{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T20:44:35Z","timestamp":1793738675992,"version":"4.6.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T00:00:00Z","timestamp":1551052800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T00:00:00Z","timestamp":1551052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["202836\/Z\/16\/Z"],"award-info":[{"award-number":["202836\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Assessment of suicide risk in individuals with severe mental illness is currently inconsistent, and based on clinical decision-making with or without tools developed for other purposes. We aimed to develop and validate a predictive model for suicide using data from linked population-based registers in individuals with severe mental illness. A national cohort of 75,158 Swedish individuals aged 15\u201365 with a diagnosis of severe mental illness (schizophrenia-spectrum disorders, and bipolar disorder) with 574,018 clinical patient episodes between 2001 and 2008, split into development (58,771 patients, 494 suicides) and external validation (16,387 patients, 139 suicides) samples. A multivariable derivation model was developed to determine the strength of pre-specified routinely collected socio-demographic and clinical risk factors, and then tested in external validation. We measured discrimination and calibration for prediction of suicide at 1 year using specified risk cut-offs. A 17-item clinical risk prediction model for suicide was developed and showed moderately good measures of discrimination (c-index 0.71) and calibration. For risk of suicide at 1 year, using a pre-specified 1% cut-off, sensitivity was 55% (95% confidence interval [CI] 47\u201363%) and specificity was 75% (95% CI 74\u201375%). Positive and negative predictive values were 2% and 99%, respectively. The model was used to generate a simple freely available web-based probability-based risk calculator (\n                    <jats:underline>Ox<\/jats:underline>\n                    ford\n                    <jats:underline>M<\/jats:underline>\n                    ental\n                    <jats:underline>I<\/jats:underline>\n                    llness and\n                    <jats:underline>S<\/jats:underline>\n                    uicide tool or OxMIS) without categorical cut-offs. A scalable prediction score for suicide in individuals with severe mental illness is feasible. If validated in other samples and linked to effective interventions, using a probability score may assist clinical decision-making.\n                  <\/jats:p>","DOI":"10.1038\/s41398-019-0428-3","type":"journal-article","created":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T05:03:44Z","timestamp":1551071024000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["The prediction of suicide in severe mental illness: development and validation of a clinical prediction rule (OxMIS)"],"prefix":"10.1038","volume":"9","author":[{"given":"Seena","family":"Fazel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Mallett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Fanshawe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,2,25]]},"reference":[{"key":"428_CR1","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1176\/appi.ajp.2011.11091362","volume":"168","author":"CW Hughes","year":"2011","unstructured":"Hughes, C. W. Objective assessment of suicide risk: significant improvements in assessment, classification, and prediction. Am. J. Psychiatry 168, 1233\u20134 (2011).","journal-title":"Am. J. Psychiatry"},{"key":"428_CR2","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1001\/archgenpsychiatry.2011.113","volume":"68","author":"M Nordentoft","year":"2011","unstructured":"Nordentoft, M. & Mortensen, P. B. Absolute risk of suicide after first hospital contact in mental disorder. Arch. Gen. Psychiatry 68, 1058\u201364 (2011).","journal-title":"Arch. Gen. Psychiatry"},{"key":"428_CR3","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1001\/jamapsychiatry.2016.2010","volume":"73","author":"M Nordentoft","year":"2016","unstructured":"Nordentoft, M., Erlangsen, A. & Madsen, T. Postdischarge suicides: nightmare and disgrace. JAMA Psychiatry 73, 1113\u20134 (2016).","journal-title":"JAMA