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These disorders are associated with attentional impairment, the remediation of which is important for successful therapeutic intervention. We assessed a 22q11.2DS mouse model (Df(h22q11)\/+) on a touchscreen rodent continuous performance test (rCPT) of attention and executive function that is analogous to human CPT procedures. Relative to wild-type littermates, Df(h22q11)\/+ male mice showed impaired attentional performance as shown by decreased correct response ratio (hit rate) and a reduced ability to discriminate target stimuli from non-target stimuli (discrimination sensitivity, or d\u2019). The Df(h22q11)\/+ model exhibited decreased prefrontal cortical-hippocampal oscillatory synchrony within multiple frequency ranges during quiet wakefulness, which may represent a biomarker of cognitive dysfunction. The stimulant amphetamine (0\u20131.0\u2009mg\/kg, i.p.) dose-dependently improved d\u2019 in Df(h22q11)\/+ mice whereas the highest dose of modafinil (40\u2009mg\/kg, i.p.) exacerbated their d\u2019 impairment. This is the first report to directly implicate attentional impairment in a 22q11.2DS mouse model, mirroring a key endophenotype of the human disorder. The capacity of the rCPT to detect performance impairments in the 22q11.2DS mouse model, and improvement following psychostimulant-treatment, highlights the utility and translational potential of the Df(h22q11)\/+ model and this automated behavioral procedure.<\/jats:p>","DOI":"10.1038\/s41398-018-0295-3","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T15:40:01Z","timestamp":1542210001000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Continuous performance test impairment in a 22q11.2 microdeletion mouse model: improvement by amphetamine"],"prefix":"10.1038","volume":"8","author":[{"given":"Simon R. 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