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It is likely that a multitude of mechanisms including neurogenesis, gliogenesis, synaptogenesis, angiogenesis, and vasculogenesis contribute to this volume increase. Neurotrophins, like vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF) seem to play a crucial mediating role in several of these mechanisms. We hypothesized that two regulatory SNPs in the <jats:italic>VEGF<\/jats:italic> and <jats:italic>BDNF<\/jats:italic> gene influence the changes in hippocampal volume following ECT. We combined genotyping and brain MRI assessment in a sample of older adults suffering from major depressive disorder to test this hypothesis. Our results show an effect of rs699947 (in the promotor region of <jats:italic>VEGF<\/jats:italic>) on hippocampal volume changes following ECT. However, we did not find a clear effect of rs6265 (in <jats:italic>BDNF<\/jats:italic>). To the best of our knowledge, this is the first study investigating possible genetic mechanisms involved in hippocampal volume change during ECT treatment.<\/jats:p>","DOI":"10.1038\/s41398-019-0530-6","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T13:00:58Z","timestamp":1566306058000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Hippocampal volume change following ECT is mediated by rs699947 in the promotor region of VEGF"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2989-6600","authenticated-orcid":false,"given":"Maarten J. 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