Psychiatry"},{"key":"428_CR4","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-004732","volume":"4","author":"L Quinlivan","year":"2014","unstructured":"Quinlivan, L. et al. Scales for predicting risk following self-harm: an observational study in 32 hospitals in England. BMJ Open 4, e004732 (2014).","journal-title":"BMJ Open"},{"key":"428_CR5","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1192\/bjp.bp.115.170050","volume":"209","author":"MK Chan","year":"2016","unstructured":"Chan, M. K. et al. Predicting suicide following self-harm: systematic review of risk factors and risk scales. Br. J. Psychiatry 209, 277\u201383 (2016).","journal-title":"Br. J. Psychiatry"},{"key":"428_CR6","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1192\/pb.bp.116.054940","volume":"41","author":"M Large","year":"2017","unstructured":"Large, M., Galletly, C., Myles, N., Ryan, C. J. & Myles, H. Known unknowns and unknown unknowns in suicide risk assessment: evidence from meta-analyses of aleatory and epistemic uncertainty. BJPsych Bull. 41, 160\u20133 (2017).","journal-title":"BJPsych Bull."},{"key":"428_CR7","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1192\/bjp.211.3.183","volume":"211","author":"S Fazel","year":"2017","unstructured":"Fazel, S. & Wolf, A. Suicide risk assessment tools do not perform worse than clinical judgement. Br. J. Psychiatry 211, 183 (2017).","journal-title":"Br. J. Psychiatry"},{"key":"428_CR8","doi-asserted-by":"publisher","first-page":"h4978","DOI":"10.1136\/bmj.h4978","volume":"351","author":"JM Bolton","year":"2015","unstructured":"Bolton, J. M., Gunnell, D. & Turecki, G. Suicide risk assessment and intervention in people with mental illness. BMJ 351, h4978 (2015).","journal-title":"BMJ"},{"key":"428_CR9","unstructured":"US Department of Health. Office of the Surgeon General and National Action Alliance for Suicide Prevention. The 2012 National Strategy for Suicide Prevention: Goals and Objectives for Action (HHS, Washington, DC, 2012)."},{"key":"428_CR10","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.eurpsy.2011.06.003","volume":"27","author":"D Wasserman","year":"2012","unstructured":"Wasserman, D. et al. The European Psychiatric Association (EPA) guidance on suicide treatment and prevention. Eur Psychiatry 27, 129\u201341 (2012).","journal-title":"Eur Psychiatry"},{"key":"428_CR11","unstructured":"National Institute for Health and Care Excellence. CG16: The Short-term Physical and Psychological Management and Secondary Prevention of Self-harm in Primary and Secondary Care (NICE, London, 2004)."},{"key":"428_CR12","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1177\/0004867416661039","volume":"50","author":"G Carter","year":"2016","unstructured":"Carter, G. et al. Royal Australian and New Zealand College of Psychiatrists clinical practice guideline for the management of deliberate self-harm. Aust. N. Z. J. Psychiatry 50, 939\u20131000 (2016).","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"428_CR13","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1001\/jamapsychiatry.2017.2647","volume":"74","author":"EJ Bromet","year":"2017","unstructured":"Bromet, E. J. et al. Association between psychotic experiences and subsequent suicidal thoughts and behaviors: a cross-national analysis from the World Health Organization World Mental Health Surveys. JAMA Psychiatry 74, 1136\u201344 (2017).","journal-title":"JAMA Psychiatry"},{"key":"428_CR14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055176","volume":"8","author":"M Nordentoft","year":"2013","unstructured":"Nordentoft, M. et al. Excess mortality, causes of death and life expectancy in 270,770 patients with recent onset of mental disorders in Denmark, Finland and Sweden. PLoS ONE 8, e55176 (2013).","journal-title":"PLoS ONE"},{"key":"428_CR15","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/S2215-0366(17)30078-0","volume":"4","author":"C Hjorth\u00f8j","year":"2017","unstructured":"Hjorth\u00f8j, C., St\u00fcrup, A. E., McGrath, J. J. & Nordentoft, M. Years of potential life lost and life expectancy in schizophrenia: a systematic review and meta-analysis. Lancet Psychiatry 4, 295\u2013301 (2017).","journal-title":"Lancet Psychiatry"},{"key":"428_CR16","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1093\/schbul\/sbx131","volume":"44","author":"RM Cassidy","year":"2018","unstructured":"Cassidy, R. M., Yang, F., Kapczinski, F. & Passos, I. C. Risk factors for suicidality in patients with schizophrenia: a systematic review, meta-analysis, and meta-regression of 96 Studies. Schizophr. Bull. 44, 787\u201397 (2018).","journal-title":"Schizophr. Bull."