_CR20","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1111\/bdi.12228","volume":"17","author":"GN Pandey","year":"2015","unstructured":"Pandey, G. N., Rizavi, H. S., Tripathi, M. & Ren, X. Region-specific dysregulation of glycogen synthase kinase-3beta and beta-catenin in the postmortem brains of subjects with bipolar disorder and schizophrenia. Bipolar Disord. 17, 160\u2013171 (2015).","journal-title":"Bipolar Disord."},{"key":"126_CR21","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.ejphar.2008.02.075","volume":"586","author":"T Nemoto","year":"2008","unstructured":"Nemoto, T. et al. Regulation of Akt mRNA and protein levels by glycogen synthase kinase-3beta in adrenal chromaffin cells: effects of LiCl and SB216763. Eur. J. Pharmacol. 586, 82\u201389 (2008).","journal-title":"Eur. J. Pharmacol."},{"key":"126_CR22","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1210\/en.2012-1555","volume":"154","author":"Y Hu","year":"2013","unstructured":"Hu, Y., Poopalasundaram, S., Graham, A. & Bouloux, P. M. GnRH neuronal migration and olfactory bulb neurite outgrowth are dependent on FGF receptor 1 signaling, specifically via the PI3K p110alpha isoform in chick embryo. Endocrinology  154, 388\u2013399 (2013).","journal-title":"Endocrinology"},{"key":"126_CR23","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1085\/jgp.101.2.183","volume":"101","author":"S Frings","year":"1993","unstructured":"Frings, S. Protein kinase C sensitizes olfactory adenylate cyclase. J. Gen. Physiol. 101, 183\u2013205 (1993).","journal-title":"J. Gen. Physiol."},{"key":"126_CR24","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/nature15526","volume":"527","author":"J Mertens","year":"2015","unstructured":"Mertens, J. et al. Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature 527, 95\u201399 (2015).","journal-title":"Nature"},{"key":"126_CR25","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.1111\/j.1460-9568.2005.04112.x","volume":"21","author":"A Veyrac","year":"2005","unstructured":"Veyrac, A. et al. Expression of collapsin response mediator proteins 1, 2 and 5 is differentially regulated in newly generated and mature neurons of the adult olfactory system. Eur. J. Neurosci. 21, 2635\u20132648 (2005).","journal-title":"Eur. J. Neurosci."},{"key":"126_CR26","doi-asserted-by":"publisher","first-page":"4406","DOI":"10.1093\/hmg\/dds273","volume":"21","author":"V Bader","year":"2012","unstructured":"Bader, V. et al. Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits. Hum. Mol. Genet. 21, 4406\u20134418 (2012).","journal-title":"Hum. Mol. Genet."},{"key":"126_CR27","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1001\/archpsyc.1994.03950110009002","volume":"51","author":"JI Nurnberger Jr.","year":"1994","unstructured":"Nurnberger, J. I.Jr. et al. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch. Gen. Psychiatry 51, 849\u2013859 (1994).","journal-title":"Arch. Gen. Psychiatry"},{"key":"126_CR28","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1192\/bjp.134.4.382","volume":"134","author":"SA Montgomery","year":"1979","unstructured":"Montgomery, S. A. & Asberg, M. A new depression scale designed to be sensitive to change. Br. J. Psychiatry 134, 382\u2013389 (1979).","journal-title":"Br. J. Psychiatry"},{"key":"126_CR29","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1192\/bjp.133.5.429","volume":"133","author":"RC Young","year":"1978","unstructured":"Young, R. C., Biggs, J. T., Ziegler, V. E. & Meyer, D. A. A rating scale for mania: reliability, validity and sensitivity. Br. J. Psychiatry 133, 429\u2013435 (1978).","journal-title":"Br. J. Psychiatry"},{"key":"126_CR30","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1038\/mp.2012.120","volume":"18","author":"S Kano","year":"2013","unstructured":"Kano, S. et al. Genome-wide profiling of multiple histone methylations in olfactory cells: further implications for cellular susceptibility to oxidative stress in schizophrenia. Mol. Psychiatry 18, 740\u2013742 (2013).","journal-title":"Mol. Psychiatry"},{"key":"126_CR31","volume-title":"Stata Statistical Software: Release 13","author":"StataCorp.","year":"2013","unstructured":"StataCorp. Stata Statistical Software: Release 13. (StataCorp LP, College Station, TX, 2013)."