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In the present work we sought to examine the duration of this behavioral effect as well as the molecular readouts involved. Our results showed that NVP-AAM077 reduced the immobility in the forced swim test 30\u2009min and 24\u2009h after its administration. However, this effect waned 7 days later. The rapid antidepressant-like response seems to be associated with increases in the GluA1 subunit of \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, mammalian target of rapamycin (mTOR) signaling, glia markers such as glial fibrillary acidic protein (GFAP) and excitatory amino acid transporter 1 (EAAT1), and a rapid mobilization of intracellular stores of brain-derived neurotrophic factor (BDNF) in the medial prefrontal cortex.<\/jats:p>","DOI":"10.1038\/s41398-018-0131-9","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T16:11:17Z","timestamp":1523981477000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Signaling pathways responsible for the rapid antidepressant-like effects of a GluN2A-preferring NMDA receptor antagonist"],"prefix":"10.1038","volume":"8","author":[{"given":"Marta","family":"Gordillo-Salas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuencisla","family":"Pilar-Cu\u00e9llar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves P.","family":"Auberson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0570-4931","authenticated-orcid":false,"given":"Albert","family":"Adell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,18]]},"reference":[{"key":"131_CR1","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.tips.2009.09.002","volume":"30","author":"P Skolnick","year":"2009","unstructured":"Skolnick, P., Popik, P. & Trullas, R. 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