},{"key":"428_CR17","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1002\/wps.20128","volume":"13","author":"E Chesney","year":"2014","unstructured":"Chesney, E., Goodwin, G. M. & Fazel, S. Risks of all\u2010cause and suicide mortality in mental disorders: a meta\u2010review. World Psychiatry 13, 153\u201360 (2014).","journal-title":"World Psychiatry"},{"key":"428_CR18","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s10654-009-9350-y","volume":"24","author":"JF Ludvigsson","year":"2009","unstructured":"Ludvigsson, J. F., Otterblad-Olausson, P., Pettersson, B. U. & Ekbom, A. The Swedish personal identity number: possibilities and pitfalls in healthcare and medical research. Eur. J. Epidemiol. 24, 659\u201367 (2009).","journal-title":"Eur. J. Epidemiol."},{"key":"428_CR19","unstructured":"Johannesson, I. The Total Population Register of Statistics Sweden. New Possibilities and Better Quality (Statistics Sweden, \u00d6rebro, 2002)."},{"key":"428_CR20","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-450","volume":"11","author":"JF Ludvigsson","year":"2011","unstructured":"Ludvigsson, J. F. et al. External review and validation of the Swedish national inpatient register. BMC Public Health 11, 450 (2011).","journal-title":"BMC Public Health"},{"key":"428_CR21","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1002\/pds.1294","volume":"16","author":"B Wettermark","year":"2007","unstructured":"Wettermark, B. et al. The new Swedish Prescribed Drug Register\u2014opportunities for pharmacoepidemiological research and experience from the first six months. Pharmacoepidemiol. Drug Saf. 16, 726\u201335 (2007).","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"428_CR22","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1017\/S0033291796004631","volume":"27","author":"J Neeleman","year":"1997","unstructured":"Neeleman, J. & Wessely, S. Changes in classification of suicide in England and Wales: time trends and associations with coroners\u2019 professional backgrounds. Psychol. Med. 27, 467\u2013472 (1997).","journal-title":"Psychol. Med."},{"key":"428_CR23","unstructured":"National Board of Health and Welfare. www.socialstyrelsen.se\/Statistik\/statistik_amne\/dodsorsaker\/Dodsorsaksregistret.htm (2008)."},{"key":"428_CR24","doi-asserted-by":"publisher","first-page":"g7594","DOI":"10.1136\/bmj.g7594","volume":"350","author":"GS Collins","year":"2015","unstructured":"Collins, G. S., Reitsma, J. B., Altman, D. G. & Moons, K. G. Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement. BMJ 350, g7594 (2015).","journal-title":"BMJ"},{"key":"428_CR25","doi-asserted-by":"crossref","unstructured":"Hor, K. & Taylor, M. Suicide and schizophrenia: a systematic review of rates and risk factors. J. Psychopharmacol. 24(4 Suppl.), 81\u201390 (2010).","DOI":"10.1177\/1359786810385490"},{"key":"428_CR26","doi-asserted-by":"publisher","first-page":"b604","DOI":"10.1136\/bmj.b604","volume":"338","author":"P Royston","year":"2009","unstructured":"Royston, P., Moons, K. G., Altman, D. G. & Vergouwe, Y. Prognosis and prognostic research: developing a prognostic model. BMJ 338, b604 (2009).","journal-title":"BMJ"},{"key":"428_CR27","doi-asserted-by":"crossref","unstructured":"Royston, P., Sauerbrei, W. Multivariable Model-building (Wiley, Chichester, 2008).","DOI":"10.1002\/9780470770771"},{"key":"428_CR28","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1136\/bmj.b2393","volume":"338","author":"J Sterne","year":"2009","unstructured":"Sterne, J. et al. Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls. BMJ 338, 157\u201360 (2009).","journal-title":"BMJ"},{"key":"428_CR29","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1093\/biomet\/86.4.948","volume":"86","author":"J Barnard","year":"1999","unstructured":"Barnard, J. & Rubin, D. Small-sample degrees of freedom with multiple imputation. Biometrika 86, 948\u201355 (1999).","journal-title":"Biometrika"},{"key":"428_CR30","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1016\/S0895-4356(03)00207-5","volume":"56","author":"S Bleeker","year":"2003","unstructured":"Bleeker, S. et al. External validation is necessary in prediction research: a clinical example. J. Clin. Epidemiol. 56, 826\u201332 (2003).","journal-title":"J. Clin. Epidemiol."},{"key":"428_CR31","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.jclinepi.2004.06.017","volume":"58","author":"Y Vergouwe","year":"2005","unstructured":"Vergouwe, Y., Steyerberg, E. W., Eijkemans, M. J. & Habbema, J. D. F. Substantial effective sample sizes were required for external validation studies of predictive logistic regression models. J. Clin. Epidemiol. 58, 475\u201383 (2005).","journal-title":"J. Clin. Epidemiol."},{"key":"428_CR32","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4","volume":"15","author":"FE Harrell","year":"1996","unstructured":"Harrell, F. E., Lee, K. L. & Mark, D. B. Tutorial in biostatistics multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat. Med. 15, 361\u201387 (1996).","journal-title":"Stat. Med."},{"key":"428_CR33","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1002\/sim.4780091109","volume":"9","author":"J Van Houwelingen","year":"1990","unstructured":"Van Houwelingen, J. & Le Cessie, S. Predictive value of statistical models. Stat. Med. 9, 1303\u201325 (1990).","journal-title":"Stat. Med."},{"key":"428_CR34","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1001\/jama.1982.03320430047030","volume":"247","author":"FE Harrell","year":"1982","unstructured":"Harrell, F. E., Califf, R. M., Pryor, D. B., Lee, K. L. & Rosati, R. A. Evaluating the yield of medical tests. JAMA 247, 2543\u20136 (1982).","journal-title":"JAMA"},{"key":"428_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1175\/1520-0493(1950)078<0001:VOFEIT>2.0.CO;2","volume":"78","author":"GW Brier","year":"1950","unstructured":"Brier, G. W. Verification of forecasts expressed in terms of probability. Mon. Weather Rev. 78, 1\u20133 (1950).","journal-title":"Mon. Weather Rev."},{"key":"428_CR36","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/sim.2929","volume":"27","author":"MJ Pencina","year":"2008","unstructured":"Pencina, M. J., D\u2019Agostino, R. B., D\u2019Agostino, R. B. & Vasan, R. S. Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat. Med. 27, 157\u201372 (2008).","journal-title":"Stat. Med."},{"key":"428_CR37","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/S2215-0366(14)70223-8","volume":"1","author":"S Fazel","year":"2014","unstructured":"Fazel, S., Wolf, A., Palm, C. & Lichtenstein, P. Violent crime, suicide, and premature mortality in patients with schizophrenia and related disorders: a 38-year total population study in Sweden. Lancet Psychiatry 1, 44\u201354 (2014).","journal-title":"Lancet Psychiatry"},{"key":"428_CR38","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/S2215-0366(16)30030-X","volume":"3","author":"G Zalsman","year":"2016","unstructured":"Zalsman, G. et al. Suicide prevention strategies revisited: 10-year systematic review. Lancet Psychiatry 3, 646\u201359 (2016).","journal-title":"Lancet Psychiatry"},{"key":"428_CR39","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1192\/bjp.187.1.9","volume":"187","author":"K Hawton","year":"2005","unstructured":"Hawton, K., Sutton, L., Haw, C., Sinclair, J. & Deeks, J. J. Schizophrenia and suicide: systematic review of risk factors. Br. J. Psychiatry 187, 9\u201320 (2005).","journal-title":"Br. J. Psychiatry"},{"key":"428_CR40","unstructured":"University of Manchester. The National Confidential Inquiry into Suicide and Homicide by People with Mental Illness. Making Mental Health Care Safer: Annual Report and 20-year Review (University of Manchester, Manchester, 2016)."