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We developed an iOS app (\n                    <jats:italic>PPD ACT<\/jats:italic>\n                    ) to recruit, consent, screen, and enable DNA collection from women with a lifetime history of PPD to sufficiently power genome-wide association studies. In 1 year, we recruited 7344 women with a history of PPD and have biobanked 2946 DNA samples from the US. This sample of PPD cases was notably severely affected and within 2 years of their worst episode of PPD. Clinical validation was performed within a hospital setting on a subset of participants and recall validity assessed 6\u20139 months after initial assessment to ensure reliability of screening tools. Here we detail the creation of the\n                    <jats:italic>PPD ACT<\/jats:italic>\n                    mobile app including design, ethical, security, and deployment considerations. We emphasize the importance of multidisciplinary collaboration to correctly implement such a research project. Additionally, we describe our ability to customize the\n                    <jats:italic>PPD ACT<\/jats:italic>\n                    platform to deploy internationally in order to collect a global sample of women with PPD.\n                  <\/jats:p>","DOI":"10.1038\/s41398-018-0305-5","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T08:12:20Z","timestamp":1543479140000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["PPD ACT: an app-based genetic study of postpartum depression"],"prefix":"10.1038","volume":"8","author":[{"given":"Jerry","family":"Guintivano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Krohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enda M.","family":"Byrne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali K.","family":"Henders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Ploner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8298-1436","authenticated-orcid":false,"given":"Katherine","family":"Kirk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4069-8020","authenticated-orcid":false,"given":"Nicholas G.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannette","family":"Milgrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7421-3357","authenticated-orcid":false,"given":"Naomi R.","family":"Wray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick F.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Meltzer-Brody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,29]]},"reference":[{"key":"305_CR1","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1097\/01.AOG.0000183597.31630.db","volume":"106","author":"NI Gavin","year":"2005","unstructured":"Gavin, N. 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