},{"key":"126_CR32","doi-asserted-by":"publisher","first-page":"E4462","DOI":"10.1073\/pnas.1700111114","volume":"114","author":"BTD Tobe","year":"2017","unstructured":"Tobe, B. T. D. et al. Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis. Proc. Natl Acad. Sci. USA 114, E4462\u2013E4471 (2017).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"126_CR33","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1038\/nprot.2015.084","volume":"10","author":"T Fujii","year":"2015","unstructured":"Fujii, T. et al. Direct metabolomics for plant cells by live single-cell mass spectrometry. Nat. Protoc. 10, 1445\u20131456 (2015).","journal-title":"Nat. Protoc."},{"key":"126_CR34","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.celrep.2015.12.021","volume":"14","author":"S Darmanis","year":"2016","unstructured":"Darmanis, S. et al. Simultaneous multiplexed measurement of RNA and proteins in single cells. Cell Rep. 14, 380\u2013389 (2016).","journal-title":"Cell Rep."},{"key":"126_CR35","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.cell.2016.04.019","volume":"165","author":"MH Spitzer","year":"2016","unstructured":"Spitzer, M. H. & Nolan, G. P. Mass cytometry: single cells, many features. Cell 165, 780\u2013791 (2016).","journal-title":"Cell"},{"key":"126_CR36","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.mehy.2004.07.019","volume":"64","author":"M Toth","year":"2005","unstructured":"Toth, M. The epsilon theory: a novel synthesis of the underlying molecular and electrophysiological mechanisms of primary generalized epilepsy and the possible mechanism of action of valproate. Med. Hypotheses 64, 267\u2013272 (2005).","journal-title":"Med. Hypotheses"},{"key":"126_CR37","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s12035-011-8210-4","volume":"44","author":"E Abrial","year":"2011","unstructured":"Abrial, E., Lucas, G., Scarna, H., Haddjeri, N. & Lambas-Senas, L. A role for the PKC signaling system in the pathophysiology and treatment of mood disorders: involvement of a functional imbalance? Mol. Neurobiol. 44, 407\u2013419 (2011).","journal-title":"Mol. Neurobiol."},{"issue":"Suppl. 1","key":"126_CR38","doi-asserted-by":"publisher","first-page":"S15","DOI":"10.1016\/j.jad.2004.01.002","volume":"79","author":"N Brunello","year":"2004","unstructured":"Brunello, N. Mood stabilizers: protecting the mood\u2026protecting the brain. J. Affect. Disord. 79(Suppl. 1), S15\u2013S20 (2004).","journal-title":"J. Affect. Disord."},{"key":"126_CR39","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/nmeth.2694","volume":"11","author":"AR Wu","year":"2014","unstructured":"Wu, A. R. et al. Quantitative assessment of single-cell RNA-sequencing methods. Nat. Methods 11, 41\u201346 (2014).","journal-title":"Nat. Methods"},{"key":"126_CR40","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/nbt.3102","volume":"33","author":"F Buettner","year":"2015","unstructured":"Buettner, F. et al. Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells. Nat. Biotechnol. 33, 155\u2013160 (2015).","journal-title":"Nat. Biotechnol."},{"key":"126_CR41","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/j.cell.2015.05.002","volume":"161","author":"EZ Macosko","year":"2015","unstructured":"Macosko, E. Z. et al. Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets. Cell 161, 1202\u20131214 (2015).","journal-title":"Cell"},{"key":"126_CR42","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3389\/fnmol.2011.00016","volume":"4","author":"RS Jope","year":"2011","unstructured":"Jope, R. S. Glycogen synthase kinase-3 in the etiology and treatment of mood disorders. Front. Mol. Neurosci. 4, 16 (2011).","journal-title":"Front. Mol. Neurosci."},{"key":"126_CR43","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1002\/ajmg.b.30498","volume":"144B","author":"HM Lachman","year":"2007","unstructured":"Lachman, H. M. et al. Increase in GSK3beta gene copy number variation in bipolar disorder. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B, 259\u2013265 (2007).","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"126_CR44","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/npp.2012.172","volume":"38","author":"F Benedetti","year":"2013","unstructured":"Benedetti, F. et al. Lithium and GSK3-beta promoter gene variants influence white matter microstructure in bipolar disorder. Neuropsychopharmacology  38, 313\u2013327 (2013).","journal-title":"Neuropsychopharmacology"},{"key":"126_CR45","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/j.1601-183X.2010.00566.x","volume":"9","author":"F Benedetti","year":"2010","unstructured":"Benedetti, F. et al. Temporal lobe grey matter volume in schizophrenia is associated with a genetic polymorphism influencing glycogen synthase kinase 3-beta activity. Genes Brain Behav. 9, 365\u2013371 (2010).","journal-title":"Genes Brain Behav."},{"key":"126_CR46","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.jpsychires.2015.01.016","volume":"62","author":"RT de Sousa","year":"2015","unstructured":"de Sousa, R. T. et al. Lithium increases platelet serine-9 phosphorylated GSK-3beta levels in drug-free bipolar disorder during depressive episodes. J. Psychiatr. Res. 62, 78\u201383 (2015).","journal-title":"J. Psychiatr. Res."},{"key":"126_CR47","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1111\/j.1399-5618.2010.00866.x","volume":"12","author":"X Li","year":"2010","unstructured":"Li, X., Liu, M., Cai, Z., Wang, G. & Li, X. Regulation of glycogen synthase kinase-3 during bipolar mania treatment. Bipolar Disord. 12, 741\u2013752 (2010).","journal-title":"Bipolar Disord."},{"key":"126_CR48","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1038\/npp.2010.43","volume":"35","author":"A Polter","year":"2010","unstructured":"Polter, A. et al. Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances. Neuropsychopharmacology  35, 1761\u20131774 (2010).","journal-title":"Neuropsychopharmacology"},{"key":"126_CR49","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/376509a0","volume":"376","author":"Y Goshima","year":"1995","unstructured":"Goshima, Y., Nakamura, F., Strittmatter, P. & Strittmatter, S. M. Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33. Nature 376, 509\u2013514 (1995).","journal-title":"Nature"},{"key":"126_CR50","doi-asserted-by":"publisher","first-page":"6197","DOI":"10.1523\/JNEUROSCI.16-19-06197.1996","volume":"16","author":"LH Wang","year":"1996","unstructured":"Wang, L. H. & Strittmatter, S. M. A family of rat CRMP genes is differentially expressed in the nervous system. J. Neurosci. 16, 6197\u20136207 (1996).","journal-title":"J. Neurosci."},{"key":"126_CR51","doi-asserted-by":"publisher","first-page":"31375","DOI":"10.1074\/jbc.M109.009951","volume":"284","author":"JM Brittain","year":"2009","unstructured":"Brittain, J. M. et al. An atypical role for collapsin response mediator protein 2 (CRMP-2) in neurotransmitter release via interaction with presynaptic voltage-gated calcium channels. J. Biol. Chem. 284, 31375\u201331390 (2009).","journal-title":"J. Biol. Chem."},{"key":"126_CR52","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1038\/mp.2015.77","volume":"20","author":"TT Quach","year":"2015","unstructured":"Quach, T. T., Honnorat, J., Kolattukudy, P. E., Khanna, R. & Duchemin, A. M. CRMPs: critical molecules for neurite morphogenesis and neuropsychiatric diseases. Mol. Psychiatry 20, 1037\u20131045 (2015).","journal-title":"Mol. Psychiatry"},{"key":"126_CR53","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1038\/nprot.2015.088","volume":"10","author":"M Fujii","year":"2015","unstructured":"Fujii, M., Matano, M., Nanki, K. & Sato, T. Efficient genetic engineering of human intestinal organoids using electroporation. Nat. Protoc. 10, 1474\u20131485 (2015).","journal-title":"Nat. Protoc."}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41398-018-0126-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-018-0126-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-018-0126-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T06:17:04Z","timestamp":1671517024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41398-018-0126-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,18]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,12]]}},"alternative-id":["126"],"URL":"https:\/\/doi.org\/10.1038\/s41398-018-0126-6","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,18]]},"assertion":[{"value":"6 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"81"}}