},{"key":"428_CR41","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1001\/archpsyc.62.4.427","volume":"62","author":"P Qin","year":"2005","unstructured":"Qin, P. & Nordentoft, M. Suicide risk in relation to psychiatric hospitalization: evidence based on longitudinal registers. Arch. Gen. Psychiatry 62, 427\u201332 (2005).","journal-title":"Arch. Gen. Psychiatry"},{"key":"428_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-017-0072-8","volume":"8","author":"GD Batty","year":"2018","unstructured":"Batty, G. D. et al. Psychosocial characteristics as potential predictors of suicide in adults: an overview of the evidence with new results from prospective cohort studies. Transl. Psychiatry 8, 22 (2018).","journal-title":"Transl. Psychiatry"},{"key":"428_CR43","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1016\/S0140-6736(12)60239-6","volume":"379","author":"S Leucht","year":"2012","unstructured":"Leucht, S. et al. Antipsychotic drugs versus placebo for relapse prevention in schizophrenia: a systematic review and meta-analysis. Lancet 379, 2063\u201371 (2012).","journal-title":"Lancet"},{"key":"428_CR44","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1177\/070674370705200903","volume":"52","author":"A Cipriani","year":"2007","unstructured":"Cipriani, A., Geddes, J. R., Furukawa, T. A. & Barbui, C. Metareview on short-term effectiveness and safety of antidepressants for depression: an evidence-based approach to inform clinical practice. Can. J. Psychiatry 52, 553\u201362 (2007).","journal-title":"Can. J. Psychiatry"},{"key":"428_CR45","doi-asserted-by":"publisher","first-page":"c3222","DOI":"10.1136\/bmj.c3222","volume":"341","author":"B Runeson","year":"2010","unstructured":"Runeson, B., Tidemalm, D., Dahlin, M., Lichtenstein, P. & L\u00e5ngstr\u00f6m, N. Method of attempted suicide as predictor of subsequent successful suicide: national long term cohort study. BMJ 341, c3222 (2010).","journal-title":"BMJ"},{"key":"428_CR46","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1001\/jamapsychiatry.2014.1754","volume":"72","author":"RC Kessler","year":"2015","unstructured":"Kessler, R. C. et al. Predicting suicides after psychiatric hospitalization in US Army soldiers: the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). JAMA Psychiatry 72, 49\u201357 (2015).","journal-title":"JAMA Psychiatry"},{"key":"428_CR47","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1176\/appi.ajp.2016.16010077","volume":"174","author":"Y Barak-Corren","year":"2016","unstructured":"Barak-Corren, Y. et al. Predicting suicidal behavior from longitudinal electronic health records. Am. J. Psychiatry 174, 154\u201362 (2016).","journal-title":"Am. J. Psychiatry"},{"key":"428_CR48","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1176\/appi.ajp.2011.10111704","volume":"168","author":"K Posner","year":"2011","unstructured":"Posner, K. et al. The Columbia\u2013Suicide Severity Rating Scale: initial validity and internal consistency findings from three multisite studies with adolescents and adults. Am. J. Psychiatry 168, 1266\u201377 (2011).","journal-title":"Am. J. Psychiatry"},{"key":"428_CR49","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1037\/bul0000084","volume":"143","author":"JC Franklin","year":"2017","unstructured":"Franklin, J. C. et al. Risk factors for suicidal thoughts and behaviors: a meta-analysis of 50 years of research. Psychol. Bull. 143, 187\u2013232 (2017).","journal-title":"Psychol. Bull."}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41398-019-0428-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-019-0428-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-019-0428-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T10:26:27Z","timestamp":1671186387000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41398-019-0428-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,25]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["428"],"URL":"https:\/\/doi.org\/10.1038\/s41398-019-0428-3","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,25]]},"assertion":[{"value":"26 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"H.L. reports grants from Shire and has served as a speaker for Eli-Lilly and Shire outside of the submitted work. A.W. is employed by the Clinical Practice Research Datalink (CPRD), a division of the UK Medicines and Healthcare products Regulatory Agency (MHRA), but the views expressed in this publication are his own and do not represent the official position of either the CPRD or the MHRA. The remaining authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"98"}}