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A recent finding that 18 patients\u2019 manic-depressive cycles oscillated in synchrony with biweekly surges in amplitude of the moon\u2019s tides provided a clue to the cause of the sleep-disturbances. Analyses of one of the patients\u2019 sleep\u2013wake cycles suggest that his mood cycles arose when a circadian rhythm that normally is entrained to dawn and controls the daily onset of wakefulness became entrained instead to 24.8-h recurrences of every second 12.4-h tidal cycle. The finding provides the basis for a comprehensive description of the pathogenesis and pathophysiology of the mood cycle.<\/jats:p>","DOI":"10.1038\/s41398-018-0203-x","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T10:18:28Z","timestamp":1534155508000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Bipolar mood cycles associated with lunar entrainment of a circadian rhythm"],"prefix":"10.1038","volume":"8","author":[{"given":"Thomas A.","family":"Wehr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,13]]},"reference":[{"key":"203_CR1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1001\/archpsyc.1972.01750270005001","volume":"27","author":"WE Bunney Jr","year":"1972","unstructured":"Bunney, W. E. Jr, Murphy, D. L., Goodwin, F. K. & Borge, G. F. 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